Enriched

INHIBIT HYPERPIGMENTATION

• Prevents DNA damage through antioxidant activity.
• Prevent melanosome transfer from melanocytes to surrounding skin cells.

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TREATING ROSACEA, ACNE AND OTHER INFLAMMATORY SKIN CONDITIONS

• Reduce the inflammatory response by inhibiting inflammatory messengers.
• Provides long-lasting protection against bacteria through activation of anti-microbial peptides
• Reduce sebum (oil) production, thus preventing bacterial growth and inflammation.

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TREATING AND PREVENTING PREMATURE SKIN AGING

• Stimulate collagen synthesis and significantly increase skin elasticity.
• Prevents the breakdown of collagen and elastin through antioxidant and anti-inflammatory activity.
• Prevents DNA damage through antioxidant activity.
• Increases production of ceramides as well as other stratum corneum lipids to improve skin barrier funtion.
• Niacinamide boosts cellular energy and may enhance energy-dependent cellular processes such as DNA repair.

• Hyaluronic acid is a naturally occurring biopolymer possessing numerous functions within the body, including wound repair, cell migration, and cell signalling. 
• With age, hyaluronic acid in the skin decreases sharply, resulting in a loss of hydration, volume and plumpness. Lines and wrinkles also appear, leaving skin looking dull and lacklustre. 
• Hyaluronic acid comes in various molecular sizes. Larger molecules stay on the surface and give the skin a ‘dewy’ look, while smaller molecules penetrate deeper into the skin to deliver their hydration and plumping benefits.
• The cellular and physiological effects of Hyaluronic acid directly depend on the molecular weight of HA present. Therefore, the selection of HA weight is of critical importance. 
• The cellular and physiological effects of Hyaluronic acid directly depend on the molecular weight of HA present. Therefore, the selection of HA weight is of critical importance. 
• High molecular weight: Doesn't penetrate the epidermis.
  Very low molecular weight: Penetrate the skin efficiently but can induce a pro-inflammatory response.
  Low molecular weight HA [50 kDa]: Penetrates into the skin well and does not cause inflammation.

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HYDRATION

• Hyaluronic acid can bind water up to 1000 times its volume and contributes to cellular growth, adhesion, and membrane receptor function. 
• Hyaluronic acid reinforces the intercellular structures and produces the elastoviscous fluid matrix that firmly envelops collagen and elastin fibres. 
• Hyaluronic acid holds moisture and provides firmness and radiance to the skin.

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ANTI-AGING

• Hyaluronic acid increases pro-collagen I synthesis and reduce skin roughness.
• Hyaluronic acid has an important role in skin aging. Cells lose their ability to produce Hyaluronic acid with aging. The skin becomes drier, thinner, and looser, leading to wrinkling, among other significant changes. 
• Skin aging is also associated with a decrease of skin moisture. Hyaluronic acid has a unique capacity to link and retain water molecules. Hyaluronic acid is a natural component that is present in the whole body. It is naturally and constantly renewed because of its rapid degradation, but its renewal tends to slow with age and external aggressions. Therefore it is necessary to act very early, sustaining an optimal hyaluronic acid turnover, similar to that of young skin, in order to prevent the signs of aging.
• In relation to its biological effects at the skin level, it is known that hyaluronic acid is actively involved in skin cell signalling (by binding the CD44 and LYVE-1 receptors) and thus influences the extracellular matrix (ECM) stability.
• Hyaluronic acid has an impact on the growth of keratinocytes (skin cells) which protect the epidermis from aging and promotes elasticity. 

KEY BENEFITS

Medilan imitates many functions of human skin lipids, and it is nearly twice as effective as the physiological lipids in human skin.

Medilan™ has clinically proven safety and efficacy. It is designed to treat skin barrier impairment and severely compromised skin conditions such as rosacea, eczema, and psoriasis. Its exceptional purity surpasses monograph compliance and performs excellently in clinical trials.

In clinical trials, Medilan maintains skin hydration for up to 2 days after application and increases the rate of epidermal healing by 35% due to its ability to create a moist wound-healing environment. 

