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your dermal diagnosis™ results

Good day

We're thrilled you're taking proactive steps to understand your skin better. Below, you'll find your most recent Dermal Diagnosis™ results. Use this data as a roadmap to achieving healthier skin.
Date Dermal Diagnosis™ Profile and Treatment Plan

DERMAL DIAGNOSIS™ RESULT BREAKDOWN


Aging Score Hydration Score Pigmentation Score Inflammation category
Date Dermal Diagnosis™

DERMAL DIAGNOSIS™ RESULT BREAKDOWN

Aging Score
Hydration Score
Pigmentation Score
Inflammation category



's Dermal Diagnosis™ Profile

Aging . Dry . Pigmentation . Rosacea
Benefits of your ADPR skin type
Reduced Oiliness

Reduced Oiliness

skincare awareness

skincare awareness

  • Reduced Oiliness: You are less likely to experience the sheen and discomfort associated with oily skin types. This can contribute to a matte finish and potentially less clogged pores outside of breakout areas.

  • Comprehensive Skin Awareness: Managing your skin's diverse needs often results in a heightened understanding and attentiveness to skin health, encouraging proactive and informed skincare choices.

Barriers to your skin health
Rosacea

Rosacea

Dehydrated Skin

Dehydrated Skin

Pigmentation

Pigmentation

Aging skin

Aging skin

  • Rosacea Flare-ups: Characterized by redness, visible blood vessels, and sometimes pimples or pustules, rosacea can be triggered by various factors, including certain foods, beverages, temperatures, and stress, making management complex.

  • Compromised Skin Barrier: Dryness and rosacea contribute to a weakened skin barrier, making the skin more susceptible to irritants, allergens, and environmental damage. This compromised barrier can lead to increased sensitivity and reactivity.

  • Dehydration: Dry skin inherently struggles to retain moisture, leading to tightness, flakiness, and discomfort. The lack of adequate hydration can exacerbate the appearance of aging signs and rosacea symptoms.

  • Sensitivity to Skincare Ingredients: Your skin can react adversely to common skincare ingredients, including certain alcohols, fragrances, and exfoliants, making it challenging to find suitable products that do not aggravate the skin.

  • Hyperpigmentation: Issues such as uneven skin tone, dark spots, and melasma are prominent and require consistent management and treatment.

  • Increased Visible Aging Signs: The combination of dryness and inflammation can accelerate the appearance of aging signs such as fine lines, wrinkles, and loss of elasticity, particularly in rosacea-affected areas.

your frustrations

  • Impaired and dehydrated skin barrier.
  • Rough skin texture with breakouts in certain rosacea types.
  • Sensitive skin that reacts to various stimuli and products.
  • Skin prone to redness and inflammation.
  • Uneven skin tone with dark spots or patches.

your goals

  • Bright; hydrated and healthy skin.
  • No redness and inflammation.
  • Prevention and correction of premature skin aging including lines and wrinkles.
  • Protected; smooth and healed skin barrier.
  • Radiant skin with an even skin tone.

Aging . Dry . Pigmentation . Rosacea

treatment objectives

Inhibit hyperpigmentation
Inhibit hyperpigmentation

Inhibit the pathways in the hyperpigmentation process to stop the stimulation, production and transfer of melanin (pigment cells).

Deeply Hydrate and Nourish
Deeply Hydrate and Nourish

Advance the skin's hydration capabilities by boosting its capacity to attract and retain moisture at a cellular level. Promote the enhancement of the skin's own hydrating agents, ensuring sustained moisture balance and preventing dryness.

Prevent & Repair Premature Aging
Prevent & Repair Premature Aging

Protect the skin from factors that accelerate aging, such as UV exposure and pollution, and correct existing signs of aging, like fine lines, wrinkles, and loss of elasticity.

Skin Barrier Restoration
Skin Barrier Restoration

Repair damaged skin barrier and restore barrier function. Boost the protective skin layer by increasing the production of elastin, collagen, ceramides, and lipids.

Reduce Inflammation
Reduce Inflammation

Alleviate inflammation and redness by restoring equilibrium to the skin's microbiome. Focus on creating a harmonious skin environment that supports healthy bacterial flora, essential for maintaining skin health and preventing breakouts.

