Dermaplan™

Firsthand™ Treatment

Name: Firsthand™ Treatment
Brand: Dermaplan™
SKU: DP-FHAND50
Price: 34000 KRW
Availability: InStock

4.9 / 5.0 from 27 reviews

₩34,000

SIZE: 50 mL

Dry skin

Rough texture

Inflammation

Eczema

Ichthyosis

Rejuvenize, brighten and soothe dehydrated hands.

Firsthand™ stands as an advanced Physiological Ceramide-Dominant Barrier-Repair Therapy, constructed with a robust spectrum of moisturizing agents, constituting an intelligent moisturizing complex. The potency of this hand emulsion is amplified by its multifunctional formulation designed to promote collagen synthesis, attenuate the impact of solar damage, inhibit the reduction of skin elasticity, and mend a compromised skin barrier.

Key components such as Ceramides, Cholesterol, and Fatty acids work synergistically to reinforce the integrity of the skin's lipid barrier, bolstering its resilience against external insults. Incorporating Niacinamide invigorates cellular energy and ameliorates skin tone and texture, while d-panthenol, a potent vitamin B5 derivative, provides potent anti-inflammatory effects and aids in skin repair. Moreover, adding hyaluronic acid ensures optimum hydration by attracting and retaining moisture, which is vital for maintaining the skin's suppleness and health.

After utilizing Firsthand™, hands manifest signs of rejuvenation and radiance, while desiccation is thoroughly alleviated. The physiological enhancements rendered by Firsthand™ result in hands that appear and feel younger and stronger and exhibit enhanced health.

Emollients

Emollients are crucial in dermatological care, primarily because they enhance skin hydration and barrier function. Here's a brief overview of their physiological effects and roles in managing various skin conditions.

Physiological Effects

Hydration of Stratum Corneum: Emollients increase moisture content in the stratum corneum, the outermost layer of the skin, by reducing transepidermal water loss (TEWL). This is achieved through occlusion, which traps water in the skin.
Restoration of Skin Barrier Function: They aid in replenishing the skin's lipid barrier, which is essential for maintaining skin integrity and protective function.
Soothing and Smoothing Effects: Emollients smooth, flaky skin cells, making the skin surface appear smoother. They also provide a soothing effect, which can reduce itching and discomfort.
Anti-inflammatory Properties: Some emollients have ingredients that offer mild anti-inflammatory benefits, helping to reduce redness and irritation.

Role in Managing Dermatological Conditions

Atopic Dermatitis (Eczema): Emollients are a cornerstone in the management of eczema, helping to maintain skin hydration, reduce flare-ups, and minimize the need for topical corticosteroids.
Psoriasis: Regular use of emollients can reduce scaling and dryness associated with psoriasis, improving the efficacy of other topical treatments.
Ichthyosis and Xerosis: These conditions, characterized by dry, scaly skin, benefit significantly from emollients, which help hydrate and soften the skin.
Aging Skin: Emollients improve the appearance of aging skin by hydrating and reducing the visibility of fine lines and wrinkles.
Skin Protection: Emollients can protect the skin from irritation and breakdown in individuals with incontinence or those who are bedridden.

References

Proksch, E., & Lachapelle, J. M. (2005). The Management of Dry Skin with Topical Emollients. American Journal of Clinical Dermatology.
Lynde, C. W. (2001). Moisturizers: What They Are and a Practical Approach to Product Selection. Skin Therapy Letter.
Lodén, M. (2003). Role of Topical Emollients and Moisturizers in the Treatment of Dry Skin Barrier Disorders. American Journal of Clinical Dermatology.

d-Panthenol

d-Panthenol's multifaceted effects on skin hydration, barrier strengthening, and wound healing make it a valuable component in the management of various dermatological conditions, from dry skin to post-procedure care.

d-Panthenol, also known as pro-vitamin B5, is a popular dermatological ingredient due to its beneficial effects on the skin. Here's a brief overview of its physiological effects and roles in managing various skin conditions:

Physiological Effects

Hydration: d-Panthenol is a humectant, meaning it helps to attract and retain moisture in the skin. This leads to increased skin hydration, which can improve skin softness and elasticity.
Wound Healing and Repair: It plays a role in the synthesis of lipids and proteins, essential for skin repair. d-Panthenol has been shown to accelerate re-epithelialization in wound healing.
Anti-Inflammatory Effect: d-Panthenol can reduce inflammation, making it beneficial in treating skin irritations and erythema.
Skin Barrier Strengthening: By enhancing the synthesis of lipids and proteins, d-Panthenol contributes to the strengthening of the skin's barrier function, protecting against irritants and environmental damage.
Soothing and Softening: It soothes the skin and makes it feel softer and smoother, which can be particularly beneficial for dry or rough skin textures.

