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Dermal Diagnosis™ | AOB Pregnancy Dermal Diagnosis™ | AOB Pregnancy Dermal Diagnosis™ | AOB Pregnancy Dermal Diagnosis™ | AOB Pregnancy
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Dermal Diagnosis™ | AOB Pregnancy

Treatment pack for Dermal Diagnosis: AOB during pregnancy

Sale price$241.74 Regular price$268.54

Cleanser size:

Cleanser size

Sunscreen:

Sunscreen

Anti-Acne

Anti-Acne

DNA repair

DNA repair

↓ Sebum

↓ Sebum

Anti-Aging

Anti-Aging

Skin Smoothing

Skin Smoothing



Free Gifts with your treatment pack:
Microfibre Sponge
Microfibre Sponge
Free with 175ml Cleanser
Cotton Bag
Cotton Bag
Dermal Diagnosis™ | AOB Pregnancy
Dermal Diagnosis™ | AOB Pregnancy Sale price$241.74 Regular price$268.54

MORNING

EVENING

It's a time of profound changes, not just in your life but in your body, including your skin. You're navigating the complex interplay of oily skin, signs of aging, and breakouts, which can become particularly pronounced due to the hormonal shifts that accompany pregnancy.

Oily skin during pregnancy can lead to a shinier complexion and may contribute to more frequent breakouts or exacerbate existing acne. These hormonal fluctuations can also accelerate certain aging processes in the skin, such as developing fine lines or losing firmness. Managing this combination requires a delicate balance, focusing on controlling excess oil while providing anti-aging benefits and addressing breakouts with safe, gentle ingredients.

For your oily and aging skin, it's crucial to use products that regulate oil production without stripping the skin of its natural moisture, which can trigger more oil production. Niacinamide is anexcellent ingredient for your skin type, as it can help regulate sebum production, minimize pores, and offer anti-aging benefits.

When dealing with breakouts, the key is to use gentle, effective treatments that won't irritate your skin or pose any risk during pregnancy. Ingredients like azelaic acid can be particularly helpful, as they have antibacterial properties that target acne-causing bacteria, reduce inflammation, and help fade post-acne marks without harsh side effects.

It's also important to incorporate a gentle, exfoliating step into your routine to help manage oiliness and prevent clogged pores, which can lead to breakouts. Safe concentrations of salicylic acid can gently exfoliate the skin, removing dead skin cells and excess oil.

Sun protection is non-negotiable, especially given the increased sensitivity to the sun that can come with pregnancy, and to help protect against UV damage and the potential for pregnancy-related pigmentation issues.

During this time, it's essential to approach your skincare routine with patience and kindness. Your body is doing the incredible work of supporting new life, and your skin may need some time to adjust.

Your treatment protocol should prioritize safety and efficacy, focusing on maintaining skin health and addressing aging concerns without compromising your or your baby's well-being. Always consult with your healthcare provider or a dermatologist if you are concerned about introducing new products into your skincare routine during your pregnancy.

Benefits of your AOB Pregnancy skin type
hydrated skin

hydrated skin

Even Skin Tone

Even Skin Tone

protective barrier

protective barrier

  • Natural Hydration: Your oily skin provides a natural layer of hydration, forming a protective barrier against environmental damage. This helps to keep the skin plump and potentially reduces the appearance of fine lines and wrinkles.

  • Protective Barrier: The excess sebum can act as a protective barrier against environmental aggressors, potentially reducing the impact of pollutants and other irritants.

  • Even Skin Tone: The lack of hyperpigmentation issues means that you enjoy a more consistent and even skin tone.

Barriers to your skin health
Acne Breakouts

Acne Breakouts

Sebum Control

Sebum Control

Enlarged Pores

Enlarged Pores

Congested Pores

Congested Pores

  • Breakouts and Acne: The propensity for clogged pores can lead to blackheads, whiteheads, and more severe forms of acne, which can be challenging to manage and may lead to scarring or post-inflammatory hyperpigmentation.

  • Sebum Control: Controlling excess oil and shine, especially in the T-zone area, can be a constant struggle, affecting the skin's overall appearance.

  • Enlarged pores: The excess oil production can lead to enlarged pores and increase the likelihood of blackheads, whiteheads, and acne, which can be challenging to manage alongside aging skin concerns.

  • Aging Skin: While oily skin may be more resilient to the formation of fine lines and wrinkles, addressing other signs of aging, such as loss of firmness or elasticity, can be complicated by the need to also manage oiliness and enlarged pores.

