Dermaplan™ | Eczema Prone Skin

your dermal diagnosis™ results

Good day

We're thrilled you're taking proactive steps to understand your skin better. Below, you'll find your most recent Dermal Diagnosis™ results. Use this data as a roadmap to achieving healthier skin.

Date	Dermal Diagnosis™	Profile and Treatment Plan

DERMAL DIAGNOSIS™ RESULT BREAKDOWN

Aging Score	Hydration Score	Pigmentation Score	Inflammation category

Date	Dermal Diagnosis™

DERMAL DIAGNOSIS™ RESULT BREAKDOWN

Aging Score
Hydration Score
Pigmentation Score
Inflammation category

's Dermal Diagnosis™ Profile

Eczema / Dermatitis

benefits

barriers

goals

YOUR SKIN'S MAIN CHARACTERISTICS

Rough Texture

↓ Barrier Function

Sensitivity

Barriers to your skin health

Rough Skin Texture

↓ Barrier Function

Sensitivity

Compromised Skin Barrier: The skin's natural barrier is weakened by the diverse concerns of your skin, making it more susceptible to irritants, allergens, and environmental damage.
Sensitivity: Sensitive skin may react with stinging, burning, itching, or redness to various triggers, including certain skincare ingredients, environmental factors, and stress. This sensitivity can make finding suitable skincare products that do not exacerbate these symptoms challenging.
Dryness: Chronic dryness challenges the skin's ability to retain moisture, leading to discomfort and enhancing the visibility of aging signs.

your frustrations

Persistent Itchiness: Constant urge to scratch that can be extremely distressing and can interfere with daily activities, work, and sleep.
Skin Discomfort: Beyond itchiness, the skin may feel sore, tight, or painfully dry, adding to the overall discomfort.
Visible Symptoms: Red, inflamed, or flaky skin, especially on visible areas like the face, hands, and neck, can lead to self-consciousness and impact social interactions.
Impact on Social Life: The appearance of the skin and the need to avoid certain activities or environments can lead to withdrawal from social events and activities.
Sleep Disturbances: Itchiness and discomfort can disrupt sleep patterns, leading to fatigue and affecting overall well-being.
Treatment Challenges: Finding effective treatments can be a process of trial and error, and the ongoing need for management can be time-consuming and sometimes disheartening.
Lifestyle Restrictions: The need to avoid certain fabrics, products, and activities can feel limiting and frustrating.
Emotional and Mental Health: The chronic nature of eczema and its visible symptoms can lead to anxiety, depression, and decreased self-esteem.
Financial Burden: The cost of treatments, moisturizers, and gentle skin care products can add up, causing financial strain.

your goals

Effective Itch Relief: Find treatments that effectively minimize or eliminate the constant itchiness, providing comfort and reducing the urge to scratch.
Improve Skin Hydration and Health: Develop a daily skincare routine that maintains the skin's moisture barrier, reducing dryness, flakiness, and discomfort.
Enhance Skin Appearance: Reduce visible signs of eczema such as redness, inflammation, and lesions, especially in exposed areas, improving confidence and self-esteem.
Social and Recreational Activities: Manage eczema in a way that allows for greater participation in social events and activities without discomfort or self-consciousness.
Improved Sleep Comfort: Alleviate night-time itchiness and discomfort, enabling restful sleep and improving overall well-being.
Optimize Treatment Plan: Finding the most effective, personalized treatment strategy, minimizing trial and error.
Enhance Quality of Life: Reduce the overall impact of eczema on daily living, including emotional and mental health, through effective management and support.
Manage Costs: Affordable and sustainable options for skincare and treatment, alleviating financial stress associated with managing eczema.

Eczema / Dermatitis

treatment objectives

include

Moisturizing Cleanser that's soap- and fragrance-free and will reinforce your skin's natural barrier while maintaining hydration levels.
Ointments with breathable occlusive agents that create a physical barrier over the skin, locking in moisture.
Ceramide-enriched moisturizers that will reinforce the skin barrier.
Emollients that will fill the gaps between skin cells, helping to replace lost moisture. Apply within minutes after bathing to lock in moisture.
Anti-inflammatory agents that will soothe and calm the skin.
Cool, Short Baths or Showers - Limit bathing time and use lukewarm water. Gently pat your skin dry and apply moisturizer immediately afterward.
Humidifiers in dry environments will help keep your skin hydrated.
Cotton and Soft Fabrics - Wear loose-fitting clothes made from soft, natural fibers like cotton. Avoid rough, scratchy fibers and tight clothing.

avoid

Irritants and Allergens may include dust, pet hair, synthetic fragrances, wool, harsh soaps, and certain food and laundry detergents. Identify and avoid allergens that may trigger flare-ups.
Extreme Temperatures - both very hot and very cold environments can exacerbate eczema. Protect your skin in cold, windy weather.
Long, hot showers or baths will strip your skin of its protective oils and fats.
Stress is a well-known trigger for eczema flare-ups. Engage in stress-reducing activities and practice relaxation techniques.
Scratching worsens symptoms and damages the skin. Keep nails short and consider wearing soft gloves at night.
Over-exfoliation and scrubbing will damage your skin barrier.
UV rays can not only cause harm but can also trigger eczema flare-ups.
Tight clothing and synthetic fabrics that can irritate the skin.

Eczema / Dermatitis

Active Ingredients your skin needs

Essential Fatty Acids

Essential Fatty Acids: Nourishing Your Skin from Within

In the realm of dermatological science, essential fatty acids (EFAs) have emerged as unsung heroes, offering a multifaceted approach to improving skin health in patients with conditions such as eczema and dry skin.

Pharmacological Advantages

EFAs are not only instrumental in maintaining the skin's structural integrity but also possess anti-inflammatory properties. They serve as precursors for pro-resolving lipid mediators like resolvins and protectins, which help reduce skin inflammation, itching, and redness—common symptoms of eczema.

Physiological Harmony

EFAs contribute to maintaining the balance of skin hydration. They enhance the skin's ability to retain water, leaving it supple and hydrated. Moreover, EFAs can modulate the skin's immune response, reducing the severity of allergic reactions and flare-ups often seen in dermatological conditions like eczema.

Biochemical Brilliance

Essential fatty acids, including omega-3 and omega-6, are the building blocks of the skin's lipid barrier. This barrier acts as a protective shield, preventing excessive moisture loss and shielding the skin from external aggressors. EFAs play a pivotal role in maintaining this barrier's integrity by contributing to the synthesis of ceramides and lipids that bind skin cells together.

References

Elias, P. M. et al. (2008). Skin diseases associated with decreased epidermal lipogenesis. Annals of the New York Academy of Sciences, 1141(1), 1-13.
Ziboh, V. A. et al. (2000). Biochemical basis of the essential fatty acid requirement for normative growth in neonatal baboons. American Journal of Clinical Nutrition, 71(1), 3-11.
Serhan, C. N. (2014). Pro-resolving lipid mediators are leads for resolution physiology. Nature, 510(7503), 92-101.
Levesque, A. et al. (2018). Omega-3 fatty acids: Anti-inflammatory and skin barrier benefits. Omega-3 Fatty Acids: Keys to Nutritional Health, 303-315.
Nicolaou, A. (2013). Eicosanoids in skin inflammation. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 88(1), 131-138.
Meydani, S. N. et al. (2018). Nutrition interventions in aging and age-associated diseases. Annals of the New York Academy of Sciences, 1418(1), 34-51.

