DermExcel™

DermRepair: Trial

Name: DermRepair: Trial
Brand: DermExcel™
SKU: DX-DERMR05
Price: 13.00 CAD
Availability: InStock

4.9 / 5.0 from 496 reviews

$13.00

SIZE: 5 mL

↓ inflammation

anti-redness

barrier repair

↑ Elasticity

Anti-Aging

A specialized Vitamin K moisturizer formulated to address facial redness, spider veins, and inflammation associated with Rosacea and other inflammatory skin conditions. Its unique blend of active ingredients works synergistically to reduce skin irritation and support the impaired skin barrier.

Vitamin K in this formula aids in the reduction of vascular conditions such as spider veins, while Medilan provides superior moisturizing and hydrating effects. Arnica oil, known for its anti-inflammatory properties, further enhances the product's ability to soothe and calm irritated skin.

DermRepair also serves as an effective post-procedure treatment, helping to prevent and treat bruising caused by broken capillaries following surgical and non-surgical aesthetic procedures. Its skin-replenishing ingredients, including Glycerin, Petrolatum, and Jojoba oil, provide additional hydration and support to the skin barrier.

DermRepair is a clinically proven, specialized moisturizer that offers a comprehensive approach to managing and improving skin health, particularly in conditions of inflammation and vascular irregularities.

Vitamin K1

Vitamin K1, known as phylloquinone, is primarily recognized for its crucial role in blood coagulation. Beyond its well-known effects on blood clotting, recent research has highlighted its potential benefits in skin care, particularly in managing bruising and dark circles under the eyes and improving skin elasticity. Its mechanisms of action involve regulating blood clotting and reducing blood leakage into the skin and soft tissues. This property makes it particularly useful in topical treatments to minimize bruising and under-eye dark circles, often caused by fragile capillaries leaking small amounts of blood.

Studies have suggested that when applied topically, Vitamin K1 can help reduce the severity and duration of bruising after laser procedures or surgical treatments. It is believed to aid in the body's process of reabsorbing blood near the skin's surface, thereby reducing the appearance of bruises.

Physiological Effects

Blood Clotting and Bruising: Vitamin K1 is critical in blood clotting. It helps reduce the appearance of bruises on the skin by aiding the body's natural healing process in resolving blood clots.

Improving Skin Elasticity: It is believed to help improve skin elasticity and may reduce the appearance of wrinkles.
Wound Healing: Vitamin K1 can assist in the skin's healing process, although its effectiveness in wound healing needs further research.
Under-Eye Circles: The topical application of Vitamin K1 is thought to reduce the appearance of dark circles under the eyes by strengthening capillary walls and reducing the visibility of blood vessels beneath the skin.

Role in Managing Dermatological Conditions

Postoperative Bruising: It is often used in topical creams to reduce bruising following cosmetic skin procedures.
Dark Circles Under the Eyes: Creams containing Vitamin K1 diminish the appearance of dark circles caused by visible blood vessels or hyperpigmentation.
Skin Aging: Its potential anti-aging properties might benefit products targeting aging skin concerns.

References

Shah, N. S., et al. (2002). The effects of topical vitamin K on bruising after laser treatment. Journal of the American Academy of Dermatology.
Cohen, J. L., & Bhatia, A. C. (2009). The role of topical vitamin K oxide gel in the resolution of postprocedural purpura. Journal of Drugs in Dermatology.
AlQdah, T. (2021). Vitamin K in Dermatology. Dermatology Practical & Conceptual.

4-Ethoxybenzaldehyde

4-Ethoxybenzaldehyde is a distinctive ingredient in skincare. It is notable for its ability to inhibit Prostaglandin E2 (PGE2), a compound linked to inflammation, redness, and skin aging. Its unique mode of action in inhibiting PGE2 sets it apart from other skincare ingredients, particularly in addressing inflammation and preserving skin structure.

PGE2 is a potent mediator of inflammation, contributing to pain, cell injury, and chronic inflammatory conditions. It plays a role in skin aging by inhibiting collagen production and inducing MMP1, which degrades key skin matrix components.

By suppressing PGE2, 4-Ethoxybenzaldehyde effectively addresses these skin concerns, offering benefits in reducing inflammation and skin redness and counteracting signs of aging.

