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Sale price$45.00 USD

SIZE: 50 mL

DermNourish™, a meticulously crafted formula, aids in hydrating parched, sensitive, or impaired skin, replenishing much-needed moisture. It provides a robust shield, fortifying skin's barrier function and alleviating the discomfort of dry, distressed, and post-procedural skin.

Non-acnegenic, free from fragrances and colorants, DermNourish™ aims to minimize potential irritations and contact dermatitis. Key components include DuraQuench™ IQ SA and Niacinamide, both beneficial for skin's moisture retention and barrier fortification, and D-Panthenol, which soothes skin. Tocopherol, an antioxidant, protects against environmental stressors, while Sodium Hyaluronate bolsters skin hydration. DermNourish™ represents an advanced skin nourishment approach.


Emollients are crucial in dermatological care, primarily because they enhance skin hydration and barrier function. Here's a brief overview of their physiological effects and roles in managing various skin conditions.


d-Panthenol's multifaceted effects on skin hydration, barrier strengthening, and wound healing make it a valuable component in the management of various dermatological conditions, from dry skin to post-procedure care.

d-Panthenol, also known as pro-vitamin B5, is a popular dermatological ingredient due to its beneficial effects on the skin. Here's a brief overview of its physiological effects and roles in managing various skin conditions:

Physiological Effects of d-Panthenol:
  1. Hydration: d-Panthenol is a humectant, meaning it helps to attract and retain moisture in the skin. This leads to increased skin hydration, which can improve skin softness and elasticity.
  2. Wound Healing and Repair: It plays a role in the synthesis of lipids and proteins, essential for skin repair. d-Panthenol has been shown to accelerate re-epithelialization in wound healing.
  3. Anti-Inflammatory Effect: d-Panthenol can reduce inflammation, making it beneficial in treating skin irritations and erythema.
  4. Skin Barrier Strengthening: By enhancing the synthesis of lipids and proteins, d-Panthenol contributes to the strengthening of the skin's barrier function, protecting against irritants and environmental damage.
  5. Soothing and Softening: It soothes the skin and makes it feel softer and smoother, which can be particularly beneficial for dry or rough skin textures.
Role in Managing Dermatological Conditions:
  1. Minor Wounds and Skin Irritations: Due to its role in skin repair and anti-inflammatory properties, d-Panthenol is used in the treatment of minor wounds, cuts, and skin irritations.
  2. Dermatitis and Eczema: It helps in managing conditions like dermatitis and eczema by reducing inflammation and enhancing skin barrier function.
  3. Dry Skin Conditions (Xerosis): Its moisturizing properties make it effective in treating dry skin, providing relief from itching and scaling.
  4. Post-procedure Care: d-Panthenol is often used in post-procedure care, such as after laser treatments or chemical peels, to aid in skin recovery and reduce inflammation.
  • Proksch, E., & Nissen, H. P. (2002). Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation. Journal of Dermatological Treatment.
  • Ebner, F., Heller, A., Rippke, F., & Tausch, I. (2002). Topical use of dexpanthenol in skin disorders. American Journal of Clinical Dermatology.
  • Camargo, F. B. Jr, Gaspar, L. R., & Maia Campos, P. M. B. G. (2011). Skin moisturizing effects of panthenol-based formulations. Journal of Cosmetic Science.

Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.

Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.

Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.


Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan found throughout the body's connective, epithelial, and neural tissues. Most abundantly present in the skin, eyes, and synovial fluid, HA is renowned for its exceptional capacity to retain moisture — a single gram can hold up to six liters of water.

In skincare, the primary appeal of hyaluronic acid lies in its unparalleled hydrating abilities. As a humectant, HA attracts and retains moisture from the environment, providing intense hydration to the skin. This hydrating property contributes significantly to maintaining skin plumpness, suppleness, and elasticity.

Beyond hydration, hyaluronic acid also plays a vital role in skin repair and regeneration. It supports the skin's healing and repair processes, and its anti-inflammatory properties help calm irritated skin. Moreover, HA's ability to promote collagen production, a crucial protein for skin elasticity, further underscores its anti-aging benefits.

