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DermRepair: Trial DermRepair: Trial DermRepair: Trial DermRepair: Trial

DermRepair: Trial

Sale price$13.00

SIZE: 5 mL

↓ inflammation

↓ inflammation

anti-redness

anti-redness

barrier repair

barrier repair

↑ Elasticity

↑ Elasticity

Anti-Aging

Anti-Aging


A specialized Vitamin K moisturizer formulated to address facial redness, spider veins, and inflammation associated with Rosacea and other inflammatory skin conditions. Its unique blend of active ingredients works synergistically to reduce skin irritation and support the impaired skin barrier.

Vitamin K in this formula aids in the reduction of vascular conditions such as spider veins, while Medilan provides superior moisturizing and hydrating effects. Arnica oil, known for its anti-inflammatory properties, further enhances the product's ability to soothe and calm irritated skin.

DermRepair also serves as an effective post-procedure treatment, helping to prevent and treat bruising caused by broken capillaries following surgical and non-surgical aesthetic procedures. Its skin-replenishing ingredients, including Glycerin, Petrolatum, and Jojoba oil, provide additional hydration and support to the skin barrier.

DermRepair is a clinically proven, specialized moisturizer that offers a comprehensive approach to managing and improving skin health, particularly in conditions of inflammation and vascular irregularities.


Vitamin K1

Vitamin K1, known as phylloquinone, is primarily recognized for its crucial role in blood coagulation. Beyond its well-known effects on blood clotting, recent research has highlighted its potential benefits in skin care, particularly in managing bruising and dark circles under the eyes and improving skin elasticity. Its mechanisms of action involve regulating blood clotting and reducing blood leakage into the skin and soft tissues. This property makes it particularly useful in topical treatments to minimize bruising and under-eye dark circles, often caused by fragile capillaries leaking small amounts of blood.

Studies have suggested that when applied topically, Vitamin K1 can help reduce the severity and duration of bruising after laser procedures or surgical treatments. It is believed to aid in the body's process of reabsorbing blood near the skin's surface, thereby reducing the appearance of bruises.


Physiological Effects

Blood Clotting and Bruising: Vitamin K1 is critical in blood clotting. It helps reduce the appearance of bruises on the skin by aiding the body's natural healing process in resolving blood clots.

  1. Improving Skin Elasticity: It is believed to help improve skin elasticity and may reduce the appearance of wrinkles.
  2. Wound Healing: Vitamin K1 can assist in the skin's healing process, although its effectiveness in wound healing needs further research.
  3. Under-Eye Circles: The topical application of Vitamin K1 is thought to reduce the appearance of dark circles under the eyes by strengthening capillary walls and reducing the visibility of blood vessels beneath the skin.

Role in Managing Dermatological Conditions

  • Postoperative Bruising: It is often used in topical creams to reduce bruising following cosmetic skin procedures.
  • Dark Circles Under the Eyes: Creams containing Vitamin K1 diminish the appearance of dark circles caused by visible blood vessels or hyperpigmentation.
  • Skin Aging: Its potential anti-aging properties might benefit products targeting aging skin concerns.

References

  • Shah, N. S., et al. (2002). The effects of topical vitamin K on bruising after laser treatment. Journal of the American Academy of Dermatology.
  • Cohen, J. L., & Bhatia, A. C. (2009). The role of topical vitamin K oxide gel in the resolution of postprocedural purpura. Journal of Drugs in Dermatology.
  • AlQdah, T. (2021). Vitamin K in Dermatology. Dermatology Practical & Conceptual.
4-Ethoxybenzaldehyde

4-Ethoxybenzaldehyde is a distinctive ingredient in skincare. It is notable for its ability to inhibit Prostaglandin E2 (PGE2), a compound linked to inflammation, redness, and skin aging. Its unique mode of action in inhibiting PGE2 sets it apart from other skincare ingredients, particularly in addressing inflammation and preserving skin structure.

PGE2 is a potent mediator of inflammation, contributing to pain, cell injury, and chronic inflammatory conditions. It plays a role in skin aging by inhibiting collagen production and inducing MMP1, which degrades key skin matrix components.

By suppressing PGE2, 4-Ethoxybenzaldehyde effectively addresses these skin concerns, offering benefits in reducing inflammation and skin redness and counteracting signs of aging.

