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Inflacin serum

Sale priceR 796.00 ZAR

SIZE: 30 mL

A medical-grade treatment with a potent blend of anti-inflammatory and acne-combating ingredients to address skin issues in oily, acne-prone, and combination skin types. The formulation prioritizes preserving skin hydration while effectively eliminating skin concerns like pimples and blackheads.

The serum's composition includes Salicylic acid, known for its proficiency in unclogging pores and reducing acne-related inflammation. Zinc PCA is critical in regulating sebum production and minimizing oily skin complications. Niacinamide shrinks enlarged pores and alleviates inflammation related to acne and rosacea. Lastly, Retinol stimulates cell turnover, aids in the fight against premature aging, and enhances overall skin texture and tone.

As a holistic approach, Inflacin Serum reduces current skin issues and aims to prevent future skin complications, thus promoting a healthier skin condition.


Zinc PCA

Zinc PCA, also known as Zinc Pyrrolidone Carboxylic Acid, is a skin care ingredient that combines the mineral zinc with a hydrating molecule PCA (Pyrrolidone Carboxylic Acid). It is renowned for its numerous benefits in skincare, particularly for its anti-inflammatory, antimicrobial, and sebum-regulating properties.

Zinc PCA is derived from zinc, an essential mineral known for its antioxidant and skin-soothing capabilities. Zinc is also noted for its role in wound healing and its ability to reduce inflammation, which can be particularly beneficial for acne-prone and irritated skin. The PCA component is a natural moisturizing factor (NMF) found in the skin, which helps maintain the skin's hydration levels.

One of the key benefits of Zinc PCA is its ability to regulate sebum production. Excess sebum can lead to acne and oily skin, and Zinc PCA helps to moderate this by inhibiting the activity of the enzyme 5-alpha reductase, which is involved in oil production. This makes it an effective ingredient in formulations targeting oily and acne-prone skin (Schueller, R. and Romanowski, P., 2003).

In addition to its sebum-regulating properties, Zinc PCA possesses antimicrobial properties, which further contribute to its efficacy in treating acne. By reducing the presence of acne-causing bacteria on the skin, it helps to prevent and reduce acne breakouts.

Moreover, Zinc PCA's anti-inflammatory properties make it beneficial for soothing irritated skin and reducing redness and inflammation associated with various skin conditions, including acne, rosacea, and eczema.

Physiological Effects of Zinc PCA
  1. Sebum Regulation: Zinc PCA reduce and regulate sebum secretion and production, making it beneficial for oily and acne-prone skin by controlling excess oil production.
  2. Antimicrobial Action: Zinc has antimicrobial properties, particularly effective against acne-causing bacteria, reducing acne breakouts.
  3. Anti-inflammatory Effects: Zinc PCA reduces inflammation, which is beneficial in treating inflammatory skin conditions like acne and rosacea.
  4. Moisture Retention: PCA is a natural moisturizing factor (NMF) that helps maintain skin hydration, enhancing the skin’s moisture retention capabilities.
  5. Wound Healing: Zinc is essential for wound healing processes, aiding in the repair and regeneration of skin tissues.
Role in Managing Dermatological Conditions
  1. Acne Management: Its ability to regulate sebum production and provide antimicrobial action makes Zinc PCA a valuable ingredient in acne treatments.
  2. Oily Skin: It's beneficial in controlling excess oiliness and maintaining a balanced skin environment.
  3. Sensitive Skin Conditions: Due to its anti-inflammatory properties, Zinc PCA soothes sensitive skin and conditions like rosacea.
  4. Skin Hydration: Its role as an NMF helps in maintaining skin hydration, useful in treating dry skin conditions.
References
  • Schagen, S. K., et al. (2012). Discovering the link between nutrition and skin aging. Dermato-endocrinology.
  • Firooz, A., et al. (2011). Zinc therapy in dermatology: a review. Dermatology Research and Practice.
  • Gupta, M., et al. (2014). Zinc therapy in dermatology. Indian Dermatology Online Journal.
  • Schueller, R. and Romanowski, P. (2003). Conditioning Agents for Hair and Skin. Cosmetic Science and Technology Series. Marcel Dekker Inc., New York, USA.
Niacinamide

Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It has been shown to be effective in reducing the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function makes it beneficial for all skin types, particularly for those with eczema or mature skin.

Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the skin's epidermis, helping to fade dark spots and even out skin tone.

Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.

Physiological Effects of Niacinamide
  1. Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, which are lipids that keep the skin hydrated and protect against environmental damage.
  2. Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
  3. Sebum Regulation: Niacinamide can regulate sebum production, which helps in controlling excess oiliness and can be beneficial for acne-prone skin.
  4. Hyperpigmentation Reduction: It is known to reduce hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
  5. Anti-aging Effects: Niacinamide helps in reducing the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
  6. Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.
Role in Managing Dermatological Conditions
  1. Acne and Oily Skin: By regulating sebum and reducing inflammation, niacinamide is effective in managing acne and oily skin conditions.
  2. Hyperpigmentation and Melasma: Its ability to reduce melanin transfer makes it beneficial in treating hyperpigmentation and melasma.
  3. Aging Skin: Its anti-aging properties make niacinamide a popular ingredient in skincare products targeting wrinkles and loss of firmness.
  4. Skin Barrier Disorders: Niacinamide is beneficial in the treatment of skin barrier disorders like atopic dermatitis and eczema, by enhancing barrier function and hydration.
  5. Photodamage and Skin Protection: It helps in mitigating the effects of photodamage and provides some degree of protection against environmental damage.
References
  • Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
  • Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
  • Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
  • Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.
Salicylic acid

Salicylic acid, a renowned beta hydroxy acid (BHA), stands as a cornerstone in the realm of dermatology and skincare due to its exceptional keratolytic and comedolytic properties. It has a unique ability to penetrate oil-laden hair follicle pores, making it particularly effective in treating acne-prone and oily skin types.

Salicylic acid works by dissolving the type of skin debris that clogs pores and causes acne, namely sebum and dead skin cells. It's a mild anti-bacterial- and a powerful anti-inflammatory agent, which help to reduce the redness and swelling associated with breakouts.

What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin not just on the surface, but within the pores themselves. This is due to its oil-soluble nature, allowing it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.

Furthermore, salicylic acid also has the capacity to adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions, both in terms of count and severity. Additionally, salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.

Physiological Effects of Salicylic Acid
  1. Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
  2. Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
  3. Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
  4. Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
  5. Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, making it effective in treating acne located deep within the pores.
Role in Managing Dermatological Conditions
  1. Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effective in both preventing and treating existing acne lesions.
  2. Psoriasis: Its keratolytic properties make it useful in softening and removing scales associated with psoriasis.
  3. Warts: Salicylic acid is commonly used in the treatment of warts due to its ability to exfoliate and remove the thickened skin.
  4. Seborrheic Dermatitis: It helps in managing seborrheic dermatitis by reducing scaling and redness.
  5. Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with keratosis pilaris.
References
  • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
  • Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
  • Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
  • Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.
Retinoic acid analogue

Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skincare, particularly in treating acne and signs of skin aging.

Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In the treatment of acne, it promotes the turnover of skin cells, reducing the likelihood of pore clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.

In anti-aging skincare, retinoic acid's ability to stimulate collagen production is a key benefit. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids in skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster and shedding pigmented and damaged cells.

Despite its benefits, retinoic acid can be quite irritating to the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.

Hydroxypinacolone Retinoate (HPR), is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without the need for conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.

HPR is considered more gentle and less irritating compared to traditional retinoic acid, while offering comparable benefits. With HPR everyone has access to the benefits of prescription retinoids, without the risk of side effects.