  • Inflammation: The inflammation associated with breakouts can accelerate skin aging, contribute to wrinkles, and cause skin to lose elasticity over time.

  • Product Selection: Identifying skincare and makeup products that address oiliness, prevent and treat breakouts, and tackle aging signs without irritating can be a complex task.

your frustrations

  • Breakouts, clogged pores and inflamed skin.
  • Oily and shiny skin with enlarged pores.
  • Premature skin aging.
  • Sensitive skin that reacts to various stimuli and products.

your goals

  • No breakouts or inflammation.
  • No stinging, itching, burning, or other skin discomforts.
  • Prevention and correction of premature skin aging, including lines and wrinkles.
  • Regulated sebum (oil) production with clear and minimized pores.

Aging . Oily . Breakouts During Pregnancy

treatment objectives

Reduce Inflammation
Reduce Inflammation

Down-regulate the inflammatory response, balance the skin microbiome and prevent bacterial infiltration.

Prevent premature aging
Prevent premature aging

Protect skin against environmental damage and premature aging. Prevent Collagen destruction by inhibiting free radical- and collagen destructive enzyme activity.

Clear Acne Breakouts
Clear Acne Breakouts

Reduce and eliminate breakouts by down-regulating the inflammatory response and balancing the skin microbiome.

Unclog pores
Unclog pores

Dissolve and extract cellular debris and prevent skin cells from clumping together in pores to ensure that the pores remain clear and free from blockages, which can lead to breakouts.

Regulate sebum
Regulate sebum

Balance oil production to minimize shine and reduce the likelihood of congestion and breakouts without stripping the skin of its natural oils.

Smooth skin texture
Smooth skin texture

Replace dull and dead skin cells with remodelled skin layers. Resurfacing procedures can induce new collagen formation with a more structured pattern.

include

  • Broad spectrum sunscreen with antioxidants - preventing premature aging and protecting DNA.
  • Chemical exfoliating ingredients that accelerate cell turnover and reveal new skin cells.
  • Sebum regulating and pore minimizing ingredients.
  • Skin identical medical-grade ingredients that penetrate the skin to activate a biological response.

avoid

  • Damaging lifestyle habits, e.g., smoking, tanning beds, excessive sun, and sugar consumption.
  • Toners and foaming cleansers containing soap & sulfates.
  • Fragrance in skincare products.
  • Harsh anti-bacterial products that disrupt the skin's natural microbiome.
  • Irritating plant extracts and essential oils that will trigger adverse reactions.

Aging . Oily . Breakouts During Pregnancy

Active Ingredients in your treatment

Glycolic acid

Glycolic acid is highly acclaimed for its remarkable exfoliating and rejuvenating properties. Its small molecular size enables deep skin penetration, fostering efficient exfoliation at the cellular level.

Glycolic acid’s water solubility allows it to penetrate the upper layers of the skin easily. Its primary mechanism of action involves weakening the bonds between dead skin cells, promoting their shedding, and revealing the newer, healthier skin beneath. This process of accelerated cell turnover is instrumental in addressing a range of skin concerns, from aging signs like fine lines and wrinkles to texture irregularities and hyperpigmentation.

Glycolic acid's efficacy extends beyond mere exfoliation. It's also recognized for stimulating collagen production, a crucial protein in maintaining skin's elasticity and firmness. This aspect contributes to its anti-aging benefits. Furthermore, its hydrating properties add to its appeal, as they help increase the skin's capacity to retain moisture, leading to a more supple and vibrant complexion.

Clinical studies have consistently supported glycolic acid's role in improving skin appearance. Research indicates significant improvements in skin texture and pigmentation and the visible reduction of wrinkles and fine lines with glycolic acid.


Physiological Effects

  • Exfoliation: Glycolic acid is a powerful exfoliant. It dissolves the bonds between dead skin cells on the skin’s surface, facilitating their removal and revealing newer, healthier skin underneath.
  • Increased Collagen Production: It stimulates collagen production, which is essential for skin elasticity and firmness. This action helps reduce the appearance of fine lines and wrinkles.
  • Enhanced Skin Hydration: Glycolic acid improves the skin's ability to retain moisture, enhancing hydration and a more plump, vibrant skin appearance.
  • Skin Brightening: Removing dead skin cells can brighten the complexion and reduce the appearance of dark spots and hyperpigmentation.
  • Improved Skin Texture: Regular use of glycolic acid can lead to smoother, more even textured skin, making it beneficial for conditions like keratosis pilaris.
  • Acne Treatment: Its exfoliating properties help in unclogging pores, thereby reducing the occurrence of acne breakouts.