DNA Protection and Repair
DNA Protection and Repair

Safeguard and repair UV-induced DNA damage, utilizing a blend of UV defense, Retinol, Niacinamide, and antioxidants. This strategy prevents future damage and aids in the repair of existing cellular impairments.

include

  • Anti-inflammatory, anti-microbial and pigmentation-disruptive ingredients.
  • Broad spectrum sunscreen with antioxidants - preventing premature aging and protecting DNA.
  • Effective barrier repair agents restore your skin's natural barrier and prevent premature aging.
  • Hypoallergenic and pigmentation-disruptive ingredients.
  • Skin-identical medical-grade ingredients that penetrate the skin to activate a biological response.

avoid

  • Damaging lifestyle habits, e.g., smoking, tanning beds, excessive sun, and sugar consumption.
  • Toners and foaming cleansers containing soap & sulfates.
  • Fragrance in skincare products.
  • Harsh anti-bacterial products that disrupt the skin's natural microbiome.
  • Irritating plant extracts and essential oils that will trigger adverse reactions.

Aging . Dry . Pigmentation . Rosacea

Active Ingredients your skin needs

Retinoic acid analogue

Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skin care, particularly in treating acne and signs of skin aging.

Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In treating acne, it promotes the turnover of skin cells, reducing the likelihood of pore-clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.

Retinoic acid's ability to stimulate collagen production is a key benefit in anti-aging skincare. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster, and shedding pigmented and damaged cells.

Despite its benefits, retinoic acid can irritate the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.

Hydroxypinacolone Retinoate (HPR) is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without needing conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.

HPR is considered more gentle and less irritating than traditional retinoic acid while offering comparable benefits. With HPR, everyone has access to the benefits of prescription retinoids without the risk of side effects.


Physiological Effects

  • Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
  • Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
  • Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
  • Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
  • Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
  • Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.

Special Benefits

  • Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
  • Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
  • Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
  • Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
  • Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.

References

  • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
  • Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
  • Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
  • Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
  • Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.
Azelaic acid

Azelaic acid, a naturally occurring dicarboxylic acid, is an effective ingredient in dermatological treatments, particularly for acne, rosacea, and hyperpigmentation, with antimicrobial and anti-inflammatory properties.


Physiological Effects

  • Anti-Inflammatory Properties: Azelaic acid reduces inflammation, effectively treating inflammatory skin conditions like acne and rosacea.
  • Antimicrobial Action: It possesses antimicrobial properties that target acne-causing bacteria (Propionibacterium acnes), helping to reduce acne outbreaks.
  • Keratolytic Effects: It helps unclog pores and reduce the formation of comedones (black and whiteheads) by normalizing the shedding of skin cells.
  • Depigmenting Agent: Azelaic acid effectively treats hyperpigmentation disorders, including melasma, as it inhibits tyrosinase, an enzyme involved in melanin production.

Role in Managing Dermatological Conditions

  • Acne: Azelaic acid inhibits the proliferation of acne-causing bacteria on the skin’s surface, thereby reducing bacterial growth and inflammation. Its antibacterial activity is primarily against Propionibacterium acnes, a key bacterium involved in the development of acne. Furthermore, azelaic acid helps unclog pores and reduce skin cell buildup, effectively treating mild to moderate acne.
  • Rosacea: Azelaic acid's anti-inflammatory action helps to reduce redness and swelling associated with rosacea. In addition, azelaic acid's ability to reduce keratinization (the process by which skin cells become more fibrous and less flexible) contributes to its effectiveness in this condition.
  • Pigmentation: Azelaic acid effectively treats melasma and post-inflammatory hyperpigmentation by inhibiting tyrosinase, an enzyme in melanin production. This helps to reduce the formation of excess pigment and can lead to a more even skin tone.

