DermExcel™

Retinol Serum

Name: Retinol Serum
Brand: DermExcel™
SKU: DX-RET
Price: 1334.0 ZAR
Availability: InStock
Rating: 4.92 (2583 reviews)

4.9 / 5.0 from 2583 reviews

R 1,334.00 ZAR

SIZE: 30 mL

An advanced skincare formula that leverages the potency of active ingredients like Hydroxypinacolone Retinoate, Niacinamide, and Argireline. Hydroxypinacolone Retinoate, a form of retinoid, works at the cellular level to stimulate epidermal growth, counteracting both intrinsic and extrinsic signs of aging. It aids in reducing hyperpigmentation and evening skin tone while promoting the growth of collagen and elastin, proteins that are vital for maintaining skin's elasticity and structure.

Another key ingredient, Niacinamide, is instrumental in supporting cell health in the skin. It helps build and protect skin cells from environmental stresses like sunlight, pollution, and toxins, while also playing a significant role in acne treatment.

Argireline, a powerful peptide, adds to the formula's efficacy by slowing down muscle movement in the face, thus decreasing the appearance of wrinkles and expression lines. It enhances collagen production, which firms the skin and increases its elasticity. Additionally, it provides hydration, keeping the skin well-moisturized.

DermExcel Retinol Serum stimulates collagen production, reduces inflammation, inhibits pigmentation, and accelerates cell turnover, all contributing to a healthier and more youthful complexion. It also aids in reducing sebum production and unclogging pores, making it a potent tool in the battle against acne.

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USE DURING PREGNANCY

Given the inclusion of retinoid (Hydroxypinacolone Retinoate), DermExcel Retinol Serum is not recommended for use during pregnancy.

While DermExcel Retinol Serum is designed to deliver exceptional skincare results, pregnancy is a unique journey that requires specialized care. We adhere to medical science, and current data suggests avoiding retinoids during pregnancy. Always consult your healthcare provider for the safest skincare choices during this important life stage.

Even though studies indicate that topical retinol do not suggest an increased risk of retinoid embryopathy, the safety of its use during pregnancy has not been definitively established. The cautious approach is to avoid its use during this life stage, unless otherwise advised by a qualified healthcare provider.

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References

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Retinol Serum

R 1,334.00 ZAR

Stimulates Collagen Production - the protein that provides structure and elasticity to the skin. This helps to reduce the appearance of wrinkles and fine lines.
Reduces Hyperpigmentation and dark spots, leading to a more even skin tone.
Protects Skin Cells from environmental stresses such as sunlight, pollution, and toxins.
Decreases Wrinkles and Expression Lines by slowing down the movement of facial muscles.
Reduce And Prevent Pigmentation by inhibiting the enzymes responsible for pigmentation.
Promotes Skin Hydration by enhancing the skin's ability to retain moisture, leading to a healthier and more youthful appearance.
Accelerates Cell Turnover by promoting faster cell turnover. This helps the skin to rejuvenate faster, revealing healthier, fresher skin cells.
Regulate Sebum Production to help unclog pores and reduce the risk of acne outbreaks.
Reduce Inflammation: Anti-inflammatory action improves skin texture and appearance and helps mitigate acne formation.
Improves DNA Communication Between Cells Assists in reversing DNA damage that causes skin aging and to prevent cells from clumping and sticking together inside pores.

Cleanse: Start with a clean, dry face. Use your DermExcel cleanser to remove dirt and excess oil from your skin.
Apply: The best time to apply the serum is when your skin is still slightly damp after cleansing. This allows your skin to better absorb the potent ingredients in the serum. So, after cleansing your face, don't completely dry your skin; leave it slightly damp. Take a small amount of Retinol Serum (1-2 pumps or a pea-sized amount should suffice) and gently apply it to the face.
Massage: Using your fingertips, gently massage the serum into your skin in a circular motion. This helps to ensure the serum is evenly distributed and absorbed.
Wait: Allow the serum to absorb fully into the skin before applying other skincare products. This typically takes a few minutes.
Follow-up: Once the serum has been fully absorbed, continue with the rest of your skincare routine, such as applying sunscreen (in the morning).

By following these detailed steps, you will maximize the benefits of Retinol Serum.

Active ingredients

ArG
Matrixyl 3000
Nc4
ra3

Full ingredient list

Aqua, Niacinamide, Acetyl Hexapeptide-8 & Caprylyl Glycol, Dimethyl Isosorbide & Hydroxypinacolone Retinoate, Glycerin, Hydroxypropyl Cyclodextrin & Palmitoyl Tripeptide-38, Sodium Acrylates Copolymer & Lecithin, Phenoxyethanol & Ethylhexylglycerin, Acrylates copolymer, Glycerin, C14-22 Alkane, Pentaerythrityl Tetra-Di-t-Butyl Hydroxyhydrocinnamate

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Retinol Serum

benefits

Reduce Hyperpigmentation

Inhibits the enzymes responsible for pigmentation, reducing the occurrence of dark spots and uneven skin tone.