Emollients

Emollients are crucial in dermatological care, primarily because they enhance skin hydration and barrier function. Here's a brief overview of their physiological effects and roles in managing various skin conditions.

Physiological Effects

Hydration of Stratum Corneum: Emollients increase moisture content in the stratum corneum, the outermost layer of the skin, by reducing transepidermal water loss (TEWL). This is achieved through occlusion, which traps water in the skin.
Restoration of Skin Barrier Function: They aid in replenishing the skin's lipid barrier, which is essential for maintaining skin integrity and protective function.
Soothing and Smoothing Effects: Emollients smooth, flaky skin cells, making the skin surface appear smoother. They also provide a soothing effect, which can reduce itching and discomfort.
Anti-inflammatory Properties: Some emollients have ingredients that offer mild anti-inflammatory benefits, helping to reduce redness and irritation.

Role in Managing Dermatological Conditions

Atopic Dermatitis (Eczema): Emollients are a cornerstone in the management of eczema, helping to maintain skin hydration, reduce flare-ups, and minimize the need for topical corticosteroids.
Psoriasis: Regular use of emollients can reduce scaling and dryness associated with psoriasis, improving the efficacy of other topical treatments.
Ichthyosis and Xerosis: These conditions, characterized by dry, scaly skin, benefit significantly from emollients, which help hydrate and soften the skin.
Aging Skin: Emollients improve the appearance of aging skin by hydrating and reducing the visibility of fine lines and wrinkles.
Skin Protection: Emollients can protect the skin from irritation and breakdown in individuals with incontinence or those who are bedridden.

References

Proksch, E., & Lachapelle, J. M. (2005). The Management of Dry Skin with Topical Emollients. American Journal of Clinical Dermatology.
Lynde, C. W. (2001). Moisturizers: What They Are and a Practical Approach to Product Selection. Skin Therapy Letter.
Lodén, M. (2003). Role of Topical Emollients and Moisturizers in the Treatment of Dry Skin Barrier Disorders. American Journal of Clinical Dermatology.

Lipid Bilayer Technology

Lipid bilayer technology in dermatology focuses on mimicking and reinforcing the skin's natural lipid barrier, which is vital for maintaining skin health and integrity.

Physiological Effects

Reinforcement of Skin Barrier: Lipid bilayer technology aims to replicate the skin's natural barrier, particularly beneficial for damaged or compromised skin. This reinforcement helps in reducing transepidermal water loss (TEWL) and enhancing skin hydration.
Restoration of Lipid Composition: It helps in replenishing the essential lipids that are often deficient in certain skin conditions, thereby restoring the skin's natural protective barrier.
Improvement in Skin Texture and Hydration: By restoring the lipid bilayer, this technology improves skin texture and overall hydration, leading to healthier, more resilient skin.
Reduction of Inflammation and Irritation: It can help in reducing inflammation and irritation, particularly in conditions where the skin barrier is compromised.

Role in Managing Dermatological Conditions

Atopic Dermatitis (Eczema): Lipid bilayer technology is particularly beneficial in managing eczema, as it helps in restoring the deficient skin barrier function, reducing dryness, and controlling flare-ups.
Psoriasis: In psoriasis, where the skin barrier is also disrupted, this technology aids in hydrating the skin and reducing scaling.
Aging Skin: The aging skin, which naturally loses lipids over time, benefits from lipid bilayer technology as it helps in maintaining skin hydration and elasticity.
Dry Skin Conditions (Xerosis, Ichthyosis): Enhancing the skin’s lipid content can significantly improve symptoms of dryness and scaling in these conditions.
Sensitive Skin: For sensitive skin types, lipid bilayer technology can provide a gentle and effective way to strengthen the skin barrier without causing irritation.

References

Del Rosso, J. Q., & Levin, J. (2011). The Clinical Relevance of Maintaining the Functional Integrity of the Stratum Corneum in both Healthy and Disease-affected Skin. Journal of Clinical and Aesthetic Dermatology.
Rawlings, A. V., & Harding, C. R. (2004). Moisturization and Skin Barrier Function. Dermatologic Therapy.
Man, M. Q., Xin, S. J., Song, S. P., Cho, S. Y., Zhang, X. J., Tu, C. X., ... & Elias, P. M. (2009). Variation of Skin Surface pH, Sebum Content and Stratum Corneum Hydration with Age and Gender in a Large Chinese Population. Skin Pharmacology and Physiology.

d-Panthenol

d-Panthenol's multifaceted effects on skin hydration, barrier strengthening, and wound healing make it a valuable component in the management of various dermatological conditions, from dry skin to post-procedure care.

d-Panthenol, also known as pro-vitamin B5, is a popular dermatological ingredient due to its beneficial effects on the skin. Here's a brief overview of its physiological effects and roles in managing various skin conditions:

Physiological Effects

Hydration: d-Panthenol is a humectant, meaning it helps to attract and retain moisture in the skin. This leads to increased skin hydration, which can improve skin softness and elasticity.
Wound Healing and Repair: It plays a role in the synthesis of lipids and proteins, essential for skin repair. d-Panthenol has been shown to accelerate re-epithelialization in wound healing.
Anti-Inflammatory Effect: d-Panthenol can reduce inflammation, making it beneficial in treating skin irritations and erythema.
Skin Barrier Strengthening: By enhancing the synthesis of lipids and proteins, d-Panthenol contributes to the strengthening of the skin's barrier function, protecting against irritants and environmental damage.
Soothing and Softening: It soothes the skin and makes it feel softer and smoother, which can be particularly beneficial for dry or rough skin textures.

Role in Managing Dermatological Conditions

Minor Wounds and Skin Irritations: Due to its role in skin repair and anti-inflammatory properties, d-Panthenol is used in the treatment of minor wounds, cuts, and skin irritations.
Dermatitis and Eczema: It helps in managing conditions like dermatitis and eczema by reducing inflammation and enhancing skin barrier function.
Dry Skin Conditions (Xerosis): Its moisturizing properties make it effective in treating dry skin, providing relief from itching and scaling.
Post-procedure Care: d-Panthenol is often used in post-procedure care, such as after laser treatments or chemical peels, to aid in skin recovery and reduce inflammation.

References

Proksch, E., & Nissen, H. P. (2002). Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation. Journal of Dermatological Treatment.
Ebner, F., Heller, A., Rippke, F., & Tausch, I. (2002). Topical use of dexpanthenol in skin disorders. American Journal of Clinical Dermatology.
Camargo, F. B. Jr, Gaspar, L. R., & Maia Campos, P. M. B. G. (2011). Skin moisturizing effects of panthenol-based formulations. Journal of Cosmetic Science.

Medilan™

Medilan™'s unique formulation and hypoallergenic properties make it a valuable component in managing various dermatological conditions, particularly for hydrating and soothing sensitive and dry skin.

Medilan™, an ultra-refined, hypoallergenic medical-grade lanolin, has proven to be very beneficial for managing dermatological conditions. Below is a brief overview of its physiological effects and roles in managing various skin conditions.