Role in Managing Dermatological Conditions

  • Aging Skin: Glycolic acid is widely used in anti-aging products to reduce signs of aging, such as fine lines, wrinkles, and age spots.
  • Acne-Prone Skin: It helps manage acne by exfoliating the skin and removing blockage from pores.
  • Hyperpigmentation: It effectively treats hyperpigmentation by accelerating the removal of hyperpigmented skin cells.
  • Textural Irregularities: Glycolic acid can improve skin texture and is beneficial for treating keratosis pilaris and other conditions of rough skin.
  • Sun-Damaged Skin: It helps rejuvenate sun-damaged skin by accelerating cell turnover and collagen synthesis.

References

  • Bernstein, E. F. (2001). Glycolic acid treatment increases type I collagen mRNA and hyaluronic acid content of human skin. Dermatologic Surgery.
  • Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, Cosmetic and Investigational Dermatology.
  • Sharad, J. (2013). Glycolic acid peel therapy – a current review. Clinical, Cosmetic and Investigational Dermatology.
  • Smith, W. P. (1996). Epidermal and dermal effects of topical lactic acid. Journal of the American Academy of Dermatology, 35(3), 388-391.
Azelaic acid

Azelaic acid, a naturally occurring dicarboxylic acid, is an effective ingredient in dermatological treatments, particularly for acne, rosacea, and hyperpigmentation, with antimicrobial and anti-inflammatory properties.


Physiological Effects

  • Anti-Inflammatory Properties: Azelaic acid reduces inflammation, effectively treating inflammatory skin conditions like acne and rosacea.
  • Antimicrobial Action: It possesses antimicrobial properties that target acne-causing bacteria (Propionibacterium acnes), helping to reduce acne outbreaks.
  • Keratolytic Effects: It helps unclog pores and reduce the formation of comedones (black and whiteheads) by normalizing the shedding of skin cells.
  • Depigmenting Agent: Azelaic acid effectively treats hyperpigmentation disorders, including melasma, as it inhibits tyrosinase, an enzyme involved in melanin production.

Role in Managing Dermatological Conditions

  • Acne: Azelaic acid inhibits the proliferation of acne-causing bacteria on the skin’s surface, thereby reducing bacterial growth and inflammation. Its antibacterial activity is primarily against Propionibacterium acnes, a key bacterium involved in the development of acne. Furthermore, azelaic acid helps unclog pores and reduce skin cell buildup, effectively treating mild to moderate acne.
  • Rosacea: Azelaic acid's anti-inflammatory action helps to reduce redness and swelling associated with rosacea. In addition, azelaic acid's ability to reduce keratinization (the process by which skin cells become more fibrous and less flexible) contributes to its effectiveness in this condition.
  • Pigmentation: Azelaic acid effectively treats melasma and post-inflammatory hyperpigmentation by inhibiting tyrosinase, an enzyme in melanin production. This helps to reduce the formation of excess pigment and can lead to a more even skin tone.

References

  • Fitton, A., & Goa, K. L. (1991). Azelaic Acid. Drugs.
  • Gollnick, H., & Schramm, M. (1998). Topical drug treatment in acne. Dermatology.
  • Passeron, T., et al. (2019). Melasma treatment: A novel approach using a topical agent that contains an anti-estrogen and a low-dose retinoid. G Ital Dermatol Venereol.
  • Wolf, J. E., Kerrouche, N., & Arsonnaud, S. (2006). Efficacy and safety of once-daily metronidazole 1% gel compared with twice-daily azelaic acid 15% gel in the treatment of rosacea. Cutis, 77(4 Suppl), 3-11.
  • Hollinger, J. C., Angra, K., & Halder, R. M. (2018). Are natural ingredients effective in the management of hyperpigmentation? A systematic review. The Journal of clinical and aesthetic dermatology, 11(2), 28.
Bakuchiol

Bakuchiol's mechanism of action is similar to retinol's; it stimulates collagen production and accelerates cell turnover, improving skin texture and tone. It also helps reduce the appearance of fine lines, wrinkles, and hyperpigmentation, making it an effective ingredient in anti-aging skincare products.

One of the key advantages of bakuchiol over traditional retinol is its gentleness on the skin. Retinol is known for potential side effects like dryness, redness, and irritation, particularly in sensitive skin or when used in high concentrations. Bakuchiol, however, is far less irritating. In addition to its anti-aging properties, bakuchiol exhibits antioxidant and anti-inflammatory properties, further contributing to its skin benefits. It helps protect the skin from oxidative stress and can soothe it, reducing redness and inflammation.