References

  • Fitton, A., & Goa, K. L. (1991). Azelaic Acid. Drugs.
  • Gollnick, H., & Schramm, M. (1998). Topical drug treatment in acne. Dermatology.
  • Passeron, T., et al. (2019). Melasma treatment: A novel approach using a topical agent that contains an anti-estrogen and a low-dose retinoid. G Ital Dermatol Venereol.
  • Wolf, J. E., Kerrouche, N., & Arsonnaud, S. (2006). Efficacy and safety of once-daily metronidazole 1% gel compared with twice-daily azelaic acid 15% gel in the treatment of rosacea. Cutis, 77(4 Suppl), 3-11.
  • Hollinger, J. C., Angra, K., & Halder, R. M. (2018). Are natural ingredients effective in the management of hyperpigmentation? A systematic review. The Journal of clinical and aesthetic dermatology, 11(2), 28.
Alpha Arbutin

Alpha Arbutin is a derivative of hydroquinone and a biosynthetic active ingredient. Its primary action is inhibiting tyrosinase, a key enzyme involved in the synthesis of melanin, the pigment responsible for skin color. Alpha Arbutin effectively reduces melanin production in the skin by inhibiting tyrosin activity. This gradually lightens hyperpigmented areas, such as age spots, melasma, and scars, resulting in a more even skin tone.

One of the significant advantages of Alpha Arbutin over other skin-lightening agents is its safety profile. Unlike hydroquinone, which has been associated with potential side effects and is restricted in many countries, Alpha Arbutin is considered safe and less irritating to the skin, even at higher concentrations. This makes it a suitable ingredient for all skin types, including sensitive skin.

In addition to its skin-lightening properties, Alpha Arbutin has also shown antioxidant effects, helping to protect the skin from oxidative stress caused by environmental factors like UV radiation and pollution.


Physiological Effects

  • Melanin Inhibition: Alpha Arbutin works by inhibiting tyrosinase, the enzyme responsible for melanin production in the skin. This action reduces the formation of melanin, leading to a lightening of skin pigmentation.
  • Even Skin Tone: Regular use of alpha arbutin can lead to a more even skin tone overall, reducing the appearance of age spots and hyperpigmentation.
  • Reduced Skin Discoloration: It effectively reduces the appearance of dark spots and areas of hyperpigmentation, such as those caused by acne, sun damage, or hormonal changes.
  • Safer Alternative to Hydroquinone: While structurally similar to hydroquinone, alpha arbutin is a safer option with a lower risk of side effects.

Role in Managing Dermatological Conditions

  • Hyperpigmentation: Alpha arbutin treats melasma, sun spots, and post-inflammatory hyperpigmentation from acne.
  • Skin Brightening: Provide a more radiant and uniform skin tone.
  • Anti-Aging: Reduce the appearance of age-related spots and uneven skin tone.
Bakuchiol

Bakuchiol's mechanism of action is similar to retinol's; it stimulates collagen production and accelerates cell turnover, improving skin texture and tone. It also helps reduce the appearance of fine lines, wrinkles, and hyperpigmentation, making it an effective ingredient in anti-aging skincare products.

One of the key advantages of bakuchiol over traditional retinol is its gentleness on the skin. Retinol is known for potential side effects like dryness, redness, and irritation, particularly in sensitive skin or when used in high concentrations. Bakuchiol, however, is far less irritating. In addition to its anti-aging properties, bakuchiol exhibits antioxidant and anti-inflammatory properties, further contributing to its skin benefits. It helps protect the skin from oxidative stress and can soothe it, reducing redness and inflammation.

Bakuchiol's retinol-like effects and its antioxidant, anti-inflammatory, and antibacterial properties make it an effective ingredient for various skin concerns, especially for those seeking natural alternatives in anti-aging and acne treatment.


Physiological Effects

  • Retinol-like Function: Bakuchiol mimics the actions of retinol, stimulating collagen production. This helps reduce the appearance of fine lines and wrinkles and improves skin elasticity.
  • Antioxidant Properties: It offers antioxidant benefits, protecting the skin from oxidative stress and damage caused by environmental factors like UV radiation.
  • Anti-inflammatory Effects: Bakuchiol has anti-inflammatory properties, which can help soothe the skin and reduce redness and irritation.
  • Improved Skin Tone and Texture: Regular use of bakuchiol can improve skin tone and texture, making it smoother and more even.
  • Acne Management: Bakuchiol's antibacterial properties and ability to regulate sebum production make it effective in managing acne.