The molecular size of hyaluronic acid influences its skin penetration and efficacy. High-molecular-weight HA remains on the skin's surface, providing hydration and forming a barrier against moisture loss. In contrast, low-molecular-weight HA penetrates deeper into the skin's layers, offering more profound hydrating and rejuvenating effects.

Hyaluronic acid's remarkable ability to hydrate, improve skin elasticity, aid in wound healing, and provide antioxidant protection makes it valuable in managing various dermatological conditions, particularly aging, dryness, and sensitive skin.

Lipid Bilayer Technology

Lipid bilayer technology in dermatology focuses on mimicking and reinforcing the skin's natural lipid barrier, which is vital for maintaining skin health and integrity. Here's a brief overview of the physiological effects and roles in managing various skin conditions:

Physiological Effects of Lipid Bilayer Technology:
  1. Reinforcement of Skin Barrier: Lipid bilayer technology aims to replicate the skin's natural barrier, particularly beneficial for damaged or compromised skin. This reinforcement helps in reducing transepidermal water loss (TEWL) and enhancing skin hydration.
  2. Restoration of Lipid Composition: It helps in replenishing the essential lipids that are often deficient in certain skin conditions, thereby restoring the skin's natural protective barrier.
  3. Improvement in Skin Texture and Hydration: By restoring the lipid bilayer, this technology improves skin texture and overall hydration, leading to healthier, more resilient skin.
  4. Reduction of Inflammation and Irritation: It can help in reducing inflammation and irritation, particularly in conditions where the skin barrier is compromised.
Role in Managing Dermatological Conditions:
  1. Atopic Dermatitis (Eczema): Lipid bilayer technology is particularly beneficial in managing eczema, as it helps in restoring the deficient skin barrier function, reducing dryness, and controlling flare-ups.
  2. Psoriasis: In psoriasis, where the skin barrier is also disrupted, this technology aids in hydrating the skin and reducing scaling.
  3. Aging Skin: The aging skin, which naturally loses lipids over time, benefits from lipid bilayer technology as it helps in maintaining skin hydration and elasticity.
  4. Dry Skin Conditions (Xerosis, Ichthyosis): Enhancing the skin’s lipid content can significantly improve symptoms of dryness and scaling in these conditions.
  5. Sensitive Skin: For sensitive skin types, lipid bilayer technology can provide a gentle and effective way to strengthen the skin barrier without causing irritation.
  • Del Rosso, J. Q., & Levin, J. (2011). The Clinical Relevance of Maintaining the Functional Integrity of the Stratum Corneum in both Healthy and Disease-affected Skin. Journal of Clinical and Aesthetic Dermatology.
  • Rawlings, A. V., & Harding, C. R. (2004). Moisturization and Skin Barrier Function. Dermatologic Therapy.
  • Man, M. Q., Xin, S. J., Song, S. P., Cho, S. Y., Zhang, X. J., Tu, C. X., ... & Elias, P. M. (2009). Variation of Skin Surface pH, Sebum Content and Stratum Corneum Hydration with Age and Gender in a Large Chinese Population. Skin Pharmacology and Physiology.
DermExcel™ | DermNourish
DermNourish Sale price$45.00 USD
  • Dry skin: DermNourish™ moisture-rich formula helps replenish hydration, alleviating dryness and discomfort.
  • Sensitive skin: The absence of fragrances and colorants in the formulation makes DermNourish™ suitable for sensitive skin types, minimizing potential irritations.
  • Compromised skin: Enhance the skin’s barrier function and provide the necessary care.
  • Itching: Relieves itching, particularly in dry or distressed skin.
  • Post-procedure skin care: Use DermNourish™ following dermatological procedures to help nourish and comfort the skin, supporting its recovery.
  • Skin exposed to environmental stressors: DermNourish™ contains antioxidants that protect the skin from environmental damage.
  • Cleanse: Start with a clean face. Use your DermExcel cleanser to remove dirt and excess oil from your skin.
  • Application: Apply DermNourish to damp skin. Moisturizers are most effective if you use them while your skin is damp because damp skin absorbs the product more readily. That also gives the moisturizer a chance to lock in that hydration. Dispense DermNourish onto your fingertips. Smooth the product evenly over your face. Ensure you cover all dry or sensitive areas.
  • Massage: Using your fingertips, gently massage the product into your skin in a circular motion until fully absorbed.
  • Consistency: Use DermNourish™ once or twice daily, depending on skin dryness or sensitivity severity.

