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Sale priceP522.00 BWP

SIZE: 120 mL

A maximum strength medicated scalp treatment to relieve itching, irritation, redness, flaking, and scaling associated with dandruff and seborrheic dermatitis.

A powerful formula that combines 2% Salicylic acid and 2% Zinc pyrithione for maximum effectiveness and life-changing results.

Our advanced formulation is enriched with Ceramides, fatty acids, and Cholesterol, intelligently combining to repair, strengthen, and revive the skin barrier. This powerhouse blend of potent ingredients supports the dermis in retaining moisture, preventing water loss, and restoring the skin structure, resulting in a healthier, more vibrant complexion.

Zinc Pyrithione, an antifungal, antimicrobial, and antibacterial agent, works by reducing the amount of fungus that triggers inflammation and scaling. Zinc Pyrithione also treats pityrosporum folliculitis (fungal acne) on the face and other body parts.

Salicylic acid gently exfoliates the scalp, removing dead skin cells and excess oil, contributing to dandruff and itchiness. As a result, it unclogs hair follicles, promoting a healthier scalp environment.

Zinc Pyrithione

Zinc pyrithione, a compound with potent antifungal and antibacterial properties, has established itself as a cornerstone in the treatment of various skin conditions, particularly those involving Malassezia yeast. Its effectiveness against seborrheic dermatitis and dandruff, which are often associated with an overgrowth of Malassezia species, makes it a key ingredient for many dermatological conditions.

Zinc pyrithione’s mode of action is multifaceted, primarily targeting the membrane of fungi and bacteria, thereby disrupting their growth and replication. One of its significant mechanisms involves inhibiting fungal cell membrane transport by blocking the energy production pathway, which is crucial for cell survival.

In Malassezia, yeast, a natural inhabitant of the skin flora, can overgrow and cause conditions like seborrheic dermatitis and dandruff; zinc pyrithione's antifungal action is particularly beneficial. It reduces the yeast population on the skin, thereby alleviating the symptoms associated with its overgrowth, such as flaking, irritation, and redness.

Its efficacy in treating seborrheic dermatitis is attributed to its ability to reduce the Malassezia count, diminish inflammatory responses, and soothe the skin. Similarly, in dandruff, which is often linked to an excess of Malassezia, zinc pyrithione effectively reduces flaking and itchiness, promoting a healthier scalp environment.

The efficacy of zinc pyrithione in the treatment of seborrheic dermatitis and dandruff is well-documented. Its safety profile and efficacy have been confirmed by numerous studies, with significant improvements observed in both scalp and skin conditions following regular use.

Physiological effects of Zinc Pyrithione
  1. Antifungal Activity: It is effective against a range of fungi, including those that cause dandruff and seborrheic dermatitis. Zinc Pyrithione inhibits the division of fungal cells, reducing their proliferation.
  2. Antibacterial Properties: This compound also exhibits antibacterial activity, making it useful in treating and preventing bacterial skin infections.
  3. Anti-inflammatory Effects: Zinc Pyrithione can reduce inflammation, which is beneficial in alleviating symptoms of various inflammatory skin conditions.
  4. Sebum Regulation: It helps in regulating sebum production, which can be beneficial for oily skin and conditions like acne.
Role in Managing Dermatologocal Conditions
  1. Dandruff and Seborrheic Dermatitis: Zinc Pyrithione is a common ingredient in anti-dandruff shampoos and is effective in controlling the flaking and itching associated with these conditions.
  2. Psoriasis: It can help manage the symptoms of psoriasis, particularly in reducing scaling and redness.
  3. Acne: Due to its antibacterial and anti-inflammatory properties, Zinc Pyrithione can be beneficial in the treatment of acne.
  4. Fungal Infections: It is effective in treating various fungal skin infections due to its antifungal properties.
  • Warshaw, E. M., et al. (2005). Efficacy of Zinc Pyrithione in Seborrheic Dermatitis and Dandruff. Dermatology.
  • Pierard-Franchimont, C., et al. (2002). Antidandruff shampoo efficacy in dandruff/seborrhoeic dermatitis. International Journal of Cosmetic Science.
  • Scheman, A., et al. (2000). Antimicrobial Activity of Zinc Pyrithione. American Journal of Infection Control.

Salicylic acid, a renowned beta hydroxy acid (BHA), stands as a cornerstone in the realm of dermatology and skincare due to its exceptional keratolytic and comedolytic properties. It has a unique ability to penetrate oil-laden hair follicle pores, making it particularly effective in treating acne-prone and oily skin types.

Salicylic acid works by dissolving the type of skin debris that clogs pores and causes acne, namely sebum and dead skin cells. It's a mild anti-bacterial- and a powerful anti-inflammatory agent, which help to reduce the redness and swelling associated with breakouts.

What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin not just on the surface, but within the pores themselves. This is due to its oil-soluble nature, allowing it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.

Furthermore, salicylic acid also has the capacity to adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions, both in terms of count and severity. Additionally, salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.