Bakuchiol's retinol-like effects and its antioxidant, anti-inflammatory, and antibacterial properties make it an effective ingredient for various skin concerns, especially for those seeking natural alternatives in anti-aging and acne treatment.


Physiological Effects

  • Retinol-like Function: Bakuchiol mimics the actions of retinol, stimulating collagen production. This helps reduce the appearance of fine lines and wrinkles and improves skin elasticity.
  • Antioxidant Properties: It offers antioxidant benefits, protecting the skin from oxidative stress and damage caused by environmental factors like UV radiation.
  • Anti-inflammatory Effects: Bakuchiol has anti-inflammatory properties, which can help soothe the skin and reduce redness and irritation.
  • Improved Skin Tone and Texture: Regular use of bakuchiol can improve skin tone and texture, making it smoother and more even.
  • Acne Management: Bakuchiol's antibacterial properties and ability to regulate sebum production make it effective in managing acne.

Role in Managing Dermatological Conditions

  • Aging Skin: Bakuchiol is popular in anti-aging skincare because it stimulates collagen production and reduces signs of aging.
  • Sensitive Skin: As a gentler alternative to retinol, it is suitable for sensitive skin types that cannot tolerate traditional retinoids.
  • Acne-Prone Skin: Its antibacterial and anti-inflammatory properties are beneficial in acne treatments.
  • Hyperpigmentation: Bakuchiol can help treat hyperpigmentation, enhance skin radiance, and reduce dark spots.

References

  • Chaudhuri, R. K., & Bojanowski, K. (2014). Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. International Journal of Cosmetic Science.
  • Dhaliwal, S., et al. (2019). Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing. British Journal of Dermatology.
  • Sivamani, R. K., et al. (2019). Clinical efficacy of a bakuchiol, niacinamide and zinc pyrithione formulation in facial sebum control and mild acne. Journal of Cosmetic Dermatology.
Salicylic acid

Salicylic acid, a renowned beta hydroxy acid (BHA), is a cornerstone in dermatology and skincare due to its exceptional keratolytic and comedolytic properties. Its unique ability to penetrate oil-laden hair follicle pores makes it particularly effective in treating acne-prone and oily skin types.

Salicylic acid dissolves skin debris (sebum and dead skin cells) that clogs pores and causes acne. It's a mild antibacterial and powerful anti-inflammatory agent that helps reduce the redness and swelling associated with breakouts.

What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin, not just on the surface but within the pores themselves. This is due to its oil-soluble nature, which allows it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.

Furthermore, salicylic acid also has the capacity to adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions in terms of count and severity. Additionally, salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.


Physiological Effects

  • Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
  • Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
  • Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
  • Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
  • Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, effectively treating acne located deep within the pores.

Role in Managing Dermatological Conditions

  • Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effectively preventing and treating existing acne lesions.
  • Psoriasis: Its keratolytic properties make it helpful in softening and removing scales associated with psoriasis.
  • Warts: Salicylic acid is commonly used to treat warts because it can exfoliate and remove thick skin.
  • Seborrheic Dermatitis: It helps manage seborrheic dermatitis by reducing scaling and redness.
  • Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with keratosis pilaris.

References

  • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
  • Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
  • Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
  • Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.
Aloe Vera

Aloe vera is well-regarded for its medicinal applications and has been a staple in skincare and health for centuries. It’s rich in vitamins, enzymes, minerals, and amino acids, contributing to its many skin benefits.

Aloe vera contains polysaccharides, which are crucial in its moisturizing and anti-inflammatory properties. These polysaccharides help bind moisture to the skin, making aloe vera an excellent hydrating agent for dry and damaged skin.

One of the key benefits of aloe vera is its soothing and healing properties, particularly beneficial for burns, abrasions, and skin irritations. It has been shown to accelerate the healing of minor burns and reduce skin inflammation. Various studies have supported its effectiveness in treating first- and second-degree burns, highlighting its role in enhancing collagen synthesis and skin regeneration.

Aloe vera's anti-inflammatory properties are attributed to compounds like glycoproteins and polysaccharides. These compounds help reduce pain and swelling associated with skin irritations and wounds. Aloe vera also contains aloin and emodin, which provide analgesic, antibacterial, and antiviral properties, further extending its therapeutic potential.

Aloe Vera has numerous physiological effects on the skin due to its rich composition of vitamins, enzymes, minerals, and amino acids. The presence of antioxidants such as vitamins C and E, along with beta-carotene, contributes to its anti-aging benefits, helping to improve skin firmness and keep the skin hydrated.


