Inflacin serum

Regulate sebum (oil) production and excretion

SALICYLIC ACID; NIACINAMIDE; ZINC PCA; RETINOL

• The excretion of lipids by the sebaceous glands is controlled hormonally.
• The sebaceous glands are located all over the body but are the largest and most numerous in the face, back, chest, and shoulders.
• These glands become more active during puberty because of increased androgens, particularly testosterone, which spurs sebum production.
• This imbalance between sebum production and secretion capacity leads to a blockage of sebum in the hair follicle, followed by inflammation.
• Hormones continue to affect sebaceous gland activity into adulthood.

All main active ingredients in Inflacin serum contribute to sebum regulation.

Prevent dead skin cells and oil build-up in the pores

SALICYLIC ACID; RETINOL

• The first stage of acne is also known as comedogenesis (formation of comedones).
• The exfoliated dead skin cells stick together inside the hair follicle, resulting in a clogged pore or comedone. 
• This is caused by several factors, including:
  

• Increased amounts of sebum.
• Inflammation of the sides of the hair follicle prevents the release of the exfoliated keratinocytes.
• Increased cohesion of keratinocytes.

Retinol reduces skin cells' positive and negative charges, making them less "sticky."

Salicylic acid decongests pores by dissolving and extracting dirt, oil, and cell debris in pores and follicles.

Prevent bacterial infiltration

SALICYLIC ACID; NIACINAMIDE; ZINC PCA; RETINOL

• The keratinocyte plug and sebum are excellent food sources for bacteria.
• The bacteria invade the comedone and release inflammatory factors that lead to the next stage of acne.

All main active ingredients in Inflacin serum contribute to preventing and treating bacterial infiltration.

Down-regulate the inflammatory response

SALICYLIC ACID; NIACINAMIDE; ZINC PCA; RETINOL

• Inflammation continues with increased redness and pus.
• This is clinically detectable as a papule or pustule.
• Continued inflammation may lead to so much inflammation that the hair follicle ruptures and the bacteria and debris are released into the dermis.
• When severe, this can lead to scarring.

All main active ingredients in Inflacin serum contribute to down-regulation of the inflammatory response.

A constant interplay exists among the skin, micro-organisms, and the environment to maintain a delicate balance. Disturbance of this balance negatively influences both the microflora and skin health.

In Rosacea, the micro-environment of the affected skin is substantially altered, resulting in a shift in the proportion or speciation of the resident microflora. Several micro-organisms have been shown to be increased or immuno-reactive in patients with rosacea.

Or skin contains pattern recognition receptors (PPR). These receptors detect harmful bacteria on our skin. When they detect these harmful bacteria, they bind to them and activate an immune response.

Receptors (PPR) don't activate the immune response for normal micro-flora on our skin. Rosacea-prone skin receptors (PPR) are hyper-reactive and/or have decreased tolerance. They have heightened sensitivity and trigger the inflammatory response of normal microbes, leading to the initial signs of rosacea.

This inflammatory environment leads to increased leucocyte and cathelicidin expression (anti-microbial peptide), causing certain normal microbes to be eliminated.

With normal flora out of the way, the opportunity arise for the overgrowth of other microbes to fill the space of the eliminated normal flora. The normal microbes' balance gets disturbed.

Alterations in the micro-flora create a further imbalance that further elevates the inflammation process.

This leads to the worsening of the disease, and symptoms become more severe.

SALICYLIC ACID

Anti-inflammatory: Decrease the inflammation process which leads to breakouts, redness, and skin damage.

Anti-microbial: Inhibits the production of various aspects necessary for bacterial reproduction.

Keratolytic and Comedolytic: Decongests pores by dissolving and extracting dirt, oil, and cellular debris in the pores and follicles. Disrupts cellular junctions to exfoliate dead skin cells.

Sebum(oil) regulator: Balance sebum levels by penetrating deep inside the pores.

RETINOL

Anti-inflammatory: Suppresses pro-inflammatory cytokine expression. It is a potent anti-inflammatory agent able to control leukocytic functions.

Anti-bacterial: Significant antibacterial activities against Gram-positive and Gram-negative bacteria.

Anti-keratinizing: Inhibits skin cells (keratinocytes) from abnormally multiplying.

Sebum (oil) regulator: Reduce sebaceous glands activity, leading to less pore-clogging and potentially less oil production.

NIACINAMIDE

Anti-inflammatory: Reduce the inflammatory response by inhibiting inflammatory messengers.

Anti-microbial: Provides long-lasting protection against bacteria by activating an anti-microbial peptide response.

Sebum (oil) regulator: Regulate / Balance sebum (oil) production, preventing bacterial growth and inflammation.

Antioxidant: Prevent DNA damage and activation of inflammatory enzymes.

ZINC PCA

Anti-inflammatory: Inhibits mast cell degranulation and thereby reduces histamine secretion, an important mediator of inflammatory response.

Anti-bacterial: The topical application of Zinc PCA hinders microbial growth. It possesses antiseptic properties that limit the proliferation of acne-causing bacteria in the skin.

Sebum (oil) regulator: Inhibits the activity of the 5 alpha-reductase enzymes to control excessive sebum production.