4-Ethoxybenzaldehyde has significant dermatological implications, particularly in its ability to modulate inflammatory processes and influence skin aging.

Physiological Effects

Inhibition of Prostaglandin E2 (PGE2): 4-Ethoxybenzaldehyde is noted for its unique ability to inhibit the release of PGE2, a potent mediator of inflammation. By suppressing PGE2, it potentially reduces inflammation, pain, and cellular injury.
Reduction of Skin Redness: By inhibiting PGE2, which can cause vasodilation and increase vascular permeability, 4-Ethoxybenzaldehyde may reduce skin redness and the visible signs of inflammation.
Anti-Aging Effects: PGE2 is known to inhibit collagen production and induce the expression of matrix metallopeptidases (MMPs), particularly MMP1. MMPs degrade extracellular matrix proteins, contributing to photoaging. Therefore, 4-Ethoxybenzaldehyde's inhibition of PGE2 could slow skin aging by preserving collagen and reducing ECM degradation.

Role in Managing Dermatological Conditions

Inflammatory Skin Conditions: Its anti-inflammatory properties could make 4-Ethoxybenzaldehyde beneficial in treating conditions characterized by inflammation, such as specific dermatitis, rosacea, and possibly acne.
Skin Aging and Photoaging: 4-Ethoxybenzaldehyde may be used in anti-aging treatments to help maintain skin firmness and integrity by inhibiting factors that contribute to the degradation of collagen and the extracellular matrix.
Chronic Inflammation and Autoimmune Diseases: Given PGE2's role in exacerbating chronic inflammation and autoimmune diseases, 4-Ethoxybenzaldehyde might have potential applications in managing these conditions, although specific to skin manifestations.

References

Medilan™

Medilan™'s unique formulation and hypoallergenic properties make it a valuable component in managing various dermatological conditions, particularly for hydrating and soothing sensitive and dry skin.

Medilan™, an ultra-refined, hypoallergenic medical-grade lanolin, has proven to be very beneficial for managing dermatological conditions. Below is a brief overview of its physiological effects and roles in managing various skin conditions.

Physiological Effects

Emollient: Medilan™ is an excellent emollient, helping to soften and smooth the skin by retaining moisture. It creates an occlusive barrier, which reduces transepidermal water loss (TEWL).
Moisturizing: It is highly effective in moisturizing dry and rough skin, enhancing skin hydration by trapping and sealing in moisture.
Hypoallergenic: Medilan™ is ultra-purified to minimize the risk of allergic reactions, making it suitable for sensitive skin types.
Wound Healing: Medilan™ aids in the healing process of minor cuts, abrasions, and burns by maintaining a moist wound environment.
Skin Barrier Function: It enhances the skin's barrier function, protecting against environmental irritants and reducing the risk of skin infections.
Lipid Replenishment: Medilan™ mimics the lipids found in human skin, helping to restore the lipid barrier of the skin, especially beneficial in dry and chapped skin conditions.
Skin Penetration and Hydration: It can penetrate the skin and aid in water retention in the stratum corneum, the outermost layer of the skin, thus enhancing hydration.
Occlusive Properties: Medilan™ helps reduce transepidermal water loss by forming a barrier on the skin surface, thereby retaining moisture and improving skin barrier function.

Role in Managing Dermatological Conditions

Eczema and Dry Skin Conditions: Medilan™ is a valuable ingredient in treating eczema and other dry skin conditions due to its soothing, hydrating, and occlusive properties.
Wound Healing: While primarily used for its emollient effects, the properties of Medilan™ also aid in healing minor wounds and skin irritations.
Sensitive Skin Care: Its hypoallergenic nature makes it suitable for sensitive skin, reducing the risk of irritation or allergic reactions.
Nipple Care in Breastfeeding: Soothes and heals cracked and sore nipples in breastfeeding mothers.
Chapped Lips and Skin: It effectively treats chapped lips and skin, providing a barrier that seals in moisture and protects from harsh weather conditions.

References

Lodén, M., & Maibach, H. I. (2000). Dry skin and moisturizers: chemistry and function. CRC Press.
Suleman, H., et al. (2000). Role of lanolin in managing eczema and dry skin conditions. Community Nurse.
DiNardo, J. C. (2000). Is lanolin allergy a myth? Dermatitis.
Stone, L. (2000). Medilan: a hypoallergenic lanolin for emollient therapy. British Journal of Nursing.
ResearchGate Article on Medilan™ highlighting its role in skin care and emollient therapy.