Decrease Lines & Wrinkles

Promote Skin Hydration

Enhance skin renewal

Promote faster cell turnover, leading to faster skin rejuvenation, revealing healthier, fresher skin cells.

Anti-Inflammatory

Regulate Sebum Production

Regulate sebum production, which helps to unclog pores and reduce the risk of acne outbreaks.

Improve Skin Cell DNA

Optimizes DNA communication between cells, promoting healthier cellular behavior and improving physiological function.

Retinol Serum

INDICATIONS

Aging Skin

Dry & Dehydrated Skin

Dull & Lifeless Skin

Pigmentation

Acne / Breakouts

Rough Skin Texture

Red & Inflamed skin

Retinol Serum

MODE OF ACTION

Improve Skin Barrier

Stimulate collagen synthesis and significantly increase skin elasticity.
Prevents the breakdown of collagen and elastin through antioxidant and anti-inflammatory activity.
Prevents DNA damage through antioxidant activity.
Increases production of ceramides as well as other stratum corneum lipids to improve skin barrier funtion.

Inflammation (Rosacea & Acne)

Retinol

Retinol improves and corrects the DNA communication between the cells to prevent the cells from clumping and sticking together.
Retinol will also reduce the production of sebum and will assist in increasing exfoliation and unclogging of pores.
Retinol will reduce inflammation that contributes to the formation of acne.

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Niacinamide

Reduce the inflammatory response by inhibiting inflammatory messengers.
Provides long-lasting protection against bacteria through activation of anti-microbial peptides.
Reduce sebum (oil) production, thus preventing bacterial growth and inflammation.

Anti-Aging

Inside our skin, we have retinol receptors called retinoic acid receptors (RAR) and retinoid X receptors (RXR). Retinol acts on those receptors to speed up skin cell production. Retinol also encourages collagen production, so, essentially, it triggers your skin to act younger. Old cells die faster, making way for new, young, healthy cells.

Prevention: Retinol focuses on preventing wrinkle or aging formation on a cellular level by preventing the degradation of collagen and elastin.
Correction: Retinol and Niacinamide stimulate the production of collagen. This formula will also reduce inflammation, which significantly degrades collagen and elastin within the skin.

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Hyaluronic acid

Hyaluronic acid increases pro-collagen I synthesis and reduce skin roughness.

Hyaluronic acid has an important role in skin aging. Cells lose their ability to produce Hyaluronic acid with aging. The skin becomes drier, thinner, and looser, leading to wrinkling, among other significant changes.
Skin aging is also associated with a decrease of skin moisture. Hyaluronic acid has a unique capacity to link and retain water molecules. Hyaluronic acid is a natural component that is present in the whole body. It is naturally and constantly renewed because of its rapid degradation, but its renewal tends to slow with age and external aggressions. Therefore it is necessary to act very early, sustaining an optimal hyaluronic acid turnover, similar to that of young skin, in order to prevent the signs of aging.
In relation to its biological effects at the skin level, it is known that hyaluronic acid is actively involved in skin cell signalling (by binding the CD44 and LYVE-1 receptors) and thus influences the extracellular matrix (ECM) stability.
Hyaluronic acid has an impact on the growth of keratinocytes (skin cells) which protect the epidermis from aging and promotes elasticity.

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Matrixyl 3000

Matrixyl® Synthe'6 is a powerful lipopeptide that stimulates the synthesis of six major cell-building components that are natural ingredients in the skin’s matrix.
This peptide helps to rebuild several types of collagen found in the skin that are especially beneficial, along with fibronectin and hyaluronic acid.
Matrixyl® Synthe'6 assists in restoring collagen and elastin, while strengthening the skin’s matrix including:

Smoothing out the appearance of pronounced wrinkles
Increasing firmness of skin
Improving photo damaged skin
Improving overall texture

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Argireline

Argireline® peptide solution C is the first anti-wrinkle hexapeptide with a Botulinum Toxin-like mechanism of action. It reduces the depth of the facial wrinkles caused by the contraction of muscles of facial expression, especially in the forehead and around the eyes.

This hexapeptide relaxes the muscles responsible for the formation of expression lines.
The release of neurotransmitters is impaired, resulting in weakened facial contractions, thus inhibiting the formation of wrinkles.

Pigmentation

Retinol

Tyrosinase inhibitor: Retinol inhibits the enzymes responsible for pigmentation.
Melanosome transfer inhibitor: DermExcel Retinol serum also includes Niacinamide, inhibiting pigment transfer to skin cells.
Keratolytic: Retinol will also accelerate the cell turnover to such an extent that it outpaces melanin production.