Physiological Effects

  • Moisturizing and Hydrating: Aloe Vera enhances skin hydration, making it effective for dry and dehydrated skin. Its mucopolysaccharides help to bind moisture into the skin.
  • Wound Healing: It accelerates wound healing by enhancing collagen synthesis and cross-linking. This effect is particularly useful in healing burns, abrasions, and cuts.
  • Anti-inflammatory Properties: Aloe Vera contains compounds like aloin and anthraquinones that have anti-inflammatory properties, making it beneficial in reducing skin inflammation.
  • Antimicrobial Activity: It possesses antimicrobial properties, which help in preventing infections in wounds and burns.
  • Antioxidant Properties: The presence of vitamins C and E and beta-carotene provides it with antioxidant properties, which can help protect the skin from free radical damage.
  • Soothing Effect: Aloe Vera is known for its soothing effects on the skin, particularly in conditions like sunburn.

Role in Managing Dermatological Conditions

  • Burns and Wound Care: Aloe Vera's wound-healing and soothing properties make it effective in treating burns, including sunburns and minor skin abrasions.
  • Acne Treatment: Due to its antimicrobial and anti-inflammatory properties, it can help treat acne.
  • Eczema and Psoriasis: Its moisturizing, anti-inflammatory, and soothing properties are beneficial in managing symptoms of eczema and psoriasis.
  • Aging Skin: Aloe Vera's antioxidant properties and ability to improve collagen production can help reduce the signs of aging.
  • Skin Hydration: It's a common ingredient in moisturizers and other skin care products for its hydrating properties.

References

  • Surjushe, A., Vasani, R., & Saple, D. G. (2008). Aloe vera: A short review. Indian Journal of Dermatology.
  • Maenthaisong, R., Chaiyakunapruk, N., Niruntraporn, S., & Kongkaew, C. (2007). The efficacy of aloe vera used for burn wound healing: A systematic review. Burns.
  • Rajeswari, R., Umadevi, M., Rahale, C. S., Pushpa, R., Selvavenkadesh, S., Kumar, K. S., & Bhowmik, D. (2012). Aloe vera: The miracle plant its medicinal and traditional uses in India. Journal of Pharmacognosy and Phytochemistry.
Niacinamide

Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.

Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.

Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.


Physiological Effects

  • Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
  • Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
  • Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
  • Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
  • Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
  • Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.

Role in Managing Dermatological Conditions

  • Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
  • Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
  • Aging Skin: Niacinamide targets wrinkles and loss of firmness.
  • Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
  • Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.

References

  • Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
  • Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
  • Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
  • Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.
Alpha Arbutin

Alpha Arbutin is a derivative of hydroquinone and a biosynthetic active ingredient. Its primary action is inhibiting tyrosinase, a key enzyme involved in the synthesis of melanin, the pigment responsible for skin color. Alpha Arbutin effectively reduces melanin production in the skin by inhibiting tyrosin activity. This gradually lightens hyperpigmented areas, such as age spots, melasma, and scars, resulting in a more even skin tone.

One of the significant advantages of Alpha Arbutin over other skin-lightening agents is its safety profile. Unlike hydroquinone, which has been associated with potential side effects and is restricted in many countries, Alpha Arbutin is considered safe and less irritating to the skin, even at higher concentrations. This makes it a suitable ingredient for all skin types, including sensitive skin.

In addition to its skin-lightening properties, Alpha Arbutin has also shown antioxidant effects, helping to protect the skin from oxidative stress caused by environmental factors like UV radiation and pollution.


Physiological Effects

  • Melanin Inhibition: Alpha Arbutin works by inhibiting tyrosinase, the enzyme responsible for melanin production in the skin. This action reduces the formation of melanin, leading to a lightening of skin pigmentation.
  • Even Skin Tone: Regular use of alpha arbutin can lead to a more even skin tone overall, reducing the appearance of age spots and hyperpigmentation.
  • Reduced Skin Discoloration: It effectively reduces the appearance of dark spots and areas of hyperpigmentation, such as those caused by acne, sun damage, or hormonal changes.
  • Safer Alternative to Hydroquinone: While structurally similar to hydroquinone, alpha arbutin is a safer option with a lower risk of side effects.