Active ingredients

  • Eml
  • d-Panthenol
  • Nc4
  • HA2
  • Lipid Bilayer Technology

Full ingredient list

Aqua, Glycerin, Cetearyl Alcohol & Polysorbate 60, Petrolatum, Cetyl Stearate & Isostearyl Isostearate & Cetyl Alcohol & Potassium Cetyl Phosphate & Stearic Acid, Light Paraffinum Liquidum, Cyclopentasiloxane & C30-45 Alkyl Cetearyl Dimethicone Crosspolymer & PEG/PPG-20/23 Dimethicone, Niacinamide, Tocopherol, d-Panthenol, Sodium Hyaluronate



Intense hydration

Powerful synergy of medical-grade ingredients to provide deep, long-lasting skin hydration.

Sun-Damaged Skin Repair

Aids in repairing skin affected by sun damage, providing nourishment and support for better recovery.

Improve Skin Texture

Target and improve rough skin texture, making it smoother and more even-toned.

Enhanced Skin Elasticity

Healthy and improved skin barrier, leading to enhanced skin elasticity and suppleness.

Repair barrier function

Repair, strengthen, and restore the skin barrier, promoting better moisture retention and overall skin health.


Supports skin cell renewal and improve the appearance of aging skin by revitalizing and reparative action.



  • Skin that feels and looks rough and dry
  • Dull skin tone
  • Flaking skin, which may cause an ashy appearance
  • A feeling of skin tightness
  • Itchy uncomfortable skin



DermNourish mode of action

moisturizing & barrier repair

  • Lipid Bilayer Technology amplifies lipid production and replenish the lamellar bilayers that are critical for normal barrier function and antimicrobial defence.
  • They are quickly absorbed into the underlying nucleated cell layers, where they incorporate into lamellar bodies.
  • This Barrier Repair Therapy furthermore reduce inflammation by several mechanisms, leading to a smoother surface with less friction and greater light refraction.

Replenish lipid bilayers critical for normal barrier function.

  • Emollients soften and smooth the skin. They function by filling the gaps between skin cells and replace missing lipids.
  • They function by filling the gaps between skin cells and replacing the missing lipids.
  • Emollients flatten the curled edges of the individual skin cells (corneocytes), leading to a smoother surface with less friction and greater light refraction.

Fill the gaps between skin cells and replace missing lipids.

  • Humectants are water-soluble materials with high water absorption capabilities.
  • They draw moisture from the air into the skin and/or draw moisture from the dermis into the epidermis.
  • Humectants can help to diminish the appearance of fine lines and wrinkles by plumping up the skin, giving it a more youthful appearance.

Attract water to the skin to maintain its moisture balance.

  • Creates a protective layer on top of the skin that locks in moisture and prevent transepidermal water loss (TEWL).
  • The barrier formed by occlusives also protects the skin from external irritants such as pollutants, allergens, and harsh weather conditions, contributing to skin sensitivity and damage.
  • For dry, cracked, or irritated skin, occlusives provide immediate relief by covering the affected area and preventing further moisture loss, allowing the skin to heal more effectively.

Creates a protective layer on top of skin to lock moisture in.



Customer Reviews

Based on 463 reviews
Anika Ludick
Rose Gold Lip Butter Ball

The packaging is aesthetically pleasing and the product feels like silk on your lips. It immediately calms dry lips and stays on for a great period of time.

Nulandi Coetzee
Best product ever

I am using DermNourish in summer and it is perfect, but when winter comes I add Enriched to my skincare regime. Enriched is absolutely fantastic. My skin stays so soft all winter long. Thank you to Dermexel for the exelent product range.

Marie-louise Pietersen


Feeling Fresh

I’ve been in the products for the past 6 months. Amazing results. I stuggle with acne and scaring. Have now seen much improvement. Love it. Ps. The lip balm is the best

Ann-Marie Piquita
Exceptional product

Hydrating & moisturizing, leaves skin feeling great!

Elsabe Immelman

Best product I have ever used...




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