Role in Managing Dermatological Conditions

  • Aging Skin: Bakuchiol is popular in anti-aging skincare because it stimulates collagen production and reduces signs of aging.
  • Sensitive Skin: As a gentler alternative to retinol, it is suitable for sensitive skin types that cannot tolerate traditional retinoids.
  • Acne-Prone Skin: Its antibacterial and anti-inflammatory properties are beneficial in acne treatments.
  • Hyperpigmentation: Bakuchiol can help treat hyperpigmentation, enhance skin radiance, and reduce dark spots.

References

  • Chaudhuri, R. K., & Bojanowski, K. (2014). Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. International Journal of Cosmetic Science.
  • Dhaliwal, S., et al. (2019). Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing. British Journal of Dermatology.
  • Sivamani, R. K., et al. (2019). Clinical efficacy of a bakuchiol, niacinamide and zinc pyrithione formulation in facial sebum control and mild acne. Journal of Cosmetic Dermatology.
Niacinamide

Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.

Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.

Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.


Physiological Effects

  • Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
  • Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
  • Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
  • Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
  • Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
  • Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.

Role in Managing Dermatological Conditions

  • Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
  • Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
  • Aging Skin: Niacinamide targets wrinkles and loss of firmness.
  • Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
  • Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.

References

  • Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
  • Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
  • Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
  • Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.
Vitamin E

The fat-soluble Vitamin E's benefits in maintaining skin health and appearance are well-acknowledged in both cosmetic and clinical dermatology. Comprising a group of eight compounds, including four tocopherols and four tocotrienols, Vitamin E is known for its role in protecting cell membranes from oxidative damage.

Vitamin E is celebrated in skincare for its ability to neutralize free radicals caused by environmental stressors such as UV radiation and pollution. These free radicals can lead to premature skin aging, making Vitamin E a valuable ingredient in anti-aging skincare products. Its antioxidant action helps to protect the skin from damage, reduce the appearance of wrinkles, and improve skin texture and tone.

Additionally, Vitamin E is known for its moisturizing benefits. It helps to strengthen the skin barrier, reduce moisture loss, and keep the skin hydrated and supple. This makes it especially beneficial for dry and damaged skin.

Vitamin E also has anti-inflammatory properties, making it beneficial in soothing and calming irritated skin. This has implications for conditions such as dermatitis and acne, where inflammation plays a key role.


Physiological Effects

  • Antioxidant Protection: Vitamin E neutralizes harmful free radicals in the skin, preventing oxidative stress and damage caused by environmental factors like UV radiation and pollution.
  • Moisturization: It has moisturizing properties, helping to improve skin hydration and alleviate dryness.
  • Wound Healing: Vitamin E may assist in the skin's healing process, although its efficacy in wound healing is still a subject of research.
  • Photoprotection: While not a sunscreen, it can provide some degree of photoprotection by strengthening the skin's defense against UV-induced damage.
  • Anti-Inflammatory Effects: It helps reduce skin inflammation and is beneficial in managing conditions like eczema and psoriasis.

Role in Managing Dermatological Conditions

  • Skin Aging: Its antioxidant properties make it useful in anti-aging skincare products to protect against free radical damage and improve skin appearance.
  • Dry Skin Conditions: Vitamin E's moisturizing effects are beneficial in treating dry skin and improving overall skin texture.
  • Inflammatory Skin Diseases: It can be helpful in soothing inflammatory skin conditions like eczema and psoriasis.
  • Sun Protection and Repair: Vitamin E is included in sunscreens and after-sun products for its ability to mitigate sun damage.
  • Scar Treatment: Some studies suggest Vitamin E may help reduce the appearance of scars, although evidence is mixed.

