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Dermdefence SPF 50

Sale price$35.00 USD

SIZE: 50 mL

Dermdefence SPF 50 is a pioneering sunscreen offering superior protection against the sun while preserving your skin's cellular and DNA health. The innovative formula exceeds standard UV protection, guarding against UVA, UVB, damaging infrared rays, and blue light. Offering wide-ranging protection bolsters your skin's restorative abilities, promoting a healthier and more resilient complexion.

This sunscreen stands out with its ability to halt the formation of UV radiation-induced free radicals, known to expedite skin aging and cause various skin conditions. By reducing UV-caused erythema, it actively fights visible aging signs. Dermdefence SPF 50 also contains antioxidants, Tinosorb S, Glycerin, and Squalane, making it an excellent choice for those with skin conditions like Acne, Rosacea, or Eczema.

Designed to be fragrance-free and anti-comedogenic, Dermdefence SPF 50 ensures no skin irritation or pore clogging. Its lightweight, non-greasy texture provides easy application and rapid absorption, without leaving a white cast.

Dermdefence SPF 50 also serves as a primer, providing a smooth finish for easy makeup application and ensuring a flawless look all day. Dermdefence SPF 50 provides unparalleled sun protection that will shield your skin and nurture its unique needs, maintaining its health and radiance.

UVA Filters

Neo Heliopan® 357, commonly known as Avobenzone offers significant benefits from biochemical, pharmacological, and physiological perspectives:

Biochemical Benefits
  • UVA Absorption: It functions by absorbing UVA radiation, particularly in the 320-400 nm range, which includes both UVA1 and UVA2 rays. Biochemically, it absorbs high-energy UVA photons and releases the energy as lower-energy photons, thereby preventing the UV radiation from penetrating deeper into the skin and causing cellular damage.
  • Prevention of Photoaging: By absorbing UVA rays, it helps prevent the biochemical processes that lead to photoaging, such as degradation of collagen and elastin, which are vital for maintaining skin structure and elasticity.
Pharmacological Advantages
  • Protection Against Long-Term Skin Damage: Help to protect the skin from long-term damage such as photoaging, hyperpigmentation, and the development of certain types of skin cancer associated with UVA exposure.
  • Synergistic Effect: Often used in combination with other UVB and UVA filters, it contributes to a broad-spectrum protection profile, enhancing the overall efficacy of sunscreen.
Physiological Impact
  • Skin Aging Prevention: Protects the skin from UVA radiation and minimizing the signs of aging caused by UVA-induced damage.
  • Enhanced Skin Health: By filtering out harmful UVA rays, it aids in maintaining overall skin health, preventing the breakdown of DNA in skin cells, and reducing oxidative stress.
Coenzyme Q10

CoQ10 is a potent ingredient that offers comprehensive benefits for skin health and appearance. Its role in energy production, combined with its antioxidant and anti-aging properties, makes it an invaluable for photoprotection, anti-aging, and overall skin vitality. Its incorporation into DermExcel sunscreen represents a holistic approach to skin health, addressing both protective and restorative needs.

Biochemical Benefits
  • Cellular Energy Production: CoQ10 plays a crucial role in the mitochondrial electron transport chain, which is essential for the production of ATP, the primary energy currency of the cell. This function is vital for maintaining the health and vitality of skin cells.
  • Antioxidant Properties: It acts as a lipophilic antioxidant, neutralizing free radicals and preventing oxidative damage to cell membranes, proteins, and DNA. This is particularly important in the skin, which is frequently exposed to oxidative stress from environmental factors like UV radiation.
Pharmacological Advantages
  • Anti-Aging Effects: CoQ10's antioxidant properties contribute to its anti-aging effects. By reducing oxidative stress, it helps to minimize the visible signs of aging, such as wrinkles and fine lines.
  • Photoprotection: It enhances the skin's defense against photoaging caused by exposure to UV rays. CoQ10 helps to mitigate the degradation of collagen and elastin, proteins essential for maintaining skin elasticity and firmness.
Physiological Impact
  • Skin Barrier Enhancement: CoQ10 contributes to the strength and health of the skin barrier, improving its ability to retain moisture and protect against external irritants and pollutants.
  • Skin Repair and Regeneration: It supports the skin's natural ability to repair itself and regenerate, maintaining a healthy, youthful appearance. This is particularly beneficial in mature skin, where natural levels of CoQ10 may be depleted.
DermExcel™ | Dermdefence SPF 50
Dermdefence SPF 50 Sale price$35.00 USD
  • Sun Protection: To provide broad-spectrum protection against UVA, UVB, infrared rays, and blue light, safeguarding your skin's cellular and DNA health.
  • Anti-Aging: To prevent UV radiation-induced free radicals and reduce UV-induced redness, contributing to skin aging.
  • Sensitive Skin Conditions: Suitable for skin conditions like Acne, Rosacea, or Eczema as it's non-irritating and won't clog pores.
  • Daily Moisturizing: Suitable for daily use to keep skin moisturized and protected.
  • Primer Before Makeup: Can be used as a primer, providing a smooth base for makeup application.
  • Skin Comfort: For those seeking a sunscreen that is lightweight and easy to apply, absorbing quickly without leaving any white residue.