Physiological Effects

Emollient: Medilan™ is an excellent emollient, helping to soften and smooth the skin by retaining moisture. It creates an occlusive barrier, which reduces transepidermal water loss (TEWL).
Moisturizing: It is highly effective in moisturizing dry and rough skin, enhancing skin hydration by trapping and sealing in moisture.
Hypoallergenic: Medilan™ is ultra-purified to minimize the risk of allergic reactions, making it suitable for sensitive skin types.
Wound Healing: Medilan™ aids in the healing process of minor cuts, abrasions, and burns by maintaining a moist wound environment.
Skin Barrier Function: It enhances the skin's barrier function, protecting against environmental irritants and reducing the risk of skin infections.
Lipid Replenishment: Medilan™ mimics the lipids found in human skin, helping to restore the lipid barrier of the skin, especially beneficial in dry and chapped skin conditions.
Skin Penetration and Hydration: It can penetrate the skin and aid in water retention in the stratum corneum, the outermost layer of the skin, thus enhancing hydration.
Occlusive Properties: Medilan™ helps reduce transepidermal water loss by forming a barrier on the skin surface, thereby retaining moisture and improving skin barrier function.

Role in Managing Dermatological Conditions

Eczema and Dry Skin Conditions: Medilan™ is a valuable ingredient in treating eczema and other dry skin conditions due to its soothing, hydrating, and occlusive properties.
Wound Healing: While primarily used for its emollient effects, the properties of Medilan™ also aid in healing minor wounds and skin irritations.
Sensitive Skin Care: Its hypoallergenic nature makes it suitable for sensitive skin, reducing the risk of irritation or allergic reactions.
Nipple Care in Breastfeeding: Soothes and heals cracked and sore nipples in breastfeeding mothers.
Chapped Lips and Skin: It effectively treats chapped lips and skin, providing a barrier that seals in moisture and protects from harsh weather conditions.

References

Lodén, M., & Maibach, H. I. (2000). Dry skin and moisturizers: chemistry and function. CRC Press.
Suleman, H., et al. (2000). Role of lanolin in managing eczema and dry skin conditions. Community Nurse.
DiNardo, J. C. (2000). Is lanolin allergy a myth? Dermatitis.
Stone, L. (2000). Medilan: a hypoallergenic lanolin for emollient therapy. British Journal of Nursing.
ResearchGate Article on Medilan™ highlighting its role in skin care and emollient therapy.

Niacinamide

Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.

Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.

Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.

Physiological Effects

Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.

Role in Managing Dermatological Conditions

Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
Aging Skin: Niacinamide targets wrinkles and loss of firmness.
Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.

References

Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.

Occlusives

Occlusives are a class of substances used in dermatology that work by forming a protective barrier on the surface of the skin. This barrier plays a crucial role in skin care and the management of various dermatological conditions.

Occlusives are a vital component in skincare, particularly for conditions characterized by impaired skin barrier function and excessive dryness. Their ability to lock in moisture and protect the skin from external irritants makes them invaluable in both therapeutic and preventive dermatology.

Physiological Effects

Moisture Retention: Occlusives reduce transepidermal water loss (TEWL) by creating a physical barrier over the skin, which traps moisture and prevents its evaporation, thereby keeping the skin hydrated.
Skin Barrier Enhancement: They help in enhancing the skin's natural barrier function, protecting against environmental irritants and harmful substances.
Soothing Effect: By preventing water loss and protecting the skin, occlusives can have a soothing effect, particularly on dry, irritated, or compromised skin.
Improved Skin Texture: Regular use of occlusive agents can lead to improved skin texture, making the skin appear smoother and softer.

Role in Managing Dermatological Conditions

Dry Skin Conditions (Xerosis): Occlusives are essential in the management of dry skin, helping to maintain hydration and reduce scaliness and itching.
Eczema and Atopic Dermatitis: They are commonly used in the treatment of eczema and atopic dermatitis to hydrate the skin and reduce symptoms like itching and inflammation.
Psoriasis: In psoriasis, occlusives can help in managing scaling and dryness, and are often used in combination with other topical treatments.
Wound Healing: Occlusives can be used in wound care to maintain a moist environment, which is conducive to healing.
Prevention of Irritant Contact Dermatitis: They protect the skin from irritants, especially in individuals with occupational exposures to harsh chemicals or frequent hand washing.

References

Rawlings, A. V., & Harding, C. R. (2004). Moisturization and skin barrier function. Dermatologic Therapy.
Lodén, M. (2003). Role of Topical Emollients and Moisturizers in the Treatment of Dry Skin Barrier Disorders. American Journal of Clinical Dermatology.
Proksch, E., & Lachapelle, J. M. (2005). The Management of Dry Skin with Topical Emollients. American Journal of Clinical Dermatology.

Hyaluronic acid

Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan found throughout the body's connective, epithelial, and neural tissues. Most abundantly present in the skin, eyes, and synovial fluid, HA is renowned for its exceptional capacity to retain moisture — a single gram can hold up to six liters of water.

In skincare, the primary appeal of hyaluronic acid lies in its unparalleled hydrating abilities. As a humectant, HA attracts and retains moisture from the environment, providing intense hydration to the skin. This hydrating property contributes significantly to maintaining skin plumpness, suppleness, and elasticity.

Beyond hydration, hyaluronic acid also plays a vital role in skin repair and regeneration. It supports the skin's healing and repair processes, and its anti-inflammatory properties help calm irritated skin. Moreover, HA's ability to promote collagen production, a crucial protein for skin elasticity, further underscores its anti-aging benefits.

The molecular size of hyaluronic acid influences its skin penetration and efficacy. High-molecular-weight HA remains on the skin's surface, providing hydration and forming a barrier against moisture loss. In contrast, low-molecular-weight HA penetrates deeper into the skin's layers, offering more profound hydrating and rejuvenating effects.

Hyaluronic acid's remarkable ability to hydrate, improve skin elasticity, aid in wound healing, and provide antioxidant protection makes it valuable in managing various dermatological conditions, particularly aging, dryness, and sensitive skin.

Physiological Effects

Hydration: Hyaluronic acid is a powerful humectant that can hold up to 1000 times its weight in water, significantly enhancing skin hydration and leading to plumper, more hydrated skin.
Skin Elasticity and Wrinkle Reduction: By increasing skin moisture, it improves skin elasticity, reduces the appearance of fine lines and wrinkles, and gives the skin a more youthful appearance.
Wound Healing: It plays a role in wound healing due to its ability to regulate inflammation levels and signal the body to build more blood vessels in the damaged area.
Barrier Enhancement: Hyaluronic acid helps reinforce the skin's natural barriers, protecting against environmental factors and retaining moisture.
Antioxidant Properties: It provides antioxidant defense against free-radical damage from the sun and pollution.

Role in Managing Dermatological Conditions

Aging Skin: Its ability to reduce wrinkles and improve skin elasticity makes it popular in anti-aging skincare products.
Dry Skin: Hyaluronic acid is beneficial in treating dry skin conditions by providing intense hydration.
Wound Care: Its role in wound healing is leveraged in post-procedure care, such as after laser treatments, and in healing minor cuts and abrasions.
Acne Scars: It can help treat acne scars by promoting skin regeneration and reducing inflammation.
Sensitive Skin: Hyaluronic acid is suitable for sensitive skin due to its gentle nature. It provides hydration without irritating.