Role in Managing Dermatological Conditions

Minor Wounds and Skin Irritations: Due to its role in skin repair and anti-inflammatory properties, d-Panthenol is used in the treatment of minor wounds, cuts, and skin irritations.
Dermatitis and Eczema: It helps in managing conditions like dermatitis and eczema by reducing inflammation and enhancing skin barrier function.
Dry Skin Conditions (Xerosis): Its moisturizing properties make it effective in treating dry skin, providing relief from itching and scaling.
Post-procedure Care: d-Panthenol is often used in post-procedure care, such as after laser treatments or chemical peels, to aid in skin recovery and reduce inflammation.

References

Proksch, E., & Nissen, H. P. (2002). Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation. Journal of Dermatological Treatment.
Ebner, F., Heller, A., Rippke, F., & Tausch, I. (2002). Topical use of dexpanthenol in skin disorders. American Journal of Clinical Dermatology.
Camargo, F. B. Jr, Gaspar, L. R., & Maia Campos, P. M. B. G. (2011). Skin moisturizing effects of panthenol-based formulations. Journal of Cosmetic Science.

Niacinamide

Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.

Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.

Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.

Physiological Effects

Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.

Role in Managing Dermatological Conditions

Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
Aging Skin: Niacinamide targets wrinkles and loss of firmness.
Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.

References

Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.

Medilan™

Medilan™'s unique formulation and hypoallergenic properties make it a valuable component in managing various dermatological conditions, particularly for hydrating and soothing sensitive and dry skin.

Medilan™, an ultra-refined, hypoallergenic medical-grade lanolin, has proven to be very beneficial for managing dermatological conditions. Below is a brief overview of its physiological effects and roles in managing various skin conditions.

Physiological Effects

Emollient: Medilan™ is an excellent emollient, helping to soften and smooth the skin by retaining moisture. It creates an occlusive barrier, which reduces transepidermal water loss (TEWL).
Moisturizing: It is highly effective in moisturizing dry and rough skin, enhancing skin hydration by trapping and sealing in moisture.
Hypoallergenic: Medilan™ is ultra-purified to minimize the risk of allergic reactions, making it suitable for sensitive skin types.
Wound Healing: Medilan™ aids in the healing process of minor cuts, abrasions, and burns by maintaining a moist wound environment.
Skin Barrier Function: It enhances the skin's barrier function, protecting against environmental irritants and reducing the risk of skin infections.
Lipid Replenishment: Medilan™ mimics the lipids found in human skin, helping to restore the lipid barrier of the skin, especially beneficial in dry and chapped skin conditions.
Skin Penetration and Hydration: It can penetrate the skin and aid in water retention in the stratum corneum, the outermost layer of the skin, thus enhancing hydration.
Occlusive Properties: Medilan™ helps reduce transepidermal water loss by forming a barrier on the skin surface, thereby retaining moisture and improving skin barrier function.

Role in Managing Dermatological Conditions

Eczema and Dry Skin Conditions: Medilan™ is a valuable ingredient in treating eczema and other dry skin conditions due to its soothing, hydrating, and occlusive properties.
Wound Healing: While primarily used for its emollient effects, the properties of Medilan™ also aid in healing minor wounds and skin irritations.
Sensitive Skin Care: Its hypoallergenic nature makes it suitable for sensitive skin, reducing the risk of irritation or allergic reactions.
Nipple Care in Breastfeeding: Soothes and heals cracked and sore nipples in breastfeeding mothers.
Chapped Lips and Skin: It effectively treats chapped lips and skin, providing a barrier that seals in moisture and protects from harsh weather conditions.