Vitamin E

The fat-soluble Vitamin E's benefits in maintaining skin health and appearance are well-acknowledged in both cosmetic and clinical dermatology. Comprising a group of eight compounds, including four tocopherols and four tocotrienols, Vitamin E is known for its role in protecting cell membranes from oxidative damage.

Vitamin E is celebrated in skincare for its ability to neutralize free radicals caused by environmental stressors such as UV radiation and pollution. These free radicals can lead to premature skin aging, making Vitamin E a valuable ingredient in anti-aging skincare products. Its antioxidant action helps to protect the skin from damage, reduce the appearance of wrinkles, and improve skin texture and tone.

Additionally, Vitamin E is known for its moisturizing benefits. It helps to strengthen the skin barrier, reduce moisture loss, and keep the skin hydrated and supple. This makes it especially beneficial for dry and damaged skin.

Vitamin E also has anti-inflammatory properties, making it beneficial in soothing and calming irritated skin. This has implications for conditions such as dermatitis and acne, where inflammation plays a key role.

Physiological Effects

Antioxidant Protection: Vitamin E neutralizes harmful free radicals in the skin, preventing oxidative stress and damage caused by environmental factors like UV radiation and pollution.
Moisturization: It has moisturizing properties, helping to improve skin hydration and alleviate dryness.
Wound Healing: Vitamin E may assist in the skin's healing process, although its efficacy in wound healing is still a subject of research.
Photoprotection: While not a sunscreen, it can provide some degree of photoprotection by strengthening the skin's defense against UV-induced damage.
Anti-Inflammatory Effects: It helps reduce skin inflammation and is beneficial in managing conditions like eczema and psoriasis.

Role in Managing Dermatological Conditions

Skin Aging: Its antioxidant properties make it useful in anti-aging skincare products to protect against free radical damage and improve skin appearance.
Dry Skin Conditions: Vitamin E's moisturizing effects are beneficial in treating dry skin and improving overall skin texture.
Inflammatory Skin Diseases: It can be helpful in soothing inflammatory skin conditions like eczema and psoriasis.
Sun Protection and Repair: Vitamin E is included in sunscreens and after-sun products for its ability to mitigate sun damage.
Scar Treatment: Some studies suggest Vitamin E may help reduce the appearance of scars, although evidence is mixed.

References

Thiele, J. J., Hsieh, S. N., & Ekanayake-Mudiyanselage, S. (1998). Vitamin E: Critical Review of Its Current Use in Cosmetic and Clinical Dermatology. Dermatologic Surgery, 24(7), 805–813.
Ratz-Łyko, A., & Arct, J. (2016). Anti-inflammatory and anti-aging properties of active skin care ingredients. Journal of Clinical and Aesthetic Dermatology, 9(9), 36–40.
Keen, M. A., & Hassan, I. (2016). Vitamin E in dermatology. Indian Dermatology Online Journal.
Ekanayake-Mudiyanselage, S., & Thiele, J. (2007). Vitamin E in human skin: Organ-specific physiology and considerations for its use in dermatology. Molecular Aspects of Medicine.
Nachbar, F., & Korting, H. C. (1995). The role of vitamin E in normal and damaged skin. Journal of Molecular Medicine.

USE DURING PREGNANCY

DermRepair: Trial is safe to use during pregnancy.

SHIPPING

Shipping Guarantee: Guiding you to healthy skin isn’t only about our products; it's also about getting them to you as swiftly as the science behind them. That's why Dermal Health offers a shipping guarantee you can rely on.
Where We Ship From: Orders are dispatched from our facilities in USA and Australia, tailored to your shipping address for optimal efficiency.
Who We Ship With: We trust only well-known, popular, and dependable courier services with your packages.
When You'll Get It: Expect confident skin soon! Shipping addresses in the USA and Australia will enjoy delivery within 1-4 business days. International orders will receive their orders from 6 to 25 business days, depending on the service you select during checkout. Your estimated delivery date will reflect during checkout so that you can mark your calendar.
Tracking Your Order: Eager to start your DermExcel journey? We don't blame you! You'll receive a tracking number after you place your order so that you can follow your package.