References

Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology.
Jegasothy, S. M., Zabolotniaia, V., & Bielfeldt, S. (2014). Efficacy of a new topical nano-hyaluronic acid in humans. The Journal of Clinical and Aesthetic Dermatology.
Wollina, U., & Abdel-Naser, M. B. (2019). Hyaluronic acid in the treatment and prevention of skin diseases: Molecular biological, pharmaceutical and clinical aspects. Skin Pharmacology and Physiology.

Ceramides

Ceramides, a family of lipid molecules naturally present in the skin, are integral to the structure and function of the skin barrier. They are a type of lipid that, along with cholesterol and fatty acids, forms a critical part of the stratum corneum, the outermost layer of the skin. This layer is essential for maintaining skin hydration and protecting against environmental aggressors.

Ceramides, which make up about 50% of the skin's lipid composition, play a pivotal role in maintaining the skin's barrier integrity and preventing transepidermal water loss (TEWL). By doing so, they help keep the skin hydrated and supple.

The loss or reduction of ceramides in the skin barrier is associated with several dermatological conditions, including eczema and psoriasis, where the skin becomes dry, itchy, and prone to irritation and infection. Studies have shown that the application of ceramide-containing moisturizers can effectively improve skin barrier function and increase skin hydration levels.

Ceramides are particularly beneficial for aging skin, which naturally loses ceramides over time, leading to drier and more fragile skin. By replenishing the skin's ceramide content, these products can help combat the signs of aging, such as fine lines and wrinkles.

Ceramides are integral to maintaining skin health, particularly in conditions where the skin barrier is compromised. Their role in hydrating the skin, reducing sensitivity, and improving barrier function makes them an essential component in the management of various dermatological conditions, especially eczema, psoriasis, and dry or aging skin.

Physiological Effects

Barrier Function: Ceramides are critical components of the skin's lipid barrier. They help to prevent moisture loss and protect against environmental aggressors like pollutants and irritants.
Hydration: By maintaining the barrier integrity, ceramides keep the skin hydrated, preventing dryness and keeping the skin supple.
Reducing Skin Sensitivity: They play a role in reducing skin sensitivity and irritation, helping to calm inflamed and reactive skin.
Anti-aging Properties: Ceramides can improve skin elasticity and firmness, helping to reduce the appearance of fine lines and wrinkles.
Wound Healing: There is evidence to suggest that ceramides can aid in the skin's natural wound healing process.

Role in Managing Dermatological Conditions

Eczema and Atopic Dermatitis: Ceramides are often used in the treatment of eczema and atopic dermatitis, where the skin barrier is compromised, leading to dryness, itching, and inflammation.
Psoriasis: They can help in managing psoriasis by maintaining skin hydration and barrier function, reducing scaling and dryness.
Aging Skin: Ceramide-containing products are beneficial in anti-aging regimens due to their ability to improve skin barrier function and elasticity.
Dry Skin (Xerosis): In the treatment of dry skin, ceramides help in restoring skin hydration and barrier function.
Sensitive Skin: Products containing ceramides are suitable for sensitive skin as they help to restore the skin's natural barrier and reduce irritation.

References

Del Rosso, J. Q., & Levin, J. (2011). The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. Journal of Clinical and Aesthetic Dermatology.
Farwanah, H., Wohlrab, J., Neubert, R. H. H., & Raith, K. (2005). Ceramides and skin function. American Journal of Clinical Dermatology.
Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato-Venereologica.

Humectants

Humectants are a vital component in skincare, particularly for conditions characterized by impaired skin barrier function and excessive dryness. Their ability to attract and retain moisture in the skin makes them invaluable in both therapeutic and preventive dermatology.

Physiological Effects

Moisture Attraction: Humectants draw moisture from the environment and the deeper layers of the skin to the outer layer (stratum corneum), enhancing skin hydration.
Enhancing Skin Barrier Function: By improving skin hydration, humectants help to maintain and improve the skin's barrier function, protecting against irritants and reducing transepidermal water loss (TEWL).
Skin Elasticity and Appearance: Improved hydration can enhance skin elasticity and reduce the appearance of fine lines and wrinkles, giving the skin a plumper and smoother look.
Soothing Effect: Humectants can have a soothing effect on the skin, particularly in conditions involving dryness or irritation.

Role in Managing Dermatological Conditions

Dry Skin (Xerosis): Humectants are key ingredients in many moisturizers and are highly effective in managing dry skin by providing and maintaining hydration.
Eczema and Dermatitis: Their moisturizing and soothing properties help in relieving symptoms of eczema and dermatitis, such as dryness, itching, and irritation.
Aging Skin: Humectants are used in anti-aging skincare products due to their ability to hydrate the skin and improve its appearance.
Psoriasis: They can aid in reducing the dryness and scaling associated with psoriasis.
Acne-Prone Skin: Certain humectants can be beneficial in acne treatments, as they provide necessary hydration without clogging pores.

References

Lodén, M. (2005). Role of Topical Emollients and Moisturizers in the Treatment of Dry Skin Barrier Disorders. American Journal of Clinical Dermatology.
Rawlings, A. V., & Canestrari, D. A. (2011). Moisturizer technology versus clinical performance. Dermatologic Therapy.
Fluhr, J. W., Darlenski, R., & Surber, C. (2008). Glycerol and the skin: holistic approach to its origin and functions. British Journal of Dermatology.

MORNING

EVENING

CLEANSE

REPAIR

MOISTURIZE & PROTECT

MORNING

EVENING

Cleanser

Cremedify

Preparation: Ensure your skin is damp. For full-body cleansing, it is best to use Cremedify during a shower or bath.
Application: Apply a generous amount of Cremedify to the affected areas.
Massage: Gently massage the cleanser into your skin in circular motions, focusing on areas with dryness, itching, psoriasis, atopic dermatitis, or eczema.
Rinsing: Rinse off thoroughly with lukewarm water. Avoid using hot water as it can dry out the skin further.
Pat Dry: Gently pat your skin dry with a soft towel leaving the skin damp. Do not rub, as this can irritate the skin.

Bathing for skin barrier repair and regulation

Regular, gentle bathing helps remove irritants and dead skin cells so the skin barrier can work to repair itself.
Soak in lukewarm water for 10 to 15 minutes, which is long enough to rehydrate but not so long as to significantly weaken the skin barrier.
Apply moisturizer soon after bathing. Consider “soaking and smearing” where you soak affected areas, then cover them with ointment.
Even topical corticosteroids can be applied to wet skin, immediately after baths, to help capture moisture while also improving medication delivery.
For additional benefits, incorporate occasional bleach baths. While most people think bleach baths help skin because they’re antibacterial and antifungal, the greater benefit may actually be in their anti-inflammatory properties and ability to help balance skin pH.

Treatment

Curexema

Application: Immediately after patting your skin dry, apply Curexema to the affected areas. Using it while the skin is still slightly damp can help lock in moisture.
Amount: Use enough cream to cover the affected areas with a thin, even layer.
Massage: Gently massage the cream into your skin until it is fully absorbed. Pay extra attention to particularly dry or irritated spots.
Frequency: Apply Curexema twice daily, in the morning and before bedtime, or as directed by a healthcare professional.

