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Time Freeze Eye serum Time Freeze Eye serum Time Freeze Eye serum Time Freeze Eye serum

Time Freeze Eye serum

Sale price¥9,900

SIZE: 15 mL

Anti-Aging

Anti-Aging

Antioxidant

Antioxidant

Moisturizing

Moisturizing

Firming

Firming

↑ Elasticity

↑ Elasticity


Time Freeze Eye Serum is a potent firming formulation specifically designed to ameliorate concerns of lines, wrinkles, puffiness, and sagging skin beneath the eyes. The serum tightens the skin upon application and has a long-lasting impact, significantly contributing to an uplifted and defined face contour.

Its power derives from key ingredients such as Acetyl Hexapeptide-8, known for its ability to reduce the appearance of wrinkles by inhibiting neural signals that cause facial muscles to tense, indirectly leading to a smoother skin surface. Bioskinup Contour™, a blend of botanical extracts, offers anti-edema properties that mitigate puffiness.

Retinol, specifically in the form of Hydroxypinacolone Retinoate, a less irritating retinoid, facilitates cellular renewal, aiding the skin in appearing firm and reducing the visibility of age-related changes. Furthermore, antioxidants, such as Tocopherol (Vitamin E), guard against harmful free radicals, fostering the resilience of the skin.

The formulation is scientifically balanced, ensuring optimal absorption and maximum efficacy without compromising skin health. Time Freeze Eye Serum is rooted in robust science, leveraging bioactive compounds to enhance the skin's overall texture and appearance.


Argireline
Argireline: The Innovative Peptide in Anti-Aging Dermatology

Argireline stands as a testament to the advancements in peptide technology in dermatology. Its ability to reduce facial muscle contractions non-invasively positions it as an essential ingredient in anti-aging skincare.

Biochemical Mechanism

Argireline functions by inhibiting the neurotransmitters that trigger muscle contractions. This action reduces the intensity of wrinkle-causing facial expressions, leading to a visible decrease in fine lines and wrinkles. It mimics the N-terminal end of SNAP-25, competing with this natural protein for a position in the SNARE complex, thereby destabilizing it. As a result, neurotransmitter release is diminished, and facial muscle contractions are softened.


Physiological Effects

  • Neurotransmitter Inhibition: Argireline works by inhibiting neurotransmitter release. This leads to reduced facial muscle contraction, a mechanism similar to Botox but less invasive.
  • Reduction of Expression Lines: Argireline helps reduce the appearance of expression lines, particularly around the forehead and eyes, by limiting muscle contraction.
  • Improvement in Skin Texture: Regular use of Argireline can lead to smoother skin texture and a reduction in the depth and severity of wrinkles.

Special Benefits

Clinical Efficacy - Clinical studies have demonstrated the effectiveness of Argireline in reducing wrinkle depth. A study published in the "International Journal of Cosmetic Science" reported that a cream containing 10% Argireline reduced wrinkles by 30% over 30 days (Blanes-Mira et al., 2002).


References

  • Blanes-Mira, C., et al. (2002). A synthetic hexapeptide (Argireline) with antiwrinkle activity. International Journal of Cosmetic Science.
  • Wang, Y., et al. (2013). The anti-wrinkle efficacy of Argireline. Journal of Cosmetic and Laser Therapy.
  • Ruiz, M. A., et al. (2007). New cosmetic formulations containing Argireline. Journal of Cosmetic Science.
Vitamin E

The fat-soluble Vitamin E's benefits in maintaining skin health and appearance are well-acknowledged in both cosmetic and clinical dermatology. Comprising a group of eight compounds, including four tocopherols and four tocotrienols, Vitamin E is known for its role in protecting cell membranes from oxidative damage.

Vitamin E is celebrated in skincare for its ability to neutralize free radicals caused by environmental stressors such as UV radiation and pollution. These free radicals can lead to premature skin aging, making Vitamin E a valuable ingredient in anti-aging skincare products. Its antioxidant action helps to protect the skin from damage, reduce the appearance of wrinkles, and improve skin texture and tone.

