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Cremedify

Sale price$26.00 USD

SIZE: 400 mL

An Emollient-Rich and Lipid-Replenishing Body Cream Cleanser for Ichthyosis, Eczema, Psoriasis, and Other Dry Skin Conditions.

Creamy is a non-foaming moisturizing cleanser formulated to effectively soothe, nourish, and calm dry, itching, psoriasis, atopic dermatitis, and eczema-prone skin.

Cremedify contains Intelligent Lipid Bilayer technology that forms a double structural layer on the skin's surface to regulate water loss, strengthen and regenerate the skin's natural barrier and ensure long-lasting hydration.

Cremedify includes essential fatty acids to support the epidermal barrier and effectively clean sensitive and dry skin while improving overall skin health.

Take control of your skin's well-being with Cremedify, and embrace the transformative power of our scientifically-backed, ultra-gentle moisturizing cleanser.


Emollients

Emollients play a crucial role in dermatological care, primarily by enhancing skin hydration and barrier function. Here's a brief overview of their physiological effects and roles in managing various skin conditions:

Physiological Effects of Emollients:
  1. Hydration of Stratum Corneum: Emollients increase moisture content in the stratum corneum, the outermost layer of the skin, by reducing transepidermal water loss (TEWL). This is achieved through occlusion, which traps water in the skin.
  2. Restoration of Skin Barrier Function: They aid in replenishing the lipid barrier of the skin, which is essential for maintaining skin integrity and protective function.
  3. Soothing and Smoothing Effects: Emollients smooth flaky skin cells, making the skin surface appear smoother. They also provide a soothing effect, which can reduce itching and discomfort.
  4. Anti-inflammatory Properties: Some emollients have ingredients that offer mild anti-inflammatory benefits, helping to reduce redness and irritation.
Role in Managing Dermatological Conditions:
  1. Atopic Dermatitis (Eczema): Emollients are a cornerstone in the management of eczema, helping to maintain skin hydration, reduce flare-ups, and minimize the need for topical corticosteroids.
  2. Psoriasis: Regular use of emollients can reduce scaling and dryness associated with psoriasis, improving the efficacy of other topical treatments.
  3. Ichthyosis and Xerosis: These conditions characterized by dry, scaly skin benefit significantly from emollients, which help in hydrating and softening the skin.
  4. Aging Skin: Emollients improve the appearance of aging skin by hydrating and reducing the visibility of fine lines and wrinkles.
  5. Skin Protection: In individuals with incontinence or those bedridden, emollients can protect the skin from irritation and breakdown.
References
  • Proksch, E., & Lachapelle, J. M. (2005). The Management of Dry Skin with Topical Emollients. American Journal of Clinical Dermatology.
  • Lynde, C. W. (2001). Moisturizers: What They Are and a Practical Approach to Product Selection. Skin Therapy Letter.
  • Lodén, M. (2003). Role of Topical Emollients and Moisturizers in the Treatment of Dry Skin Barrier Disorders. American Journal of Clinical Dermatology.
Humectants

Humectants are a vital component in skincare, particularly for conditions characterized by impaired skin barrier function and excessive dryness. Their ability to attract and retain moisture in the skin makes them invaluable in both therapeutic and preventive dermatology.