4-Ethoxybenzaldehyde has significant dermatological implications, particularly in its ability to modulate inflammatory processes and influence skin aging.


Physiological Effects

  • Inhibition of Prostaglandin E2 (PGE2): 4-Ethoxybenzaldehyde is noted for its unique ability to inhibit the release of PGE2, a potent mediator of inflammation. By suppressing PGE2, it potentially reduces inflammation, pain, and cellular injury.
  • Reduction of Skin Redness: By inhibiting PGE2, which can cause vasodilation and increase vascular permeability, 4-Ethoxybenzaldehyde may reduce skin redness and the visible signs of inflammation.
  • Anti-Aging Effects: PGE2 is known to inhibit collagen production and induce the expression of matrix metallopeptidases (MMPs), particularly MMP1. MMPs degrade extracellular matrix proteins, contributing to photoaging. Therefore, 4-Ethoxybenzaldehyde's inhibition of PGE2 could slow skin aging by preserving collagen and reducing ECM degradation.

Role in Managing Dermatological Conditions

  • Inflammatory Skin Conditions: Its anti-inflammatory properties could make 4-Ethoxybenzaldehyde beneficial in treating conditions characterized by inflammation, such as specific dermatitis, rosacea, and possibly acne.
  • Skin Aging and Photoaging: 4-Ethoxybenzaldehyde may be used in anti-aging treatments to help maintain skin firmness and integrity by inhibiting factors that contribute to the degradation of collagen and the extracellular matrix.
  • Chronic Inflammation and Autoimmune Diseases: Given PGE2's role in exacerbating chronic inflammation and autoimmune diseases, 4-Ethoxybenzaldehyde might have potential applications in managing these conditions, although specific to skin manifestations.

References

Medilan™

Medilan™'s unique formulation and hypoallergenic properties make it a valuable component in managing various dermatological conditions, particularly for hydrating and soothing sensitive and dry skin.

Medilan™, an ultra-refined, hypoallergenic medical-grade lanolin, has proven to be very beneficial for managing dermatological conditions. Below is a brief overview of its physiological effects and roles in managing various skin conditions.


Physiological Effects

  • Emollient: Medilan™ is an excellent emollient, helping to soften and smooth the skin by retaining moisture. It creates an occlusive barrier, which reduces transepidermal water loss (TEWL).
  • Moisturizing: It is highly effective in moisturizing dry and rough skin, enhancing skin hydration by trapping and sealing in moisture.
  • Hypoallergenic: Medilan™ is ultra-purified to minimize the risk of allergic reactions, making it suitable for sensitive skin types.
  • Wound Healing: Medilan™ aids in the healing process of minor cuts, abrasions, and burns by maintaining a moist wound environment.
  • Skin Barrier Function: It enhances the skin's barrier function, protecting against environmental irritants and reducing the risk of skin infections.
  • Lipid Replenishment: Medilan™ mimics the lipids found in human skin, helping to restore the lipid barrier of the skin, especially beneficial in dry and chapped skin conditions.
  • Skin Penetration and Hydration: It can penetrate the skin and aid in water retention in the stratum corneum, the outermost layer of the skin, thus enhancing hydration.
  • Occlusive Properties: Medilan™ helps reduce transepidermal water loss by forming a barrier on the skin surface, thereby retaining moisture and improving skin barrier function.

Role in Managing Dermatological Conditions

  • Eczema and Dry Skin Conditions: Medilan™ is a valuable ingredient in treating eczema and other dry skin conditions due to its soothing, hydrating, and occlusive properties.
  • Wound Healing: While primarily used for its emollient effects, the properties of Medilan™ also aid in healing minor wounds and skin irritations.
  • Sensitive Skin Care: Its hypoallergenic nature makes it suitable for sensitive skin, reducing the risk of irritation or allergic reactions.
  • Nipple Care in Breastfeeding: Soothes and heals cracked and sore nipples in breastfeeding mothers.
  • Chapped Lips and Skin: It effectively treats chapped lips and skin, providing a barrier that seals in moisture and protects from harsh weather conditions.