Let Curexema absorb into the skin for a few minutes before dressing or applying wet wraps.
Wear cotton gloves over your hands while you sleep to help lock in the moisturizer and prevent scratching.

Protection

Mediment

Preparation: Ensure the skin is clean before applying Mediment.
Application: Apply a thin layer of Mediment to the severely dry or irritated areas.
Amount: Use just enough to cover the affected area with a thin, protective barrier.
Spread: Gently spread the ointment without rubbing it in thoroughly, allowing it to form a semi-occlusive barrier.
Frequency: Use Mediment as needed throughout the day, especially when skin feels excessively dry or irritated or after exposure to harsh environmental conditions.
Particular Areas: Pay special attention to areas prone to excessive dryness and irritation, such as elbows, knees, and hands.

Additional tips

bleach

Data suggests mild bleach and water solution can decrease inflammation, itching and potentially the amount of Staphylococcus aureus bacteria on the skin, which can lead to skin infections in eczema.

Use a half-cup of household bleach for a full tub of water, one-quarter cup for a half tub.
Soak up to 10 minutes, then rinse off.
Some healthcare providers suggest doing these two to three times per week.

People with bleach sensitivities or allergic asthma that might be aggravated by chlorine fumes should consult with their healthcare provider before starting bleach bath therapy.
Don't use excessively hot or cold water
Don't add any other products or ingredients to the bath
Don't soak for longer than 15 minutes
Don't submerge your head or face under the water

Cremedify

Curexema

Mediment

The Dermaplan Eczema Treatment Pack is an integrated skin care regimen designed specifically for individuals with eczema, psoriasis, atopic dermatitis, and those prone to dry, itching skin. This comprehensive treatment pack combines the power of three synergistic products to provide deep moisturization, strengthen the skin's natural barrier, and promote rapid healing of irritated and damaged skin.

This pack delivers a multi-faceted approach to skincare, featuring advanced technologies such as Intelligent Lipid Bilayer and Dual Lipid Bilayer. By mimicking the skin's natural protective layers, these technologies provide long-lasting hydration, regulate water loss, and strengthen and regenerate the skin's natural barrier.

The treatment pack harnesses the benefits of a rich blend of ingredients, including ceramides, essential fatty acids, cholesterol, and niacinamide, known for their ability to repair and maintain the epidermal barrier. Additional ingredients such as DuraQuench IQ SA, Medilan, and a variety of moisturizing agents like white soft paraffin, jojoba oil, and shea butter work in harmony to soothe and nourish the skin, alleviating symptoms of redness, excessive dryness, cracking, and scaling.

Suitable for the entire family, including infants and the elderly, the Dermaplan Eczema Treatment Pack is formulated with purity, tolerance, and efficacy in mind, ensuring that even the most sensitive skin can benefit from its healing properties. Whether part of a daily skincare routine or as a targeted treatment for flare-ups, this pack offers a holistic solution to managing and relieving the challenges of eczema-prone skin.

Dermaplan™

Eczema Prone Treatment pack

$72.17

$80.00

4.7 / 5.0 from 24 reviews

irritated skin

Inflammation

Rough texture

Dry skin

products included

SHIPPING

Shipping Guarantee: Guiding you to healthy skin isn’t only about our products; it's also about getting them to you as swiftly as the science behind them. That's why Dermal Health offers a shipping guarantee you can rely on.
Where We Ship From: Orders are dispatched from our facilities in USA and Australia, tailored to your shipping address for optimal efficiency.
Who We Ship With: We trust only well-known, popular, and dependable courier services with your packages.
When You'll Get It: Expect confident skin soon! Shipping addresses in the USA and Australia will enjoy delivery within 1-4 business days. International orders will receive their orders from 6 to 25 business days, depending on the service you select during checkout. Your estimated delivery date will reflect during checkout so that you can mark your calendar.
Tracking Your Order: Eager to start your DermExcel journey? We don't blame you! You'll receive a tracking number after you place your order so that you can follow your package.

For any shipping inquiries, our customer service team is ready to assist.

RETURNS

Dermal Health Science 30-Day Confidence Guarantee: We are passionate about guiding you to healthy skin through medical science. We believe in the quality and effectiveness of our products so much that we offer a 30-Day Confidence Guarantee.

If you're unsatisfied with your purchase, simply return it within 30 days for a full refund.

Healthy Skin Is Not Complicated and neither is our return policy. Please visit our detailed return policy or contact our friendly customer service team for more information.

Feel as confident in us as we want you to feel in your skin.

SECURE PAYMENT

Dermal Health Science Secure Payment Promise: We utilize cutting-edge encryption and security measures to ensure your payment details remain as unblemished as your skin.

Our Secure Payment Promise backs every transaction with DermExcel. We partner with trusted payment providers to create the best shopping experience for you.

Simple. Effective. Ethical. That's not just our skincare philosophy but our approach to your security too.

Free Gifts with Eczema Prone Treatment pack:

Travel bag

Microfibre face towel

Eczema Prone Treatment pack

$72.17

$80.00

Eczema / Dermatitis

products in your treatment pack

cleanse

Dermaplan™

Cremedify

$26.00

4.7 / 5.0 from 24 reviews

SIZE: 400 mL

Allergies

irritated skin

Inflammation

Ichthyosis

Eczema

An Emollient-Rich and Lipid-Replenishing Body Cream Cleanser for Ichthyosis, Eczema, Psoriasis, and Other Dry Skin Conditions. It contains Intelligent Lipid Bilayer technology that forms a double structural layer on the skin's surface to regulate water loss, strengthen and regenerate the skin's natural barrier and ensure long-lasting hydration. The essential fatty acids in the non-foaming Cremedify formula supports the compromised epidermal barrier and improves overall skin health.

Emollients

Physiological Effects

Hydration of Stratum Corneum: Emollients increase moisture content in the stratum corneum, the outermost layer of the skin, by reducing transepidermal water loss (TEWL). This is achieved through occlusion, which traps water in the skin.
Restoration of Skin Barrier Function: They aid in replenishing the skin's lipid barrier, which is essential for maintaining skin integrity and protective function.
Soothing and Smoothing Effects: Emollients smooth, flaky skin cells, making the skin surface appear smoother. They also provide a soothing effect, which can reduce itching and discomfort.
Anti-inflammatory Properties: Some emollients have ingredients that offer mild anti-inflammatory benefits, helping to reduce redness and irritation.

Role in Managing Dermatological Conditions

Atopic Dermatitis (Eczema): Emollients are a cornerstone in the management of eczema, helping to maintain skin hydration, reduce flare-ups, and minimize the need for topical corticosteroids.
Psoriasis: Regular use of emollients can reduce scaling and dryness associated with psoriasis, improving the efficacy of other topical treatments.
Ichthyosis and Xerosis: These conditions, characterized by dry, scaly skin, benefit significantly from emollients, which help hydrate and soften the skin.
Aging Skin: Emollients improve the appearance of aging skin by hydrating and reducing the visibility of fine lines and wrinkles.
Skin Protection: Emollients can protect the skin from irritation and breakdown in individuals with incontinence or those who are bedridden.