For any shipping inquiries, our customer service team is ready to assist.

RETURNS

Dermal Health Science 30-Day Confidence Guarantee: We are passionate about guiding you to healthy skin through medical science. We believe in the quality and effectiveness of our products so much that we offer a 30-Day Confidence Guarantee.

If you're unsatisfied with your purchase, simply return it within 30 days for a full refund.

Healthy Skin Is Not Complicated and neither is our return policy. Please visit our detailed return policy or contact our friendly customer service team for more information.

Feel as confident in us as we want you to feel in your skin.

SECURE PAYMENT

Dermal Health Science Secure Payment Promise: We utilize cutting-edge encryption and security measures to ensure your payment details remain as unblemished as your skin.

Our Secure Payment Promise backs every transaction with DermExcel. We partner with trusted payment providers to create the best shopping experience for you.

Simple. Effective. Ethical. That's not just our skincare philosophy but our approach to your security too.

DermRepair: Trial

$13.00

Facial Redness: Soothe irritated skin and reduce redness.
Spider veins: Address vascular irregularities and promote vascular health.
Inflammation: Scientifically backed formulation that soothes and calms irritated skin and reduces inflammation, promoting skin comfort.
Rosacea: Alleviate Rosacea symptoms, characterized by redness, flushing, and visible blood vessels.
Impaired Skin Barrier: Reinforce the compromised skin barrier, enhancing its integrity and resilience. This helps to reduce moisture loss, protect the skin from external irritants, and promote healthy skin function.
Dry Skin: Skin-replenishing formulation that provides superior hydration and nourishment.
Bruising: Prevent and treat bruising caused by capillary damage, promoting faster healing and recovery.
Post-Procedure Care: Prevent and treat bruising from broken capillaries following surgical and non-surgical aesthetic procedures. Enhance the healing process and help to minimize any post-procedure discomfort.
Overall Skin Health: Nourishes and rejuvenates the skin, promoting a healthier and youthful complexion.

Active ingredients

Vitamin K1

4-Ethoxybenzaldehyde

Medilan™

Vitamin E

Stearic acid

Full ingredient list

Aqua, Cetyl alcohol, Glycerin, Petrolatum, Stearic acid, Jojoba oil, Polysorbate 20, Lanolin, Phylloquinone, Arnica oil, Marine exopolysaccharide, Acrylates/C10-30 alkyl acrylate crosspolymer, 4-Ethoxybenzaldehyde, Tocopherol, Triethanolamine.

Morning & / or Evening

Application time: Morning and/or Evening.
Frequency: Use once or twice daily, depending on the severity of skin dryness or sensitivity, or use according to your dermal Diagnosis treatment instructions.

1. Cleanse

Start with clean and dry skin.
Use your DermExcel cleanser to remove dirt and excess oil from your skin.

2. Apply

Dispense moisturizer onto your fingertips. Smooth the product evenly over your face. Ensure you cover all dry or sensitive areas.
Using your fingertips, gently massage the product into your skin in a circular motion until fully absorbed.

Important note

Apply your moisturizer to damp skin. Moisturizers are most effective if you use them while your skin is damp because damp skin absorbs the product more readily. That also gives the moisturizer a chance to lock in that hydration.

DermRepair: Trial

product benefits

Reduce spider veins

Reduces facial redness and spider veins by improving vascular health, promoting better blood flow, and strengthening the walls of blood vessels.

soothe inflamed skin

It soothes inflammation by calming the skin's immune response, reducing redness and swelling associated with irritation.

Repair barrier function

It repairs the barrier function by supporting the regeneration of the skin's protective layers, enhancing its capacity to defend against external damage.

Stimulate healing

Accelerates healing after procedures by reducing inflammation and supporting the skin's barrier, facilitating a smoother and more rapid recovery process.

dermrepair

mode of action

4-Ethoxybenzaldehyde

4-Ethoxybenzaldehyde is the first and only ingredient proven to inhibit the release of Prostaglandin E2 (PGE2).

