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Litaderm serum

Sale priceL£8,176,000.00 LBP

SIZE: 30 mL

A scientifically formulated correction serum that targets various skin concerns, promoting a healthy and radiant complexion. Its powerful blend of multi-tasking active ingredients is supported by peer-reviewed medical literature, ensuring its effectiveness in improving and preventing hyperpigmentation, melasma, redness, acne, rosacea, premature aging, and pigmentation.

The key active ingredients in Litaderm Serum work synergistically to deliver remarkable benefits. Niacinamide, at 10% concentration, enhances skin appearance by reducing hyperpigmentation, promoting even skin tone, and combating inflammation related to acne and rosacea. At 1%, Bakuchiol provides targeted treatment for signs of aging and skin damage, supporting a youthful complexion. With a potent 10% concentration, Azelaic acid reduces hyperpigmentation, redness, and inflammation, contributing to overall healthier skin. Arbutin, comprising 4% of the formula, further aids in correcting hyperpigmentation and promoting a more even complexion.

With its carefully selected ingredients, Litaderm Serum offers a dynamic formulation that comprehensively addresses various skin concerns. Supported by scientific evidence, this serum effectively targets hyperpigmentation, melasma, redness, acne, rosacea, premature aging, and pigmentation. Regularly using Litaderm Serum improves skin tone, texture, and overall radiance, resulting in healthy, radiant, and even-toned skin. Experience the benefits of this targeted approach to achieve a revitalized and rejuvenated appearance.


Arbutin

Alpha Arbutin, is a derivative of hydroquinone and a biosynthetic active ingredient. The primary action of Alpha Arbutin is its inhibition of tyrosinase, a key enzyme involved in the synthesis of melanin, the pigment responsible for skin color. By inhibiting tyrosinase activity, Alpha Arbutin effectively reduces melanin production in the skin. This leads to a gradual lightening of hyperpigmented areas, such as age spots, melasma, and scars, resulting in a more even skin tone.

One of the significant advantages of Alpha Arbutin over other skin-lightening agents is its safety profile. Unlike hydroquinone, which has been associated with potential side effects and is restricted in many countries, Alpha Arbutin is considered safe and less irritating to the skin, even at higher concentrations. This makes it a suitable ingredient for all skin types, including sensitive skin.

In addition to its skin-lightening properties, Alpha Arbutin has also shown antioxidant effects, helping to protect the skin from oxidative stress caused by environmental factors like UV radiation and pollution.

Physiological Effects of Alpha Arbutin
  1. Melanin Inhibition: Alpha Arbutin works by inhibiting tyrosinase, the enzyme responsible for melanin production in the skin. This action reduces the formation of melanin, leading to a lightening of skin pigmentation.
  2. Even Skin Tone: Regular use of alpha arbutin can lead to an overall more even skin tone, reducing the appearance of age spots and hyperpigmentation.
  3. Reduced Skin Discoloration: It is effective in reducing the appearance of dark spots and areas of hyperpigmentation, such as those caused by acne, sun damage, or hormonal changes.
  4. Safer Alternative to Hydroquinone: While structurally similar to hydroquinone, alpha arbutin is a safer option with a lower risk of side effects.
Role in Managing Dermatological Conditions
  1. Hyperpigmentation: Alpha arbutin treats melasma, sun spots, and post-inflammatory hyperpigmentation from acne.
  2. Skin Brightening: Provide a more radiant and uniform skin tone.
  3. Anti-Aging: Reduce the appearance of age-related spots and uneven skin tone.
Azelaic acid

Azelaic acid, a naturally occurring dicarboxylic acid, is an effective ingredient in dermatological treatments, particularly for acne, rosacea, and hyperpigmentation with both antimicrobial and anti-inflammatory properties.

Acne: Azelaic acid functions by inhibiting the proliferation of acne-causing bacteria on the skin’s surface, thereby reducing bacterial growth and inflammation. Its antibacterial activity is primarily against Propionibacterium acnes, a key bacterium involved in the development of acne. Furthermore, azelaic acid helps to unclog pores and reduce skin cell buildup, making it effective in treating mild to moderate acne.

Rosacea: Azelaic acid's anti-inflammatory action helps to reduce redness and swelling associated with rosacea. In addition, azelaic acid's ability to reduce keratinization (the process by which skin cells become more fibrous and less flexible) contributes to its effectiveness in this condition.

Pigmentation: Azelaic acid effectively treats melasma and post-inflammatory hyperpigmentation by inhibiting tyrosinase, an enzyme involved in melanin production. This helps to reduce the formation of excess pigment and can lead to a more even skin tone.