References

  • Lodén, M., & Maibach, H. I. (2000). Dry skin and moisturizers: chemistry and function. CRC Press.
  • Suleman, H., et al. (2000). Role of lanolin in managing eczema and dry skin conditions. Community Nurse.
  • DiNardo, J. C. (2000). Is lanolin allergy a myth? Dermatitis.
  • Stone, L. (2000). Medilan: a hypoallergenic lanolin for emollient therapy. British Journal of Nursing​​.
  • ResearchGate Article on Medilan™ highlighting its role in skin care and emollient therapy​​.
Vitamin E

The fat-soluble Vitamin E's benefits in maintaining skin health and appearance are well-acknowledged in both cosmetic and clinical dermatology. Comprising a group of eight compounds, including four tocopherols and four tocotrienols, Vitamin E is known for its role in protecting cell membranes from oxidative damage.

Vitamin E is celebrated in skincare for its ability to neutralize free radicals caused by environmental stressors such as UV radiation and pollution. These free radicals can lead to premature skin aging, making Vitamin E a valuable ingredient in anti-aging skincare products. Its antioxidant action helps to protect the skin from damage, reduce the appearance of wrinkles, and improve skin texture and tone.

Additionally, Vitamin E is known for its moisturizing benefits. It helps to strengthen the skin barrier, reduce moisture loss, and keep the skin hydrated and supple. This makes it especially beneficial for dry and damaged skin.

Vitamin E also has anti-inflammatory properties, making it beneficial in soothing and calming irritated skin. This has implications for conditions such as dermatitis and acne, where inflammation plays a key role.


Physiological Effects

  • Antioxidant Protection: Vitamin E neutralizes harmful free radicals in the skin, preventing oxidative stress and damage caused by environmental factors like UV radiation and pollution.
  • Moisturization: It has moisturizing properties, helping to improve skin hydration and alleviate dryness.
  • Wound Healing: Vitamin E may assist in the skin's healing process, although its efficacy in wound healing is still a subject of research.
  • Photoprotection: While not a sunscreen, it can provide some degree of photoprotection by strengthening the skin's defense against UV-induced damage.
  • Anti-Inflammatory Effects: It helps reduce skin inflammation and is beneficial in managing conditions like eczema and psoriasis.

Role in Managing Dermatological Conditions

  • Skin Aging: Its antioxidant properties make it useful in anti-aging skincare products to protect against free radical damage and improve skin appearance.
  • Dry Skin Conditions: Vitamin E's moisturizing effects are beneficial in treating dry skin and improving overall skin texture.
  • Inflammatory Skin Diseases: It can be helpful in soothing inflammatory skin conditions like eczema and psoriasis.
  • Sun Protection and Repair: Vitamin E is included in sunscreens and after-sun products for its ability to mitigate sun damage.
  • Scar Treatment: Some studies suggest Vitamin E may help reduce the appearance of scars, although evidence is mixed.

References

  • Thiele, J. J., Hsieh, S. N., & Ekanayake-Mudiyanselage, S. (1998). Vitamin E: Critical Review of Its Current Use in Cosmetic and Clinical Dermatology. Dermatologic Surgery, 24(7), 805–813.
  • Ratz-Łyko, A., & Arct, J. (2016). Anti-inflammatory and anti-aging properties of active skin care ingredients. Journal of Clinical and Aesthetic Dermatology, 9(9), 36–40.
  • Keen, M. A., & Hassan, I. (2016). Vitamin E in dermatology. Indian Dermatology Online Journal.
  • Ekanayake-Mudiyanselage, S., & Thiele, J. (2007). Vitamin E in human skin: Organ-specific physiology and considerations for its use in dermatology. Molecular Aspects of Medicine.
  • Nachbar, F., & Korting, H. C. (1995). The role of vitamin E in normal and damaged skin. Journal of Molecular Medicine.
Stearic acid

Stearic acid, a saturated fatty acid, offers a multitude of benefits particularly for patients dealing with eczema and other dry skin-related dermatological conditions.

Biochemical Benefits

Stearic acid is a natural component of the skin's protective barrier, the stratum corneum. It plays a pivotal role in maintaining the barrier's integrity. 

Eczema is characterized by a compromised skin barrier, leading to increased transepidermal water loss (TEWL) and susceptibility to external irritants. 