Suppressing Prostaglandin E2 (PGE2) physiologically treats:

Inflammation
Skin redness
Skin aging

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PROSTAGLANDIN E2 (PGE2) CAUSE REDNESS AND INFLAMMATION

Prostaglandins are a group of physiologically active signaling molecules found in almost every human tissue. It is a potent inflammatory mediator leading to inflammation, pain, and cell injury. PGE2 exacerbates chronic inflammation and various autoimmune diseases.

PGE2 exacerbates inflammation reactions by:

Inducing vascular hyperpermeability - the excessive leakage of fluid and proteins from blood vessels to the interstitial space.
Relaxing the vascular smooth muscle (causing vasodilatation). This process induces red flare, heat, and swelling.

______

PROSTAGLANDIN E2 (PGE2) ACCELERATE THE SKIN AGING PROCESS

PGE2 inhibits collagen production.
PGE2 induces fibroblasts to express matrix metallopeptidase 1 (MMP1). MMPs degrade extracellular matrix (ECM) proteins such as collagen, fibronectin, elastin, and proteoglycans, contributing to photoaging.

Vitamin K

BARRIER REPAIR

Vitamin K strengthens the skin's natural barrier function, enabling it to grow stronger and retain hydration for longer.

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ANTI-INFLAMMATORY

Vitamin K inhibits the inflammation cascade and is, therefore, beneficial for conditions such as eczema and psoriasis.
Vitamin K acts as an anti-inflammatory by suppressing nuclear factor κB (NF-κB) signal transduction.
Vitamin K protects against oxidative stress by blocking the generation of reactive oxygen species.

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WOUND HEALING

Vitamin K is essential in the body's healing process as it is responsible for blood clotting and wound healing.

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BLOOD VESSEL REPAIR

Vitamin K improves and maintains blood vessel elasticity and vein integrity.
Vitamin K can minimise broken capillaries under the skin and helps with varicose veins. Vitamin K produces a protein that lowers vascular proliferation and mineralisation, which can halt the development of varicose veins.
Vitamin K has an important role in the 'mop-up' of extravasated breakdown products of blood – i.e. haemosiderin deposition. This is responsible for the change from reddish to the brownish colour of a bruise but also for the facilitation of the ultimate resolution in the aftermath of the bruising process.

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ANTI-AGING

Vitamin K is a coenzyme that works with Matrix γ-carboxyglutamic acid protein.
This protein inhibits the calcification (hardening) of elastin, which leads to inflammation and is part of aging.
In this action as a coenzyme, vitamin K keeps elastin (the soft connective tissue) from deterioration.

Glycerin

Humectant. It allows the skin to retain moisture. It increases skin hydration, relieves dryness, and refreshes the skin’s surface.
Emollient. Soften rough or dry patches on the skin.
Anti-microbial. It helps to protect the skin from harmful microorganisms.

Medilan™

KEY BENEFITS

Medilan imitates many functions of human skin lipids, which is nearly twice as effective as the physiological lipids in human skin.

Medilan™ has clinically proven safety and efficacy. It is designed to treat skin barrier impairment and severely compromised skin conditions such as rosacea, eczema, and psoriasis. Its exceptional purity surpasses monograph compliance and performs excellently in clinical trials.

In clinical trials, Medilan maintains skin hydration for up to 2 days after application and increases the rate of epidermal healing by 35% due to its ability to create a moist wound-healing environment.

Medilan™ is hypoallergenic and delivers outstanding efficacy in dermatological applications. Studies have shown no allergic or irritant skin reactions to Medilan, even in severely compromised skin.

Lanolin's efficacy as a medical material and acceptance in the Pharmaceutical Industry is reflected in all major Pharmacopeia containing monographs on lanolin.

______

REPLENISHING ESSENTIAL LIPIDS

Medilan™ supplements the skin with the lipids essential to skin health.

Due to its chemical and physical similarity, it imitates and augments many of the skin's natural lipids.

______

REPAIRING THE SKIN’S NATURAL BARRIER

Medilan™ effectively accelerates the repair of the skin’s natural barrier function.

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PROTECTING AGAINST MICROBIAL INFECTION

Medilan is proven to control a variety of microorganisms.