Physiological Effects of Azelaic Acid:
  1. Anti-Inflammatory Properties: Azelaic acid reduces inflammation, making it effective in treating inflammatory skin conditions like acne and rosacea.
  2. Antimicrobial Action: It possesses antimicrobial properties that target acne-causing bacteria (Propionibacterium acnes), helping to reduce acne outbreaks.
  3. Keratolytic Effects: It helps to unclog pores and reduce the formation of comedones (blackheads and whiteheads) by normalizing the shedding of skin cells.
  4. Depigmenting Agent: Azelaic acid is effective in treating hyperpigmentation disorders, including melasma, as it inhibits tyrosinase, an enzyme involved in melanin production.
References
  • Fitton, A., & Goa, K. L. (1991). Azelaic Acid. Drugs.
  • Gollnick, H., & Schramm, M. (1998). Topical drug treatment in acne. Dermatology.
  • Passeron, T., et al. (2019). Melasma treatment: A novel approach using a topical agent that contains an anti-estrogen and a low-dose retinoid. G Ital Dermatol Venereol.
  • Wolf, J. E., Kerrouche, N., & Arsonnaud, S. (2006). Efficacy and safety of once-daily metronidazole 1% gel compared with twice-daily azelaic acid 15% gel in the treatment of rosacea. Cutis, 77(4 Suppl), 3-11.
  • Hollinger, J. C., Angra, K., & Halder, R. M. (2018). Are natural ingredients effective in the management of hyperpigmentation? A systematic review. The Journal of clinical and aesthetic dermatology, 11(2), 28.
Niacinamide

Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It has been shown to be effective in reducing the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function makes it beneficial for all skin types, particularly for those with eczema or mature skin.

Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the skin's epidermis, helping to fade dark spots and even out skin tone.

Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.

Physiological Effects of Niacinamide
  1. Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, which are lipids that keep the skin hydrated and protect against environmental damage.
  2. Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
  3. Sebum Regulation: Niacinamide can regulate sebum production, which helps in controlling excess oiliness and can be beneficial for acne-prone skin.
  4. Hyperpigmentation Reduction: It is known to reduce hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
  5. Anti-aging Effects: Niacinamide helps in reducing the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
  6. Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.
Role in Managing Dermatological Conditions
  1. Acne and Oily Skin: By regulating sebum and reducing inflammation, niacinamide is effective in managing acne and oily skin conditions.
  2. Hyperpigmentation and Melasma: Its ability to reduce melanin transfer makes it beneficial in treating hyperpigmentation and melasma.
  3. Aging Skin: Its anti-aging properties make niacinamide a popular ingredient in skincare products targeting wrinkles and loss of firmness.
  4. Skin Barrier Disorders: Niacinamide is beneficial in the treatment of skin barrier disorders like atopic dermatitis and eczema, by enhancing barrier function and hydration.
  5. Photodamage and Skin Protection: It helps in mitigating the effects of photodamage and provides some degree of protection against environmental damage.
References
  • Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
  • Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
  • Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
  • Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.
Bakuchiol

Bakuchiol's mechanism of action is similar to that of retinol; it stimulates collagen production and accelerates cell turnover, leading to improved skin texture and tone. It helps in reducing the appearance of fine lines, wrinkles, and hyperpigmentation, making it an effective ingredient in anti-aging skincare products.

One of the key advantages of bakuchiol over traditional retinol is its gentleness on the skin. Retinol is known for potential side effects like dryness, redness, and irritation, particularly in sensitive skin or when used in high concentrations. Bakuchiol, however, has been shown to be far less irritating. In addition to its anti-aging properties, bakuchiol also exhibits antioxidant and anti-inflammatory properties, further contributing to its skin benefits. It helps to protect the skin from oxidative stress and can soothe the skin, reducing redness and inflammation.

Bakuchiol's retinol-like effects, combined with its antioxidant, anti-inflammatory, and antibacterial properties, make it an effective ingredient for a variety of skin concerns, especially for those seeking natural alternatives in anti-aging and acne treatment.