Medilan™ is hypoallergenic and delivers outstanding efficacy in dermatological applications. Studies have shown no allergic or irritant skin reactions to Medilan, even in severely compromised skin.

Lanolin's efficacy as a medical material and acceptance in the Pharmaceutical Industry is reflected in all major Pharmacopeia containing monographs on lanolin.

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REPLENISHING ESSENTIAL LIPIDS

Medilan™ supplements the skin with the lipids essential to skin health.

Due to its chemical and physical similarity, it imitates and augments many of the skin's natural lipids.

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REPAIRING THE SKIN’S NATURAL BARRIER

Medilan™ effectively accelerates the repair of the skin’s natural barrier function.

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PROTECTING AGAINST MICROBIAL INFECTION

Medilan is proven to control a variety of microorganisms.

• Staphylococcus aureus is a gram-positive bacteria responsible for the infection that leads to inflammatory symptoms in eczema sufferers. Medilan has been proven to reduce colonies of this bacteria by 99% after 24 hours.
• Candidiasis is an overgrowth of yeast that leads to unpleasant symptoms, such as itching and soreness around the skin's mucous membranes. Medilan has been proven to reduce the levels of Candida albicans to a level that controls candidiasis symptoms.
• Pseudomonas aeruginosa is a gram-negative bacteria that can attack wound sites and lead to infection. Wound infection is common in immunocompromised individuals. Medilan has shown potent antibacterial effects against this organism.

D-Panthenol stimulates the proliferation of dermal fibroblasts and can accelerate cell turnover.

WOUND HEALING

• D-Panthenol is part of medical wound-healing formulations for its ability to help treat skin injuries, burns, and sunburn.
• It's also beneficial after medical and cosmetic surgeries for its wound healing properties.
• It treats superficial and deep wounds by increasing cell turnover and fibroblast proliferation.

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REPAIR SKIN BARRIER FUNCTION

• D-Panthenol promotes skin barrier repair by enhancing lipid synthesis and epidermal differentiation. This helps hydrate the outermost layer of the skin and locks in moisture.
• D-Panthenol increases the mobility of proteins and lipids in dehydrated skin, improving its elasticity and hydration.

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ANTI-INFLAMMATORY

• Panthenol’s moisturizing properties also contribute to its anti-inflammatory nature.
• Keeping the skin moisturized can help prevent it from becoming sensitive and easily irritated. As such, panthenol can help improve the roughness, dryness, itching, redness, and scaling associated with conditions such as eczema, contact dermatitis, and psoriasis.
• Studies indicate that D-Panthenol may alleviate facial redness resulting from winter xerosis in people with sensitive skin.

• Humectant. It allows the skin to retain moisture. It increases skin hydration, relieves dryness, and refreshes the skin’s surface.
• Emollient. Soften rough or dry patches on the skin.
• Anti-microbial. Help to protect the skin from harmful microorganisms.

Essential fatty acids (EFAs) offers a multifaceted approach to improving skin health in patients with conditions such as eczema and dry skin. 

Biochemical Brilliance

Essential fatty acids, including omega-3 and omega-6, are the building blocks of the skin's lipid barrier. This barrier acts as a protective shield, preventing excessive moisture loss and shielding the skin from external aggressors. EFAs play a pivotal role in maintaining this barrier's integrity by contributing to the synthesis of ceramides and lipids that bind skin cells together.

Pharmacological Advantages

EFAs are not only instrumental in maintaining the skin's structural integrity but also possess anti-inflammatory properties. They serve as precursors for pro-resolving lipid mediators like resolvins and protectins, which help reduce skin inflammation, itching, and redness—common symptoms of eczema.

Physiological Harmony

EFAs contribute to maintaining the balance of skin hydration. They enhance the skin's ability to retain water, leaving it supple and hydrated. Moreover, EFAs can modulate the skin's immune response, reducing the severity of allergic reactions and flare-ups often seen in dermatological conditions like eczema.