Additionally, Vitamin E is known for its moisturizing benefits. It helps to strengthen the skin barrier, reduce moisture loss, and keep the skin hydrated and supple. This makes it especially beneficial for dry and damaged skin.

Vitamin E also has anti-inflammatory properties, making it beneficial in soothing and calming irritated skin. This has implications for conditions such as dermatitis and acne, where inflammation plays a key role.


Physiological Effects

  • Antioxidant Protection: Vitamin E neutralizes harmful free radicals in the skin, preventing oxidative stress and damage caused by environmental factors like UV radiation and pollution.
  • Moisturization: It has moisturizing properties, helping to improve skin hydration and alleviate dryness.
  • Wound Healing: Vitamin E may assist in the skin's healing process, although its efficacy in wound healing is still a subject of research.
  • Photoprotection: While not a sunscreen, it can provide some degree of photoprotection by strengthening the skin's defense against UV-induced damage.
  • Anti-Inflammatory Effects: It helps reduce skin inflammation and is beneficial in managing conditions like eczema and psoriasis.

Role in Managing Dermatological Conditions

  • Skin Aging: Its antioxidant properties make it useful in anti-aging skincare products to protect against free radical damage and improve skin appearance.
  • Dry Skin Conditions: Vitamin E's moisturizing effects are beneficial in treating dry skin and improving overall skin texture.
  • Inflammatory Skin Diseases: It can be helpful in soothing inflammatory skin conditions like eczema and psoriasis.
  • Sun Protection and Repair: Vitamin E is included in sunscreens and after-sun products for its ability to mitigate sun damage.
  • Scar Treatment: Some studies suggest Vitamin E may help reduce the appearance of scars, although evidence is mixed.

References

  • Thiele, J. J., Hsieh, S. N., & Ekanayake-Mudiyanselage, S. (1998). Vitamin E: Critical Review of Its Current Use in Cosmetic and Clinical Dermatology. Dermatologic Surgery, 24(7), 805–813.
  • Ratz-Łyko, A., & Arct, J. (2016). Anti-inflammatory and anti-aging properties of active skin care ingredients. Journal of Clinical and Aesthetic Dermatology, 9(9), 36–40.
  • Keen, M. A., & Hassan, I. (2016). Vitamin E in dermatology. Indian Dermatology Online Journal.
  • Ekanayake-Mudiyanselage, S., & Thiele, J. (2007). Vitamin E in human skin: Organ-specific physiology and considerations for its use in dermatology. Molecular Aspects of Medicine.
  • Nachbar, F., & Korting, H. C. (1995). The role of vitamin E in normal and damaged skin. Journal of Molecular Medicine.
Peptides

Peptides are short chains of amino acids with a wide range of biological functions and skin benefits. They are essentially small fragments of proteins, which are fundamental components of all living cells, including collagen and elastin in the skin.

In skincare, peptides are known for enhancing skin repair and rejuvenation. They function as signaling molecules, instructing cells to perform specific tasks such as producing collagen and elastin, vital for maintaining the skin's firmness and elasticity. This makes peptides especially beneficial in anti-aging products, as they can help reduce the appearance of fine lines and wrinkles.

Research has shown that certain peptides can improve skin barrier function, increase hydration, and soothe skin inflammation. This makes them suitable for products targeting dry, sensitive, or inflamed skin.

Peptides, with their diverse functions in promoting collagen production, strengthening the skin barrier, wound healing, and anti-inflammatory actions, are pivotal in managing various dermatological conditions, particularly in anti-aging, sensitive skin care, and wound healing applications.


Physiological Effects

  • Collagen Production: Certain peptides, known as signal peptides, stimulate collagen production in the skin, enhancing skin firmness and reducing the appearance of fine lines and wrinkles.
  • Skin Barrier Strengthening: Peptides can strengthen the skin barrier, improve hydration, and protect against environmental damage.
  • Wound Healing: Some peptides play a role in the skin's natural healing process, aiding tissue repair and regeneration.
  • Anti-Inflammatory Effects: Certain peptides have anti-inflammatory properties, helping to soothe and calm irritated skin.
  • Antimicrobial Action: Some peptides possess antimicrobial properties, potentially helping to manage acne and other skin infections.

