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Inflacin serum

Sale price¥9,700 JPY

SIZE: 30 mL

A medical-grade treatment with a potent blend of anti-inflammatory and acne-combating ingredients to address skin issues in oily, acne-prone, and combination skin types. The formulation prioritizes preserving skin hydration while effectively eliminating skin concerns like pimples and blackheads.

The serum's composition includes Salicylic acid, known for its proficiency in unclogging pores and reducing acne-related inflammation. Zinc PCA is critical in regulating sebum production and minimizing oily skin complications. Niacinamide shrinks enlarged pores and alleviates inflammation related to acne and rosacea. Lastly, Retinol stimulates cell turnover, aids in the fight against premature aging, and enhances overall skin texture and tone.

As a holistic approach, Inflacin Serum reduces current skin issues and aims to prevent future skin complications, thus promoting a healthier skin condition.


Zinc PCA

Zinc PCA, also known as Zinc Pyrrolidone Carboxylic Acid, is a skin care ingredient that combines the mineral zinc with a hydrating molecule PCA (Pyrrolidone Carboxylic Acid). It is renowned for its numerous benefits in skincare, particularly for its anti-inflammatory, antimicrobial, and sebum-regulating properties.

Zinc PCA is derived from zinc, an essential mineral known for its antioxidant and skin-soothing capabilities. Zinc is also noted for its role in wound healing and its ability to reduce inflammation, which can be particularly beneficial for acne-prone and irritated skin. The PCA component is a natural moisturizing factor (NMF) found in the skin, which helps maintain the skin's hydration levels.

One of the key benefits of Zinc PCA is its ability to regulate sebum production. Excess sebum can lead to acne and oily skin, and Zinc PCA helps to moderate this by inhibiting the activity of the enzyme 5-alpha reductase, which is involved in oil production. This makes it an effective ingredient in formulations targeting oily and acne-prone skin (Schueller, R. and Romanowski, P., 2003).

In addition to its sebum-regulating properties, Zinc PCA possesses antimicrobial properties, which further contribute to its efficacy in treating acne. By reducing the presence of acne-causing bacteria on the skin, it helps to prevent and reduce acne breakouts.

Moreover, Zinc PCA's anti-inflammatory properties make it beneficial for soothing irritated skin and reducing redness and inflammation associated with various skin conditions, including acne, rosacea, and eczema.

Nc4

Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.

Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.

Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.

BHA3-

Salicylic acid, a renowned beta hydroxy acid (BHA), is a cornerstone in dermatology and skincare due to its exceptional keratolytic and comedolytic properties. It uniquely penetrates oil-laden hair follicle pores, making it particularly effective in treating acne-prone and oily skin types.

Salicylic acid works by dissolving skin debris that clogs pores and causes acne, namely sebum and dead skin cells. It's a mild anti-bacterial- and a powerful anti-inflammatory agent, which helps to reduce the redness and swelling associated with breakouts.

What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin not just on the surface but within the pores themselves. This is due to its oil-soluble nature, which allows it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.

Furthermore, salicylic acid also can adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions in terms of count and severity. Additionally, salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.

Ra5

Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skin care, particularly in treating acne and signs of skin aging.

Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In treating acne, it promotes the turnover of skin cells, reducing the likelihood of pore-clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.

Retinoic acid's ability to stimulate collagen production is a key benefit in anti-aging skincare. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster, and shedding pigmented and damaged cells.

Despite its benefits, retinoic acid can irritate the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.

Hydroxypinacolone Retinoate (HPR) is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without needing conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.

HPR is considered more gentle and less irritating than traditional retinoic acid while offering comparable benefits. With HPR, everyone has access to the benefits of prescription retinoids without the risk of side effects.

