DermNourish

LIPID-BILAYER BARRIER REPAIR TECHNOLOGY

DermNourish physiologically replenishes the lipid bilayers that are critical for normal barrier function and antimicrobial defense.

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EMOLLIENTS

Fill the gaps between skin cells and replace missing lipids.

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HUMECTANTS

Draw moisture from the air into the skin and the underlying dermis into the epidermis.

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OCCLUSIVES

Creates a protective layer on top of the skin that prevents water loss and “seals” in moisture.

Niacinamide

• Reduce the inflammatory response by inhibiting inflammatory messengers.
• Provides long-lasting protection against bacteria through activation of anti-microbial peptides

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dPanthenol

Soothes and reduces inflammation:

• Panthenol’s moisturizing properties also contribute to its anti-inflammatory nature.
• Keeping the skin moisturized can help prevent it from becoming sensitive and easily irritated. As such, panthenol can help improve the roughness, dryness, itching, redness, and scaling associated with conditions such as eczema, contact dermatitis, and psoriasis.
• A 2019 study adds that panthenol may alleviate facial redness resulting from winter xerosis in people with sensitive skin.

Promotes wound healing:

• D-Panthenol is part of medical wound-healing formulations for its ability to help treat skin injuries, burns, and sunburn.
• D-Panthenol is also beneficial after medical and cosmetic surgeries for its wound healing properties.
• It treats superficial and deep wounds by increasing cell turnover and fibroblast proliferation.
• A 2020 review on the role of d-panthenol on wound healing states that it is excellent for post-procedural wounds, especially when used immediately after skin damage.

Niacinamide

• Niacinamide increases barrier layer proteins such as involucrin, filaggrin and keratin. Filaggrin is critical in the formation of natural skin moisturising factors.
• It stimulates the synthesis of ceramides and other intercellular lipids, decreasing trans-epidermal water loss (TEWL) and strengthening the skin's barrier against irritants and allergens.
• Aquaporin 3 is a gene that encodes water-permeable channels. The upregulation of aquaporin 3 is associated with Atopic Dermatitis / Eczema (AD), which leads to water loss through the skin. Niacinamide prevents the upregulation of aquaporin 3, thereby decreasing water permeability and water loss.
• Eczema/Atopic Dermatitis (AD) is an inflammatory skin condition. Niacinamide has anti-inflammatory properties by inhibiting PARP-1 and the associated expression of inflammatory cytokines, chemokines, adhesion molecules and inflammatory mediators.
• Increased cyclic adenosine monophosphate (cAMP) phosphodiesterase (PDE) contributes to increased histamine and IgE levels in Atopic Dermatitis.
• Increases production of ceramides as well as other stratum corneum lipids to improve skin barrier function.

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d-Panthenol

• Panthenol promotes skin barrier repair by enhancing lipid synthesis and epidermal differentiation. This helps hydrate the outermost layer of the skin and locks in moisture.
• A 2016 study also found that d-panthenol increases the mobility of proteins and lipids in dehydrated skin, improving its elasticity and hydration. It also retains or increases molecular fluidity to compensate for reduced hydration.
• D-Panthenol is part of medical wound-healing formulations for its ability to help treat skin injuries, burns, and sunburn.
• D-Panthenol is also beneficial after medical and cosmetic surgeries for its wound healing properties.
• It treats superficial and deep wounds by increasing cell turnover and fibroblast proliferation.
• A 2020 review on the role of d-panthenol on wound healing states that it is excellent for post-procedural wounds, especially when used immediately after skin damage.

Hyaluronic acid

• Hyaluronic acid increases pro-collagen I synthesis and reduce skin roughness.
• Hyaluronic acid has an important role in skin aging. Cells lose their ability to produce Hyaluronic acid with aging. The skin becomes drier, thinner, and looser, leading to wrinkling, among other significant changes. 
• Skin aging is also associated with a decrease of skin moisture. Hyaluronic acid has a unique capacity to link and retain water molecules. Hyaluronic acid is a natural component that is present in the whole body. It is naturally and constantly renewed because of its rapid degradation, but its renewal tends to slow with age and external aggressions. Therefore it is necessary to act very early, sustaining an optimal hyaluronic acid turnover, similar to that of young skin, in order to prevent the signs of aging.
• In relation to its biological effects at the skin level, it is known that hyaluronic acid is actively involved in skin cell signalling (by binding the CD44 and LYVE-1 receptors) and thus influences the extracellular matrix (ECM) stability.
• Hyaluronic acid has an impact on the growth of keratinocytes (skin cells) which protect the epidermis from aging and promotes elasticity. 

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Niacinamide

• Stimulate collagen synthesis and significantly increase skin elasticity.
• Prevents the breakdown of collagen and elastin through antioxidant and anti-inflammatory activity.
• Prevents DNA damage through antioxidant activity.
• Increases production of ceramides as well as other stratum corneum lipids to improve skin barrier funtion.
• Niacinamide boosts cellular energy and may enhance energy-dependent cellular processes such as DNA repair.