Skip to content


Your cart is empty

Medi-Zinc Cleanser

Sale price$24.00 USD



A powerful hypoallergenic medicated solution with beneficial properties attributed to its active constituent, Zinc Pyrithione. This chemical compound, FDA-approved and clinically recognized, delivers strong antibacterial and antifungal action, making the cleanser an ideal choice for managing skin conditions associated with redness, flaking, irritation, and itching.

Zinc Pyrithione's efficacy, compounded by a gentle cleansing base, facilitates the lifting and removing of impurities, leaving the complexion refreshed. Concurrently, it sustains a tranquil skin environment, reducing inflammation and discomfort. As a daily cleansing aid, Medi-Zinc Cleanser proposes a reliable, scientifically-backed intervention in fostering skin health and comfort.

Zinc Pyrithione

Zinc pyrithione, a compound with potent antifungal and antibacterial properties, has established itself as a cornerstone in the treatment of various skin conditions, particularly those involving Malassezia yeast. Its effectiveness against seborrheic dermatitis and dandruff, which are often associated with an overgrowth of Malassezia species, makes it a key ingredient for many dermatological conditions.

Zinc pyrithione’s mode of action is multifaceted, primarily targeting the membrane of fungi and bacteria, thereby disrupting their growth and replication. One of its significant mechanisms involves inhibiting fungal cell membrane transport by blocking the energy production pathway, which is crucial for cell survival.

In Malassezia, yeast, a natural inhabitant of the skin flora, can overgrow and cause conditions like seborrheic dermatitis and dandruff; zinc pyrithione's antifungal action is particularly beneficial. It reduces the yeast population on the skin, thereby alleviating the symptoms associated with its overgrowth, such as flaking, irritation, and redness.

Its efficacy in treating seborrheic dermatitis is attributed to its ability to reduce the Malassezia count, diminish inflammatory responses, and soothe the skin. Similarly, in dandruff, which is often linked to an excess of Malassezia, zinc pyrithione effectively reduces flaking and itchiness, promoting a healthier scalp environment.

The efficacy of zinc pyrithione in the treatment of seborrheic dermatitis and dandruff is well-documented. Its safety profile and efficacy have been confirmed by numerous studies, with significant improvements observed in both scalp and skin conditions following regular use.

Physiological effects of Zinc Pyrithione
  1. Antifungal Activity: It is effective against a range of fungi, including those that cause dandruff and seborrheic dermatitis. Zinc Pyrithione inhibits the division of fungal cells, reducing their proliferation.
  2. Antibacterial Properties: This compound also exhibits antibacterial activity, making it useful in treating and preventing bacterial skin infections.
  3. Anti-inflammatory Effects: Zinc Pyrithione can reduce inflammation, which is beneficial in alleviating symptoms of various inflammatory skin conditions.
  4. Sebum Regulation: It helps in regulating sebum production, which can be beneficial for oily skin and conditions like acne.
Role in Managing Dermatologocal Conditions
  1. Dandruff and Seborrheic Dermatitis: Zinc Pyrithione is a common ingredient in anti-dandruff shampoos and is effective in controlling the flaking and itching associated with these conditions.
  2. Psoriasis: It can help manage the symptoms of psoriasis, particularly in reducing scaling and redness.
  3. Acne: Due to its antibacterial and anti-inflammatory properties, Zinc Pyrithione can be beneficial in the treatment of acne.
  4. Fungal Infections: It is effective in treating various fungal skin infections due to its antifungal properties.
  • Warshaw, E. M., et al. (2005). Efficacy of Zinc Pyrithione in Seborrheic Dermatitis and Dandruff. Dermatology.
  • Pierard-Franchimont, C., et al. (2002). Antidandruff shampoo efficacy in dandruff/seborrhoeic dermatitis. International Journal of Cosmetic Science.
  • Scheman, A., et al. (2000). Antimicrobial Activity of Zinc Pyrithione. American Journal of Infection Control.
DermExcel™ | Medi-Zinc Cleanser
Medi-Zinc Cleanser Sale price$24.00 USD
  • Rosacea: The anti-inflammatory and antibacterial properties of Zinc Pyrithione help manage and alleviate the symptoms of rosacea.
  • Acne: The antibacterial properties of Zinc Pyrithione in Medi-Zinc Cleanser make it effective in managing acne by reducing bacteria on the skin's surface and controlling inflammation.
  • Seborrheic Dermatitis: This condition, which causes flaky, itchy, red skin, can be managed with the antifungal and anti-inflammatory properties of Zinc Pyrithione.
  • Redness: control and reduce redness associated with skin conditions like rosacea, dermatitis, and eczema.
  • Irritation: It is indicated for soothing skin irritation caused by various factors, including environmental aggressors, allergies, or sensitivities.
  • Itching: Medi-Zinc Cleanser provides relief from itching in itchy skin conditions such as contact dermatitis, insect bites, or allergic reactions.
  • Enlarged Pore Size: Helps minimize the appearance of enlarged pores.
  • Hyperpigmentation: Help to lighten areas of hyperpigmentation on the skin, leading to a more even skin tone.
  • Sensitive skin: Its hypoallergenic formulation makes it suitable for individuals with sensitive skin, providing a gentle and non-irritating cleansing option.
  • Psoriasis: The anti-inflammatory properties of Zinc Pyrithione can help manage the redness and irritation associated with psoriasis.
  • Eczema: While not a cure, the cleanser may help soothe the itching and inflammation associated with eczema.