Physiological Effects of Bakuchiol
  1. Retinol-like Function: Bakuchiol mimics the actions of retinol, stimulating collagen production, which helps in reducing the appearance of fine lines and wrinkles, improving skin elasticity.
  2. Antioxidant Properties: It offers antioxidant benefits, protecting the skin from oxidative stress and damage caused by environmental factors like UV radiation.
  3. Anti-inflammatory Effects: Bakuchiol has anti-inflammatory properties, which can help soothe the skin and reduce redness and irritation.
  4. Improved Skin Tone and Texture: Regular use of bakuchiol can lead to an improvement in skin tone and texture, making it smoother and more even.
  5. Acne Management: Its antibacterial properties, combined with the ability to regulate sebum production, make bakuchiol effective in managing acne.
Role in Managing Dermatological Conditions
  1. Aging Skin: Bakuchiol is popular in anti-aging skincare due to its ability to stimulate collagen production and reduce signs of aging.
  2. Sensitive Skin: As a gentler alternative to retinol, it is suitable for sensitive skin types that cannot tolerate traditional retinoids.
  3. Acne-Prone Skin: Its antibacterial and anti-inflammatory properties are beneficial in acne treatments.
  4. Hyperpigmentation: Bakuchiol can help in treating hyperpigmentation, enhancing skin radiance and reducing dark spots.
References
  • Chaudhuri, R. K., & Bojanowski, K. (2014). Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. International Journal of Cosmetic Science.
  • Dhaliwal, S., et al. (2019). Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing. British Journal of Dermatology.
  • Sivamani, R. K., et al. (2019). Clinical efficacy of a bakuchiol, niacinamide and zinc pyrithione formulation in facial sebum control and mild acne. Journal of Cosmetic Dermatology.
DermExcel™ | Litaderm Serum
Litaderm serum Sale priceL£8,176,000.00 LBP
  • Aging Skin: Target early signs of aging, including fine lines and wrinkles, by promoting cell renewal and improving skin elasticity.
  • Hyperpigmentation: Specifically formulated to improve and prevent hyperpigmentation, helping to reduce the appearance of dark spots, uneven skin tone, and discoloration.
  • Melasma: Indicated for individuals who have developed patches of facial skin discoloration, due to hormonal changes such as pregnancy or birth control use.
  • Redness and Inflammation: The active ingredients work synergistically to calm inflammation and reduce redness, promoting a more balanced and even-toned complexion.
  • Skin Damage: By boosting skin health and supporting skin regeneration, Litaderm Serum is indicated for individuals who have skin damage, possibly due to environmental factors like sun exposure.
  • Acne: Reduce inflammation associated with acne, regulate sebum production, and minimize the appearance of blemishes, contributing to clearer and healthier skin.
  • Rosacea: Reduce the visible signs of rosacea, including redness and enlarged blood vessels.
  • Dull Lifeless Skin: Reduces melanin production, leading to a more even skin tone.
  • Overall Skin Health: Nourishes and rejuvenates the skin, promoting a healthier and youthful complexion.
  • Normal, Oily, and Combination skin types: Apply Litaderm Serum at night.
  • Dry skin types: Apply Litaderm Serum in the morning and/or at night.
  • Cleanse: Start with a clean, dry face. Use your DermExcel cleanser to remove dirt and excess oil from your skin.
  • Apply: The best time to apply the serum is when your skin is still slightly damp after cleansing. This allows your skin to better absorb the potent ingredients in the serum. So, after cleansing your face, don't completely dry your skin; leave it slightly damp. Take a small amount of Liatderm Serum (1-2 pumps or a pea-sized amount should suffice) and gently apply it to the face.
  • Massage: Using your fingertips, gently massage the serum into your skin in a circular motion. This helps to ensure the serum is evenly distributed and absorbed.
  • Wait: Allow the serum to absorb fully into the skin before applying other skincare products. This typically takes a few minutes.
  • Follow-up: Once the serum has been fully absorbed, continue with the rest of your skincare routine, such as applying sunscreen (in the morning).

By following these detailed steps, you will maximize the benefits of Litaderm Serum.

Active ingredients

  • Arbutin
  • Azelaic acid
  • Niacinamide
  • Bakuchiol

Full ingredient list

Aqua, Macrogol, Azelaic acid, Nicotinamide, Glycerine, Arbutin, Jojoba Oil, Bakuchiol, Isostearyl Alcohol · Butylene Glycol Cocoate Ethylcellulose, Butylene glycol, Ceteth-20 · Cetyl Alcohol, Glyceryl Stearate, Steareth-20, C12-15 Alkane, Phenylpropanol, Propanediol, Caprylyl Glycol, Tocopherol

Litaderm serum

benefits

Targeted Acne Treatment

Reduce acne breakouts by eliminating acne-causing bacteria and managing inflammation.

Sebum Regulation

Regulates excess sebum production, reducing complications and improving the appearance of oily and enlarged pores.

Pigmentation Treatment

Litaderm Serum effectively treat hyperpigmentation by targeting all the phases of the hyperpigmentation process.

Anti-Inflammatory

Reduce inflammation related to acne, rosacea, and premature aging due to its potent anti-inflammatory ingredients.