Role in Managing Dermatological Conditions

  • Hyperpigmentation: Alpha arbutin treats melasma, sun spots, and post-inflammatory hyperpigmentation from acne.
  • Skin Brightening: Provide a more radiant and uniform skin tone.
  • Anti-Aging: Reduce the appearance of age-related spots and uneven skin tone.
Vitamin E

The fat-soluble Vitamin E's benefits in maintaining skin health and appearance are well-acknowledged in both cosmetic and clinical dermatology. Comprising a group of eight compounds, including four tocopherols and four tocotrienols, Vitamin E is known for its role in protecting cell membranes from oxidative damage.

Vitamin E is celebrated in skincare for its ability to neutralize free radicals caused by environmental stressors such as UV radiation and pollution. These free radicals can lead to premature skin aging, making Vitamin E a valuable ingredient in anti-aging skincare products. Its antioxidant action helps to protect the skin from damage, reduce the appearance of wrinkles, and improve skin texture and tone.

Additionally, Vitamin E is known for its moisturizing benefits. It helps to strengthen the skin barrier, reduce moisture loss, and keep the skin hydrated and supple. This makes it especially beneficial for dry and damaged skin.

Vitamin E also has anti-inflammatory properties, making it beneficial in soothing and calming irritated skin. This has implications for conditions such as dermatitis and acne, where inflammation plays a key role.


Physiological Effects

  • Antioxidant Protection: Vitamin E neutralizes harmful free radicals in the skin, preventing oxidative stress and damage caused by environmental factors like UV radiation and pollution.
  • Moisturization: It has moisturizing properties, helping to improve skin hydration and alleviate dryness.
  • Wound Healing: Vitamin E may assist in the skin's healing process, although its efficacy in wound healing is still a subject of research.
  • Photoprotection: While not a sunscreen, it can provide some degree of photoprotection by strengthening the skin's defense against UV-induced damage.
  • Anti-Inflammatory Effects: It helps reduce skin inflammation and is beneficial in managing conditions like eczema and psoriasis.

Role in Managing Dermatological Conditions

  • Skin Aging: Its antioxidant properties make it useful in anti-aging skincare products to protect against free radical damage and improve skin appearance.
  • Dry Skin Conditions: Vitamin E's moisturizing effects are beneficial in treating dry skin and improving overall skin texture.
  • Inflammatory Skin Diseases: It can be helpful in soothing inflammatory skin conditions like eczema and psoriasis.
  • Sun Protection and Repair: Vitamin E is included in sunscreens and after-sun products for its ability to mitigate sun damage.
  • Scar Treatment: Some studies suggest Vitamin E may help reduce the appearance of scars, although evidence is mixed.

References

  • Thiele, J. J., Hsieh, S. N., & Ekanayake-Mudiyanselage, S. (1998). Vitamin E: Critical Review of Its Current Use in Cosmetic and Clinical Dermatology. Dermatologic Surgery, 24(7), 805–813.
  • Ratz-Łyko, A., & Arct, J. (2016). Anti-inflammatory and anti-aging properties of active skin care ingredients. Journal of Clinical and Aesthetic Dermatology, 9(9), 36–40.
  • Keen, M. A., & Hassan, I. (2016). Vitamin E in dermatology. Indian Dermatology Online Journal.
  • Ekanayake-Mudiyanselage, S., & Thiele, J. (2007). Vitamin E in human skin: Organ-specific physiology and considerations for its use in dermatology. Molecular Aspects of Medicine.
  • Nachbar, F., & Korting, H. C. (1995). The role of vitamin E in normal and damaged skin. Journal of Molecular Medicine.
Coenzyme Q10

CoQ10 is a potent ingredient that offers comprehensive skin health and appearance benefits. Its role in energy production and its antioxidant and anti-aging properties make it invaluable for photoprotection, anti-aging, and overall skin vitality. Its incorporation into DermExcel sunscreen represents a holistic approach to skin health, addressing protective and restorative needs.


Physiological Impact

  • Skin Barrier Enhancement: CoQ10 contributes to the strength and health of the skin barrier, improving its ability to retain moisture and protect against external irritants and pollutants.
  • Skin Repair and Regeneration: It supports the skin's natural ability to repair itself and regenerate, maintaining a healthy, youthful appearance. This is particularly beneficial in mature skin, where natural levels of CoQ10 may be depleted.

Pharmacological Advantages

  • Anti-Aging Effects: CoQ10's antioxidant properties contribute to its anti-aging effects. By reducing oxidative stress, it helps to minimize the visible signs of aging, such as wrinkles and fine lines.
  • Photoprotection: It enhances the skin's defense against photoaging caused by exposure to UV rays. CoQ10 helps to mitigate the degradation of collagen and elastin, proteins essential for maintaining skin elasticity and firmness.