References

Proksch, E., & Lachapelle, J. M. (2005). The Management of Dry Skin with Topical Emollients. American Journal of Clinical Dermatology.
Lynde, C. W. (2001). Moisturizers: What They Are and a Practical Approach to Product Selection. Skin Therapy Letter.
Lodén, M. (2003). Role of Topical Emollients and Moisturizers in the Treatment of Dry Skin Barrier Disorders. American Journal of Clinical Dermatology.

Humectants

Physiological Effects

Moisture Attraction: Humectants draw moisture from the environment and the deeper layers of the skin to the outer layer (stratum corneum), enhancing skin hydration.
Enhancing Skin Barrier Function: By improving skin hydration, humectants help to maintain and improve the skin's barrier function, protecting against irritants and reducing transepidermal water loss (TEWL).
Skin Elasticity and Appearance: Improved hydration can enhance skin elasticity and reduce the appearance of fine lines and wrinkles, giving the skin a plumper and smoother look.
Soothing Effect: Humectants can have a soothing effect on the skin, particularly in conditions involving dryness or irritation.

Role in Managing Dermatological Conditions

Dry Skin (Xerosis): Humectants are key ingredients in many moisturizers and are highly effective in managing dry skin by providing and maintaining hydration.
Eczema and Dermatitis: Their moisturizing and soothing properties help in relieving symptoms of eczema and dermatitis, such as dryness, itching, and irritation.
Aging Skin: Humectants are used in anti-aging skincare products due to their ability to hydrate the skin and improve its appearance.
Psoriasis: They can aid in reducing the dryness and scaling associated with psoriasis.
Acne-Prone Skin: Certain humectants can be beneficial in acne treatments, as they provide necessary hydration without clogging pores.

References

Lodén, M. (2005). Role of Topical Emollients and Moisturizers in the Treatment of Dry Skin Barrier Disorders. American Journal of Clinical Dermatology.
Rawlings, A. V., & Canestrari, D. A. (2011). Moisturizer technology versus clinical performance. Dermatologic Therapy.
Fluhr, J. W., Darlenski, R., & Surber, C. (2008). Glycerol and the skin: holistic approach to its origin and functions. British Journal of Dermatology.

Glycerin

Glycerin, also known as glycerol, is a simple polyol compound widely used in dermatology due to its excellent moisturizing properties.

Glycerin's excellent hydrating properties, combined with its ability to soothe and improve skin barrier function, make it a highly valued ingredient in treating and managing various dermatological conditions, particularly those involving dryness and compromised skin barrier.

Physiological Effects

Hydration: Glycerin is a humectant that attracts water to the skin. It draws moisture from the environment and the deeper layers of the skin to the outer layer (stratum corneum), improving hydration.
Skin Barrier Function: By enhancing skin hydration, glycerin helps to maintain and improve the skin's barrier function, protecting against irritants and reducing transepidermal water loss (TEWL).
Soothing Effect: Its soothing effect on the skin can reduce irritation and discomfort in various skin conditions.
Elasticity and Resilience: Glycerin can improve skin elasticity and resilience, making the skin appear healthier and more supple.
Wound Healing: Some studies suggest that glycerin may accelerate wound healing processes and improve skin repair.

Role in Managing Dermatological Conditions

Dry Skin Conditions (Xerosis): Glycerin is a key ingredient in many moisturizers and is highly effective in managing dry skin by providing deep hydration.
Eczema and Dermatitis: Its moisturizing and soothing properties help relieve the symptoms of eczema and dermatitis, such as dryness, itching, and irritation.
Psoriasis: Glycerin can aid in reducing the dryness and scaling associated with psoriasis.
Aging Skin: It is beneficial in anti-aging products because it hydrates the skin and improves its elasticity.
Wound Care: Glycerin-based products may be used to treat minor wounds and burns due to their potential role in enhancing wound healing.

References

Fluhr, J. W., Darlenski, R., & Surber, C. (2008). Glycerol and the skin: holistic approach to its origin and functions. British Journal of Dermatology.
Harding, C. R. (2004). The stratum corneum: structure and function in health and disease. Dermatologic Therapy.
Lodén, M. (2005). Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. American Journal of Clinical Dermatology.

Niacinamide

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.

Physiological Effects

Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.

Role in Managing Dermatological Conditions

Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
Aging Skin: Niacinamide targets wrinkles and loss of firmness.
Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.

References

Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.

Essential Fatty Acids

Essential Fatty Acids: Nourishing Your Skin from Within

Pharmacological Advantages

Physiological Harmony

Biochemical Brilliance

References

Elias, P. M. et al. (2008). Skin diseases associated with decreased epidermal lipogenesis. Annals of the New York Academy of Sciences, 1141(1), 1-13.
Ziboh, V. A. et al. (2000). Biochemical basis of the essential fatty acid requirement for normative growth in neonatal baboons. American Journal of Clinical Nutrition, 71(1), 3-11.
Serhan, C. N. (2014). Pro-resolving lipid mediators are leads for resolution physiology. Nature, 510(7503), 92-101.
Levesque, A. et al. (2018). Omega-3 fatty acids: Anti-inflammatory and skin barrier benefits. Omega-3 Fatty Acids: Keys to Nutritional Health, 303-315.
Nicolaou, A. (2013). Eicosanoids in skin inflammation. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 88(1), 131-138.
Meydani, S. N. et al. (2018). Nutrition interventions in aging and age-associated diseases. Annals of the New York Academy of Sciences, 1418(1), 34-51.

Learn more on Cremedify

repair & moisturize

Dermaplan™

Curexema

$25.00

4.7 / 5.0 from 24 reviews

SIZE: 400 mL

Ichthyosis

Eczema

Inflammation

Rough texture

Dry skin

Intense multi-lamellar moisturizing complex for extreme dry skin conditions, including eczema, dermatitis, psoriasis, and ichthyosis. Curexema replenishes the skin's essential lipids for optimal dry skin recovery. Powered by advanced Dual Lipid Bilayer Technology, Curexema creates a double structural layer on the skin's surface, expertly regulating water loss and reinforcing the skin's natural barrier. Curexema also provides essential energy for skin cell repair, reduces inflammation, and restores the skin's structural integrity.

Lipid Bilayer Technology

Lipid bilayer technology in dermatology focuses on mimicking and reinforcing the skin's natural lipid barrier, which is vital for maintaining skin health and integrity.

Physiological Effects

Reinforcement of Skin Barrier: Lipid bilayer technology aims to replicate the skin's natural barrier, particularly beneficial for damaged or compromised skin. This reinforcement helps in reducing transepidermal water loss (TEWL) and enhancing skin hydration.
Restoration of Lipid Composition: It helps in replenishing the essential lipids that are often deficient in certain skin conditions, thereby restoring the skin's natural protective barrier.
Improvement in Skin Texture and Hydration: By restoring the lipid bilayer, this technology improves skin texture and overall hydration, leading to healthier, more resilient skin.
Reduction of Inflammation and Irritation: It can help in reducing inflammation and irritation, particularly in conditions where the skin barrier is compromised.