Skin Barrier Enhancement

Niacinamide in the serum enhances the skin's barrier function, protecting it from environmental stressors.

Anti-Aging

Promotes skin elasticity and reduces skin damage, helping to treat and prevent premature aging incl. fine lines and wrinkles.

Rosacea Treatment

Reduce redness and visible facial blood vessels as well as microbial activity associated with Rosacea.

Anti-Microbial

Controls and manage microbial activity to promote a healthy skin microbiome.

Litaderm serum

INDICATIONS

Acne / Breakouts

Aging Skin

Dry & Dehydrated Skin

Dull & Lifeless Skin

Enlarged Pores

Pigmentation

Red & Inflamed skin

Shaving Bumps

Litaderm serum

MODE OF ACTION

Litaderm serum mode of action

treating pigmentation

BAKUCHIOL

α-MSH activates the hyperpigmentation process by binding to receptors that upregulate tyrosinase expression.

BAKUCHIOL BLOCKS MELANOCYTE-STIMULATING HORMONE AND TYROSINASE ACTIVATION.

AZELAIC ACID & ARBUTIN

Inhibiting tyrosinase, the crucial enzyme for the initial stages of melanin synthesis, is vital for effective pigmentation treatment.

AZELAIC ACID AND ARBUTIN BLOCK TYROSINASE CATALYTIC ACTIVITY AND FUNCTIONALITY.

NIACINAMIDE

Niacinamide disrupts the transfer of pigment-containing melanosomes to skin cells. This action effectively reduces hyperpigmentation by limiting the distribution of melanin on the skin's surface.

NIACINAMIDE INHIBITS TRANSFER OF PIGMENT TO SKIN CELLS

AZELAIC ACID

Azelaic acid prevents abnormal hyperactive melanocytes from multiplying, by interfering with DNA synthesis and mitochondrial enzymes, with no cytotoxic effect on normal, healthy-functioning melanocytes.

AZELAIC INHIBITS ABNORMAL FUNCTIONING MELANOCYTES.

disease education

rosacea stages and treatment objectives

A constant interplay exists among the skin, micro-organisms, and the environment to maintain a delicate balance. Disturbance of this balance negatively influences both the microflora and skin health.

In Rosacea, the micro-environment of the affected skin is substantially altered, resulting in a shift in the proportion or speciation of the resident microflora. Several micro-organisms have been shown to be increased or immuno-reactive in patients with rosacea.

Or skin contains pattern recognition receptors (PPR). These receptors detect harmful bacteria on our skin. When they detect these harmful bacteria, they bind to them and activate an immune response.

Receptors (PPR) don't activate the immune response for normal micro-flora on our skin. Rosacea-prone skin receptors (PPR) are hyper-reactive and/or have decreased tolerance. They have heightened sensitivity and trigger the inflammatory response of normal microbes, leading to the initial signs of rosacea.

  • Healthy skin with a perfect balance between normal microflora and skin receptors.
  • The function of the pathogen recognizing receptos receptors (PPR) is to detect and bind to harmful molecules and then to activate the immune response.
  • These receptors should not trigger an immune response by binding to normal microflora.
  • PPR (receptors) of Rosacea-prone skin bind to normal flora (they are not supposed to) and activate the immune response that causes inflammation.
  • PPR (receptors) of Rosacea-prone skin is hyper-reactive and sensitive. They can be activated by various environmental agents (fragrance, heat, spicy food, etc.)
  • Inflammation leads to an increase in white blood cells (leucocytes) and antimicrobial peptides (cathelicidins), causing certain normal microbes to be eliminated.
  • The disruption of the body's normal microbial community leads to an imbalance, where potentially harmful microbes overgrow and occupy spaces left by the eliminated beneficial microbes.
  • The negative feedback loop continues where alterations in the micro-flora lead to increased inflammation, which in turn exacerbates Rosacea, resulting in more severe symptoms.

Litaderm action on

Pigmentation Phases

Litaderm serum mode of action

treating pigmentation

BAKUCHIOL

α-MSH activates the hyperpigmentation process by binding to receptors that upregulate tyrosinase expression.

BAKUCHIOL BLOCKS MELANOCYTE-STIMULATING HORMONE AND TYROSINASE ACTIVATION.

AZELAIC ACID & ARBUTIN

Inhibiting tyrosinase, the crucial enzyme for the initial stages of melanin synthesis, is vital for effective pigmentation treatment.

AZELAIC ACID AND ARBUTIN BLOCK TYROSINASE CATALYTIC ACTIVITY AND FUNCTIONALITY.