References

Lodén, M., & Maibach, H. I. (2000). Dry skin and moisturizers: chemistry and function. CRC Press.
Suleman, H., et al. (2000). Role of lanolin in managing eczema and dry skin conditions. Community Nurse.
DiNardo, J. C. (2000). Is lanolin allergy a myth? Dermatitis.
Stone, L. (2000). Medilan: a hypoallergenic lanolin for emollient therapy. British Journal of Nursing.
ResearchGate Article on Medilan™ highlighting its role in skin care and emollient therapy.

Ceramides

Ceramides, a family of lipid molecules naturally present in the skin, are integral to the structure and function of the skin barrier. They are a type of lipid that, along with cholesterol and fatty acids, forms a critical part of the stratum corneum, the outermost layer of the skin. This layer is essential for maintaining skin hydration and protecting against environmental aggressors.

Ceramides, which make up about 50% of the skin's lipid composition, play a pivotal role in maintaining the skin's barrier integrity and preventing transepidermal water loss (TEWL). By doing so, they help keep the skin hydrated and supple.

The loss or reduction of ceramides in the skin barrier is associated with several dermatological conditions, including eczema and psoriasis, where the skin becomes dry, itchy, and prone to irritation and infection. Studies have shown that the application of ceramide-containing moisturizers can effectively improve skin barrier function and increase skin hydration levels.

Ceramides are particularly beneficial for aging skin, which naturally loses ceramides over time, leading to drier and more fragile skin. By replenishing the skin's ceramide content, these products can help combat the signs of aging, such as fine lines and wrinkles.

Ceramides are integral to maintaining skin health, particularly in conditions where the skin barrier is compromised. Their role in hydrating the skin, reducing sensitivity, and improving barrier function makes them an essential component in the management of various dermatological conditions, especially eczema, psoriasis, and dry or aging skin.

Physiological Effects

Barrier Function: Ceramides are critical components of the skin's lipid barrier. They help to prevent moisture loss and protect against environmental aggressors like pollutants and irritants.
Hydration: By maintaining the barrier integrity, ceramides keep the skin hydrated, preventing dryness and keeping the skin supple.
Reducing Skin Sensitivity: They play a role in reducing skin sensitivity and irritation, helping to calm inflamed and reactive skin.
Anti-aging Properties: Ceramides can improve skin elasticity and firmness, helping to reduce the appearance of fine lines and wrinkles.
Wound Healing: There is evidence to suggest that ceramides can aid in the skin's natural wound healing process.

Role in Managing Dermatological Conditions

Eczema and Atopic Dermatitis: Ceramides are often used in the treatment of eczema and atopic dermatitis, where the skin barrier is compromised, leading to dryness, itching, and inflammation.
Psoriasis: They can help in managing psoriasis by maintaining skin hydration and barrier function, reducing scaling and dryness.
Aging Skin: Ceramide-containing products are beneficial in anti-aging regimens due to their ability to improve skin barrier function and elasticity.
Dry Skin (Xerosis): In the treatment of dry skin, ceramides help in restoring skin hydration and barrier function.
Sensitive Skin: Products containing ceramides are suitable for sensitive skin as they help to restore the skin's natural barrier and reduce irritation.

References

Del Rosso, J. Q., & Levin, J. (2011). The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. Journal of Clinical and Aesthetic Dermatology.
Farwanah, H., Wohlrab, J., Neubert, R. H. H., & Raith, K. (2005). Ceramides and skin function. American Journal of Clinical Dermatology.
Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato-Venereologica.

SHIPPING

Shipping Guarantee: Guiding you to healthy skin isn’t only about our products; it's also about getting them to you as swiftly as the science behind them. That's why Dermal Health offers a shipping guarantee you can rely on.
Where We Ship From: Orders are dispatched from our facilities in USA and Australia, tailored to your shipping address for optimal efficiency.
Who We Ship With: We trust only well-known, popular, and dependable courier services with your packages.
When You'll Get It: Expect confident skin soon! Shipping addresses in the USA and Australia will enjoy delivery within 1-4 business days. International orders will receive their orders from 6 to 25 business days, depending on the service you select during checkout. Your estimated delivery date will reflect during checkout so that you can mark your calendar.
Tracking Your Order: Eager to start your DermExcel journey? We don't blame you! You'll receive a tracking number after you place your order so that you can follow your package.

For any shipping inquiries, our customer service team is ready to assist.