Biochemical Benefits

  • Cellular Energy Production: CoQ10 plays a crucial role in the mitochondrial electron transport chain, which is essential for the production of ATP, the primary energy currency of the cell. This function is vital for maintaining the health and vitality of skin cells.
  • Antioxidant Properties: It acts as a lipophilic antioxidant, neutralizing free radicals and preventing oxidative damage to cell membranes, proteins, and DNA. This is particularly important in the skin, which is frequently exposed to oxidative stress from environmental factors like UV radiation.
Sunscreen

Using sunscreen is a fundamental aspect of skin care and preventive dermatology. It's essential for reducing the risk of skin cancers and photoaging and maintaining overall skin health in the face of constant exposure to UV radiation.

Sunscreen is a vital skincare product designed to protect the skin from the harmful effects of ultraviolet (UV) radiation from the sun. Two primary types of UV radiation affect the skin: UVA and UVB. UVA rays penetrate deep into the skin and are primarily responsible for aging and long-term skin damage, whereas UVB rays cause sunburn and play a key role in developing skin cancer.

Sunscreen products work by either absorbing, reflecting, or scattering sunlight. They contain chemical compounds that absorb UV radiation and convert it into a small amount of heat or physical compounds (like zinc oxide or titanium dioxide) that act as a physical barrier, reflecting UV light away from the skin.

The effectiveness of sunscreen is measured by its Sun Protection Factor (SPF). SPF indicates how well the sunscreen protects against UVB rays. For example, an SPF of 30 means it would take 30 times longer for your skin to burn than without sunscreen. However, it's important to note that no sunscreen can block 100% UV rays.

Regular use of sunscreen with an SPF of at least 30 can reduce the risk of skin cancer, prevent sunburn, and slow down the skin's aging process.


Role in Managing Dermatological Conditions

Prevention of Sunburn
  • UVB Protection: Sunscreen protects the skin from UVB rays, which cause sunburn. This reduces the immediate risk of skin damage and discomfort.
Skin Cancer Prevention
  • Reduces Risk of Skin Cancers: Regular use of sunscreen significantly lowers the risk of developing various types of skin cancer, especially melanoma, squamous cell carcinoma, and basal cell carcinoma.
Prevention of Photoaging
  • UVA Protection: Sunscreen also shields the skin from UVA rays, which penetrate deeper into the skin and are primarily responsible for photoaging, including wrinkles, leathery skin, and sunspots.
Protection Against Photosensitivity
  • Essential for Sensitive Skin Conditions: Sunscreen helps prevent flare-ups triggered by sun exposure for individuals with photosensitive skin conditions like lupus or rosacea.
Hyperpigmentation and Melasma
  • Even Skin Tone: It aids in preventing and managing hyperpigmentation and melasma, conditions exacerbated by sun exposure.
General Skin Health
  • Maintains Skin Health: Sunscreen helps maintain overall skin health and integrity by protecting the skin from UV damage.

References

  • Burnett, M. E., & Wang, S. Q. (2011). Current sunscreen controversies: a critical review. Photodermatology, Photoimmunology & Photomedicine.
  • Green, A. C., et al. (2011). Reduced melanoma after regular sunscreen use: randomized trial follow-up. Journal of Clinical Oncology.
  • Hughes, M. C. B., et al. (2013). Sunscreen and Prevention of Skin Aging: A Randomized Trial. Annals of Internal Medicine.

Aging . Oily . Breakouts During Pregnancy

products in your treatment pack

cleanse

cleanse


Unclog Pores

Unclog Pores

Minimize Pores

Minimize Pores

Anti-Acne

Anti-Acne

anti-redness

anti-redness

↓ inflammation

↓ inflammation

Scientifically formulated, this skincare solution regulates sebum production and alleviates pore congestion. With a 3% concentration of Salicylic acid, it reduces skin irritation and redness and effectively cleanses impurities. It also includes Medical-Grade Aloe Vera for soothing and hydrating effects, ideal for dehydrated skin from acne treatments.

Pore Control Cleanser is a balanced blend of ingredients that normalize oil production, dislodge sebum plugs, reduce inflammation, and nourish the skin, promoting a clear and healthy complexion.


Salicylic acid

Salicylic acid, a renowned beta hydroxy acid (BHA), is a cornerstone in dermatology and skincare due to its exceptional keratolytic and comedolytic properties. Its unique ability to penetrate oil-laden hair follicle pores makes it particularly effective in treating acne-prone and oily skin types.