Role in Managing Dermatological Conditions

  • Aging Skin: Peptides can stimulate collagen production and improve skin elasticity.
  • Sensitive Skin Conditions: Peptides are beneficial for sensitive or inflamed skin due to their soothing properties.
  • Acne-Prone Skin: Antimicrobial peptides can be effective in acne treatment formulations.
  • Wound Care and Repair: Peptides improve wound healing and reduce scarring.

References

  • Gorouhi, F., & Maibach, H. I. (2009). Role of topical peptides in preventing or treating aged skin. International Journal of Cosmetic Science.
  • Schagen, S. K. (2012). Topical peptide treatments with effective anti-aging results. Cosmetics.
  • Varani, J., et al. (2001). Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. Journal of Investigative Dermatology.
Retinoic acid analogue

Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skin care, particularly in treating acne and signs of skin aging.

Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In treating acne, it promotes the turnover of skin cells, reducing the likelihood of pore-clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.

Retinoic acid's ability to stimulate collagen production is a key benefit in anti-aging skincare. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster, and shedding pigmented and damaged cells.

Despite its benefits, retinoic acid can irritate the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.

Hydroxypinacolone Retinoate (HPR) is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without needing conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.

HPR is considered more gentle and less irritating than traditional retinoic acid while offering comparable benefits. With HPR, everyone has access to the benefits of prescription retinoids without the risk of side effects.


Physiological Effects

  • Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
  • Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
  • Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
  • Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
  • Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
  • Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.

Special Benefits

  • Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
  • Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
  • Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
  • Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
  • Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.

References

  • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
  • Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
  • Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
  • Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
  • Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.
Bioskinup Contour

Bioskinup Contour 3R demonstrates a comprehensive mechanism of action targeting periorbital puffiness and dark circles. It stimulates collagen and elastin production, enhancing skin firmness and vascular wall resistance.

Clinical studies highlight its ability to maintain skin health under UV radiation, suggesting adaptogenic properties. In vivo evaluations reveal significant improvements in skin and ocular acceptability, with reductions in puffiness, dark circles, and under-eye bags. Instrumental assessments confirm its efficacy in enhancing microcirculation and skin tone, validating its dermatocosmetic benefits for the eye area.

Time Freeze Eye serum
Time Freeze Eye serum Sale price¥9,900
  • Lines and Wrinkles: Time Freeze Eye Serum is designed to address the appearance of lines and wrinkles around the delicate eye area, helping to minimize their visibility and promote a smoother appearance.
  • Puffiness: This serum is formulated to assist in reducing puffiness or under-eye bags, providing a more refreshed and rejuvenated look.
  • Sagging Skin: Time Freeze Eye Serum offers corrective action for sagging skin under the eyes, contributing to a firmer and lifted appearance.
  • Aging Concerns: The serum targets common signs of aging such as lines, wrinkles, puffiness, and sagging skin, making it suitable for individuals seeking to improve the overall youthful appearance of their eye area.
  • Rejuvenation: By combining a potent blend of ingredients, Time Freeze Eye Serum aims to rejuvenate the skin around the eyes, revitalizing the appearance and promoting a more vibrant and energized look.

Active ingredients

    Argireline

    Bioskinup Contour 3R demonstrates a comprehensive mechanism of action targeting periorbital puffiness and dark circles. It stimulates collagen and elastin production, enhancing skin firmness and vascular wall resistance.

    Clinical studies highlight its ability to maintain skin health under UV radiation, suggesting adaptogenic properties. In vivo evaluations reveal significant improvements in skin and ocular acceptability, with reductions in puffiness, dark circles, and under-eye bags. Instrumental assessments confirm its efficacy in enhancing microcirculation and skin tone, validating its dermatocosmetic benefits for the eye area.

    Vitamin E

    Bioskinup Contour 3R demonstrates a comprehensive mechanism of action targeting periorbital puffiness and dark circles. It stimulates collagen and elastin production, enhancing skin firmness and vascular wall resistance.

    Clinical studies highlight its ability to maintain skin health under UV radiation, suggesting adaptogenic properties. In vivo evaluations reveal significant improvements in skin and ocular acceptability, with reductions in puffiness, dark circles, and under-eye bags. Instrumental assessments confirm its efficacy in enhancing microcirculation and skin tone, validating its dermatocosmetic benefits for the eye area.