RETURNS

Dermal Health Science 30-Day Confidence Guarantee: We are passionate about guiding you to healthy skin through medical science. We believe in the quality and effectiveness of our products so much that we offer a 30-Day Confidence Guarantee.

If you're unsatisfied with your purchase, simply return it within 30 days for a full refund.

Healthy Skin Is Not Complicated and neither is our return policy. Please visit our detailed return policy or contact our friendly customer service team for more information.

Feel as confident in us as we want you to feel in your skin.

SECURE PAYMENT

Dermal Health Science Secure Payment Promise: We utilize cutting-edge encryption and security measures to ensure your payment details remain as unblemished as your skin.

Our Secure Payment Promise backs every transaction with DermExcel. We partner with trusted payment providers to create the best shopping experience for you.

Simple. Effective. Ethical. That's not just our skincare philosophy but our approach to your security too.

Firsthand™ Treatment

₩34,000

Aging hands: The inclusion of collagen-stimulating ingredients such as Niacinamide helps reduce the visible signs of aging, such as fine lines, wrinkles, and sun damage, making Firsthand beneficial for aging hands.
Dry Skin (Xerosis): Provides intense hydration to address the symptoms of dry skin, such as tightness, roughness, and flakiness.
Loss of elasticity: By promoting collagen synthesis and improving hydration, Firsthand helps enhance the elasticity and firmness of the hands, making it a suitable option for addressing loss of elasticity.
Sun-damaged hands: The collagen-boosting properties of Firsthand, coupled with its moisturizing agents, contribute to the reduction of sun-induced skin damage, promoting a more youthful and even skin tone.
Ichthyosis: Effective in addressing the scaling, roughness, and excessive dryness associated with ichthyosis, a genetic disorder that impairs the skin's ability to retain moisture.
Impaired barrier function: Firsthand's Physiological Ceramide-Dominant Barrier-Repair Therapy aids in repairing and strengthening the skin's natural barrier, which may be compromised due to environmental factors, harsh products, or excessive dryness.
Rough and textured hands: The combination of moisturizing agents, ceramides, and fatty acids in Firsthand works to improve the texture of the skin, providing a smoother and softer feel.
General hand care: Firsthand can be used as a part of a regular hand care routine to maintain optimal hydration, protect the skin barrier, and promote overall hand health.

Active ingredients

Emollients

Barrier Function: Ceramides are critical components of the skin's lipid barrier. They help to prevent moisture loss and protect against environmental aggressors like pollutants and irritants.
Hydration: By maintaining the barrier integrity, ceramides keep the skin hydrated, preventing dryness and keeping the skin supple.
Reducing Skin Sensitivity: They play a role in reducing skin sensitivity and irritation, helping to calm inflamed and reactive skin.
Anti-aging Properties: Ceramides can improve skin elasticity and firmness, helping to reduce the appearance of fine lines and wrinkles.
Wound Healing: There is evidence to suggest that ceramides can aid in the skin's natural wound healing process.

Eczema and Atopic Dermatitis: Ceramides are often used in the treatment of eczema and atopic dermatitis, where the skin barrier is compromised, leading to dryness, itching, and inflammation.
Psoriasis: They can help in managing psoriasis by maintaining skin hydration and barrier function, reducing scaling and dryness.
Aging Skin: Ceramide-containing products are beneficial in anti-aging regimens due to their ability to improve skin barrier function and elasticity.
Dry Skin (Xerosis): In the treatment of dry skin, ceramides help in restoring skin hydration and barrier function.
Sensitive Skin: Products containing ceramides are suitable for sensitive skin as they help to restore the skin's natural barrier and reduce irritation.

Del Rosso, J. Q., & Levin, J. (2011). The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. Journal of Clinical and Aesthetic Dermatology.
Farwanah, H., Wohlrab, J., Neubert, R. H. H., & Raith, K. (2005). Ceramides and skin function. American Journal of Clinical Dermatology.
Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato-Venereologica.

d-Panthenol

Barrier Function: Ceramides are critical components of the skin's lipid barrier. They help to prevent moisture loss and protect against environmental aggressors like pollutants and irritants.
Hydration: By maintaining the barrier integrity, ceramides keep the skin hydrated, preventing dryness and keeping the skin supple.
Reducing Skin Sensitivity: They play a role in reducing skin sensitivity and irritation, helping to calm inflamed and reactive skin.
Anti-aging Properties: Ceramides can improve skin elasticity and firmness, helping to reduce the appearance of fine lines and wrinkles.
Wound Healing: There is evidence to suggest that ceramides can aid in the skin's natural wound healing process.