Role in Managing Dermatological Conditions

Atopic Dermatitis (Eczema): Lipid bilayer technology is particularly beneficial in managing eczema, as it helps in restoring the deficient skin barrier function, reducing dryness, and controlling flare-ups.
Psoriasis: In psoriasis, where the skin barrier is also disrupted, this technology aids in hydrating the skin and reducing scaling.
Aging Skin: The aging skin, which naturally loses lipids over time, benefits from lipid bilayer technology as it helps in maintaining skin hydration and elasticity.
Dry Skin Conditions (Xerosis, Ichthyosis): Enhancing the skin’s lipid content can significantly improve symptoms of dryness and scaling in these conditions.
Sensitive Skin: For sensitive skin types, lipid bilayer technology can provide a gentle and effective way to strengthen the skin barrier without causing irritation.

References

Del Rosso, J. Q., & Levin, J. (2011). The Clinical Relevance of Maintaining the Functional Integrity of the Stratum Corneum in both Healthy and Disease-affected Skin. Journal of Clinical and Aesthetic Dermatology.
Rawlings, A. V., & Harding, C. R. (2004). Moisturization and Skin Barrier Function. Dermatologic Therapy.
Man, M. Q., Xin, S. J., Song, S. P., Cho, S. Y., Zhang, X. J., Tu, C. X., ... & Elias, P. M. (2009). Variation of Skin Surface pH, Sebum Content and Stratum Corneum Hydration with Age and Gender in a Large Chinese Population. Skin Pharmacology and Physiology.

Niacinamide

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.

Physiological Effects

Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.

Role in Managing Dermatological Conditions

Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
Aging Skin: Niacinamide targets wrinkles and loss of firmness.
Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.

References

Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.

Ceramides

Physiological Effects

Barrier Function: Ceramides are critical components of the skin's lipid barrier. They help to prevent moisture loss and protect against environmental aggressors like pollutants and irritants.
Hydration: By maintaining the barrier integrity, ceramides keep the skin hydrated, preventing dryness and keeping the skin supple.
Reducing Skin Sensitivity: They play a role in reducing skin sensitivity and irritation, helping to calm inflamed and reactive skin.
Anti-aging Properties: Ceramides can improve skin elasticity and firmness, helping to reduce the appearance of fine lines and wrinkles.
Wound Healing: There is evidence to suggest that ceramides can aid in the skin's natural wound healing process.

Role in Managing Dermatological Conditions

Eczema and Atopic Dermatitis: Ceramides are often used in the treatment of eczema and atopic dermatitis, where the skin barrier is compromised, leading to dryness, itching, and inflammation.
Psoriasis: They can help in managing psoriasis by maintaining skin hydration and barrier function, reducing scaling and dryness.
Aging Skin: Ceramide-containing products are beneficial in anti-aging regimens due to their ability to improve skin barrier function and elasticity.
Dry Skin (Xerosis): In the treatment of dry skin, ceramides help in restoring skin hydration and barrier function.
Sensitive Skin: Products containing ceramides are suitable for sensitive skin as they help to restore the skin's natural barrier and reduce irritation.

References

Del Rosso, J. Q., & Levin, J. (2011). The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. Journal of Clinical and Aesthetic Dermatology.
Farwanah, H., Wohlrab, J., Neubert, R. H. H., & Raith, K. (2005). Ceramides and skin function. American Journal of Clinical Dermatology.
Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato-Venereologica.

d-Panthenol

Physiological Effects

Hydration: d-Panthenol is a humectant, meaning it helps to attract and retain moisture in the skin. This leads to increased skin hydration, which can improve skin softness and elasticity.
Wound Healing and Repair: It plays a role in the synthesis of lipids and proteins, essential for skin repair. d-Panthenol has been shown to accelerate re-epithelialization in wound healing.
Anti-Inflammatory Effect: d-Panthenol can reduce inflammation, making it beneficial in treating skin irritations and erythema.
Skin Barrier Strengthening: By enhancing the synthesis of lipids and proteins, d-Panthenol contributes to the strengthening of the skin's barrier function, protecting against irritants and environmental damage.
Soothing and Softening: It soothes the skin and makes it feel softer and smoother, which can be particularly beneficial for dry or rough skin textures.

Role in Managing Dermatological Conditions

Minor Wounds and Skin Irritations: Due to its role in skin repair and anti-inflammatory properties, d-Panthenol is used in the treatment of minor wounds, cuts, and skin irritations.
Dermatitis and Eczema: It helps in managing conditions like dermatitis and eczema by reducing inflammation and enhancing skin barrier function.
Dry Skin Conditions (Xerosis): Its moisturizing properties make it effective in treating dry skin, providing relief from itching and scaling.
Post-procedure Care: d-Panthenol is often used in post-procedure care, such as after laser treatments or chemical peels, to aid in skin recovery and reduce inflammation.

References

Proksch, E., & Nissen, H. P. (2002). Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation. Journal of Dermatological Treatment.
Ebner, F., Heller, A., Rippke, F., & Tausch, I. (2002). Topical use of dexpanthenol in skin disorders. American Journal of Clinical Dermatology.
Camargo, F. B. Jr, Gaspar, L. R., & Maia Campos, P. M. B. G. (2011). Skin moisturizing effects of panthenol-based formulations. Journal of Cosmetic Science.

Medilan™

Physiological Effects

Emollient: Medilan™ is an excellent emollient, helping to soften and smooth the skin by retaining moisture. It creates an occlusive barrier, which reduces transepidermal water loss (TEWL).
Moisturizing: It is highly effective in moisturizing dry and rough skin, enhancing skin hydration by trapping and sealing in moisture.
Hypoallergenic: Medilan™ is ultra-purified to minimize the risk of allergic reactions, making it suitable for sensitive skin types.
Wound Healing: Medilan™ aids in the healing process of minor cuts, abrasions, and burns by maintaining a moist wound environment.
Skin Barrier Function: It enhances the skin's barrier function, protecting against environmental irritants and reducing the risk of skin infections.
Lipid Replenishment: Medilan™ mimics the lipids found in human skin, helping to restore the lipid barrier of the skin, especially beneficial in dry and chapped skin conditions.
Skin Penetration and Hydration: It can penetrate the skin and aid in water retention in the stratum corneum, the outermost layer of the skin, thus enhancing hydration.
Occlusive Properties: Medilan™ helps reduce transepidermal water loss by forming a barrier on the skin surface, thereby retaining moisture and improving skin barrier function.

Role in Managing Dermatological Conditions

Eczema and Dry Skin Conditions: Medilan™ is a valuable ingredient in treating eczema and other dry skin conditions due to its soothing, hydrating, and occlusive properties.
Wound Healing: While primarily used for its emollient effects, the properties of Medilan™ also aid in healing minor wounds and skin irritations.
Sensitive Skin Care: Its hypoallergenic nature makes it suitable for sensitive skin, reducing the risk of irritation or allergic reactions.
Nipple Care in Breastfeeding: Soothes and heals cracked and sore nipples in breastfeeding mothers.
Chapped Lips and Skin: It effectively treats chapped lips and skin, providing a barrier that seals in moisture and protects from harsh weather conditions.

References

Lodén, M., & Maibach, H. I. (2000). Dry skin and moisturizers: chemistry and function. CRC Press.
Suleman, H., et al. (2000). Role of lanolin in managing eczema and dry skin conditions. Community Nurse.
DiNardo, J. C. (2000). Is lanolin allergy a myth? Dermatitis.
Stone, L. (2000). Medilan: a hypoallergenic lanolin for emollient therapy. British Journal of Nursing.
ResearchGate Article on Medilan™ highlighting its role in skin care and emollient therapy.