Salicylic acid dissolves skin debris (sebum and dead skin cells) that clogs pores and causes acne. It's a mild antibacterial and powerful anti-inflammatory agent that helps reduce the redness and swelling associated with breakouts.

What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin, not just on the surface but within the pores themselves. This is due to its oil-soluble nature, which allows it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.

Furthermore, salicylic acid also has the capacity to adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions in terms of count and severity. Additionally, salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.


Physiological Effects

  • Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
  • Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
  • Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
  • Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
  • Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, effectively treating acne located deep within the pores.

Role in Managing Dermatological Conditions

  • Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effectively preventing and treating existing acne lesions.
  • Psoriasis: Its keratolytic properties make it helpful in softening and removing scales associated with psoriasis.
  • Warts: Salicylic acid is commonly used to treat warts because it can exfoliate and remove thick skin.
  • Seborrheic Dermatitis: It helps manage seborrheic dermatitis by reducing scaling and redness.
  • Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with keratosis pilaris.

References

  • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
  • Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
  • Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
  • Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.
Aloe Vera

Aloe vera is well-regarded for its medicinal applications and has been a staple in skincare and health for centuries. It’s rich in vitamins, enzymes, minerals, and amino acids, contributing to its many skin benefits.

Aloe vera contains polysaccharides, which are crucial in its moisturizing and anti-inflammatory properties. These polysaccharides help bind moisture to the skin, making aloe vera an excellent hydrating agent for dry and damaged skin.

One of the key benefits of aloe vera is its soothing and healing properties, particularly beneficial for burns, abrasions, and skin irritations. It has been shown to accelerate the healing of minor burns and reduce skin inflammation. Various studies have supported its effectiveness in treating first- and second-degree burns, highlighting its role in enhancing collagen synthesis and skin regeneration.

Aloe vera's anti-inflammatory properties are attributed to compounds like glycoproteins and polysaccharides. These compounds help reduce pain and swelling associated with skin irritations and wounds. Aloe vera also contains aloin and emodin, which provide analgesic, antibacterial, and antiviral properties, further extending its therapeutic potential.

Aloe Vera has numerous physiological effects on the skin due to its rich composition of vitamins, enzymes, minerals, and amino acids. The presence of antioxidants such as vitamins C and E, along with beta-carotene, contributes to its anti-aging benefits, helping to improve skin firmness and keep the skin hydrated.


Physiological Effects

  • Moisturizing and Hydrating: Aloe Vera enhances skin hydration, making it effective for dry and dehydrated skin. Its mucopolysaccharides help to bind moisture into the skin.
  • Wound Healing: It accelerates wound healing by enhancing collagen synthesis and cross-linking. This effect is particularly useful in healing burns, abrasions, and cuts.
  • Anti-inflammatory Properties: Aloe Vera contains compounds like aloin and anthraquinones that have anti-inflammatory properties, making it beneficial in reducing skin inflammation.
  • Antimicrobial Activity: It possesses antimicrobial properties, which help in preventing infections in wounds and burns.
  • Antioxidant Properties: The presence of vitamins C and E and beta-carotene provides it with antioxidant properties, which can help protect the skin from free radical damage.
  • Soothing Effect: Aloe Vera is known for its soothing effects on the skin, particularly in conditions like sunburn.

Role in Managing Dermatological Conditions

  • Burns and Wound Care: Aloe Vera's wound-healing and soothing properties make it effective in treating burns, including sunburns and minor skin abrasions.
  • Acne Treatment: Due to its antimicrobial and anti-inflammatory properties, it can help treat acne.
  • Eczema and Psoriasis: Its moisturizing, anti-inflammatory, and soothing properties are beneficial in managing symptoms of eczema and psoriasis.
  • Aging Skin: Aloe Vera's antioxidant properties and ability to improve collagen production can help reduce the signs of aging.
  • Skin Hydration: It's a common ingredient in moisturizers and other skin care products for its hydrating properties.

References

  • Surjushe, A., Vasani, R., & Saple, D. G. (2008). Aloe vera: A short review. Indian Journal of Dermatology.
  • Maenthaisong, R., Chaiyakunapruk, N., Niruntraporn, S., & Kongkaew, C. (2007). The efficacy of aloe vera used for burn wound healing: A systematic review. Burns.
  • Rajeswari, R., Umadevi, M., Rahale, C. S., Pushpa, R., Selvavenkadesh, S., Kumar, K. S., & Bhowmik, D. (2012). Aloe vera: The miracle plant its medicinal and traditional uses in India. Journal of Pharmacognosy and Phytochemistry.

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