By topically applying stearic acid, we are essentially providing the skin with a crucial building block it needs for repair and protection. 

This biochemical harmony aids in reinforcing the skin's natural defenses.


References

  • Rawlings, A. V. (2007). Trends in stratum corneum research and the management of dry skin conditions. International Journal of Cosmetic Science, 29(1), 7-10.
  • Nakatsuji, T., Gallo, R. L. (2012). Dermatological therapy by topical application of nonpathogenic bacteria. Journal of Investigative Dermatology Symposium Proceedings, 15(1), 24-32.
  • Loden, M., & Maibach, H. I. (2005). Voluntary human dosimetry of acutely applied topically delivered glycerol: a comparison between in vitro and in vivo assessments. Skin Research and Technology, 11(2), 87-91.
DermExcel™ | DermRepair
DermRepair: Trial Sale price$13.00
  • Facial Redness: Soothe irritated skin and reduce redness.
  • Spider veins: Address vascular irregularities and promote vascular health.
  • Inflammation: Scientifically backed formulation that soothes and calms irritated skin and reduces inflammation, promoting skin comfort.
  • Rosacea: Alleviate Rosacea symptoms, characterized by redness, flushing, and visible blood vessels.
  • Impaired Skin Barrier: Reinforce the compromised skin barrier, enhancing its integrity and resilience. This helps to reduce moisture loss, protect the skin from external irritants, and promote healthy skin function.
  • Dry Skin: Skin-replenishing formulation that provides superior hydration and nourishment.
  • Bruising: Prevent and treat bruising caused by capillary damage, promoting faster healing and recovery.
  • Post-Procedure Care: Prevent and treat bruising from broken capillaries following surgical and non-surgical aesthetic procedures. Enhance the healing process and help to minimize any post-procedure discomfort.
  • Overall Skin Health: Nourishes and rejuvenates the skin, promoting a healthier and youthful complexion.

Active ingredients

    Vitamin K1

    Stearic acid, a saturated fatty acid, offers a multitude of benefits particularly for patients dealing with eczema and other dry skin-related dermatological conditions.

    Biochemical Benefits

    Stearic acid is a natural component of the skin's protective barrier, the stratum corneum. It plays a pivotal role in maintaining the barrier's integrity. 

    Eczema is characterized by a compromised skin barrier, leading to increased transepidermal water loss (TEWL) and susceptibility to external irritants. 

    By topically applying stearic acid, we are essentially providing the skin with a crucial building block it needs for repair and protection. 

    This biochemical harmony aids in reinforcing the skin's natural defenses.


    • Rawlings, A. V. (2007). Trends in stratum corneum research and the management of dry skin conditions. International Journal of Cosmetic Science, 29(1), 7-10.
    • Nakatsuji, T., Gallo, R. L. (2012). Dermatological therapy by topical application of nonpathogenic bacteria. Journal of Investigative Dermatology Symposium Proceedings, 15(1), 24-32.
    • Loden, M., & Maibach, H. I. (2005). Voluntary human dosimetry of acutely applied topically delivered glycerol: a comparison between in vitro and in vivo assessments. Skin Research and Technology, 11(2), 87-91.
    4-Ethoxybenzaldehyde

    Stearic acid, a saturated fatty acid, offers a multitude of benefits particularly for patients dealing with eczema and other dry skin-related dermatological conditions.

    Biochemical Benefits

    Stearic acid is a natural component of the skin's protective barrier, the stratum corneum. It plays a pivotal role in maintaining the barrier's integrity. 

    Eczema is characterized by a compromised skin barrier, leading to increased transepidermal water loss (TEWL) and susceptibility to external irritants. 

    By topically applying stearic acid, we are essentially providing the skin with a crucial building block it needs for repair and protection. 

    This biochemical harmony aids in reinforcing the skin's natural defenses.


    • Rawlings, A. V. (2007). Trends in stratum corneum research and the management of dry skin conditions. International Journal of Cosmetic Science, 29(1), 7-10.
    • Nakatsuji, T., Gallo, R. L. (2012). Dermatological therapy by topical application of nonpathogenic bacteria. Journal of Investigative Dermatology Symposium Proceedings, 15(1), 24-32.
    • Loden, M., & Maibach, H. I. (2005). Voluntary human dosimetry of acutely applied topically delivered glycerol: a comparison between in vitro and in vivo assessments. Skin Research and Technology, 11(2), 87-91.
    Medilan™

    Stearic acid, a saturated fatty acid, offers a multitude of benefits particularly for patients dealing with eczema and other dry skin-related dermatological conditions.