    Peptides

    Bioskinup Contour 3R demonstrates a comprehensive mechanism of action targeting periorbital puffiness and dark circles. It stimulates collagen and elastin production, enhancing skin firmness and vascular wall resistance.

    Clinical studies highlight its ability to maintain skin health under UV radiation, suggesting adaptogenic properties. In vivo evaluations reveal significant improvements in skin and ocular acceptability, with reductions in puffiness, dark circles, and under-eye bags. Instrumental assessments confirm its efficacy in enhancing microcirculation and skin tone, validating its dermatocosmetic benefits for the eye area.

    Retinoic acid analogue

    Bioskinup Contour 3R demonstrates a comprehensive mechanism of action targeting periorbital puffiness and dark circles. It stimulates collagen and elastin production, enhancing skin firmness and vascular wall resistance.

    Clinical studies highlight its ability to maintain skin health under UV radiation, suggesting adaptogenic properties. In vivo evaluations reveal significant improvements in skin and ocular acceptability, with reductions in puffiness, dark circles, and under-eye bags. Instrumental assessments confirm its efficacy in enhancing microcirculation and skin tone, validating its dermatocosmetic benefits for the eye area.

    Bioskinup Contour

    Bioskinup Contour 3R demonstrates a comprehensive mechanism of action targeting periorbital puffiness and dark circles. It stimulates collagen and elastin production, enhancing skin firmness and vascular wall resistance.

    Clinical studies highlight its ability to maintain skin health under UV radiation, suggesting adaptogenic properties. In vivo evaluations reveal significant improvements in skin and ocular acceptability, with reductions in puffiness, dark circles, and under-eye bags. Instrumental assessments confirm its efficacy in enhancing microcirculation and skin tone, validating its dermatocosmetic benefits for the eye area.


Full ingredient list

    Aqua, Acetyl Hexapeptide-8 & Caprylyl Glycol, Propylene Glycol, Cetyl Alcohol & Glyceryl Stearate & PEG-75 Stearate & Ceteth-20 & Steareth-20, Glycerin & Caprylyl/Capryl Glucoside & Pfaffia Paniculata Root Extract & Ptychopetalum Olacoides Bark/Stem Extract & Lilium Candidum Flower Extract, Cetostearyl alcohol, Phenoxyethanol & Ethylhexylglycerin, Dimethyl Isosorbide & Hydroxypinacolone Retinoate, Tocopherol

Morning & / or Evening

  • Application time: Morning and/or Evening.
  • Frequency: Daily.

1. Cleanse

  • Start with clean and dry skin.
  • Use your DermExcel cleanser to remove dirt and excess oil from your skin.

2. Apply

  • Take a small amount of Eye Serum on your fingertip.
  • Apply the serum to the under-eye area and gently pat it onto the skin, starting from the inner corner and moving outward.
  • Allow the serum to absorb into the skin for a few minutes before applying additional skincare products or makeup.

Additional note

  • Avoid getting the serum into your eyes. If contact occurs, rinse with water.
  • It is recommended that you perform a patch test before the first use to check for potential skin sensitivity or allergic reactions. Discontinue use if any irritation occurs.

Time Freeze Eye serum

product benefits

decrease eye bags
decrease eye bags

A formulation that promotes lipolytic action (breakdown of fat cells) to reduce fat deposits in the eye area and puffiness or under-eye bags, contributing to refreshed and rejuvenated eyes.

Reduce Lines & Wrinkles
Reduce Lines & Wrinkles

Stimulates collagen and elastin production to strengthen the extracellular matrix, actively targeting lines and wrinkles to diminish visibility and promote smoother-looking skin in the delicate eye area.

Rejuvenates and Revitalizes
Rejuvenates and Revitalizes

With its potent blend of ingredients, the serum rejuvenates and revitalizes the skin around the eyes, promoting a more energized and vibrant look.

Firms and Tightens
Firms and Tightens

Upon application, it provides an intense firming action, helping to tighten the skin around the eyes for a more lifted and sculpted appearance.