DermExcel™ | Inflacin Serum
Inflacin serum Sale price¥9,700 JPY
  • Acne: Target acne-causing bacteria and reduce inflammation, minimizing the occurrence of acne breakouts.
  • Blackheads: Dissolve and extract clogged pore content, effectively treating and preventing blackheads.
  • Oily Skin: Helps to regulate excess sebum production, improving skin appearance and reducing shininess.
  • Enlarged Pores: Minimize the appearance of enlarged pores by removing dead skin cells and regulating oil production.
  • Inflammation: Reduce inflammation associated with various skin conditions, including acne, rosacea, and premature aging.
  • Premature Aging: Combat visible signs of premature aging by promoting cell turnover and stimulating cell structures.
  • Combination Skin: Helps to balance oil production and maintain the skin's moisture balance in combination skin which experiences both oily and dry areas.
  • Skin Texture and Tone: Stimulates cellular turnover, leading to improved skin texture, firmness, and skin tone.
  • Rosacea-Prone or Red Skin: The anti-inflammatory, anti-bacterial, exfoliating, and sebum regulation properties of Inflacin serum soothe and relieve skin prone to rosacea or persistent redness.
  • Shaving Bumps and Ingrown Hair: Soothe shaving bumps and prevent ingrown hairs by exfoliating the skin and preventing pore clogging.
  • Cleanse: Start with a clean, dry face. Use your DermExcel cleanser to remove dirt and excess oil from your skin.
  • Apply: Take a small amount of Inflacin Serum (1-2 pumps or a pea-sized amount should suffice) and gently apply it to the face, concentrating on the problematic areas. Avoid the eye area, as the ingredients may cause irritation.
  • Massage: Using your fingertips, gently massage the serum into your skin in a circular motion. This helps to ensure the serum is evenly distributed and absorbed.
  • Wait: Allow the serum to absorb fully into the skin before applying other skincare products. This typically takes a few minutes.
  • Follow-up: Once the serum has been fully absorbed, continue with the rest of your skincare routine, such as applying sunscreen (in the morning).

 By following these detailed steps, you will maximize the benefits of Inflacin Serum. Remember, skin may react differently to new products. Start slow, observe how your skin responds, and adjust usage accordingly.

Active ingredients

  • Zinc PCA
  • Nc4
  • BHA3-
  • Ra5

Full ingredient list

Aqua, Polyethylene Glycol, Niacinamide, Salicylic acid, Sodium Acrylates Copolymer & Lecithin, Phenoxyethanol & Ethylhexylglycerin, Zinc PCA, Dimethyl Isosorbide & Hydroxypinacolone Retinoate, Sodium Phytate & Aqua & Alcohol, Butylene Glycol, Hydrolyzed Yeast Protein, Fomes Officinalis (Mushroom) Extract, Pyridoxine, Niacinamide, Panthenol, Allantoin, Threonine, Biotin, Tocopherol, Disodium EDTA

Inflacin serum

benefits

Sebum Regulation

Regulates excess sebum production, reducing complications and improving the appearance of oily and enlarged pores.

Unblock clogged pores

Inflacin serum will dissolve and extract cellular debris from clogged pores and minimize the appearance of enlarged pores.

Anti-Inflammatory

Inflacin Serum reduces inflammation related to acne, rosacea, and premature aging due to its potent anti-inflammatory ingredients.

Reduce signs of aging

Inflacin Serum improves skin texture and firmness by promoting cell turnover, targeting visible signs of premature aging.

Bacterial Inhibition

Inhibit the growth of topical bacteria, including those contributing to acne formation.

Exfoliate and renew skin cells

Remove dead skin cells to prevent it from clogging pores, and reveal brighter, more radiant skin cells.