Physiological effects of Retinoic acid and HPR and their Role in Managing Dermatological Conditions
  1. Cell Turnover and Renewal: Promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and the generation of new cells.
  2. Skin Texture: By promoting cell renewal it improves skin texture, addressing issues like roughness and dullness.
  3. Collagen Production: It stimulates collagen production, essential for reducing the appearance of fine lines, wrinkles, and improving skin elasticity.
  4. Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
  5. Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
  6. Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.
HPR specific benefits
  1. Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
  2. Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
  3. Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
  4. Acne and Hyperpigmentation: It is effective in treating acne and reducing hyperpigmentation, often with fewer side effects compared to retinoic acid.
  5. Stability and Penetration: Being more stable and lipid-soluble, HPR penetrates the skin more effectively and is less prone to degradation.
References
  • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
  • Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
  • Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
  • Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
  • Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.
DermExcel™ | Inflacin Serum
Inflacin serum Sale priceR 796.00 ZAR
  • Acne: Target acne-causing bacteria and reduce inflammation, minimizing the occurrence of acne breakouts.
  • Blackheads: Dissolve and extract clogged pore content, effectively treating and preventing blackheads.
  • Oily Skin: Helps to regulate excess sebum production, improving skin appearance and reducing shininess.
  • Enlarged Pores: Minimize the appearance of enlarged pores by removing dead skin cells and regulating oil production.
  • Inflammation: Reduce inflammation associated with various skin conditions, including acne, rosacea, and premature aging.
  • Premature Aging: Combat visible signs of premature aging by promoting cell turnover and stimulating cell structures.
  • Combination Skin: Helps to balance oil production and maintain the skin's moisture balance in combination skin which experiences both oily and dry areas.
  • Skin Texture and Tone: Stimulates cellular turnover, leading to improved skin texture, firmness, and skin tone.
  • Rosacea-Prone or Red Skin: The anti-inflammatory, anti-bacterial, exfoliating, and sebum regulation properties of Inflacin serum soothe and relieve skin prone to rosacea or persistent redness.
  • Shaving Bumps and Ingrown Hair: Soothe shaving bumps and prevent ingrown hairs by exfoliating the skin and preventing pore clogging.
  • Cleanse: Start with a clean, dry face. Use your DermExcel cleanser to remove dirt and excess oil from your skin.
  • Apply: Take a small amount of Inflacin Serum (1-2 pumps or a pea-sized amount should suffice) and gently apply it to the face, concentrating on the problematic areas. Avoid the eye area, as the ingredients may cause irritation.
  • Massage: Using your fingertips, gently massage the serum into your skin in a circular motion. This helps to ensure the serum is evenly distributed and absorbed.
  • Wait: Allow the serum to absorb fully into the skin before applying other skincare products. This typically takes a few minutes.
  • Follow-up: Once the serum has been fully absorbed, continue with the rest of your skincare routine, such as applying sunscreen (in the morning).

 By following these detailed steps, you will maximize the benefits of Inflacin Serum. Remember, skin may react differently to new products. Start slow, observe how your skin responds, and adjust usage accordingly.

Active ingredients

  • Zinc PCA
  • Niacinamide
  • Salicylic acid
  • Retinoic acid analogue

Full ingredient list

Aqua, Polyethylene Glycol, Niacinamide, Salicylic acid, Sodium Acrylates Copolymer & Lecithin, Phenoxyethanol & Ethylhexylglycerin, Zinc PCA, Dimethyl Isosorbide & Hydroxypinacolone Retinoate, Sodium Phytate & Aqua & Alcohol, Butylene Glycol, Hydrolyzed Yeast Protein, Fomes Officinalis (Mushroom) Extract, Pyridoxine, Niacinamide, Panthenol, Allantoin, Threonine, Biotin, Tocopherol, Disodium EDTA

Inflacin serum

benefits

Sebum Regulation

Regulates excess sebum production, reducing complications and improving the appearance of oily and enlarged pores.

Blackhead Removal

Inflacin serum will dissolve and extract cellular debris from clogged pores and minimize the appearance of enlarged pores.

Anti-Inflammatory

Inflacin Serum reduces inflammation related to acne, rosacea, and premature aging due to its potent anti-inflammatory ingredients.

Anti-Aging Benefits

Inflacin Serum improves skin texture and firmness by promoting cell turnover, targeting visible signs of premature aging.

Bacterial Inhibition

Inhibit the growth of topical bacteria, including those contributing to acne formation.

Exfoliation and Cell Renewal

Remove dead skin cells to prevent it from clogging pores, and reveal brighter, more radiant skin cells.

