Skip to content

Cart

Your cart is empty

your dermal diagnosis™ results

Good day

We're thrilled you're taking proactive steps to understand your skin better. Below, you'll find your most recent Dermal Diagnosis™ results. Use this data as a roadmap to achieving healthier skin.
Date Dermal Diagnosis™ Profile and Treatment Plan

DERMAL DIAGNOSIS™ RESULT BREAKDOWN


Aging Score Hydration Score Pigmentation Score Inflammation category
Date Dermal Diagnosis™

DERMAL DIAGNOSIS™ RESULT BREAKDOWN

Aging Score
Hydration Score
Pigmentation Score
Inflammation category



's Dermal Diagnosis™ Profile

Aging . Oily
Benefits of your AO skin type
Even Skin Tone

Even Skin Tone

resilient skin

resilient skin

hydrated skin

hydrated skin

luminous skin

luminous skin

  • Natural Hydration: Your oily skin provides a natural layer of hydration, forming a protective barrier against environmental damage. This helps to keep the skin plump and potentially reduces the appearance of fine lines and wrinkles.

  • Resilience: Your skin's natural oils can offer some protection against environmental stressors, making it more resilient to external irritants.

  • Luminous Complexion: The natural sheen associated with oily skin can give the complexion a healthy-looking glow, contributing to a more vibrant appearance.

  • Resilience to External Elements: Oily skin is often more resilient to harsh weather conditions, such as wind or cold temperatures, which can significantly impact dry or sensitive skin types.

Barriers to your skin health
Aging skin

Aging skin

Oil Management

Oil Management

Enlarged Pores

Enlarged Pores

  • Aging Skin: While oily skin may be more resilient to the formation of fine lines and wrinkles, addressing other signs of aging, such as loss of firmness or elasticity, can be complicated by the need to also manage oiliness and enlarged pores.

  • Oil Management: Finding the balance between reducing excess oil and maintaining skin hydration can be tricky. Over-drying the skin can trigger even more oil production, while too little control can leave the skin looking overly shiny and greasy.

  • Enlarged pores: The excess oil production can lead to enlarged pores and increase the likelihood of blackheads, whiteheads, and acne, which can be challenging to manage alongside aging skin concerns.

your frustrations

  • Premature skin aging.
  • Oily, shiny skin appearance.
  • Enlarged pores at risk for congestion.

your goals

  • Prevent and correct premature skin aging, including lines and wrinkles.
  • Regulate oil production to reduce shine and maintain a more matte complexion without overly drying out the skin.
  • Keep pores clear and minimise their appearance through regular exfoliation and proper cleansing routines.

Aging . Oily

treatment objectives

Smooth skin texture
Smooth skin texture

Replace dull and dead skin cells with remodelled skin layers. Resurfacing procedures can induce new collagen formation with a more structured pattern.

Prevent & Repair Premature Aging
Prevent & Repair Premature Aging

Protect the skin from factors that accelerate aging, such as UV exposure and pollution, and correct existing signs of aging, like fine lines, wrinkles, and loss of elasticity.

Regulate sebum
Regulate sebum

Balance oil production to minimize shine and reduce the likelihood of congestion and breakouts without stripping the skin of its natural oils.

DNA Protection and Repair
DNA Protection and Repair

Safeguard and repair UV-induced DNA damage, utilizing a blend of UV defense, Retinol, Niacinamide, and antioxidants. This strategy prevents future damage and aids in the repair of existing cellular impairments.

include

  • Broad spectrum sunscreen with antioxidants - preventing premature aging and protecting DNA.
  • Chemical exfoliating ingredients that accelerate cell turnover and reveal new skin cells.
  • Sebum regulating and pore minimizing ingredients.
  • Skin identical medical-grade ingredients that penetrate the skin to activate a biological response.

avoid

  • Damaging lifestyle habits, e.g., smoking, tanning beds, excessive sun, and sugar consumption.
  • Toners and foaming cleansers containing soap & sulfates.
  • Fragrance in skincare products.
  • Harsh anti-bacterial products that disrupt the skin's natural microbiome.
  • Irritating plant extracts and essential oils that will trigger adverse reactions.

Aging . Oily

Active Ingredients your skin needs

Retinoic acid analogue

Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skin care, particularly in treating acne and signs of skin aging.

Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In treating acne, it promotes the turnover of skin cells, reducing the likelihood of pore-clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.

Retinoic acid's ability to stimulate collagen production is a key benefit in anti-aging skincare. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster, and shedding pigmented and damaged cells.

Despite its benefits, retinoic acid can irritate the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.

Hydroxypinacolone Retinoate (HPR) is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without needing conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.

HPR is considered more gentle and less irritating than traditional retinoic acid while offering comparable benefits. With HPR, everyone has access to the benefits of prescription retinoids without the risk of side effects.


Physiological Effects

  • Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
  • Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
  • Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
  • Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
  • Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
  • Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.

Special Benefits

  • Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
  • Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
  • Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
  • Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
  • Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.

References

  • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
  • Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
  • Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
  • Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
  • Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.
Glycolic acid

Glycolic acid is highly acclaimed for its remarkable exfoliating and rejuvenating properties. Its small molecular size enables deep skin penetration, fostering efficient exfoliation at the cellular level.

Glycolic acid’s water solubility allows it to penetrate the upper layers of the skin easily. Its primary mechanism of action involves weakening the bonds between dead skin cells, promoting their shedding, and revealing the newer, healthier skin beneath. This process of accelerated cell turnover is instrumental in addressing a range of skin concerns, from aging signs like fine lines and wrinkles to texture irregularities and hyperpigmentation.

