Dermdefence SPF 50

CoQ10 is a potent ingredient that offers comprehensive benefits for skin health and appearance. Its role in energy production, combined with its antioxidant and anti-aging properties, makes it an invaluable for photoprotection, anti-aging, and overall skin vitality. Its incorporation into DermExcel sunscreen represents a holistic approach to skin health, addressing both protective and restorative needs.

Biochemical Benefits

• Cellular Energy Production: CoQ10 plays a crucial role in the mitochondrial electron transport chain, which is essential for the production of ATP, the primary energy currency of the cell. This function is vital for maintaining the health and vitality of skin cells.
• Antioxidant Properties: It acts as a lipophilic antioxidant, neutralizing free radicals and preventing oxidative damage to cell membranes, proteins, and DNA. This is particularly important in the skin, which is frequently exposed to oxidative stress from environmental factors like UV radiation.

Pharmacological Advantages

• Anti-Aging Effects: CoQ10's antioxidant properties contribute to its anti-aging effects. By reducing oxidative stress, it helps to minimize the visible signs of aging, such as wrinkles and fine lines.
• Photoprotection: It enhances the skin's defense against photoaging caused by exposure to UV rays. CoQ10 helps to mitigate the degradation of collagen and elastin, proteins essential for maintaining skin elasticity and firmness.

Physiological Impact

• Skin Barrier Enhancement: CoQ10 contributes to the strength and health of the skin barrier, improving its ability to retain moisture and protect against external irritants and pollutants.
• Skin Repair and Regeneration: It supports the skin's natural ability to repair itself and regenerate, maintaining a healthy, youthful appearance. This is particularly beneficial in mature skin, where natural levels of CoQ10 may be depleted.

Infraguard™ is a novel and powerful antioxidant powerhouse, designed to protect the skin from the potentially harmful effects of electromagnetic radiation, specifically from 5G networks, blue light, and other environmental stressors. It functions by shielding the skin against oxidative stress and inflammation, contributing to the prevention of premature aging and maintaining overall skin health.

Physiological Effects of Infraguard

1. Protection Against Blue Light and Infrared (IR) Radiation: Infraguard is formulated to shield the skin from the harmful effects of blue light and IR radiation, which can lead to premature skin aging and damage.
2. Antioxidant Properties: It has strong antioxidant capabilities, helping to neutralize free radicals induced by environmental stressors such as pollution, IR, and blue light.
3. Anti-Aging Benefits: By protecting against IR radiation and mitigating oxidative stress, Infraguard helps to prevent signs of aging like wrinkles and loss of skin elasticity.
4. Skin Barrier Protection: Infraguard aids in reinforcing the skin's natural barrier, enhancing its resilience against environmental factors.
5. DNA Protection: Infraguard™ aids in shielding the DNA in skin cells from damage caused by environmental aggressors. This is crucial in maintaining the integrity of skin cells and preventing mutations that can lead to skin aging and other skin-related issues.

Role and Benefits in Dermatology

1. Preventing Photoaging: Infraguard's ability to protect against IR and blue light makes it beneficial in preventing photoaging, a key concern in modern dermatology. Infrared light can penetrate deeper into the skin compared to UV rays, potentially leading to increased collagen degradation and skin laxity. Infraguard® helps in mitigating these effects.
2. Combatting Environmental Stressors: Its antioxidant properties make it effective in protecting the skin from various environmental pollutants and stressors.
3. Supporting Skin Health: By improving the skin's barrier function and providing antioxidant support, Infraguard contributes to overall skin health.
4. Suitability for Diverse Skin Conditions: Given its protective and anti-aging properties, Infraguard is suitable for use in a wide range of dermatological conditions, especially those related to environmental damage and aging.

References

• Kappler, Katharina et al. "Development of an in Vitro Assay to Evaluate the Biological Impact of 5G Technology on Human Skin. Journal of Cosmetics, Dermatological Sciences and Applications, 2022, vol. 12, pp. 100-108. DOI: 10.4236/jcdsa.2022.122009​​.
• Extensive references cited within the research article including studies on 5G technology, health effects, and skin biology​​.

