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Retinol serum

Sale priceR 1,218.00 ZAR

SIZE: 30 mL

An advanced skincare formula that leverages the potency of active ingredients like Hydroxypinacolone Retinoate, Niacinamide, and Argireline. Hydroxypinacolone Retinoate, a form of retinoid, works at the cellular level to stimulate epidermal growth, counteracting both intrinsic and extrinsic signs of aging. It aids in reducing hyperpigmentation and evening skin tone while promoting the growth of collagen and elastin, proteins that are vital for maintaining skin's elasticity and structure.

Another key ingredient, Niacinamide, is instrumental in supporting cell health in the skin. It helps build and protect skin cells from environmental stresses like sunlight, pollution, and toxins, while also playing a significant role in acne treatment.

Argireline, a powerful peptide, adds to the formula's efficacy by slowing down muscle movement in the face, thus decreasing the appearance of wrinkles and expression lines. It enhances collagen production, which firms the skin and increases its elasticity. Additionally, it provides hydration, keeping the skin well-moisturized​.

DermExcel Retinol Serum stimulates collagen production, reduces inflammation, inhibits pigmentation, and accelerates cell turnover, all contributing to a healthier and more youthful complexion. It also aids in reducing sebum production and unclogging pores, making it a potent tool in the battle against acne.


Argireline
Argireline: The Innovative Peptide in Anti-Aging Dermatology

Argireline stands as a testament to the advancements in peptide technology in dermatology. Its ability to reduce facial muscle contractions non-invasively positions it as an essential ingredient in anti-aging skincare.

Biochemical Mechanism

Argireline functions by inhibiting the neurotransmitters that trigger muscle contractions. This action reduces the intensity of wrinkle-causing facial expressions, leading to a visible decrease in fine lines and wrinkles. It mimics the N-terminal end of SNAP-25, competing with this natural protein for a position in the SNARE complex, thereby destabilizing it. As a result, neurotransmitter release is diminished, and facial muscle contractions are softened.

Physiological Effects of Argireline
  1. Neurotransmitter Inhibition: Argireline works by inhibiting neurotransmitter release. This leads to reduced facial muscle contraction, a mechanism similar to Botox but less invasive.
  2. Reduction of Expression Lines: By limiting muscle contraction, Argireline helps reduce the appearance of expression lines, particularly around the forehead and eyes.
  3. Improvement in Skin Texture: Regular use of Argireline can lead to smoother skin texture and a reduction in the depth and severity of wrinkles.
Clinical Efficacy

Clinical studies have demonstrated the effectiveness of Argireline in reducing wrinkle depth. A study published in the "International Journal of Cosmetic Science" reported that a cream containing 10% Argireline reduced wrinkles by 30% over 30 days (Blanes-Mira et al., 2002).

References
  • Blanes-Mira, C., et al. (2002). A synthetic hexapeptide (Argireline) with antiwrinkle activity. International Journal of Cosmetic Science.
  • Wang, Y., et al. (2013). The anti-wrinkle efficacy of Argireline. Journal of Cosmetic and Laser Therapy.
  • Ruiz, M. A., et al. (2007). New cosmetic formulations containing Argireline. Journal of Cosmetic Science.
Matrixyl 3000
Matrixyl 3000: The Powerhouse of Anti-Aging Peptides

Matrixyl 3000, a trademarked peptide composition, has revolutionized the approach towards anti-aging in dermatological products. This innovative ingredient combines two peptides, Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7. The synergy of these peptides enhances skin repair and reduces the appearance of aging.

Biochemical Mechanism

Matrixyl 3000 works by mimicking the appearance of broken-down collagen, causing the skin to react by producing more collagen, as well as elastin. Palmitoyl Tripeptide-1 is known for its ability to stimulate collagen synthesis and firm the skin, while Palmitoyl Tetrapeptide-7 reduces inflammation, a key contributor to aging.

Clinical Efficacy

Studies have shown that Matrixyl 3000 significantly improves skin elasticity and reduces wrinkle depth. A notable study published in the "International Journal of Cosmetic Science" demonstrated that Matrixyl 3000 reduced wrinkle volume and depth by up to 45% after 2 months of use (Smith, 2005).