NIACINAMIDE

Niacinamide disrupts the transfer of pigment-containing melanosomes to skin cells. This action effectively reduces hyperpigmentation by limiting the distribution of melanin on the skin's surface.

NIACINAMIDE INHIBITS TRANSFER OF PIGMENT TO SKIN CELLS

AZELAIC ACID

Azelaic acid prevents abnormal hyperactive melanocytes from multiplying, by interfering with DNA synthesis and mitochondrial enzymes, with no cytotoxic effect on normal, healthy-functioning melanocytes.

AZELAIC INHIBITS ABNORMAL FUNCTIONING MELANOCYTES.

disease education

rosacea stages and treatment objectives

A constant interplay exists among the skin, micro-organisms, and the environment to maintain a delicate balance. Disturbance of this balance negatively influences both the microflora and skin health.

In Rosacea, the micro-environment of the affected skin is substantially altered, resulting in a shift in the proportion or speciation of the resident microflora. Several micro-organisms have been shown to be increased or immuno-reactive in patients with rosacea.

Or skin contains pattern recognition receptors (PPR). These receptors detect harmful bacteria on our skin. When they detect these harmful bacteria, they bind to them and activate an immune response.

Receptors (PPR) don't activate the immune response for normal micro-flora on our skin. Rosacea-prone skin receptors (PPR) are hyper-reactive and/or have decreased tolerance. They have heightened sensitivity and trigger the inflammatory response of normal microbes, leading to the initial signs of rosacea.

  • Healthy skin with a perfect balance between normal microflora and skin receptors.
  • The function of the pathogen recognizing receptos receptors (PPR) is to detect and bind to harmful molecules and then to activate the immune response.
  • These receptors should not trigger an immune response by binding to normal microflora.
  • PPR (receptors) of Rosacea-prone skin bind to normal flora (they are not supposed to) and activate the immune response that causes inflammation.
  • PPR (receptors) of Rosacea-prone skin is hyper-reactive and sensitive. They can be activated by various environmental agents (fragrance, heat, spicy food, etc.)
  • Inflammation leads to an increase in white blood cells (leucocytes) and antimicrobial peptides (cathelicidins), causing certain normal microbes to be eliminated.
  • The disruption of the body's normal microbial community leads to an imbalance, where potentially harmful microbes overgrow and occupy spaces left by the eliminated beneficial microbes.
  • The negative feedback loop continues where alterations in the micro-flora lead to increased inflammation, which in turn exacerbates Rosacea, resulting in more severe symptoms.

LITADERM SERUM MODE OF ACTION

ROSACEA TREATMENT

Azelaic acid

Anti-inflammatory: Decrease inflammation that leads to breakouts, redness and skin damage.

Anti-microbial: Bacteriostatic activity to both aerobic and anaerobic bacteria.

Antioxidant: Prevent DNA damage, and activation of inflammatory enzymes.

Anti-keratinizing: Inhibits skin cells from abnormally multiplying.

Sebum (oil) regulator: Inhibits sebum over-production, that contribute to bacterial growth and inflammation.

NIACINAMIDE

Anti-inflammatory: Reduce the inflammatory response by inhibiting inflammatory messengers.

Anti-microbial: Provides long-lasting protection against bacteria by activating an anti-microbial peptide response.

Sebum (oil) regulator: Inhibits sebum over-production, that contribute to bacterial growth and inflammation.

Antioxidant: Prevent DNA damage and activation of inflammatory enzymes.

BAKUCHIOL

Anti-inflammatory: Suppress pro-inflammatory cytokine expression and control leukocytic functions.

Anti-bacterial: Significant antibacterial activity against Gram-positive and negative bacteria. 

Anti-keratinizing: Inhibits skin cells from abnormally multiplying.

Sebum (oil) regulator: Reduce sebaceous glands' activity, leading to less pore clogging and potentially less oil production.

Treatment Serums

testimonials


Customer Reviews

Based on 2451 reviews
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K
Karen Botha
Amazing

I did the online skin analysis and got my results. I was skeptical to buy the full range, so I decided to get the trial sized products first to try it out. Within a week my skin was so soft and smooth, no breakouts like before. DermExcel has changed my life for sure. I will be ordering my full package once the trial products are empty. Definitely worth it.

A
Anneke Malan
Happy skin

I love it!!!!

E
Eileen Williams
Retinol serum

It’s amazing!!!

J
Jennifer Knight

Litaderm serum

I
Ilze Herholdt
Excellent products

I am so happy with all of the products. My skin has never felt this great!! Thank you for this produxt and will recommend you to everyone and anyone!

E
Esteé Van Staden

Collagen Serum

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