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DermExcel™ | Retinol Serum
DermExcel™ | Retinol Serum
DermExcel™ | Retinol Serum
DermExcel™ | Retinol Serum
DermExcel™ | Retinol Serum
DermExcel™

Retinol serum

4.9 / 5.0 from 2466 reviews
Sale price$90.00 USD

SIZE: 30 mL

An advanced skincare formula that leverages the potency of active ingredients like Hydroxypinacolone Retinoate, Niacinamide, and Argireline. Hydroxypinacolone Retinoate, a form of retinoid, works at the cellular level to stimulate epidermal growth, counteracting both intrinsic and extrinsic signs of aging. It aids in reducing hyperpigmentation and evening skin tone while promoting the growth of collagen and elastin, proteins that are vital for maintaining skin's elasticity and structure.

Another key ingredient, Niacinamide, is instrumental in supporting cell health in the skin. It helps build and protect skin cells from environmental stresses like sunlight, pollution, and toxins, while also playing a significant role in acne treatment.

Argireline, a powerful peptide, adds to the formula's efficacy by slowing down muscle movement in the face, thus decreasing the appearance of wrinkles and expression lines. It enhances collagen production, which firms the skin and increases its elasticity. Additionally, it provides hydration, keeping the skin well-moisturized​.

DermExcel Retinol Serum stimulates collagen production, reduces inflammation, inhibits pigmentation, and accelerates cell turnover, all contributing to a healthier and more youthful complexion. It also aids in reducing sebum production and unclogging pores, making it a potent tool in the battle against acne.

ArG
ArG
Argireline: The Innovative Peptide in Anti-Aging Dermatology

Argireline stands as a testament to the advancements in peptide technology in dermatology. Its ability to reduce facial muscle contractions non-invasively positions it as an essential ingredient in anti-aging skincare.

Biochemical Mechanism

Argireline functions by inhibiting the neurotransmitters that trigger muscle contractions. This action reduces the intensity of wrinkle-causing facial expressions, leading to a visible decrease in fine lines and wrinkles. It mimics the N-terminal end of SNAP-25, competing with this natural protein for a position in the SNARE complex, thereby destabilizing it. As a result, neurotransmitter release is diminished, and facial muscle contractions are softened.

Physiological Effects of Argireline
  1. Neurotransmitter Inhibition: Argireline works by inhibiting neurotransmitter release. This leads to reduced facial muscle contraction, a mechanism similar to Botox but less invasive.
  2. Reduction of Expression Lines: By limiting muscle contraction, Argireline helps reduce the appearance of expression lines, particularly around the forehead and eyes.
  3. Improvement in Skin Texture: Regular use of Argireline can lead to smoother skin texture and a reduction in the depth and severity of wrinkles.
Clinical Efficacy

Clinical studies have demonstrated the effectiveness of Argireline in reducing wrinkle depth. A study published in the "International Journal of Cosmetic Science" reported that a cream containing 10% Argireline reduced wrinkles by 30% over 30 days (Blanes-Mira et al., 2002).

References
  • Blanes-Mira, C., et al. (2002). A synthetic hexapeptide (Argireline) with antiwrinkle activity. International Journal of Cosmetic Science.
  • Wang, Y., et al. (2013). The anti-wrinkle efficacy of Argireline. Journal of Cosmetic and Laser Therapy.
  • Ruiz, M. A., et al. (2007). New cosmetic formulations containing Argireline. Journal of Cosmetic Science.
Matrixyl 3000
Matrixyl 3000
Matrixyl 3000: The Powerhouse of Anti-Aging Peptides

Matrixyl 3000, a trademarked peptide composition, has revolutionized the approach towards anti-aging in dermatological products. This innovative ingredient combines two peptides, Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7. The synergy of these peptides enhances skin repair and reduces the appearance of aging.

Biochemical Mechanism

Matrixyl 3000 works by mimicking the appearance of broken-down collagen, causing the skin to react by producing more collagen, as well as elastin. Palmitoyl Tripeptide-1 is known for its ability to stimulate collagen synthesis and firm the skin, while Palmitoyl Tetrapeptide-7 reduces inflammation, a key contributor to aging.

Clinical Efficacy

Studies have shown that Matrixyl 3000 significantly improves skin elasticity and reduces wrinkle depth. A notable study published in the "International Journal of Cosmetic Science" demonstrated that Matrixyl 3000 reduced wrinkle volume and depth by up to 45% after 2 months of use (Smith, 2005).

Clinical Efficacy

Studies have shown that Matrixyl 3000 significantly improves skin elasticity and reduces wrinkle depth. A notable study published in the "International Journal of Cosmetic Science" demonstrated that Matrixyl 3000 reduced wrinkle volume and depth by up to 45% after 2 months of use (Smith, 2005).

Matrixyl 3000 stands out as a non-irritating, highly effective ingredient. Its role in stimulating collagen and elastin production and reducing inflammation makes it a cornerstone in anti-aging skincare regimens.