Physiological Effects of Salicylic Acid
  1. Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
  2. Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
  3. Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
  4. Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
  5. Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, making it effective in treating acne located deep within the pores.
Role in Managing Dermatological Conditions
  1. Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effective in both preventing and treating existing acne lesions.
  2. Psoriasis: Its keratolytic properties make it useful in softening and removing scales associated with psoriasis.
  3. Warts: Salicylic acid is commonly used in the treatment of warts due to its ability to exfoliate and remove the thickened skin.
  4. Seborrheic Dermatitis: It helps in managing seborrheic dermatitis by reducing scaling and redness.
  5. Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with keratosis pilaris.
  • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
  • Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
  • Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
  • Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.
DermExcel™ | Follicure
Follicure Sale priceP522.00 BWP
  • Dandruff
  • Seborrheic dermatitis
  • Itchy and irritated scalp
  • Inflammation
  • Acne, body acne and conditions related to yeast / fungal infections
  • Shaving bumps / Folliculitis
  • Psoriasis

Active ingredients

  • Zinc Pyrithione
  • BHA2

Full ingredient list

Aqua, Polyethylene Glycol, Coco-Glucoside, Cocoamidopropyl Betaine, Sodium Lauroyl Sarcosinate, Salicylic acid, Zinc Pyrithione, Phenoxyethanol & Ethyl hexyl Glycerin, Acrylates Copolymer, Triethanolamine, Coco-Glucoside & Glyceryl Oleate

  • Apply Follicure to wet hair and scalp: This allows the product to evenly distribute and work effectively on the scalp. Instruct your patients to take sufficient amount Follicure and gently massage it onto the wet scalp, ensuring full coverage. Advise them to pay particular attention to areas with visible signs of dandruff, itchiness, or irritation.
  • Massage into scalp: Use the fingertips or the included scalp massager to massage Follicure into the scalp with circular motions. This helps to activate the ingredients and promotes better penetration. Leave Follicure on the scalp for approximately 5 to 10 minutes to allow the active ingredients to work effectively.
  • Rinse: After the designated time, thoroughly rinse hair and scalp with lukewarm water, ensuring that all residue is removed. It is important to rinse completely, as any remaining product on the scalp may cause irritation or reduce the effectiveness of the treatment.
  • Frequency of use: Recommend to your patient to use Follicure 2 to 3 times per week, depending on the severity of your patient's condition and their individual needs. As their symptoms improve, they may reduce the frequency of use to maintain a healthy scalp.


  • Repeat the application every time you wash your hair for 3-4 weeks. Within this timeframe, you will start to experience positive results as the Zinc Pyrithione controls the Malassezia overgrowth.
  • Consistent application of Zinc Pyrithione will result in continuous antimicrobial activity.
  • Because yeast, fungi, and bacteria do not develop resistance toward Zinc Pyrithione, you can continue to use Medi-Zinc cleanser regularly even after symptoms have cleared.
  • Make sure that the product has good contact with the skin. Lather the areas you want to treat and keep the product on the skin for 5 -10 min. for best results. This will allow the product to penetrate the follicles to reach the Malassezia optimally.
  • To keep the Malassezia yeast from returning, ensure you have enough Zinc Pyrithione hanging out in the skin around the problem areas. Do not stop your treatment after all the signs and symptoms have cleared up. Problem areas should be in contact with Zinc Pyrithione at least once per week.
  • The FDA has approved Zinc Pyrithione as very safe and effective. There is no harm in continuing to use the Zinc Pyrithione daily. Bacteria and the yeast on your skin will not become resistant to it, so there's no reason to stop using it.
  • Rinse: Always remember the 5 - 10 min. skin contact rule.




Inflammation on the scalp contributes to itchiness, redness, and irritation. Zinc pyrithione reduces inflammation on the scalp, which help to alleviate these symptoms.

Anti-fungal action

Disrupt the cell membrane of the dandruff-causing Malassezia yeast, which inhibits its growth and reduces its ability to colonize the scalp.

Sebum (oil) regulation

Sebum is an oily substance produced by the sebaceous glands on the scalp that can contribute to the development of dandruff when it is overproduced.

Keratolytic action

Exfoliate dead skin cells that accumulate and become trapped in hair follicles, leading to the overgrowth of dandruff causing Malassezia yeast.




Shaving Bumps


Seborrheic Dermatitis


Itchy Scalp

Yeast / Fungal Infections

Body Acne / Breakouts





Customer Reviews

Based on 761 reviews
Live Life

These products have been a live changer for my daughter. She has more confidence and can live life to the fullest.

Liana Pelser

It thoroughly cleanses my face and I believe it will make a difference in pigmentation long term

Danielle van Heerden
Medi-Zinc Cleanser

This cleanser always does the job. Cleanse and the fact that I keep it on my face for a while helps removing any rough bumpies.
It is just a shame that Dermexel is getting so expensive.

wendy aucamp
Medi zinc cleanser

My teenage boys love their new skin. Thanx to medi zinc cleanser

Lorraine Sauer
Excellent Dermexcel products

I've been battling for years to find a skin product that assists with breakouts and inflammation. This product actually works and my skin has never looked better than now! So grateful!

Bianca Nieuwoudt
Fantastic Cleanser

Mal oor die cleanser en xtra device van Dermexcel




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