Infraguard® is a multifunctional ingredient that extends beyond traditional sun protection. It addresses the broader spectrum of light-induced skin damage and oxidative stress, provides DNA protection, and offers anti-aging benefits. Its inclusion in the DermExcel sunscreens represents an advanced step in comprehensive skin care, targeting not just UV rays but also the often-overlooked infrared and blue light, thereby ensuring a more holistic approach to maintaining skin health and appearance.

Tinosorb® M and Tinosorb® S represent sophisticated advancements in sun protection technology.

Tinosorb® M

• Biochemical Action: A unique UV filter due to its ability to function through absorption, reflection, and scattering of UV rays.
• Physiological Impact: The triple-action mechanism of Tinosorb® M offers comprehensive sun protection. By mitigating the penetration of both UVA and UVB rays, it significantly reduces the risk of DNA damage, photoaging, and carcinogenesis. Its ability to remain on the skin's surface reduces systemic exposure, making it a safer option with minimal potential for irritation or allergic reactions.

Tinosorb® S

• Biochemical Action: A broad-spectrum UV filter with a molecular structure that allows the effective absorbtion of both UVA and UVB rays. Additionally, it enhances the photostability of other UV filters, making the sunscreen formulation more effective over time.
• Physiological Impact: By providing extensive UVA and UVB protection, Tinosorb® S plays a crucial role in preventing short-term sun damage like sunburn and long-term risks such as skin aging and skin cancer. Its photostability ensures sustained protection during sun exposure, and its compatibility with other UV filters means it can be used to formulate sunscreens that are both effective and suitable for sensitive skin.

The use of sunscreen is a fundamental aspect of skin care and preventive dermatology. It's essential not only for reducing the risk of skin cancers and photoaging but also for maintaining overall skin health in the face of constant exposure to UV radiation.

Sunscreen is a vital skincare product designed to protect the skin from the harmful effects of ultraviolet (UV) radiation from the sun. There are two primary types of UV radiation that affect the skin: UVA and UVB. UVA rays penetrate deep into the skin and are primarily responsible for aging and long-term skin damage, whereas UVB rays cause sunburn and play a key role in developing skin cancer.

Sunscreen products work by either absorbing, reflecting, or scattering sunlight. They contain chemical compounds that absorb UV radiation and convert it into a small amount of heat, or physical compounds (like zinc oxide or titanium dioxide) that act as a physical barrier, reflecting UV light away from the skin.

The effectiveness of sunscreen is measured by its Sun Protection Factor (SPF). SPF indicates how well the sunscreen protects against UVB rays. For example, an SPF of 30 means that it would take 30 times longer for your skin to burn than it would without sunscreen. However, it's important to note that no sunscreen can block 100% of UV rays.

Regular use of sunscreen with an SPF of at least 30 can reduce the risk of skin cancer, prevent sunburn, and slow down the skin's aging process.

Prevention of Sunburn

• UVB Protection: Sunscreen protects the skin from UVB rays, which are responsible for sunburn. This reduces the immediate risk of skin damage and discomfort.

Skin Cancer Prevention

• Reduces Risk of Skin Cancers: Regular use of sunscreen significantly lowers the risk of developing various types of skin cancer, especially melanoma, squamous cell carcinoma, and basal cell carcinoma.

Prevention of Photoaging

• UVA Protection: Sunscreen also shields the skin from UVA rays, which penetrate deeper into the skin and are primarily responsible for photoaging, including wrinkles, leathery skin, and sunspots.

Protection Against Photosensitivity

• Essential for Sensitive Skin Conditions: For individuals with photosensitive skin conditions like lupus or rosacea, sunscreen helps prevent flare-ups triggered by sun exposure.

Hyperpigmentation and Melasma

• Even Skin Tone: It aids in preventing and managing hyperpigmentation and melasma, conditions exacerbated by sun exposure.

General Skin Health

• Maintains Skin Health: By protecting the skin from UV damage, sunscreen helps maintain overall skin health and integrity.

References

• Burnett, M. E., & Wang, S. Q. (2011). Current sunscreen controversies: a critical review. Photodermatology, Photoimmunology & Photomedicine.
• Green, A. C., et al. (2011). Reduced melanoma after regular sunscreen use: randomized trial follow-up. Journal of Clinical Oncology.
• Hughes, M. C. B., et al. (2013). Sunscreen and Prevention of Skin Aging: A Randomized Trial. Annals of Internal Medicine.