Physiological Effects of Matrixyl 3000
  1. Collagen and Elastin Stimulation: Matrixyl 3000 promotes the production of collagen and elastin, key proteins that provide skin structure and elasticity, helping to reduce the appearance of fine lines and wrinkles.
  2. Skin Repair and Regeneration: It aids in the skin's repair process, enhancing the overall texture and tone, and may help in reversing the signs of aging.
  3. Anti-inflammatory Properties: Matrixyl 3000 can have anti-inflammatory effects, reducing inflammation and potentially aiding in skin repair.
  4. Hydration Enhancement: By improving the underlying skin structure, it can enhance skin hydration, leading to a plumper, more youthful appearance.
Role in Managing Dermatological Conditions
  1. Aging Skin: Its primary use is in anti-aging skincare products to combat wrinkles, fine lines, and other signs of aging.
  2. Improving Skin Texture and Tone: Matrixyl 3000 can improve overall skin texture, beneficial for skin that has lost smoothness or become rough due to aging.
  3. Skin Elasticity: It can help improve skin elasticity, making the skin appear firmer and more toned.
References
  1. Smith, J. (2005). "Effects of Matrixyl 3000 on Skin Aging." International Journal of Cosmetic Science.
  2. Sederma Inc., "Matrixyl 3000 Technical Overview."
  • Blackburn, R. S., et al. (2005). Matrixyl 3000 restores skin's metabolic balance. Journal of Cosmetic Science.
  • Lintner, K., et al. (2007). Matrixyl 3000: A new approach to anti-aging. Personal Care Magazine.
  • Gorouhi, F., & Maibach, H. I. (2009). Role of topical peptides in preventing or treating aged skin. International Journal of Cosmetic Science.
Nc4
Nc4

Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.

Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.

Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.
Ra3
Ra3

Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skin care, particularly in treating acne and signs of skin aging.

Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In treating acne, it promotes the turnover of skin cells, reducing the likelihood of pore-clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.

Retinoic acid's ability to stimulate collagen production is a key benefit in anti-aging skincare. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster, and shedding pigmented and damaged cells.

Despite its benefits, retinoic acid can irritate the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.

Hydroxypinacolone Retinoate (HPR) is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without needing conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.

HPR is considered more gentle and less irritating than traditional retinoic acid while offering comparable benefits. With HPR, everyone has access to the benefits of prescription retinoids without the risk of side effects.
DermExcel™ | Retinol Serum
Retinol serum Sale price$90.00 USD
  • Stimulates Collagen Production - the protein that provides structure and elasticity to the skin. This helps to reduce the appearance of wrinkles and fine lines.
  • Reduces Hyperpigmentation and dark spots, leading to a more even skin tone.
  • Protects Skin Cells from environmental stresses such as sunlight, pollution, and toxins​.
  • Decreases Wrinkles and Expression Lines by slowing down the movement of facial muscles.
  • Reduce And Prevent Pigmentation by inhibiting the enzymes responsible for pigmentation.
  • Promotes Skin Hydration by enhancing the skin's ability to retain moisture, leading to a healthier and more youthful appearance​.
  • Accelerates Cell Turnover by promoting faster cell turnover. This helps the skin to rejuvenate faster, revealing healthier, fresher skin cells.
  • Regulate Sebum Production to help unclog pores and reduce the risk of acne outbreaks.
  • Reduce Inflammation: Anti-inflammatory action improves skin texture and appearance and helps mitigate acne formation.
  • Improves DNA Communication Between Cells Assists in reversing DNA damage that causes skin aging and to prevent cells from clumping and sticking together inside pores.
  • Cleanse: Start with a clean, dry face. Use your DermExcel cleanser to remove dirt and excess oil from your skin.
  • Apply: The best time to apply the serum is when your skin is still slightly damp after cleansing. This allows your skin to better absorb the potent ingredients in the serum. So, after cleansing your face, don't completely dry your skin; leave it slightly damp. Take a small amount of Retinol Serum (1-2 pumps or a pea-sized amount should suffice) and gently apply it to the face.
  • Massage: Using your fingertips, gently massage the serum into your skin in a circular motion. This helps to ensure the serum is evenly distributed and absorbed.
  • Wait: Allow the serum to absorb fully into the skin before applying other skincare products. This typically takes a few minutes.
  • Follow-up: Once the serum has been fully absorbed, continue with the rest of your skincare routine, such as applying sunscreen (in the morning).

 By following these detailed steps, you will maximize the benefits of Retinol Serum.