    Biochemical Benefits

    Stearic acid is a natural component of the skin's protective barrier, the stratum corneum. It plays a pivotal role in maintaining the barrier's integrity. 

    Eczema is characterized by a compromised skin barrier, leading to increased transepidermal water loss (TEWL) and susceptibility to external irritants. 

    By topically applying stearic acid, we are essentially providing the skin with a crucial building block it needs for repair and protection. 

    This biochemical harmony aids in reinforcing the skin's natural defenses.


    • Rawlings, A. V. (2007). Trends in stratum corneum research and the management of dry skin conditions. International Journal of Cosmetic Science, 29(1), 7-10.
    • Nakatsuji, T., Gallo, R. L. (2012). Dermatological therapy by topical application of nonpathogenic bacteria. Journal of Investigative Dermatology Symposium Proceedings, 15(1), 24-32.
    • Loden, M., & Maibach, H. I. (2005). Voluntary human dosimetry of acutely applied topically delivered glycerol: a comparison between in vitro and in vivo assessments. Skin Research and Technology, 11(2), 87-91.
    Vitamin E

    Stearic acid, a saturated fatty acid, offers a multitude of benefits particularly for patients dealing with eczema and other dry skin-related dermatological conditions.

    Biochemical Benefits

    Stearic acid is a natural component of the skin's protective barrier, the stratum corneum. It plays a pivotal role in maintaining the barrier's integrity. 

    Eczema is characterized by a compromised skin barrier, leading to increased transepidermal water loss (TEWL) and susceptibility to external irritants. 

    By topically applying stearic acid, we are essentially providing the skin with a crucial building block it needs for repair and protection. 

    This biochemical harmony aids in reinforcing the skin's natural defenses.


    • Rawlings, A. V. (2007). Trends in stratum corneum research and the management of dry skin conditions. International Journal of Cosmetic Science, 29(1), 7-10.
    • Nakatsuji, T., Gallo, R. L. (2012). Dermatological therapy by topical application of nonpathogenic bacteria. Journal of Investigative Dermatology Symposium Proceedings, 15(1), 24-32.
    • Loden, M., & Maibach, H. I. (2005). Voluntary human dosimetry of acutely applied topically delivered glycerol: a comparison between in vitro and in vivo assessments. Skin Research and Technology, 11(2), 87-91.
    Stearic acid

    Stearic acid, a saturated fatty acid, offers a multitude of benefits particularly for patients dealing with eczema and other dry skin-related dermatological conditions.

    Biochemical Benefits

    Stearic acid is a natural component of the skin's protective barrier, the stratum corneum. It plays a pivotal role in maintaining the barrier's integrity. 

    Eczema is characterized by a compromised skin barrier, leading to increased transepidermal water loss (TEWL) and susceptibility to external irritants. 

    By topically applying stearic acid, we are essentially providing the skin with a crucial building block it needs for repair and protection. 

    This biochemical harmony aids in reinforcing the skin's natural defenses.


    • Rawlings, A. V. (2007). Trends in stratum corneum research and the management of dry skin conditions. International Journal of Cosmetic Science, 29(1), 7-10.
    • Nakatsuji, T., Gallo, R. L. (2012). Dermatological therapy by topical application of nonpathogenic bacteria. Journal of Investigative Dermatology Symposium Proceedings, 15(1), 24-32.
    • Loden, M., & Maibach, H. I. (2005). Voluntary human dosimetry of acutely applied topically delivered glycerol: a comparison between in vitro and in vivo assessments. Skin Research and Technology, 11(2), 87-91.

Full ingredient list

    Aqua, Cetyl alcohol, Glycerin, Petrolatum, Stearic acid, Jojoba oil, Polysorbate 20, Lanolin, Phylloquinone, Arnica oil, Marine exopolysaccharide, Acrylates/C10-30 alkyl acrylate crosspolymer, 4-Ethoxybenzaldehyde, Tocopherol, Triethanolamine.