Dermdefence SPF 50 Guidelines for Optimal Results:

  • Begin your day with Dermdefence SPF 50: Apply it evenly across all sun-exposed areas every morning to safeguard your skin against the harmful effects of sun exposure.
  • Persistence is key: During prolonged sun exposure, it's crucial to reapply as needed to maintain its protective barrier.
  • Prioritize skin integrity: Avoid applying sunscreen on damaged or broken skin. The product is designed for healthy skin and may cause discomfort or adverse reactions in compromised areas.
  • Protect your eyes: Be mindful when applying around the eye area. If applied too close, it may cause watering or stinging. If this occurs, rinse thoroughly with water and if the problem persists, consult your healthcare provider.

Active ingredients

  • UVA Filters
  • Coenzyme Q10

Full ingredient list

Aqua, Octyl methoxycinnamate (Uvinul® MC 80), Butyl methoxydibenzoylmethane (Avobenzone), Propylene glycol, Ethylhexyl salicylate (Octisalate), Cetyl alcohol, Glycerine, Sorbitan mono stearate, Polysorbate 20, Bis-ethylhexyloxyphenol, Methoxyphenyl triazine (Tinosorb S), Homosalate, Squalane, Ubiquinone, Phenoxyethanol, Ethylhexyl glycerine, Tocopherol (Vitamin E), Triethanolamine, Dimethicone, Acrylate crosspolymer, Disodium EDTA

Dermdefence SPF 50


Lightweight & Absorbent

A lightweight, non-greasy texture for easy application and swift absorption without leaving a white cast.


Prevents formation of UV radiation-induced free radicals and reduces UV-caused redness, effectively combating signs of aging.

DNA Damage Protection

Guards against harmful UVA, UVB, infrared rays, and blue light, protecting your skin's cellular and DNA integrity.

Makeup Primer

Acts as an effective primer, offering a smooth base for effortless makeup application, ensuring a flawless look all day.


Fragrance-free and anti-comedogenic, ensuring no skin irritation or pore clogging, making it suitable for sensitive skin.

Intensive Moisturization

The formula provides hydration, helping to maintain the skin's moisture balance, leaving it soft and supple throughout the day.

Dermdefence SPF 50


Dermdefence SPF 50

3 products in 1

1. Broad-Spectrum Sunscreen

2. Make-up Primer ensuring a flawless look all day

3. Hydrating Antioxidant Moisturizer

SPF Card



Customer Reviews

Based on 743 reviews
Sharise Janse van Rensburg
Best SPF 50

Just love the Dermdefence SPF 50! It really works. The best SPF I’ve ever used.

Lynnette Jooste

Daars nie n dag wat ek spyt is dat ek jul produk gebruik nie. Sal nie eers oorweeg om ander produk te gebruik nie. Is baie tevrede. Jul diens is puik.

Anneen Henze
Dermatint, and absolute must!

My favourite product! My go-to for an extra glow all day. The coverage is incredible

Tenisha Beyl

Never ever using another foundation again! This product is amazing!!!

Erika Schoeman
Clear, Bright Skin

Thank you for such an amazing skin care range!

Chantal van heerden

Amazing product! Foundation, sunscreen and moisturizer all in 1 product. Very convenient!




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