References

  • Thiele, J. J., Hsieh, S. N., & Ekanayake-Mudiyanselage, S. (1998). Vitamin E: Critical Review of Its Current Use in Cosmetic and Clinical Dermatology. Dermatologic Surgery, 24(7), 805–813.
  • Ratz-Łyko, A., & Arct, J. (2016). Anti-inflammatory and anti-aging properties of active skin care ingredients. Journal of Clinical and Aesthetic Dermatology, 9(9), 36–40.
  • Keen, M. A., & Hassan, I. (2016). Vitamin E in dermatology. Indian Dermatology Online Journal.
  • Ekanayake-Mudiyanselage, S., & Thiele, J. (2007). Vitamin E in human skin: Organ-specific physiology and considerations for its use in dermatology. Molecular Aspects of Medicine.
  • Nachbar, F., & Korting, H. C. (1995). The role of vitamin E in normal and damaged skin. Journal of Molecular Medicine.
Zinc Pyrithione

Zinc pyrithione, a compound with potent antifungal and antibacterial properties, has established itself as a cornerstone in the treatment of various skin conditions, particularly those involving Malassezia yeast. Its effectiveness against seborrheic dermatitis and dandruff, which are often associated with an overgrowth of Malassezia species, makes it a key ingredient for many dermatological conditions.

Zinc pyrithione’s mode of action is multifaceted, primarily targeting the membrane of fungi and bacteria, thereby disrupting their growth and replication. One of its significant mechanisms involves inhibiting fungal cell membrane transport by blocking the energy production pathway, which is crucial for cell survival.

In Malassezia, yeast, a natural inhabitant of the skin flora, can overgrow and cause conditions like seborrheic dermatitis and dandruff; zinc pyrithione's antifungal action is particularly beneficial. It reduces the yeast population on the skin, thereby alleviating the symptoms associated with its overgrowth, such as flaking, irritation, and redness.

Its efficacy in treating seborrheic dermatitis is attributed to its ability to reduce the Malassezia count, diminish inflammatory responses, and soothe the skin. Similarly, in dandruff, which is often linked to an excess of Malassezia, zinc pyrithione effectively reduces flaking and itchiness, promoting a healthier scalp environment.

The efficacy of zinc pyrithione in the treatment of seborrheic dermatitis and dandruff is well-documented. Its safety profile and efficacy have been confirmed by numerous studies, with significant improvements observed in both scalp and skin conditions following regular use.


Physiological Effects

  • Antifungal Activity: It is effective against a range of fungi, including those that cause dandruff and seborrheic dermatitis. Zinc Pyrithione inhibits the division of fungal cells, reducing their proliferation.
  • Antibacterial Properties: This compound also exhibits antibacterial activity, making it useful in treating and preventing bacterial skin infections.
  • Anti-inflammatory Effects: Zinc Pyrithione can reduce inflammation, which is beneficial in alleviating symptoms of various inflammatory skin conditions.
  • Sebum Regulation: It helps in regulating sebum production, which can be beneficial for oily skin and conditions like acne.

Role in Managing Dermatological Conditions

  • Dandruff and Seborrheic Dermatitis: Zinc Pyrithione is a common ingredient in anti-dandruff shampoos and is effective in controlling the flaking and itching associated with these conditions.
  • Psoriasis: It can help manage the symptoms of psoriasis, particularly in reducing scaling and redness.
  • Acne: Due to its antibacterial and anti-inflammatory properties, Zinc Pyrithione can be beneficial in the treatment of acne.
  • Fungal Infections: It is effective in treating various fungal skin infections due to its antifungal properties.

References

  • Warshaw, E. M., et al. (2005). Efficacy of Zinc Pyrithione in Seborrheic Dermatitis and Dandruff. Dermatology.
  • Pierard-Franchimont, C., et al. (2002). Antidandruff shampoo efficacy in dandruff/seborrhoeic dermatitis. International Journal of Cosmetic Science.
  • Scheman, A., et al. (2000). Antimicrobial Activity of Zinc Pyrithione. American Journal of Infection Control.
Peptides

Peptides are short chains of amino acids with a wide range of biological functions and skin benefits. They are essentially small fragments of proteins, which are fundamental components of all living cells, including collagen and elastin in the skin.

In skincare, peptides are known for enhancing skin repair and rejuvenation. They function as signaling molecules, instructing cells to perform specific tasks such as producing collagen and elastin, vital for maintaining the skin's firmness and elasticity. This makes peptides especially beneficial in anti-aging products, as they can help reduce the appearance of fine lines and wrinkles.