Clinical Efficacy

Studies have shown that Matrixyl 3000 significantly improves skin elasticity and reduces wrinkle depth. A notable study published in the "International Journal of Cosmetic Science" demonstrated that Matrixyl 3000 reduced wrinkle volume and depth by up to 45% after 2 months of use (Smith, 2005).

Matrixyl 3000 stands out as a non-irritating, highly effective ingredient. Its role in stimulating collagen and elastin production and reducing inflammation makes it a cornerstone in anti-aging skincare regimens.

Physiological Effects of Matrixyl 3000
  1. Collagen and Elastin Stimulation: Matrixyl 3000 promotes the production of collagen and elastin, key proteins that provide skin structure and elasticity, helping to reduce the appearance of fine lines and wrinkles.
  2. Skin Repair and Regeneration: It aids in the skin's repair process, enhancing the overall texture and tone, and may help in reversing the signs of aging.
  3. Anti-inflammatory Properties: Matrixyl 3000 can have anti-inflammatory effects, reducing inflammation and potentially aiding in skin repair.
  4. Hydration Enhancement: By improving the underlying skin structure, it can enhance skin hydration, leading to a plumper, more youthful appearance.
Role in Managing Dermatological Conditions
  1. Aging Skin: Its primary use is in anti-aging skincare products to combat wrinkles, fine lines, and other signs of aging.
  2. Improving Skin Texture and Tone: Matrixyl 3000 can improve overall skin texture, beneficial for skin that has lost smoothness or become rough due to aging.
  3. Skin Elasticity: It can help improve skin elasticity, making the skin appear firmer and more toned.
References
  1. Smith, J. (2005). "Effects of Matrixyl 3000 on Skin Aging." International Journal of Cosmetic Science.
  2. Sederma Inc., "Matrixyl 3000 Technical Overview."
  • Blackburn, R. S., et al. (2005). Matrixyl 3000 restores skin's metabolic balance. Journal of Cosmetic Science.
  • Lintner, K., et al. (2007). Matrixyl 3000: A new approach to anti-aging. Personal Care Magazine.
  • Gorouhi, F., & Maibach, H. I. (2009). Role of topical peptides in preventing or treating aged skin. International Journal of Cosmetic Science.
Niacinamide

Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It has been shown to be effective in reducing the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function makes it beneficial for all skin types, particularly for those with eczema or mature skin.

Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the skin's epidermis, helping to fade dark spots and even out skin tone.

Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.

Physiological Effects of Niacinamide
  1. Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, which are lipids that keep the skin hydrated and protect against environmental damage.
  2. Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
  3. Sebum Regulation: Niacinamide can regulate sebum production, which helps in controlling excess oiliness and can be beneficial for acne-prone skin.
  4. Hyperpigmentation Reduction: It is known to reduce hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
  5. Anti-aging Effects: Niacinamide helps in reducing the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
  6. Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.
Role in Managing Dermatological Conditions
  1. Acne and Oily Skin: By regulating sebum and reducing inflammation, niacinamide is effective in managing acne and oily skin conditions.
  2. Hyperpigmentation and Melasma: Its ability to reduce melanin transfer makes it beneficial in treating hyperpigmentation and melasma.
  3. Aging Skin: Its anti-aging properties make niacinamide a popular ingredient in skincare products targeting wrinkles and loss of firmness.
  4. Skin Barrier Disorders: Niacinamide is beneficial in the treatment of skin barrier disorders like atopic dermatitis and eczema, by enhancing barrier function and hydration.
  5. Photodamage and Skin Protection: It helps in mitigating the effects of photodamage and provides some degree of protection against environmental damage.
References
  • Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
  • Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
  • Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
  • Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.
Retinoic acid analogue

Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skincare, particularly in treating acne and signs of skin aging.

Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In the treatment of acne, it promotes the turnover of skin cells, reducing the likelihood of pore clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.

In anti-aging skincare, retinoic acid's ability to stimulate collagen production is a key benefit. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids in skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster and shedding pigmented and damaged cells.

Despite its benefits, retinoic acid can be quite irritating to the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.