Eczema and Atopic Dermatitis: Ceramides are often used in the treatment of eczema and atopic dermatitis, where the skin barrier is compromised, leading to dryness, itching, and inflammation.
Psoriasis: They can help in managing psoriasis by maintaining skin hydration and barrier function, reducing scaling and dryness.
Aging Skin: Ceramide-containing products are beneficial in anti-aging regimens due to their ability to improve skin barrier function and elasticity.
Dry Skin (Xerosis): In the treatment of dry skin, ceramides help in restoring skin hydration and barrier function.
Sensitive Skin: Products containing ceramides are suitable for sensitive skin as they help to restore the skin's natural barrier and reduce irritation.

Del Rosso, J. Q., & Levin, J. (2011). The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. Journal of Clinical and Aesthetic Dermatology.
Farwanah, H., Wohlrab, J., Neubert, R. H. H., & Raith, K. (2005). Ceramides and skin function. American Journal of Clinical Dermatology.
Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato-Venereologica.

Niacinamide

Barrier Function: Ceramides are critical components of the skin's lipid barrier. They help to prevent moisture loss and protect against environmental aggressors like pollutants and irritants.
Hydration: By maintaining the barrier integrity, ceramides keep the skin hydrated, preventing dryness and keeping the skin supple.
Reducing Skin Sensitivity: They play a role in reducing skin sensitivity and irritation, helping to calm inflamed and reactive skin.
Anti-aging Properties: Ceramides can improve skin elasticity and firmness, helping to reduce the appearance of fine lines and wrinkles.
Wound Healing: There is evidence to suggest that ceramides can aid in the skin's natural wound healing process.

Eczema and Atopic Dermatitis: Ceramides are often used in the treatment of eczema and atopic dermatitis, where the skin barrier is compromised, leading to dryness, itching, and inflammation.
Psoriasis: They can help in managing psoriasis by maintaining skin hydration and barrier function, reducing scaling and dryness.
Aging Skin: Ceramide-containing products are beneficial in anti-aging regimens due to their ability to improve skin barrier function and elasticity.
Dry Skin (Xerosis): In the treatment of dry skin, ceramides help in restoring skin hydration and barrier function.
Sensitive Skin: Products containing ceramides are suitable for sensitive skin as they help to restore the skin's natural barrier and reduce irritation.

Del Rosso, J. Q., & Levin, J. (2011). The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. Journal of Clinical and Aesthetic Dermatology.
Farwanah, H., Wohlrab, J., Neubert, R. H. H., & Raith, K. (2005). Ceramides and skin function. American Journal of Clinical Dermatology.
Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato-Venereologica.

Medilan™

Barrier Function: Ceramides are critical components of the skin's lipid barrier. They help to prevent moisture loss and protect against environmental aggressors like pollutants and irritants.
Hydration: By maintaining the barrier integrity, ceramides keep the skin hydrated, preventing dryness and keeping the skin supple.
Reducing Skin Sensitivity: They play a role in reducing skin sensitivity and irritation, helping to calm inflamed and reactive skin.
Anti-aging Properties: Ceramides can improve skin elasticity and firmness, helping to reduce the appearance of fine lines and wrinkles.
Wound Healing: There is evidence to suggest that ceramides can aid in the skin's natural wound healing process.

Eczema and Atopic Dermatitis: Ceramides are often used in the treatment of eczema and atopic dermatitis, where the skin barrier is compromised, leading to dryness, itching, and inflammation.
Psoriasis: They can help in managing psoriasis by maintaining skin hydration and barrier function, reducing scaling and dryness.
Aging Skin: Ceramide-containing products are beneficial in anti-aging regimens due to their ability to improve skin barrier function and elasticity.
Dry Skin (Xerosis): In the treatment of dry skin, ceramides help in restoring skin hydration and barrier function.
Sensitive Skin: Products containing ceramides are suitable for sensitive skin as they help to restore the skin's natural barrier and reduce irritation.