Learn more on Curexema

targeted treatment

Dermaplan™

Mediment

$26.00

4.7 / 5.0 from 24 reviews

SIZE: 100 mL

Ichthyosis

Eczema

Inflammation

Rough texture

Dry skin

A lipid-replenishing ointment expertly crafted to repair and strengthen the skin's natural protective barrier. It provides instant relief and lasting nourishment to irritated and compromised skin associated with eczema, contact dermatitis, ichthyosis, rashes, and other dry skin conditions. Mediment is a versatile skincare solution that is safe and effective for the entire family, from infants to the elderly.

Essential Fatty Acids

Essential Fatty Acids: Nourishing Your Skin from Within

Pharmacological Advantages

Physiological Harmony

Biochemical Brilliance

References

Elias, P. M. et al. (2008). Skin diseases associated with decreased epidermal lipogenesis. Annals of the New York Academy of Sciences, 1141(1), 1-13.
Ziboh, V. A. et al. (2000). Biochemical basis of the essential fatty acid requirement for normative growth in neonatal baboons. American Journal of Clinical Nutrition, 71(1), 3-11.
Serhan, C. N. (2014). Pro-resolving lipid mediators are leads for resolution physiology. Nature, 510(7503), 92-101.
Levesque, A. et al. (2018). Omega-3 fatty acids: Anti-inflammatory and skin barrier benefits. Omega-3 Fatty Acids: Keys to Nutritional Health, 303-315.
Nicolaou, A. (2013). Eicosanoids in skin inflammation. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 88(1), 131-138.
Meydani, S. N. et al. (2018). Nutrition interventions in aging and age-associated diseases. Annals of the New York Academy of Sciences, 1418(1), 34-51.

Emollients

Physiological Effects

Hydration of Stratum Corneum: Emollients increase moisture content in the stratum corneum, the outermost layer of the skin, by reducing transepidermal water loss (TEWL). This is achieved through occlusion, which traps water in the skin.
Restoration of Skin Barrier Function: They aid in replenishing the skin's lipid barrier, which is essential for maintaining skin integrity and protective function.
Soothing and Smoothing Effects: Emollients smooth, flaky skin cells, making the skin surface appear smoother. They also provide a soothing effect, which can reduce itching and discomfort.
Anti-inflammatory Properties: Some emollients have ingredients that offer mild anti-inflammatory benefits, helping to reduce redness and irritation.

Role in Managing Dermatological Conditions

Atopic Dermatitis (Eczema): Emollients are a cornerstone in the management of eczema, helping to maintain skin hydration, reduce flare-ups, and minimize the need for topical corticosteroids.
Psoriasis: Regular use of emollients can reduce scaling and dryness associated with psoriasis, improving the efficacy of other topical treatments.
Ichthyosis and Xerosis: These conditions, characterized by dry, scaly skin, benefit significantly from emollients, which help hydrate and soften the skin.
Aging Skin: Emollients improve the appearance of aging skin by hydrating and reducing the visibility of fine lines and wrinkles.
Skin Protection: Emollients can protect the skin from irritation and breakdown in individuals with incontinence or those who are bedridden.

References

Proksch, E., & Lachapelle, J. M. (2005). The Management of Dry Skin with Topical Emollients. American Journal of Clinical Dermatology.
Lynde, C. W. (2001). Moisturizers: What They Are and a Practical Approach to Product Selection. Skin Therapy Letter.
Lodén, M. (2003). Role of Topical Emollients and Moisturizers in the Treatment of Dry Skin Barrier Disorders. American Journal of Clinical Dermatology.

Occlusives

Physiological Effects

Moisture Retention: Occlusives reduce transepidermal water loss (TEWL) by creating a physical barrier over the skin, which traps moisture and prevents its evaporation, thereby keeping the skin hydrated.
Skin Barrier Enhancement: They help in enhancing the skin's natural barrier function, protecting against environmental irritants and harmful substances.
Soothing Effect: By preventing water loss and protecting the skin, occlusives can have a soothing effect, particularly on dry, irritated, or compromised skin.
Improved Skin Texture: Regular use of occlusive agents can lead to improved skin texture, making the skin appear smoother and softer.

Role in Managing Dermatological Conditions

Dry Skin Conditions (Xerosis): Occlusives are essential in the management of dry skin, helping to maintain hydration and reduce scaliness and itching.
Eczema and Atopic Dermatitis: They are commonly used in the treatment of eczema and atopic dermatitis to hydrate the skin and reduce symptoms like itching and inflammation.
Psoriasis: In psoriasis, occlusives can help in managing scaling and dryness, and are often used in combination with other topical treatments.
Wound Healing: Occlusives can be used in wound care to maintain a moist environment, which is conducive to healing.
Prevention of Irritant Contact Dermatitis: They protect the skin from irritants, especially in individuals with occupational exposures to harsh chemicals or frequent hand washing.

References

Rawlings, A. V., & Harding, C. R. (2004). Moisturization and skin barrier function. Dermatologic Therapy.
Lodén, M. (2003). Role of Topical Emollients and Moisturizers in the Treatment of Dry Skin Barrier Disorders. American Journal of Clinical Dermatology.
Proksch, E., & Lachapelle, J. M. (2005). The Management of Dry Skin with Topical Emollients. American Journal of Clinical Dermatology.

Humectants

Physiological Effects

Moisture Attraction: Humectants draw moisture from the environment and the deeper layers of the skin to the outer layer (stratum corneum), enhancing skin hydration.
Enhancing Skin Barrier Function: By improving skin hydration, humectants help to maintain and improve the skin's barrier function, protecting against irritants and reducing transepidermal water loss (TEWL).
Skin Elasticity and Appearance: Improved hydration can enhance skin elasticity and reduce the appearance of fine lines and wrinkles, giving the skin a plumper and smoother look.
Soothing Effect: Humectants can have a soothing effect on the skin, particularly in conditions involving dryness or irritation.

Role in Managing Dermatological Conditions

Dry Skin (Xerosis): Humectants are key ingredients in many moisturizers and are highly effective in managing dry skin by providing and maintaining hydration.
Eczema and Dermatitis: Their moisturizing and soothing properties help in relieving symptoms of eczema and dermatitis, such as dryness, itching, and irritation.
Aging Skin: Humectants are used in anti-aging skincare products due to their ability to hydrate the skin and improve its appearance.
Psoriasis: They can aid in reducing the dryness and scaling associated with psoriasis.
Acne-Prone Skin: Certain humectants can be beneficial in acne treatments, as they provide necessary hydration without clogging pores.

References

Lodén, M. (2005). Role of Topical Emollients and Moisturizers in the Treatment of Dry Skin Barrier Disorders. American Journal of Clinical Dermatology.
Rawlings, A. V., & Canestrari, D. A. (2011). Moisturizer technology versus clinical performance. Dermatologic Therapy.
Fluhr, J. W., Darlenski, R., & Surber, C. (2008). Glycerol and the skin: holistic approach to its origin and functions. British Journal of Dermatology.

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