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Niacinamide

Prevents DNA damage through antioxidant activity.
Prevent melanosome transfer from melanocytes to surrounding skin cells.

RETINOID

MOLECULE COMPARISON

Traditional Retinol

Stability: Moderate

Irritation: Moderate

Efficacy: Moderate

Key Notes:

Needs two-steps conversion to Retinoic acid in the skin to be moderately effective.
Moderate risk for irritation.

Retinaldehyde

Stability: Low

Irritation: High

Efficacy: High

Key Notes:

Effective after one-step conversion to Retinoic acid in the skin.
Moderate to High risk for irritation.

Hydroxypinacolone Retinoate (HPR)

Stability: Very High

Irritation: Low

Efficacy: High

Key Notes:

Effective with no need for conversion to Retinoic acid in the skin.
Binds directly to RA receptors.
Low risk for irritation.

Retinoic acid

Stability: Low

Irritation: Very High

Efficacy: Very High

Key Notes:

Very effective with no need for conversion, because it's already in its active form.
Binds directly to RA receptors.
Very high risk for irritation.
Only available in pharmacies with a prescribtion from a medical doctor.

Molecule	Stability	Irritation	Efficacy	Key Notes
Traditional Retinol	Moderate	Moderate	Moderate	Needs two-steps conversion to Retinoic acid in the skin to be moderately effective. Moderate risk for irritation.
Retinaldehyde	Low	High	High	Effective after one-step conversion to Retinoic acid in the skin. Moderate to High risk for irritation.
Hydroxypinacolone Retinoate (HPR)	Very High	Low	High	Effective with no need for conversion to Retinoic acid in the skin. Binds directly to RA receptors. Low risk for irritation.
Retinoic acid	Low	Very High	Very High	Very effective with no need for conversion, because it's already in its active form. Binds directly to RA receptors. Very high risk for irritation. Only available in pharmacies with a prescribtion from a medical doctor.

Retinol Serum

TARGET TREATMENT

1. REDUCE HYPERPIGMENTATION

2. Regulate Microbiome

3. Regulate oil production

4. Anti-inflammatory and antioxidant

5. Boost collagen production

6. Accelerate dead skin exfoliation

Treatment Serums

testimonials

Love the inflacin serum!!!!

I have been battling with my skin for more than a year now and have tried almost every brand you can think of but nothing ever worked. This serum is the only thing that helps with breakouts.

Love from me to Dermalhealth

I love there products it’s so nice and works great on my skin would recommend Deramlhealth to anyone struggling with their skin or just anyone who wants good skin.

Collagen Serum

Noticable Results

I've been using Litaderm for the past two months, which has made a difference in managing outbreaks and sun damage. My skin texture has noticeably improved, and pigment areas appear even and lighter. The product has been consistently effective and has exceeded my expectations.

One suggestion for improvement would be to consider packaging it in a tube. With the current rigid packaging, accessing any product left inside is challenging once it nears its end, especially given its premium price range. A tube design would allow users to cut it open and fully utilize all its content.

Overall, my experience with Litaderm has been excellent, and I highly recommend it to anyone over 40 looking for effective skincare solutions for outbreaks and pigmentation concerns.

Inflacon Serum

Amazing product. My 15- and 17-year olds are using it with great success. Very effective on acne, blackheads and shavings bumps & ingrown hair! Just love the product!

Retinol gives you a beautiful skin

Since I have started using retinol dermexcel I have never looked back. It gives me the glow, it calms my acne, my skin looks younger plus the serum last me for months. Totally worth it

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squeeky clean

by far my favorite face wash...leaves my skin feeling squeeky clean but not dried out

Life Changing Skincare!!

Experienced problem skin my whole life, with breakouts since my teenage years. Being using different products and prescribed treatments for years. Tried Dermal Health 2 years ago and within few weeks my skin problem was over and I received many compliments on my glowing complexion. Tried something else for last few months but Im regretting it. Being using my products again for 4 week and my skin is already thanking me. Im 45, and will never use or try anything else in my life again. Thank you Derm Excel.

Worth the spend

I recently did a skin analysis on the Dermal Health Website and order the products that were recommended by them. Within a week I could see the difference, my pores are much smaller, and my red pigment is much better.

Love the spf50

I have eczema and i get a allergic reaction to sunburn The best product to use on your face to prevent outbreak or a rash of the sun

Retinol Serum

Argireline: The Innovative Peptide in Anti-Aging Dermatology

Biochemical Mechanism

Matrixyl 3000: The Powerhouse of Anti-Aging Peptides

Customer Reviews

References

Retinol Serum

Retinol

Niacinamide

Hyaluronic acid

Matrixyl 3000

Argireline

Retinol

Niacinamide

Customer Reviews

Let customers speak for us