Research has shown that certain peptides can improve skin barrier function, increase hydration, and soothe skin inflammation. This makes them suitable for products targeting dry, sensitive, or inflamed skin.

Peptides, with their diverse functions in promoting collagen production, strengthening the skin barrier, wound healing, and anti-inflammatory actions, are pivotal in managing various dermatological conditions, particularly in anti-aging, sensitive skin care, and wound healing applications.


Physiological Effects

  • Collagen Production: Certain peptides, known as signal peptides, stimulate collagen production in the skin, enhancing skin firmness and reducing the appearance of fine lines and wrinkles.
  • Skin Barrier Strengthening: Peptides can strengthen the skin barrier, improve hydration, and protect against environmental damage.
  • Wound Healing: Some peptides play a role in the skin's natural healing process, aiding tissue repair and regeneration.
  • Anti-Inflammatory Effects: Certain peptides have anti-inflammatory properties, helping to soothe and calm irritated skin.
  • Antimicrobial Action: Some peptides possess antimicrobial properties, potentially helping to manage acne and other skin infections.

Role in Managing Dermatological Conditions

  • Aging Skin: Peptides can stimulate collagen production and improve skin elasticity.
  • Sensitive Skin Conditions: Peptides are beneficial for sensitive or inflamed skin due to their soothing properties.
  • Acne-Prone Skin: Antimicrobial peptides can be effective in acne treatment formulations.
  • Wound Care and Repair: Peptides improve wound healing and reduce scarring.

References

  • Gorouhi, F., & Maibach, H. I. (2009). Role of topical peptides in preventing or treating aged skin. International Journal of Cosmetic Science.
  • Schagen, S. K. (2012). Topical peptide treatments with effective anti-aging results. Cosmetics.
  • Varani, J., et al. (2001). Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. Journal of Investigative Dermatology.
Ceramides

Ceramides, a family of lipid molecules naturally present in the skin, are integral to the structure and function of the skin barrier. They are a type of lipid that, along with cholesterol and fatty acids, forms a critical part of the stratum corneum, the outermost layer of the skin. This layer is essential for maintaining skin hydration and protecting against environmental aggressors.

Ceramides, which make up about 50% of the skin's lipid composition, play a pivotal role in maintaining the skin's barrier integrity and preventing transepidermal water loss (TEWL). By doing so, they help keep the skin hydrated and supple.

The loss or reduction of ceramides in the skin barrier is associated with several dermatological conditions, including eczema and psoriasis, where the skin becomes dry, itchy, and prone to irritation and infection. Studies have shown that the application of ceramide-containing moisturizers can effectively improve skin barrier function and increase skin hydration levels.

Ceramides are particularly beneficial for aging skin, which naturally loses ceramides over time, leading to drier and more fragile skin. By replenishing the skin's ceramide content, these products can help combat the signs of aging, such as fine lines and wrinkles.

Ceramides are integral to maintaining skin health, particularly in conditions where the skin barrier is compromised. Their role in hydrating the skin, reducing sensitivity, and improving barrier function makes them an essential component in the management of various dermatological conditions, especially eczema, psoriasis, and dry or aging skin.


Physiological Effects

  • Barrier Function: Ceramides are critical components of the skin's lipid barrier. They help to prevent moisture loss and protect against environmental aggressors like pollutants and irritants.
  • Hydration: By maintaining the barrier integrity, ceramides keep the skin hydrated, preventing dryness and keeping the skin supple.
  • Reducing Skin Sensitivity: They play a role in reducing skin sensitivity and irritation, helping to calm inflamed and reactive skin.
  • Anti-aging Properties: Ceramides can improve skin elasticity and firmness, helping to reduce the appearance of fine lines and wrinkles.
  • Wound Healing: There is evidence to suggest that ceramides can aid in the skin's natural wound healing process.

