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d-Panthenol's multifaceted effects on skin hydration, barrier strengthening, and wound healing make it a valuable component in the management of various dermatological conditions, from dry skin to post-procedure care.

d-Panthenol, also known as pro-vitamin B5, is a widely used ingredient in skincare and dermatological treatments due to its beneficial effects on the skin. Here's a brief overview of its physiological effects and roles in managing various skin conditions:

Physiological Effects of d-Panthenol:
  1. Hydration: d-Panthenol is a humectant, meaning it helps to attract and retain moisture in the skin. This leads to increased skin hydration, which can improve skin softness and elasticity.
  2. Wound Healing and Repair: It plays a role in the synthesis of lipids and proteins, essential for skin repair. d-Panthenol has been shown to accelerate re-epithelialization in wound healing.
  3. Anti-Inflammatory Effect: d-Panthenol can reduce inflammation, making it beneficial in treating skin irritations and erythema.
  4. Skin Barrier Strengthening: By enhancing the synthesis of lipids and proteins, d-Panthenol contributes to the strengthening of the skin's barrier function, protecting against irritants and environmental damage.
  5. Soothing and Softening: It soothes the skin and makes it feel softer and smoother, which can be particularly beneficial for dry or rough skin textures.
Role in Managing Dermatological Conditions:
  1. Minor Wounds and Skin Irritations: Due to its role in skin repair and anti-inflammatory properties, d-Panthenol is used in the treatment of minor wounds, cuts, and skin irritations.
  2. Dermatitis and Eczema: It helps in managing conditions like dermatitis and eczema by reducing inflammation and enhancing skin barrier function.
  3. Dry Skin Conditions (Xerosis): Its moisturizing properties make it effective in treating dry skin, providing relief from itching and scaling.
  4. Post-procedure Care: d-Panthenol is often used in post-procedure care, such as after laser treatments or chemical peels, to aid in skin recovery and reduce inflammation.
  • Proksch, E., & Nissen, H. P. (2002). Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation. Journal of Dermatological Treatment.
  • Ebner, F., Heller, A., Rippke, F., & Tausch, I. (2002). Topical use of dexpanthenol in skin disorders. American Journal of Clinical Dermatology.
  • Camargo, F. B. Jr, Gaspar, L. R., & Maia Campos, P. M. B. G. (2011). Skin moisturizing effects of panthenol-based formulations. Journal of Cosmetic Science.