Inflacin serum

INDICATIONS

Acne / Breakouts

Aging Skin

Enlarged Pores

Excessively Oily Skin

Inflammation

Rosacea / Red Skin

Shaving Bumps

Clogged Pores

Inflacin serum

MODE OF ACTION

disease education

acne stages and treatment objectives

  • The excretion of lipids by the sebaceous glands is controlled hormonally.
  • The sebaceous glands are located all over the body but are the largest and most numerous in the face, back, chest, and shoulders.
  • These glands become more active during puberty because of increased androgens, particularly testosterone, which spurs sebum production.
  • This imbalance between sebum production and secretion capacity leads to a blockage of sebum in the hair follicle, followed by inflammation.
  • Hormones continue to affect sebaceous gland activity into adulthood.
  • The first stage of acne is called comedogenesis (formation of comedones).
  • The exfoliated dead skin cells stick together inside the hair follicle, resulting in a clogged pore or comedone.
  • This is caused by several factors, including increased amounts of sebum, inflammation of the sides of the hair follicle preventing the release of the exfoliated keratinocytes, and increased cohesion of keratinocytes.
  • Salicylic acid decongests pores by dissolving and extracting dirt, oil, and cellular debris (dead skin cells) in the pores and follicles.
  • The keratinocyte plug and sebum provide excellent food sources for bacteria.
  • The bacteria invade the comedone and release inflammatory factors that lead to the next stage of acne.
  • Salicylic acid inhibits the production of various aspects necessary for bacterial reproduction, such as fibrinogen, fibronectin, and alpha-hemolysis.
  • Inflammation continues with increased redness and pus.
  • This is clinically detectable as a papule or pustule.
  • Continued inflammation may lead to so much inflammation that the hair follicle ruptures and the bacteria and debris are released into the dermis.
  • Salicylic acid suppresses pro-inflammatory cytokine expression.

disease education

rosacea stages and treatment objectives

A constant interplay exists among the skin, micro-organisms, and the environment to maintain a delicate balance. Disturbance of this balance negatively influences both the microflora and skin health.

In Rosacea, the micro-environment of the affected skin is substantially altered, resulting in a shift in the proportion or speciation of the resident microflora. Several micro-organisms have been shown to be increased or immuno-reactive in patients with rosacea.

Or skin contains pattern recognition receptors (PPR). These receptors detect harmful bacteria on our skin. When they detect these harmful bacteria, they bind to them and activate an immune response.

Receptors (PPR) don't activate the immune response for normal micro-flora on our skin. Rosacea-prone skin receptors (PPR) are hyper-reactive and/or have decreased tolerance. They have heightened sensitivity and trigger the inflammatory response of normal microbes, leading to the initial signs of rosacea.

  • Healthy skin with a perfect balance between normal microflora and skin receptors.
  • The function of the pathogen recognizing receptos receptors (PPR) is to detect and bind to harmful molecules and then to activate the immune response.
  • These receptors should not trigger an immune response by binding to normal microflora.
  • PPR (receptors) of Rosacea-prone skin bind to normal flora (they are not supposed to) and activate the immune response that causes inflammation.
  • PPR (receptors) of Rosacea-prone skin is hyper-reactive and sensitive. They can be activated by various environmental agents (fragrance, heat, spicy food, etc.)
  • Inflammation leads to an increase in white blood cells (leucocytes) and antimicrobial peptides (cathelicidins), causing certain normal microbes to be eliminated.
  • The disruption of the body's normal microbial community leads to an imbalance, where potentially harmful microbes overgrow and occupy spaces left by the eliminated beneficial microbes.
  • The negative feedback loop continues where alterations in the micro-flora lead to increased inflammation, which in turn exacerbates Rosacea, resulting in more severe symptoms.

Inflacin serum

treating rosacea & acne

Anti-inflammatory

Inhibit the inflammation that leads to breakouts, redness, and skin damage.

Comedolytic

Unclog pores by dissolving and extracting dirt, oil, and cellular debris in the pores.

Keratolytic

Disrupts cellular junctions to exfoliate dead skin cells.

Anti-Bacterial

Inhibits the bacteria responsible for causing and aggrevating Acne and Rosacea.

Treatment Serums

testimonials


Customer Reviews

Based on 2443 reviews
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L
Leonie Wilkens
New You

It is wonderful, I absolute love it. Your skin feels so soft and refreshing.

M
Marieta Strauss

Retinol serum

B
Bianca Van Greunen
Bianca

In love with all the products..

M
Mia Bakkes
Amazing

It’s all that your skin need …
New , soft and shiny skin ..

B
Belinda Fourie
Collagen Serum

Absolutely amazing serum. See and feel a difference within the first few days of using the serum.

L
Lee-Anne Lee
Smooth skin

One of the best products that I have come across. Keeps my skin moisturised without the oily after effects

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