DermRepair: Trial

Wound Healing

• Vitamin K is essential in the body's healing process as it is responsible for blood clotting and wound healing. 

Blood Vessel Repair

• Vitamin K improves and maintains blood vessel elasticity and vein integrity.
• Vitamin K can minimise broken capillaries under the skin and helps with varicose veins. Vitamin K produces a protein that lowers vascular proliferation and mineralisation, which can halt the development of varicose veins.
• Vitamin K has an important role in the 'mop-up' of extravasated breakdown products of blood – i.e. haemosiderin deposition. This is responsible for the change from reddish to the brownish colour of a bruise but also for the facilitation of the ultimate resolution in the aftermath of the bruising process.

Anti-Aging

• Vitamin K is a coenzyme that speeds up a reaction without destroying itself.
• Vitamin K is a coenzyme that works with Matrix γ-carboxyglutamic acid protein.
  This protein inhibits the calcification (hardening) of elastin. This calcification leads to an inflammatory process and is part of the aging process.
• In this action as a coenzyme, vitamin K keeps elastin (the soft connective tissue) from deterioration.

Anti-inflammatory

• Vitamin K inhibits the inflammation cascade and is, therefore, beneficial for conditions such as eczema and psoriasis. 
• Vitamin K acts as an anti-inflammatory by suppressing nuclear factor κB (NF-κB) signal transduction.
• Vitamin K protects against oxidative stress by blocking the generation of reactive oxygen species.

Barrier Repair

• Vitamin K strengthens the skin's natural barrier function, enabling it to grow stronger and retain hydration for longer. 

Hydration

• Jojoba oil has a structural similarity with skin sebum, leading to a smoothing effect on dry skin.
• Unlike other exotic oils like argan, coconut, and olive, jojoba oil has a chemical composition that mimics your skin’s sebum more closely than any other oil.
• Jojoba oil's unique structure, which is based on straight-chain Omega 9 esters, has soothing and repairing effects while deeply moisturising the skin.

Antimicrobial

• Jojoba roots have demonstrated antimicrobial activity against several pathogens, including Candida albicans.

• Inflammation
• Skin redness
• Skin aging

• PGE2 is a potent inflammatory mediator leading to inflammation, pain, and cell injury.
• PGE2 exacerbates chronic inflammation and various autoimmune diseases.
• PGE2 exacerbates inflammation reactions by:
• Inducing vascular hyperpermeability - the excessive leakage of fluid and proteins from blood vessels to the interstitial space.
• Relaxing the vascular smooth muscle (causing vasodilatation). This process induces red flare, heat and swelling.

• PGE2 inhibits collagen production.
• PGE2 induces matrix metallopeptidase 1 (MMP1) expression by fibroblasts. MMPs are responsible for degrading the extracellular matrix (ECM) proteins such as collagen, fibronectin, elastin, and proteoglycans, contributing to photoaging.

• Humectant. It allows the skin to retain moisture. It increases skin hydration, relieves dryness, and refreshes the skin’s surface.
• Emollient. Soften rough or dry patches on the skin.
• Anti-microbial. Help to protect the skin from harmful microorganisms.

Medilan™ is Super Refined and highly purified lanolin, clinically proven to reduce the signs and symptoms of very dry, cracked skin.

Medilan™ has clinically proven safety and efficacy, designed to treat skin barrier impairment and severely compromised skin conditions such as rosacea, eczema and psoriasis.

Medilan™'s exceptional purity surpasses that of monograph compliance and has excellent performance in clinical trials.

Being rich in cholesterol and other sterols, lanolin imparts emollient and moisturising properties similar to natural skin lipids.

Medilan™ is hypoallergenic and delivers outstanding efficacy in dermatological applications.

Lanolin efficacy as a medical material and acceptance in Pharmaceutical Industry is reflected in the fact that all major Pharmacopoeia contain monographs for lanolin.

Replenishing essential lipids

• Medilan™ supplement the skin with the lipids essential to skin health.
• Medilan™ imitate and augment many of the skin's natural lipids due to its chemical and physical similarity.

Repairing the skin’s natural barrier

• Medilan™ is effective in accelerating the repair of the skin’s natural barrier function.

Protecting against microbial infection

Medilan is proven to control a variety of microorganisms.

• Staphylococcus aureus is a gram-positive bacteria responsible for the infection that leads to inflammatory symptoms in eczema sufferers. Medilan has been proven to reduce colonies of this bacteria by 99% after 24 hours.
• Candidiasis is an overgrowth of yeast that leads to unpleasant symptoms, such as itching and soreness around the skin's mucous membranes. Medilan has been proven to reduce the levels of Candida albicans to a level that controls candidiasis symptoms.
• Pseudomonas aeruginosa is a gram negative bacteria that can attack wound sites and lead to infection. Wound infection is common in immunocompromised individuals. Medilan has shown potent antibacterial effects against this organism.

Medilan summary

• Medilan imitates many of the functions of human skin lipids.
• Medilan is nearly twice as effective as the physiological lipids in human skin.
• In clinical trials, Medilan maintain skin hydration for up to 2 days after application.
• In clinical trials, Medilan increased the rate of epidermal healing by 35% due to its ability to create a moist wound-healing environment. 
• Studies have shown no allergic or irritant skin reactions to Medilan, even in severely compromised skin.

Stearic acid is a long-chain saturated fatty acid known to be the best choice for barrier repair moisturizers.

Very important in general skin health

• Fatty acids directly affect skin health because they influence the fluidity of cell membranes which regulate the entry and exit of molecules into cells.
• Fatty acids also directly affect general health because they play a role in many important cellular processes. For example, fatty acids get involved in cellular communication and are involved in immune system response.

Pseudoalteromonas Exopolysaccharides is a highly effective alternative for the popular and well-loved hyaluronic acid (HA).

• Rich in glucuronic acid, it is a hygroscopic ingredient meaning it is excellent at hydrating the skin's surface and retaining water.
• Much like HA, it acts like a sponge and draws in every ounce of water and locks it into the skin, reducing fine lines and wrinkles and giving you a smoothing finish to your complexion by decreasing any signs of roughness to the skin.
• The long-lasting hydration also helps combat the effects of free radical damage, such as exposure to harmful UV rays and pollution.

BENEFITS

Clinical studies on pseudoalteromonas ferment extract have demonstrated that it dramatically increases hydration levels in as little as seven days. With continued use over 28 days, a significant reduction in fine lines and crow's feet was observed.

• Increases hydration by helping skin retain water and preventing water loss.
• Heals skin through its regeneration properties.
• Increases collagen and elastin production to reduce wrinkle formation.
• Forms a film on the surface of the skin to boost hydration and tighten skin.

An active ingredient is known for soothing damaged skin and bruising, beneficial for inflammation and skin irritations.

Accelerate wound healing and recovery

• Topical Arnica has anti-inflammatory action.
• Arnica stimulates blood circulation and the flow of white blood cells to accelerate wound healing.

Decrease swelling

• Swelling (oedema) is caused by inflammation and fluid retention. The antibacterial and anti-inflammatory properties in arnica help to prevent facial puffiness.