Del Rosso, J. Q., & Levin, J. (2011). The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. Journal of Clinical and Aesthetic Dermatology.
Farwanah, H., Wohlrab, J., Neubert, R. H. H., & Raith, K. (2005). Ceramides and skin function. American Journal of Clinical Dermatology.
Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato-Venereologica.

Ceramides

Barrier Function: Ceramides are critical components of the skin's lipid barrier. They help to prevent moisture loss and protect against environmental aggressors like pollutants and irritants.
Hydration: By maintaining the barrier integrity, ceramides keep the skin hydrated, preventing dryness and keeping the skin supple.
Reducing Skin Sensitivity: They play a role in reducing skin sensitivity and irritation, helping to calm inflamed and reactive skin.
Anti-aging Properties: Ceramides can improve skin elasticity and firmness, helping to reduce the appearance of fine lines and wrinkles.
Wound Healing: There is evidence to suggest that ceramides can aid in the skin's natural wound healing process.

Eczema and Atopic Dermatitis: Ceramides are often used in the treatment of eczema and atopic dermatitis, where the skin barrier is compromised, leading to dryness, itching, and inflammation.
Psoriasis: They can help in managing psoriasis by maintaining skin hydration and barrier function, reducing scaling and dryness.
Aging Skin: Ceramide-containing products are beneficial in anti-aging regimens due to their ability to improve skin barrier function and elasticity.
Dry Skin (Xerosis): In the treatment of dry skin, ceramides help in restoring skin hydration and barrier function.
Sensitive Skin: Products containing ceramides are suitable for sensitive skin as they help to restore the skin's natural barrier and reduce irritation.

Del Rosso, J. Q., & Levin, J. (2011). The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. Journal of Clinical and Aesthetic Dermatology.
Farwanah, H., Wohlrab, J., Neubert, R. H. H., & Raith, K. (2005). Ceramides and skin function. American Journal of Clinical Dermatology.
Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato-Venereologica.

Full ingredient list

Aqua, white soft paraffin, extra pure lanolin, emulsifying wax, glycerin, stearic acid, ceramides, cholesterol, liquid paraffin, niacinamide, cetyl alcohol, cetomacrogol, isostearyl isostearate, potassium cetyl phosphate, cetyl stearate, stearic acid, ethyl hexyl glycerin, phenoxyethanol, carbomer, d-panthenol, sodium hyaluronate, C12-17 alkane, triethanolamine.

Firsthand™ Treatment

product benefits

Soothes Irritated Skin

Soothes and calms irritated skin by reducing inflammation and providing immediate relief, helping to restore comfort and balance to distressed skin.

Barrier Repair

Physiological barrier repair by strengthening the skin's structural integrity, reducing sensitivity and increasing the skin's ability to defend against harmful agents

Intense hydration

Shield the skin from external irritants and pollutants by forming a protective barrier, providing continuous hydration, improving skin elasticity, and supporting the skin's natural defense mechanisms.

Control moisture balance

Reduces transepidermal water loss by reinforcing the skin's natural barrier, ensuring long-lasting hydration and protection against dryness.

testimonials

Curexema

The cream is great, it isn’t greasy so it is easy to use as it absorbs almost instantly and gives relief from the burn and itch when I have a flare up. I would recommend this product to anyone who struggles with dermatitis or eczema.

Fantastic skin barrier repair

I overdid it with retinol and my skin was red and sensitive. I used this for 2 days and it sorted my skin barrier out in no time. Just glowing skin. I love it as a moisturizer. It's not greasy and I have oily combo acne prone skin. Will definitely purchase again.

This product is life changing !!!

I have tried everything on the market and nothing worked. My skin was so sensitive and even prescript medicine and ointments did not work after years of chemo and radiation treatments. Thank you for changing my life and being comfortable in my own skin again. No more itchy, dry skin and no more inflammation. I will definitely order this product again and again.

Dermabase

I bought the pack for my daughter who is coming to visit from England for Christmas. So I haven’t used the treatment products. But the Dermabase is for me. And I love love love it. I used to have to apply cream to my skin twice a day and after swimming my skin was dry. Dermabase keeps my skin hydrated after one application for 24 hours. Even after a short swim. Very good product. I was raving about it so much that my other daughter also wanted one!

1 2 3