Physiological effects of humectants
  1. Moisture Attraction: Humectants draw moisture from the environment and the deeper layers of the skin to the outer layer (stratum corneum), enhancing skin hydration.
  2. Enhancing Skin Barrier Function: By improving skin hydration, humectants help to maintain and improve the skin's barrier function, protecting against irritants and reducing transepidermal water loss (TEWL).
  3. Skin Elasticity and Appearance: Improved hydration can enhance skin elasticity and reduce the appearance of fine lines and wrinkles, giving the skin a plumper and smoother look.
  4. Soothing Effect: Humectants can have a soothing effect on the skin, particularly in conditions involving dryness or irritation.
Role in managing dermatological conditions
  1. Dry Skin (Xerosis): Humectants are key ingredients in many moisturizers and are highly effective in managing dry skin by providing and maintaining hydration.
  2. Eczema and Dermatitis: Their moisturizing and soothing properties help in relieving symptoms of eczema and dermatitis, such as dryness, itching, and irritation.
  3. Aging Skin: Humectants are used in anti-aging skincare products due to their ability to hydrate the skin and improve its appearance.
  4. Psoriasis: They can aid in reducing the dryness and scaling associated with psoriasis.
  5. Acne-Prone Skin: Certain humectants can be beneficial in acne treatments, as they provide necessary hydration without clogging pores.
References
  • Lodén, M. (2005). Role of Topical Emollients and Moisturizers in the Treatment of Dry Skin Barrier Disorders. American Journal of Clinical Dermatology.
  • Rawlings, A. V., & Canestrari, D. A. (2011). Moisturizer technology versus clinical performance. Dermatologic Therapy.
  • Fluhr, J. W., Darlenski, R., & Surber, C. (2008). Glycerol and the skin: holistic approach to its origin and functions. British Journal of Dermatology.
Glycerin

Glycerin, also known as glycerol, is a simple polyol compound widely used in dermatology due to its excellent moisturizing properties.

Glycerin's excellent hydrating properties, combined with its ability to soothe and improve skin barrier function, make it a highly valued ingredient in the treatment and management of various dermatological conditions, particularly those involving dryness and compromised skin barrier.

Physiological effects of Glycerin
  1. Hydration: Glycerin is a humectant, meaning it attracts water to the skin. It draws moisture from the environment and the deeper layers of the skin to the outer layer (stratum corneum), improving hydration.
  2. Skin Barrier Function: By enhancing skin hydration, glycerin helps to maintain and improve the skin's barrier function, protecting against irritants and reducing transepidermal water loss (TEWL).
  3. Soothing Effect: It has a soothing effect on the skin, which can be beneficial in reducing irritation and discomfort in various skin conditions.
  4. Elasticity and Resilience: Glycerin can improve skin elasticity and resilience, making the skin appear healthier and more supple.
  5. Wound Healing: Some studies suggest glycerin may play a role in accelerating wound healing processes and improving skin repair.
Role in Managing Dermatological Conditions
  1. Dry Skin Conditions (Xerosis): Glycerin is a key ingredient in many moisturizers and is highly effective in managing dry skin by providing deep hydration.
  2. Eczema and Dermatitis: Its moisturizing and soothing properties help in relieving the symptoms of eczema and dermatitis, such as dryness, itching, and irritation.
  3. Psoriasis: Glycerin can aid in reducing the dryness and scaling associated with psoriasis.
  4. Aging Skin: It is beneficial in anti-aging products due to its ability to hydrate the skin and improve its elasticity.
  5. Wound Care: Glycerin-based products may be used in the care of minor wounds and burns due to its potential role in enhancing wound healing.
References
  • Fluhr, J. W., Darlenski, R., & Surber, C. (2008). Glycerol and the skin: holistic approach to its origin and functions. British Journal of Dermatology.
  • Harding, C. R. (2004). The stratum corneum: structure and function in health and disease. Dermatologic Therapy.
  • Lodén, M. (2005). Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. American Journal of Clinical Dermatology.
Niacinamide

Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It has been shown to be effective in reducing the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function makes it beneficial for all skin types, particularly for those with eczema or mature skin.

Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the skin's epidermis, helping to fade dark spots and even out skin tone.

Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.