Staphylococcus aureus is a gram-positive bacteria responsible for the infection that leads to inflammatory symptoms in eczema sufferers. Medilan has been proven to reduce colonies of this bacteria by 99% after 24 hours.
Candidiasis is an overgrowth of yeast that leads to unpleasant symptoms, such as itching and soreness around the skin's mucous membranes. Medilan has been proven to reduce the levels of Candida albicans to a level that controls candidiasis symptoms.
Pseudomonas aeruginosa is a gram-negative bacteria that can attack wound sites and lead to infection. Wound infection is common in immunocompromised individuals. Medilan has shown potent antibacterial effects against this organism.

Fatty acids

Essential fatty acids (EFAs) offer a multifaceted approach to improving skin health in patients with eczema and dry skin conditions.

BIOCHEMICAL BRILLIANCE

Essential fatty acids, including omega-3 and omega-6, are the building blocks of the skin's lipid barrier. This barrier is a protective shield, preventing excessive moisture loss and shielding the skin from external aggressors. EFAs play a pivotal role in maintaining this barrier's integrity by contributing to the synthesis of ceramides and lipids that bind skin cells together.

PHARMACOLOGICAL ADVANTAGES

EFAs are not only instrumental in maintaining the skin's structural integrity but also possess anti-inflammatory properties. They serve as precursors for pro-resolving lipid mediators like resolvins and protectins, which help reduce skin inflammation, itching, and redness—common symptoms of eczema.

PHYSIOLOGICAL HARMONY

EFAs contribute to maintaining the balance of skin hydration. They enhance the skin's ability to retain water, leaving it supple and hydrated. Moreover, EFAs can modulate the skin's immune response, reducing the severity of allergic reactions and flare-ups often seen in dermatological conditions like eczema.

indications for DermRepair: Trial

Irritated Skin
Inflammation
Rosacea / Red Skin
Telangiectasias / Spider veins
Disrupted Skin Barrier
Injured Skin
Post-Procedure Recovery
Wound Repair

Reduce facial redness, irritation, spider veins, and inflammation.

treatment classes

moisturizing & barrier repair

Emollients

Emollients soften and smooth the skin. They fill the gaps between skin cells and replenish missing lipids, crucial for maintaining the skin's barrier function. This flattens the curled edges of individual skin cells (corneocytes), resulting in a smoother surface with enhanced light reflection.
It improves skin texture, alleviates dryness and irritation, and promotes overall health and comfort.

Fill the gaps between skin cells and replace missing lipids.

Humectants

Humectants have high water absorption capabilities and draw moisture from the air into the skin, and from the dermis to the epidermis.
By attracting and retaining moisture, humectants help maintain skin hydration, making it feel soft and supple.
They help reduce lines and wrinkles by plumping up the skin, giving it a more youthful and radiant appearance.

Attract water to the skin to maintain its moisture balance

Occlusives

Occlusives create a protective layer on top of the skin that locks in moisture, prevents transepidermal water loss (TEWL), and protects the skin from external irritants such as pollutants, allergens, and harsh weather conditions, contributing to skin sensitivity and damage.
For dry, cracked, or irritated skin, occlusives provide immediate relief by covering the affected area and preventing further moisture loss, allowing the skin to heal more effectively.

Creates a protective layer on top of skin to lock moisture in.

Lipid-Bilayer Technology

This technology amplifies lipid production and replenishes the lamellar bilayers critical for normal barrier function and antimicrobial defense.
It forms a double structural layer on the skin's surface to regenerate its natural barrier. Components are quickly absorbed into the underlying nucleated cell layers, which are then incorporated into lamellar bodies.
This barrier repair therapy reduces inflammation through several mechanisms, leading to a smoother surface with less friction and greater light refraction.

Replenish lipid bilayers critical for normal barrier function.

testimonials

The best product with a beautiful suprise

I have been using Dermexcel a long time and the results on my skin speaks for itself but what I actually wanted to compliment the brand on today was the beautiful prayer candle i received with my order. I received the candle on a day I really needed it and i just want the team to know how much I appreciated it! THANK YOU!

Amazing

I could see a change in my skin within a week

The Best!!

I love, love love their products. Won't ever use anything else again. My fave has improved so much❤️

Best products out there

I have been using Dermexel for 3 years now. I can truthfully say it is the best skincare routine I have ever used. Derm Repair is a lightweight moisturizer that nourishes my skin without making it feel oily. And you don’t have to use a lot as it is quite concentrated. Love these products!

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DermRepair: Trial

Biochemical Benefits