Role in Managing Dermatological Conditions

  • Eczema and Atopic Dermatitis: Ceramides are often used in the treatment of eczema and atopic dermatitis, where the skin barrier is compromised, leading to dryness, itching, and inflammation.
  • Psoriasis: They can help in managing psoriasis by maintaining skin hydration and barrier function, reducing scaling and dryness.
  • Aging Skin: Ceramide-containing products are beneficial in anti-aging regimens due to their ability to improve skin barrier function and elasticity.
  • Dry Skin (Xerosis): In the treatment of dry skin, ceramides help in restoring skin hydration and barrier function.
  • Sensitive Skin: Products containing ceramides are suitable for sensitive skin as they help to restore the skin's natural barrier and reduce irritation.

References

  • Del Rosso, J. Q., & Levin, J. (2011). The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. Journal of Clinical and Aesthetic Dermatology.
  • Farwanah, H., Wohlrab, J., Neubert, R. H. H., & Raith, K. (2005). Ceramides and skin function. American Journal of Clinical Dermatology.
  • Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato-Venereologica.
Sunscreen

Using sunscreen is a fundamental aspect of skin care and preventive dermatology. It's essential for reducing the risk of skin cancers and photoaging and maintaining overall skin health in the face of constant exposure to UV radiation.

Sunscreen is a vital skincare product designed to protect the skin from the harmful effects of ultraviolet (UV) radiation from the sun. Two primary types of UV radiation affect the skin: UVA and UVB. UVA rays penetrate deep into the skin and are primarily responsible for aging and long-term skin damage, whereas UVB rays cause sunburn and play a key role in developing skin cancer.

Sunscreen products work by either absorbing, reflecting, or scattering sunlight. They contain chemical compounds that absorb UV radiation and convert it into a small amount of heat or physical compounds (like zinc oxide or titanium dioxide) that act as a physical barrier, reflecting UV light away from the skin.

The effectiveness of sunscreen is measured by its Sun Protection Factor (SPF). SPF indicates how well the sunscreen protects against UVB rays. For example, an SPF of 30 means it would take 30 times longer for your skin to burn than without sunscreen. However, it's important to note that no sunscreen can block 100% UV rays.

Regular use of sunscreen with an SPF of at least 30 can reduce the risk of skin cancer, prevent sunburn, and slow down the skin's aging process.


Role in Managing Dermatological Conditions

Prevention of Sunburn
  • UVB Protection: Sunscreen protects the skin from UVB rays, which cause sunburn. This reduces the immediate risk of skin damage and discomfort.
Skin Cancer Prevention
  • Reduces Risk of Skin Cancers: Regular use of sunscreen significantly lowers the risk of developing various types of skin cancer, especially melanoma, squamous cell carcinoma, and basal cell carcinoma.
Prevention of Photoaging
  • UVA Protection: Sunscreen also shields the skin from UVA rays, which penetrate deeper into the skin and are primarily responsible for photoaging, including wrinkles, leathery skin, and sunspots.
Protection Against Photosensitivity
  • Essential for Sensitive Skin Conditions: Sunscreen helps prevent flare-ups triggered by sun exposure for individuals with photosensitive skin conditions like lupus or rosacea.
Hyperpigmentation and Melasma
  • Even Skin Tone: It aids in preventing and managing hyperpigmentation and melasma, conditions exacerbated by sun exposure.
General Skin Health
  • Maintains Skin Health: Sunscreen helps maintain overall skin health and integrity by protecting the skin from UV damage.

References

  • Burnett, M. E., & Wang, S. Q. (2011). Current sunscreen controversies: a critical review. Photodermatology, Photoimmunology & Photomedicine.
  • Green, A. C., et al. (2011). Reduced melanoma after regular sunscreen use: randomized trial follow-up. Journal of Clinical Oncology.
  • Hughes, M. C. B., et al. (2013). Sunscreen and Prevention of Skin Aging: A Randomized Trial. Annals of Internal Medicine.