Physiological Effects of Niacinamide
  1. Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, which are lipids that keep the skin hydrated and protect against environmental damage.
  2. Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
  3. Sebum Regulation: Niacinamide can regulate sebum production, which helps in controlling excess oiliness and can be beneficial for acne-prone skin.
  4. Hyperpigmentation Reduction: It is known to reduce hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
  5. Anti-aging Effects: Niacinamide helps in reducing the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
  6. Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.
Role in Managing Dermatological Conditions
  1. Acne and Oily Skin: By regulating sebum and reducing inflammation, niacinamide is effective in managing acne and oily skin conditions.
  2. Hyperpigmentation and Melasma: Its ability to reduce melanin transfer makes it beneficial in treating hyperpigmentation and melasma.
  3. Aging Skin: Its anti-aging properties make niacinamide a popular ingredient in skincare products targeting wrinkles and loss of firmness.
  4. Skin Barrier Disorders: Niacinamide is beneficial in the treatment of skin barrier disorders like atopic dermatitis and eczema, by enhancing barrier function and hydration.
  5. Photodamage and Skin Protection: It helps in mitigating the effects of photodamage and provides some degree of protection against environmental damage.
References
  • Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
  • Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
  • Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
  • Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.
Essential Fatty Acids

Essential Fatty Acids: Nourishing Your Skin from Within

In the realm of dermatological science, essential fatty acids (EFAs) have emerged as unsung heroes, offering a multifaceted approach to improving skin health in patients with conditions such as eczema and dry skin. 

Biochemical Brilliance

Essential fatty acids, including omega-3 and omega-6, are the building blocks of the skin's lipid barrier. This barrier acts as a protective shield, preventing excessive moisture loss and shielding the skin from external aggressors. EFAs play a pivotal role in maintaining this barrier's integrity by contributing to the synthesis of ceramides and lipids that bind skin cells together.

Pharmacological Advantages

EFAs are not only instrumental in maintaining the skin's structural integrity but also possess anti-inflammatory properties. They serve as precursors for pro-resolving lipid mediators like resolvins and protectins, which help reduce skin inflammation, itching, and redness—common symptoms of eczema.

Physiological Harmony

EFAs contribute to maintaining the balance of skin hydration. They enhance the skin's ability to retain water, leaving it supple and hydrated. Moreover, EFAs can modulate the skin's immune response, reducing the severity of allergic reactions and flare-ups often seen in dermatological conditions like eczema.

References
  1. Elias, P. M. et al. (2008). Skin diseases associated with decreased epidermal lipogenesis. Annals of the New York Academy of Sciences, 1141(1), 1-13.
  2. Ziboh, V. A. et al. (2000). Biochemical basis of the essential fatty acid requirement for normative growth in neonatal baboons. American Journal of Clinical Nutrition, 71(1), 3-11.
  3. Serhan, C. N. (2014). Pro-resolving lipid mediators are leads for resolution physiology. Nature, 510(7503), 92-101.
  4. Levesque, A. et al. (2018). Omega-3 fatty acids: Anti-inflammatory and skin barrier benefits. Omega-3 Fatty Acids: Keys to Nutritional Health, 303-315.
  5. Nicolaou, A. (2013). Eicosanoids in skin inflammation. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 88(1), 131-138.
  6. Meydani, S. N. et al. (2018). Nutrition interventions in aging and age-associated diseases. Annals of the New York Academy of Sciences, 1418(1), 34-51.
Cremedify
Cremedify Sale price$26.00 USD
  • Dry and dehydrated skin: Soothe, nourish, and calm dry skin by providing long-lasting hydration and supporting the skin's natural barrier.
  • Compromised skin barrier: Intelligent Lipid Bilayer technology helps to regulate water loss, strengthen, and regenerate the skin's natural barrier.
  • Ichthyosis / Itching: The moisturizing and calming ingredients in Cremedify help alleviate itching associated with dry skin.
  • Psoriasis: Aids in the management of psoriasis by moisturizing the skin, reducing redness, and supporting the skin's natural barrier function.
  • Sensitive skin: Gentle formulation suitable for individuals with sensitive skin, providing effective cleansing without irritation.
  • Atopic dermatitis / Eczema: Reinforce the skin's natural barrier and address the symptoms of eczema, including dryness, itching, and inflammation.
  • Apply a generous amount on dry or damp skin before getting in the bath or shower.
  • Step into the bath or shower and gently rinse off the cleanser, not rubbing the skin vigorously.
  • Pat yourself dry with a clean, soft towel. Avoid rubbing or excessive friction, as this may cause irritation.
  • For optimal results, follow up with Dermaplan Curexema™ directly after getting out of the bath or shower while skin is still damp.
  • Use Cremedify™ moisturizing body cleanser daily as part of your regular shower or bath routine.

