Follicure

Zinc Pyrithione has broad-spectrum antimicrobial activity:
Not only does it inhibit and reduce the burden of Malassezia on the skin, but it also targets gram-positive and gram-negative bacteria, as well as other fungi that cause ringworm, athlete's foot, and jock itch.

Zinc Pyrithione disrupts iron distribution across the yeast wall and effectively starves the yeast of some of the critical processes important in its respiratory function.

Zinc Pyrithione penetrates the hair follicle where Malassezia resides and has a unique slow-release ability. It persists in the top layer of skin even after rinsing off the product. Therefore, it imparts long-lasting control and sustained release of anti-yeast coverage and suppression of the Malassezia yeast overgrowth.

The yeast, fungi, and bacteria do not develop resistance towards Zinc Pyrithione. Consistent application of Zinc Pyrithione will, therefore, result in continuous antimicrobial activity.

• Zinc Pyrithione has broad-spectrum antimicrobial activity: It inhibits and reduces the burden of Dandruff-causing Malassezia on the skin and targets gram-positive and gram-negative bacteria and other fungi that cause ringworm, athlete's foot, and jock itch.
• Zinc Pyrithione disrupts iron distribution across the yeast wall and effectively starves the yeast of some of the critical processes important in its respiratory function.
• Zinc Pyrithione disrupts the yeast's cell membrane, preventing it from proliferating and reproducing. Zinc pyrithione binds to the cell membrane of the yeast and causes damage to its structure, which ultimately leads to cell death.
• Zinc pyrithione also interferes with the metabolic processes of the yeast. It disrupts the uptake of essential nutrients and alters the scalp's pH balance, making it more difficult for the yeast to survive and grow.
• Zinc Pyrithione penetrates the hair follicle where Malassezia resides and has a unique slow-release ability. It persists in the top layer of skin even after rinsing off the product. Therefore, it imparts long-lasting control and sustained release of anti-yeast coverage and suppression of Malassezia yeast overgrowth.
• The yeast, fungi, and bacteria do not develop resistance toward Zinc Pyrithione. Consistent application of Zinc Pyrithione will result in continuous antimicrobial activity.

• Inflammation on the scalp contributes to itchiness, redness, and irritation, which are common symptoms of dandruff. Zinc pyrithione reduces inflammation on the scalp, which help to alleviate these symptoms.
• Zinc Pyrithione positively affects the immune system by balancing pro-inflammatory and anti-inflammatory cytokines in the body. Studies published in the Journal of Dermatological Science indicate that Zinc Pyrithione increases the production of anti-inflammatory cytokines in human skin cells. These cytokines are known to be involved in the immune response and are important for regulating inflammation and promoting healing.
• Studies further indicate that Zinc Pyrithione significantly reduces the pro-inflammatory cytokines interleukin-1 and tumor necrosis factor-alpha production. This action boosts the body's natural defenses against the yeast and reduces the severity of dandruff symptoms.
• Cytokine production is a complex process that involves a delicate balance between pro-inflammatory and anti-inflammatory cytokines. Too much or too little cytokine production can lead to problems with inflammation and immune function. Zinc Pyrithione contributes to a healthy balance between inflammation and immune function.
• Zinc pyrithione also has direct anti-inflammatory effects on the skin by reducing the production of certain enzymes that contribute to inflammation.

Zinc PCA prevents excess sebum production, which is responsible for the clogging of pores and acne exacerbation. It inhibits the activity of the 5 alpha-reductase enzymes to control excessive sebum production.