Hydroxypinacolone Retinoate (HPR), is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without the need for conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.

HPR is considered more gentle and less irritating compared to traditional retinoic acid, while offering comparable benefits. With HPR everyone has access to the benefits of prescription retinoids, without the risk of side effects.

Physiological effects of Retinoic acid and HPR and their Role in Managing Dermatological Conditions
  1. Cell Turnover and Renewal: Promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and the generation of new cells.
  2. Skin Texture: By promoting cell renewal it improves skin texture, addressing issues like roughness and dullness.
  3. Collagen Production: It stimulates collagen production, essential for reducing the appearance of fine lines, wrinkles, and improving skin elasticity.
  4. Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
  5. Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
  6. Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.
HPR specific benefits
  1. Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
  2. Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
  3. Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
  4. Acne and Hyperpigmentation: It is effective in treating acne and reducing hyperpigmentation, often with fewer side effects compared to retinoic acid.
  5. Stability and Penetration: Being more stable and lipid-soluble, HPR penetrates the skin more effectively and is less prone to degradation.
References
  • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
  • Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
  • Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
  • Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
  • Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.
DermExcel™ | Retinol Serum
Retinol serum Sale priceR 1,218.00 ZAR
  • Stimulates Collagen Production - the protein that provides structure and elasticity to the skin. This helps to reduce the appearance of wrinkles and fine lines.
  • Reduces Hyperpigmentation and dark spots, leading to a more even skin tone.
  • Protects Skin Cells from environmental stresses such as sunlight, pollution, and toxins​.
  • Decreases Wrinkles and Expression Lines by slowing down the movement of facial muscles.
  • Reduce And Prevent Pigmentation by inhibiting the enzymes responsible for pigmentation.
  • Promotes Skin Hydration by enhancing the skin's ability to retain moisture, leading to a healthier and more youthful appearance​.
  • Accelerates Cell Turnover by promoting faster cell turnover. This helps the skin to rejuvenate faster, revealing healthier, fresher skin cells.
  • Regulate Sebum Production to help unclog pores and reduce the risk of acne outbreaks.
  • Reduce Inflammation: Anti-inflammatory action improves skin texture and appearance and helps mitigate acne formation.
  • Improves DNA Communication Between Cells Assists in reversing DNA damage that causes skin aging and to prevent cells from clumping and sticking together inside pores.
  • Cleanse: Start with a clean, dry face. Use your DermExcel cleanser to remove dirt and excess oil from your skin.
  • Apply: The best time to apply the serum is when your skin is still slightly damp after cleansing. This allows your skin to better absorb the potent ingredients in the serum. So, after cleansing your face, don't completely dry your skin; leave it slightly damp. Take a small amount of Retinol Serum (1-2 pumps or a pea-sized amount should suffice) and gently apply it to the face.
  • Massage: Using your fingertips, gently massage the serum into your skin in a circular motion. This helps to ensure the serum is evenly distributed and absorbed.
  • Wait: Allow the serum to absorb fully into the skin before applying other skincare products. This typically takes a few minutes.
  • Follow-up: Once the serum has been fully absorbed, continue with the rest of your skincare routine, such as applying sunscreen (in the morning).

 By following these detailed steps, you will maximize the benefits of Retinol Serum.

Active ingredients

  • Argireline
  • Matrixyl 3000
  • Niacinamide
  • Retinoic acid analogue

Full ingredient list

Aqua, Niacinamide, Acetyl Hexapeptide-8 & Caprylyl Glycol, Dimethyl Isosorbide & Hydroxypinacolone Retinoate, Glycerin, Hydroxypropyl Cyclodextrin & Palmitoyl Tripeptide-38, Sodium Acrylates Copolymer & Lecithin, Phenoxyethanol & Ethylhexylglycerin, Acrylates copolymer, Glycerin, C14-22 Alkane, Pentaerythrityl Tetra-Di-t-Butyl Hydroxyhydrocinnamate

Retinol serum

benefits

Stimulate Collagen

Collagen is the protein that provides structure and elasticity to the skin, reducing the appearance of wrinkles and fine lines.