Active ingredients

  • Zinc Pyrithione

Full ingredient list

Aqua, Polyethylene Glycol, Coco-Glucoside, Cocoamidopropyl Betaine, Sodium Lauroyl Sarcosinate, Zinc Pyrithione, Phenoxyethanol & Ethyl hexyl Glycerin, Acrylates Copolymer, Triethanolamine, Coco-Glucoside & Glyceryl Oleate

  • Apply Medi-Zinc to the affected areas in the morning and/or evening unless otherwise suggested by your treating doctor or clinical advisor.
  • Slightly wet your fingers. If you apply Medi-Zinc to your face, ensure not to wet your face before applying, this will cause the product to run into your eyes and sting.
  • Keep the product in contact with your skin for at least 5 min. This will allow the product to penetrate the follicles optimally. Tip: Keep the cleanser on your skin while you brush your teeth/bath, or get dressed.
  • Remove the cleanser with a clean, lukewarm face cloth or the microfibre face sponge. This will also help to remove excess makeup and loose peeling skin.
  • Continue treatment once / twice daily until clearance of symptoms and then for at least one week after.
  • Because yeast, fungi, and bacteria do not develop resistance toward Zinc Pyrithione, you can continue to use Medi-Zinc cleanser regularly even after symptoms have cleared.
  • Consistent application of Zinc Pyrithione will result in continuous antimicrobial activity.


  • Make sure the product has good contact with the skin. Lather the areas you would like to treat and keep the product on the skin for at least 5 min, but most preferably 10 min for best results. This will allow the product to penetrate the follicles to reach the Malassezia optimally.
  • Repeat the application nightly for at least 3-4 weeks. Within this timeframe, you will start to experience positive results as the Zinc Pyrithione controls the Malassezia overgrowth.
  • To keep the Malassezia yeast from returning, ensure you have enough Zinc Pyrithione hanging out in the skin around the problem areas. Do not stop your treatment after all the signs and symptoms have cleared up. Problem areas should be in contact with Zinc Pyrithione at least once per week.
  • The FDA has approved Zinc Pyrithione as very safe and effective. There is no harm in continuing to use the Zinc Pyrithione daily. Bacteria and the yeast on your skin will not become resistant to it, so there's no reason to stop using it.
  • Always remember the 5-10 min skin contact rule.

Medi-Zinc Cleanser


Antibacterial and Anti-fungal Action

Zinc Pyrithione is FDA-approved for effectively treating bacterial and fungal skin conditions.


Medi-Zinc cleanser down-regulates the inflammatory response and therefore reduces redness, itching, and irritation.

Sebum Regulation

Regulates excess sebum production, reducing complications and improving the appearance of oily and enlarged pores.

Symptom Management

Control and reduce symptoms such as redness, flaking, irritation, and itching, thereby improving overall skin comfort.


Suitable for individuals with sensitive skin, minimizing the risk of irritation or adverse reactions.

Promotes Healthy Skin

By addressing common skin concerns, Medi-Zinc Cleanser contributes to overall skin health.

Medi-Zinc Cleanser


Keratosis Pilaris

Shaving Bumps

Rosacea / Red Skin

Dermatitis / Eczema


Acne / Breakouts

Seborrheic Dermatitis

Tinea Versicolor

Medi-Zinc Cleanser




Customer Reviews

Based on 754 reviews
Nonsikelelo Nyoni
Reduces appearance of pores

This cleanser has reduced shine on my T zone and minimizes pores which is great as one gets older.

Chantelle Bam
Very Happy

My little 2 year old suffers from keratosis Polaris on his arms and legs, I found the cleanser and cream did start making a difference. It was only a tester size but I will definitely be getting a bigger size to continue the treatment. It was gentle enough not to burn him, but did make a difference to his skin. And I received a free lip treatment which was very thoughtful from the company.

Cheryl de Villiers
Get Rid of Blocked/Enlarged Pores with Pore Control Cleanser

I often get unsightly blocked/enlarged pores on my nose. A month ago, I started using Dermexel's Pore Control Cleanser. After only a few days I could see a marked improvement. This is an excellent cleanser for the entire face as it is very effective without being harsh on your skin.

Anneke Viljoen
Renewal Facial Cleanser

Absolutely loove this product!

Awesome cleanser

Great cleanser i use it daily, and it brightens up my skin immediately.

Charnè Schoeman

Gebruik Dermexcel vir die afgelope 3 jaar en kyk nie 'n dag terug nie. Ek het baie gehuiwer aan die begin, want ek is 'n gewone salaristrekker in die hartjie van die Karoo - elke sent moet omgedraai word...maar ek het vasgebyt en ogies toegeknyp en vandag sal ek my laaste sentjie uithaal vir my produkte. Geen produk in my verlede kon werk soos hierdie produk nie. Ek beveel dit ten sterkste aan. Knyp ogies toe aan die begin, want sodra mens dit begin gebruik kan jy slim koop en dan werk dit nie duur uit nie. En dis waar - "less is more". Prokukte hou lank omrede mens so min op 'n **** hoef te gebruik. Dankie Dermecxel - naas my man - my 2de liefde!




Submit Your Free Online Dermal Diagnosis™ Assessment.


Receive Your Free Profile & Personal Treatment Plan.


Start Your Effective & Simple Journey to Confident Skin.