Inflacin serum

INDICATIONS

Acne / Breakouts

Aging Skin

Enlarged Pores

Excessively Oily Skin

Inflammation

Rosacea / Red Skin

Shaving Bumps

Clogged Pores

Inflacin serum

MODE OF ACTION

disease education

acne stages and treatment objectives

  • The excretion of lipids by the sebaceous glands is controlled hormonally.
  • The sebaceous glands are located all over the body but are the largest and most numerous in the face, back, chest, and shoulders.
  • These glands become more active during puberty because of increased androgens, particularly testosterone, which spurs sebum production.
  • This imbalance between sebum production and secretion capacity leads to a blockage of sebum in the hair follicle, followed by inflammation.
  • Hormones continue to affect sebaceous gland activity into adulthood.
  • The first stage of acne is called comedogenesis (formation of comedones).
  • The exfoliated dead skin cells stick together inside the hair follicle, resulting in a clogged pore or comedone.
  • This is caused by several factors, including increased amounts of sebum, inflammation of the sides of the hair follicle preventing the release of the exfoliated keratinocytes, and increased cohesion of keratinocytes.
  • Salicylic acid decongests pores by dissolving and extracting dirt, oil, and cellular debris (dead skin cells) in the pores and follicles.
  • The keratinocyte plug and sebum provide excellent food sources for bacteria.
  • The bacteria invade the comedone and release inflammatory factors that lead to the next stage of acne.
  • Salicylic acid inhibits the production of various aspects necessary for bacterial reproduction, such as fibrinogen, fibronectin, and alpha-hemolysis.
  • Inflammation continues with increased redness and pus.
  • This is clinically detectable as a papule or pustule.
  • Continued inflammation may lead to so much inflammation that the hair follicle ruptures and the bacteria and debris are released into the dermis.
  • Salicylic acid suppresses pro-inflammatory cytokine expression.

disease education

rosacea stages and treatment objectives

A constant interplay exists among the skin, micro-organisms, and the environment to maintain a delicate balance. Disturbance of this balance negatively influences both the microflora and skin health.

In Rosacea, the micro-environment of the affected skin is substantially altered, resulting in a shift in the proportion or speciation of the resident microflora. Several micro-organisms have been shown to be increased or immuno-reactive in patients with rosacea.

Or skin contains pattern recognition receptors (PPR). These receptors detect harmful bacteria on our skin. When they detect these harmful bacteria, they bind to them and activate an immune response.

Receptors (PPR) don't activate the immune response for normal micro-flora on our skin. Rosacea-prone skin receptors (PPR) are hyper-reactive and/or have decreased tolerance. They have heightened sensitivity and trigger the inflammatory response of normal microbes, leading to the initial signs of rosacea.

  • Healthy skin with a perfect balance between normal microflora and skin receptors.
  • The function of the pathogen recognizing receptos receptors (PPR) is to detect and bind to harmful molecules and then to activate the immune response.
  • These receptors should not trigger an immune response by binding to normal microflora.
  • PPR (receptors) of Rosacea-prone skin bind to normal flora (they are not supposed to) and activate the immune response that causes inflammation.
  • PPR (receptors) of Rosacea-prone skin is hyper-reactive and sensitive. They can be activated by various environmental agents (fragrance, heat, spicy food, etc.)
  • Inflammation leads to an increase in white blood cells (leucocytes) and antimicrobial peptides (cathelicidins), causing certain normal microbes to be eliminated.
  • The disruption of the body's normal microbial community leads to an imbalance, where potentially harmful microbes overgrow and occupy spaces left by the eliminated beneficial microbes.
  • The negative feedback loop continues where alterations in the micro-flora lead to increased inflammation, which in turn exacerbates Rosacea, resulting in more severe symptoms.

Inflacin serum

treating rosacea & acne

Anti-inflammatory

Inhibit the inflammation that leads to breakouts, redness, and skin damage.

Comedolytic

Unclog pores by dissolving and extracting dirt, oil, and cellular debris in the pores.

Keratolytic

Disrupts cellular junctions to exfoliate dead skin cells.

Anti-Bacterial

Inhibits the bacteria responsible for causing and aggrevating Acne and Rosacea.

Treatment Serums

testimonials


Customer Reviews

Based on 2504 reviews
95%
(2372)
4%
(90)
1%
(28)
0%
(4)
0%
(10)
M
Mariska de Witt
Lovely skin feel

A lovely treatment that leaves my skin calm en nourished, wish I could bathe in it 🥰

Y
Yolandi De Beer
Miracle in a bottle

Since I started using the Inflacin Serum back in September 2020, I never stopped! The best serum for skin that is prone to break-outs. Also works on reducing the size of enlarged pores and keeps oily skin under control. I've got this one on re-order.

C
Cherise Breedt
Amazing skin

Thank you for great skincare.

A
Anesca Serrão

Retinol serum: Trial

L
Liza Moolman
Collagen serum

Cant go a day without my collagen serum

M
Madeleen Graaff
Better skin in 1 week

I struggled with break-outs and as soon as I started with the Pore Control Cleanser and Inflacin Serum, the break-outs cleared! Thank you so much!

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