Targets Sagging Skin
Targets Sagging Skin

Offers corrective action for sagging skin under the eyes, helping to restore a firmer and more youthful appearance.

Reduce inflammation and swelling
Reduce inflammation and swelling

Decrease the fluid depot by draining action to improve and prevent puffy eyes. Preserve skin cell health and slow down the aging process by reducing inflammation.

time freeze eye serum

mode of action

Time Freeze Eye serum decreases the production of pro-inflammatory mediators.

It efficiently regulates the primary inflammatory mediators that cause vessel fragility, microcirculation deficit, edema formation (swelling), and hyperpigmentation. 

Signs and symptoms

aging eye skin

Dark circles

Dark circles
  • Various factors, e.g., aging, bad lifestyle habits, sleep deprivation, and UV exposure, can trigger an immune response, leading to inflammation.
  • In the inflammatory process, melanin (pigment cells) is increased, resulting in pigmentation of the lower periorbital region, more commonly known as dark under-eye circles.

Puffy eyes - Edema (Swelling)

Puffy eyes - Edema (Swelling)
  • Inflammation causes vasodilation (widening of the blood vessels) and increased vascular permeability (the ability of blood vessel walls to pass fluid through).
  • This causes fluid to leak from the blood vessels, leading to edema (swelling).

Eyelid bags

Eyelid bags
  • Bags under the eyes are caused when the tissue structures and muscles supporting the eyelids weaken.
  • The skin may start to sag, and fat that's usually around the eye can move into the area below the eyes.
  • The space below the eyes can also gather fluid, making the area look puffy or swollen.

Fine lines and wrinkles

Fine lines and wrinkles
  • Inflammation and oxidative stress break down collagen around the eyes. Collagen is critical to keeping our skin firm, and elastin keeps it flexible.
  • Under-eye wrinkles occur when the skin around the eyes becomes thinner and loses elasticity.
  • This process can be accelerated by frequent sun exposure, smoking repeated facial movements, and certain genetic traits.

DermExcel eye serum's action on anatomical changes

treat to target

anti-inflammatory
anti-inflammatory

Regulates the primary inflammatory mediators that cause vessel fragility, microcirculation deficit, edema formation, and hyperpigmentation. 

increase lipolysis
increase lipolysis

Decrease fat deposits in the eye area by breaking fat cells apart, reducing the volume of fatty tissue.

stimulate collagen production
stimulate collagen production

Improve the extracellular matrix and stimulate the production of collagen and elastin, which restore the strength of the vascular wall and re-densify the skin.

Eye serums

testimonials

Customer Reviews

Based on 156 reviews
88%
(137)
9%
(14)
3%
(4)
0%
(0)
1%
(1)
M
Michelle Vogel

Time Freeze Eye serum

M
Maunette Kiddle
Time freeze

I love it!
Amazing products!

C
Cheryl de Villiers
Anti-Aging Time Freeze Eye Serum

I've tried many eye creams and serums in an attempt to smooth out wrinkles around my eyes and I keep coming back to Dermexcel's Time Freeze Eye Serum. A little product goes a long way and it really helps!

M
Marlise Wessels
Best products ever!

**Review for Dermexcel Products**

I've tried countless skincare brands, but Dermexcel has truly set a new standard. From the moment I applied their products, I could feel the difference – it’s like skincare and luxury fused into one. Dermexcel's commitment to quality ingredients and scientific formulations is evident, providing deep nourishment without any harsh reactions.

The textures are light, non-greasy, and absorb beautifully, leaving my skin feeling refreshed and renewed all day. I’ve seen visible improvements in my skin tone, texture, and elasticity – my complexion looks brighter, and any fine lines have softened considerably. Dermexcel’s range caters to all skin needs, whether it’s anti-aging, hydration, or blemish control, making it a one-stop solution for every skincare concern.

Beyond results, the brand’s attention to detail, from eco-conscious packaging to their thorough, informative product descriptions, demonstrates an authenticity and care for its customers. For anyone serious about skincare, Dermexcel is the ultimate investment in radiant, healthy skin. Highly recommend!

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