Reduce Hyperpigmentation

Inhibits the enzymes responsible for pigmentation, reducing the occurrence of dark spots and uneven skin tone.

Improve DNA Communication

Optimizes DNA communication between cells, promoting healthier cellular behavior and improving physiological function.

Decrease Lines & Wrinkles

Argireline, slows down the movement of facial muscles, reducing the appearance of wrinkles and expression lines​.

Promote Skin Hydration

Enhance the skin's ability to retain moisture, leading to better hydration and a more youthful appearance.

Accelerates Cell Turnover

Promote faster cell turnover, leading to faster skin rejuvenation, revealing healthier, fresher skin cells.

Anti-Inflammatory

Reduce inflammation, improving skin health and appearance and help mitigate the formation of acne.

Skin Barrier Enhancement

Niacinamide in the serum enhances the skin's barrier function, protecting it from environmental stressors.

Smooth Skin Texture

Improves skin texture and firmness by promoting cell turnover, targeting visible signs of premature aging.

Reduce Sebum Production

Regulate sebum production, which helps to unclog pores and reduce the risk of acne outbreaks.

Retinol serum

INDICATIONS

Acne / Breakouts

Aging Skin

Dry & Dehydrated Skin

Dull & Lifeless Skin

Pigmentation

Red & Inflamed skin

Rough Skin Texture

Shaving bumps

Retinol serum

MODE OF ACTION

RETINOID

MOLECULE COMPARISON

Traditional Retinol

Stability: Moderate
Irritation: Moderate
Efficacy: Moderate
Key Notes:
  • Needs two-steps conversion to Retinoic acid in the skin to be moderately effective.
  • Moderate risk for irritation.

Retinaldehyde

Stability: Low
Irritation: High
Efficacy: High
Key Notes:
  • Effective after one-step conversion to Retinoic acid in the skin.
  • Moderate to High risk for irritation.

Hydroxypinacolone Retinoate (HPR)

Stability: Very High
Irritation: Low
Efficacy: High
Key Notes:
  • Effective with no need for conversion to Retinoic acid in the skin.
  • Binds directly to RA receptors.
  • Low risk for irritation.

Retinoic acid

Stability: Low
Irritation: Very High
Efficacy: Very High
Key Notes:
  • Very effective with no need for conversion, because it's already in its active form.
  • Binds directly to RA receptors.
  • Very high risk for irritation.
  • Only available in pharmacies with a prescribtion from a medical doctor.
Molecule Stability Irritation Efficacy Key Notes
Traditional Retinol Moderate Moderate Moderate
  • Needs two-steps conversion to Retinoic acid in the skin to be moderately effective.
  • Moderate risk for irritation.
Retinaldehyde Low High High
  • Effective after one-step conversion to Retinoic acid in the skin.
  • Moderate to High risk for irritation.
Hydroxypinacolone Retinoate (HPR) Very High Low High
  • Effective with no need for conversion to Retinoic acid in the skin.
  • Binds directly to RA receptors.
  • Low risk for irritation.
Retinoic acid Low Very High Very High
  • Very effective with no need for conversion, because it's already in its active form.
  • Binds directly to RA receptors.
  • Very high risk for irritation.
  • Only available in pharmacies with a prescribtion from a medical doctor.

Retinol serum

TARGET TREATMENT

1. REDUCE HYPERPIGMENTATION

2. Regulate Microbiome

3. Regulate oil production

4. Anti-inflammatory and antioxidant

5. Boost collagen production

6. Accelerate dead skin exfoliation

Treatment Serums

testimonials


Customer Reviews

Based on 2443 reviews
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L
Leonie Wilkens
New You

It is wonderful, I absolute love it. Your skin feels so soft and refreshing.

M
Marieta Strauss

Retinol serum

B
Bianca Van Greunen
Bianca

In love with all the products..

M
Mia Bakkes
Amazing

It’s all that your skin need …
New , soft and shiny skin ..

B
Belinda Fourie
Collagen Serum

Absolutely amazing serum. See and feel a difference within the first few days of using the serum.

L
Lee-Anne Lee
Smooth skin

One of the best products that I have come across. Keeps my skin moisturised without the oily after effects

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