Active ingredients

  • Emollients
  • Humectants
  • Glycerin
  • Niacinamide
  • Essential Fatty Acids

Full ingredient list

White soft paraffin, glycerin, purified water, cetomacrogol, paraffinum liquidum, ethyl hexyl glycerin & phenoxyethanol, cetyl alcool, isostearate, potassium cetyl phosphate, cetyl stearate, stearic acid, niacinamide, decyl glucoside, lauryl glucoside, sodium hyaluronate.

Cremedify

benefits

Gentle Cleansing

Effective skin cleansing while preserving and enhancing the skin's natural oils.

Soothing

The creamy texture provides a soothing application experience, minimizing friction and irritation during the cleansing process.

Moisturization and Hydration

Draw moisture into the skin and lock it in, providing long-lasting hydration.

Reduce Inflammation

Reduce and soothe redness and inflammation in eczema-affected skin.

Barrier Repair and Strengthening

Supports the natural skin barrier and strengthen the skin's defenses against irritants and allergens.

Hypoallergenic

Free from common irritants such as harsh surfactants, fragrances, and dyes, making it suitable for sensitive and eczema-prone skin.

SIGNS AND SYMPTOMS OF

DRY SKIN


  • Skin that feels and looks rough and dry
  • Dull skin tone
  • Flaking skin
  • A feeling of skin tightness
  • Itchy uncomfortable skin
  • Ashy appearance

Optimal skin barrier vs.

Disrupted skin barrier

Barrier-Function2

Cremedify

MODE OF ACTION

Cremedify mode of action

moisturizing & barrier repair

  • Lipid Bilayer Technology amplifies lipid production and replenish the lamellar bilayers that are critical for normal barrier function and antimicrobial defence.
  • They are quickly absorbed into the underlying nucleated cell layers, where they incorporate into lamellar bodies.
  • This Barrier Repair Therapy furthermore reduce inflammation by several mechanisms, leading to a smoother surface with less friction and greater light refraction.

Replenish lipid bilayers critical for normal barrier function.

  • Emollients soften and smooth the skin. They function by filling the gaps between skin cells and replace missing lipids.
  • They function by filling the gaps between skin cells and replacing the missing lipids.
  • Emollients flatten the curled edges of the individual skin cells (corneocytes), leading to a smoother surface with less friction and greater light refraction.

Fill the gaps between skin cells and replace missing lipids.

  • Humectants are water-soluble materials with high water absorption capabilities.
  • They draw moisture from the air into the skin and/or draw moisture from the dermis into the epidermis.
  • Humectants can help to diminish the appearance of fine lines and wrinkles by plumping up the skin, giving it a more youthful appearance.

Attract water to the skin to maintain its moisture balance.

  • Creates a protective layer on top of the skin that locks in moisture and prevent transepidermal water loss (TEWL).
  • The barrier formed by occlusives also protects the skin from external irritants such as pollutants, allergens, and harsh weather conditions, contributing to skin sensitivity and damage.
  • For dry, cracked, or irritated skin, occlusives provide immediate relief by covering the affected area and preventing further moisture loss, allowing the skin to heal more effectively.

Creates a protective layer on top of skin to lock moisture in.

Dermaplan

testimonials


Customer Reviews

Based on 16 reviews
81%
(13)
19%
(3)
0%
(0)
0%
(0)
0%
(0)
K
Karen
Firsthand treatment

Love it!!!! Non greasy and keeps my hands moisturised for hours!!!

C
Charmaine Dettmer

Curexema

T
Telicia Annandale
Satisfied

Very satisfied with my product.

T
Telicia Annandale
Satisfied

Very satisfied with my product.

M
Mary Konopi
Firsthand treatment

Leaves my hands soft and well nourished.

M
Mary Konopi
Firsthand treatment

Leaves my hands soft and well nourished.

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