Active ingredients

  • ArG
  • Matrixyl 3000
  • Nc4
  • Ra3

Full ingredient list

Aqua, Niacinamide, Acetyl Hexapeptide-8 & Caprylyl Glycol, Dimethyl Isosorbide & Hydroxypinacolone Retinoate, Glycerin, Hydroxypropyl Cyclodextrin & Palmitoyl Tripeptide-38, Sodium Acrylates Copolymer & Lecithin, Phenoxyethanol & Ethylhexylglycerin, Acrylates copolymer, Glycerin, C14-22 Alkane, Pentaerythrityl Tetra-Di-t-Butyl Hydroxyhydrocinnamate

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Retinol serum

benefits

Stimulate Collagen

Collagen is the protein that provides structure and elasticity to the skin, reducing the appearance of wrinkles and fine lines.

Reduce Hyperpigmentation

Inhibits the enzymes responsible for pigmentation, reducing the occurrence of dark spots and uneven skin tone.

Improve DNA Communication

Optimizes DNA communication between cells, promoting healthier cellular behavior and improving physiological function.

Decrease Lines & Wrinkles

Argireline, slows down the movement of facial muscles, reducing the appearance of wrinkles and expression lines​.

Promote Skin Hydration

Enhance the skin's ability to retain moisture, leading to better hydration and a more youthful appearance.

Accelerates Cell Turnover

Promote faster cell turnover, leading to faster skin rejuvenation, revealing healthier, fresher skin cells.

Anti-Inflammatory

Reduce inflammation, improving skin health and appearance and help mitigate the formation of acne.

Skin Barrier Enhancement

Niacinamide in the serum enhances the skin's barrier function, protecting it from environmental stressors.

Smooth Skin Texture

Improves skin texture and firmness by promoting cell turnover, targeting visible signs of premature aging.

Reduce Sebum Production

Regulate sebum production, which helps to unclog pores and reduce the risk of acne outbreaks.

Retinol serum

INDICATIONS

Acne / Breakouts

Aging Skin

Dry & Dehydrated Skin

Dull & Lifeless Skin

Pigmentation

Red & Inflamed skin

Rough Skin Texture

Shaving bumps

Retinol serum

MODE OF ACTION

RETINOID

MOLECULE COMPARISON

Traditional Retinol

Stability: Moderate
Irritation: Moderate
Efficacy: Moderate
Key Notes:
  • Needs two-steps conversion to Retinoic acid in the skin to be moderately effective.
  • Moderate risk for irritation.

Retinaldehyde

Stability: Low
Irritation: High
Efficacy: High
Key Notes:
  • Effective after one-step conversion to Retinoic acid in the skin.
  • Moderate to High risk for irritation.

Hydroxypinacolone Retinoate (HPR)

Stability: Very High
Irritation: Low
Efficacy: High
Key Notes:
  • Effective with no need for conversion to Retinoic acid in the skin.
  • Binds directly to RA receptors.
  • Low risk for irritation.

Retinoic acid

Stability: Low
Irritation: Very High
Efficacy: Very High
Key Notes:
  • Very effective with no need for conversion, because it's already in its active form.
  • Binds directly to RA receptors.
  • Very high risk for irritation.
  • Only available in pharmacies with a prescribtion from a medical doctor.
Molecule Stability Irritation Efficacy Key Notes
Traditional Retinol Moderate Moderate Moderate
  • Needs two-steps conversion to Retinoic acid in the skin to be moderately effective.
  • Moderate risk for irritation.
Retinaldehyde Low High High
  • Effective after one-step conversion to Retinoic acid in the skin.
  • Moderate to High risk for irritation.
Hydroxypinacolone Retinoate (HPR) Very High Low High
  • Effective with no need for conversion to Retinoic acid in the skin.
  • Binds directly to RA receptors.
  • Low risk for irritation.
Retinoic acid Low Very High Very High
  • Very effective with no need for conversion, because it's already in its active form.
  • Binds directly to RA receptors.
  • Very high risk for irritation.
  • Only available in pharmacies with a prescribtion from a medical doctor.

Retinol serum

TARGET TREATMENT

1. REDUCE HYPERPIGMENTATION

2. Regulate Microbiome

3. Regulate oil production

4. Anti-inflammatory and antioxidant

5. Boost collagen production

6. Accelerate dead skin exfoliation

Treatment Serums

testimonials


Customer Reviews

Based on 2466 reviews
95%
(2334)
4%
(90)
1%
(28)
0%
(4)
0%
(10)
M
Melanie Strydom
Fantastic product

Wow, what a difference this product has made. My skin looks fantastic and the product lasts a long time.

m
marizelle de beer
Retinol Serum

Great product! I can see a difference.

S
Sue-Mari Van Rooyen
Amazing

These products are the best

L
Lerissa Rossouw

Retinol serum

C
Cornia Oberholzer
Litaderm serum

I have been using the Litaderm serum since December 2022 and my skin has never felt better. Still struggling with pigmentation though.

J
Janine Willemstijn Benadie
Retinol Serum

Absolutely love the serum. Since using Dermexcel my skin is radiant. Thanks, great product, would definitely recommend.

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