Morning & / or Evening

  • Application time: Morning and/or Evening.
  • Frequency: Use once or twice daily, depending on the severity of skin dryness or sensitivity, or use according to your dermal Diagnosis treatment instructions.

1. Cleanse

  • Start with clean and dry skin.
  • Use your DermExcel cleanser to remove dirt and excess oil from your skin.

2. Apply

  • Dispense moisturizer onto your fingertips. Smooth the product evenly over your face. Ensure you cover all dry or sensitive areas.
  • Using your fingertips, gently massage the product into your skin in a circular motion until fully absorbed.

Important note

Apply your moisturizer to damp skin. Moisturizers are most effective if you use them while your skin is damp because damp skin absorbs the product more readily. That also gives the moisturizer a chance to lock in that hydration.

DermRepair: Trial

product benefits

Reduce spider veins
Reduce spider veins

Reduces facial redness and spider veins by improving vascular health, promoting better blood flow, and strengthening the walls of blood vessels.

soothe inflamed skin
soothe inflamed skin

It soothes inflammation by calming the skin's immune response, reducing redness and swelling associated with irritation.

Repair barrier function
Repair barrier function

It repairs the barrier function by supporting the regeneration of the skin's protective layers, enhancing its capacity to defend against external damage.

Stimulate healing
Stimulate healing

Accelerates healing after procedures by reducing inflammation and supporting the skin's barrier, facilitating a smoother and more rapid recovery process.

dermrepair

mode of action

treatment classes

moisturizing & barrier repair

Emollients

Emollients
  • Emollients soften and smooth the skin. They fill the gaps between skin cells and replenish missing lipids, crucial for maintaining the skin's barrier function. This flattens the curled edges of individual skin cells (corneocytes), resulting in a smoother surface with enhanced light reflection.
  • It improves skin texture, alleviates dryness and irritation, and promotes overall health and comfort.

Fill the gaps between skin cells and replace missing lipids.

Humectants

Humectants
  • Humectants have high water absorption capabilities and draw moisture from the air into the skin, and from the dermis to the epidermis.
  • By attracting and retaining moisture, humectants help maintain skin hydration, making it feel soft and supple.
  • They help reduce lines and wrinkles by plumping up the skin, giving it a more youthful and radiant appearance.

Attract water to the skin to maintain its moisture balance

Occlusives

Occlusives
  • Occlusives create a protective layer on top of the skin that locks in moisture, prevents transepidermal water loss (TEWL), and protects the skin from external irritants such as pollutants, allergens, and harsh weather conditions, contributing to skin sensitivity and damage.
  • For dry, cracked, or irritated skin, occlusives provide immediate relief by covering the affected area and preventing further moisture loss, allowing the skin to heal more effectively.

Creates a protective layer on top of skin to lock moisture in.

Lipid-Bilayer Technology

Lipid-Bilayer Technology
  • This technology amplifies lipid production and replenishes the lamellar bilayers critical for normal barrier function and antimicrobial defense.
  • It forms a double structural layer on the skin's surface to regenerate its natural barrier. Components are quickly absorbed into the underlying nucleated cell layers, which are then incorporated into lamellar bodies.
  • This barrier repair therapy reduces inflammation through several mechanisms, leading to a smoother surface with less friction and greater light refraction.

Replenish lipid bilayers critical for normal barrier function.

testimonials

Customer Reviews

Based on 496 reviews
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L
Lilly Enslin
The best product with a beautiful suprise

I have been using Dermexcel a long time and the results on my skin speaks for itself but what I actually wanted to compliment the brand on today was the beautiful prayer candle i received with my order. I received the candle on a day I really needed it and i just want the team to know how much I appreciated it! THANK YOU!

H
Heidi Nieuwoudt
Amazing

I could see a change in my skin within a week

S
Shantez Pieterse
The Best!!

I love, love love their products. Won't ever use anything else again. My fave has improved so much❤️

B
Brenda Jordaan
Best products out there

I have been using Dermexel for 3 years now. I can truthfully say it is the best skincare routine I have ever used. Derm Repair is a lightweight moisturizer that nourishes my skin without making it feel oily. And you don’t have to use a lot as it is quite concentrated. Love these products!

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