MORNING

EVENING

Sale price3.294,00 kr

Cleanser size:

Cleanser size

Sunscreen:

Sunscreen

anti-aging

anti-aging

anti-redness

anti-redness

↓ inflammation

↓ inflammation

Moisturizing

Moisturizing

barrier repair

barrier repair


Dermal Diagnosis™ | ADPR
Dermal Diagnosis™ | ADPR Sale price3.294,00 kr

Aging . Dry . Pigmentation . Rosacea

products in your treatment pack

cleanse

cleanse

Sale price294,00 kr

SIZE: 100 mL

Itch Relief

Itch Relief

Anti-Acne

Anti-Acne

↓ inflammation

↓ inflammation

anti-redness

anti-redness

Anti-microbial

Anti-microbial

A powerful hypoallergenic medicated solution with beneficial properties attributed to its active constituent, Zinc Pyrithione. This chemical compound, FDA-approved and clinically recognized, delivers strong antibacterial and antifungal action, making the cleanser an ideal choice for managing skin conditions associated with redness, flaking, irritation, and itching.

Zinc Pyrithione's efficacy, compounded by a gentle cleansing base, facilitates the lifting and removing of impurities, leaving the complexion refreshed. Concurrently, it sustains a tranquil skin environment, reducing inflammation and discomfort. As a daily cleansing aid, Medi-Zinc Cleanser proposes a reliable, scientifically-backed intervention in fostering skin health and comfort.


Zinc Pyrithione

Zinc pyrithione, a compound with potent antifungal and antibacterial properties, has established itself as a cornerstone in the treatment of various skin conditions, particularly those involving Malassezia yeast. Its effectiveness against seborrheic dermatitis and dandruff, which are often associated with an overgrowth of Malassezia species, makes it a key ingredient for many dermatological conditions.

Zinc pyrithione’s mode of action is multifaceted, primarily targeting the membrane of fungi and bacteria, thereby disrupting their growth and replication. One of its significant mechanisms involves inhibiting fungal cell membrane transport by blocking the energy production pathway, which is crucial for cell survival.

In Malassezia, yeast, a natural inhabitant of the skin flora, can overgrow and cause conditions like seborrheic dermatitis and dandruff; zinc pyrithione's antifungal action is particularly beneficial. It reduces the yeast population on the skin, thereby alleviating the symptoms associated with its overgrowth, such as flaking, irritation, and redness.

Its efficacy in treating seborrheic dermatitis is attributed to its ability to reduce the Malassezia count, diminish inflammatory responses, and soothe the skin. Similarly, in dandruff, which is often linked to an excess of Malassezia, zinc pyrithione effectively reduces flaking and itchiness, promoting a healthier scalp environment.

The efficacy of zinc pyrithione in the treatment of seborrheic dermatitis and dandruff is well-documented. Its safety profile and efficacy have been confirmed by numerous studies, with significant improvements observed in both scalp and skin conditions following regular use.


Physiological Effects

  • Antifungal Activity: It is effective against a range of fungi, including those that cause dandruff and seborrheic dermatitis. Zinc Pyrithione inhibits the division of fungal cells, reducing their proliferation.
  • Antibacterial Properties: This compound also exhibits antibacterial activity, making it useful in treating and preventing bacterial skin infections.
  • Anti-inflammatory Effects: Zinc Pyrithione can reduce inflammation, which is beneficial in alleviating symptoms of various inflammatory skin conditions.
  • Sebum Regulation: It helps in regulating sebum production, which can be beneficial for oily skin and conditions like acne.

Role in Managing Dermatological Conditions

  • Dandruff and Seborrheic Dermatitis: Zinc Pyrithione is a common ingredient in anti-dandruff shampoos and is effective in controlling the flaking and itching associated with these conditions.
  • Psoriasis: It can help manage the symptoms of psoriasis, particularly in reducing scaling and redness.
  • Acne: Due to its antibacterial and anti-inflammatory properties, Zinc Pyrithione can be beneficial in the treatment of acne.
  • Fungal Infections: It is effective in treating various fungal skin infections due to its antifungal properties.

References

  • Warshaw, E. M., et al. (2005). Efficacy of Zinc Pyrithione in Seborrheic Dermatitis and Dandruff. Dermatology.
  • Pierard-Franchimont, C., et al. (2002). Antidandruff shampoo efficacy in dandruff/seborrhoeic dermatitis. International Journal of Cosmetic Science.
  • Scheman, A., et al. (2000). Antimicrobial Activity of Zinc Pyrithione. American Journal of Infection Control.

repair & renew

repair & renew