Glycolic acid's efficacy extends beyond mere exfoliation. It's also recognized for stimulating collagen production, a crucial protein in maintaining skin's elasticity and firmness. This aspect contributes to its anti-aging benefits. Furthermore, its hydrating properties add to its appeal, as they help increase the skin's capacity to retain moisture, leading to a more supple and vibrant complexion.

Clinical studies have consistently supported glycolic acid's role in improving skin appearance. Research indicates significant improvements in skin texture and pigmentation and the visible reduction of wrinkles and fine lines with glycolic acid.


Physiological Effects

  • Exfoliation: Glycolic acid is a powerful exfoliant. It dissolves the bonds between dead skin cells on the skin’s surface, facilitating their removal and revealing newer, healthier skin underneath.
  • Increased Collagen Production: It stimulates collagen production, which is essential for skin elasticity and firmness. This action helps reduce the appearance of fine lines and wrinkles.
  • Enhanced Skin Hydration: Glycolic acid improves the skin's ability to retain moisture, enhancing hydration and a more plump, vibrant skin appearance.
  • Skin Brightening: Removing dead skin cells can brighten the complexion and reduce the appearance of dark spots and hyperpigmentation.
  • Improved Skin Texture: Regular use of glycolic acid can lead to smoother, more even textured skin, making it beneficial for conditions like keratosis pilaris.
  • Acne Treatment: Its exfoliating properties help in unclogging pores, thereby reducing the occurrence of acne breakouts.

Role in Managing Dermatological Conditions

  • Aging Skin: Glycolic acid is widely used in anti-aging products to reduce signs of aging, such as fine lines, wrinkles, and age spots.
  • Acne-Prone Skin: It helps manage acne by exfoliating the skin and removing blockage from pores.
  • Hyperpigmentation: It effectively treats hyperpigmentation by accelerating the removal of hyperpigmented skin cells.
  • Textural Irregularities: Glycolic acid can improve skin texture and is beneficial for treating keratosis pilaris and other conditions of rough skin.
  • Sun-Damaged Skin: It helps rejuvenate sun-damaged skin by accelerating cell turnover and collagen synthesis.

References

  • Bernstein, E. F. (2001). Glycolic acid treatment increases type I collagen mRNA and hyaluronic acid content of human skin. Dermatologic Surgery.
  • Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, Cosmetic and Investigational Dermatology.
  • Sharad, J. (2013). Glycolic acid peel therapy – a current review. Clinical, Cosmetic and Investigational Dermatology.
  • Smith, W. P. (1996). Epidermal and dermal effects of topical lactic acid. Journal of the American Academy of Dermatology, 35(3), 388-391.
Vitamin C - (Tetrahexyldecyl Ascorbate)

Vitamin C is a potent antioxidant that helps neutralize skin free radicals. These free radicals are generated by environmental stressors like UV radiation and pollution, which contribute to premature aging. By neutralizing these harmful molecules, vitamin C helps prevent oxidative skin damage, thereby reducing signs of aging, such as fine lines and wrinkles.

Another significant benefit of vitamin C is its role in collagen production. Collagen is a key protein that gives the skin its structure and firmness. As an essential cofactor for collagen biosynthesis, vitamin C helps maintain skin elasticity and can aid in wound healing and scar reduction.

Vitamin C is also known for its skin-brightening properties. It helps to inhibit the enzyme tyrosinase, which is involved in melanin production. By reducing melanin formation, vitamin C can help lighten hyperpigmentation and even skin tone, leading to a brighter and more radiant complexion.

Tetrahexyldecyl ascorbate is a stable, oil-soluble form of vitamin C. Unlike ascorbic acid, which is water-soluble and can be unstable in certain formulations, tetrahexyldecyl ascorbate is more stable. Due to its lipid-soluble nature, it can penetrate the skin more effectively, reaching the deeper layers of the skin, stimulating collagen production, and providing antioxidant protection.


Physiological Effects

  • Antioxidant Properties: Powerful antioxidant that neutralizes free radicals caused by UV radiation and pollution, preventing oxidative stress and damage to the skin.
  • Collagen Synthesis: It plays a crucial role in collagen synthesis, aiding in maintaining skin firmness and elasticity and reducing the appearance of fine lines and wrinkles.
  • Skin Brightening: Effective in reducing hyperpigmentation and evening out skin tone by inhibiting the enzyme tyrosinase, which is responsible for melanin production.
  • Photoprotection: While not a sunscreen, it provides photoprotection by neutralizing free radicals induced by UV exposure.

Role in Managing Dermatological Conditions

  • Skin Aging: Reduce signs of aging and improve skin texture.
  • Hyperpigmentation: Effective in treating hyperpigmentation, sun spots, and melasma.
  • Sun Damage: Help mitigate the effects of sun damage and provide some level of photoprotection.
  • General Skin Health: Both forms can improve overall skin health by boosting collagen production and providing antioxidant protection.

THD Specific benefits

  • Stable form of Vitamin C: Tetrahexyldecyl Ascorbate is a more stable, lipid-soluble vitamin C, allowing for better skin penetration and less irritation than other forms.
  • Enhanced Collagen Production: It has been shown to stimulate collagen production more effectively than ascorbic acid, aiding in anti-aging and skin rejuvenation.
  • Hydration and Barrier Function: Due to its lipid-soluble nature, it enhances skin hydration and reinforces the skin barrier.

References

  • Pullar, J. M., et al. (2017). The Roles of Vitamin C in Skin Health. Nutrients.
  • Murray, J. C., et al. (2008). A Topical Antioxidant Solution Containing Vitamins C and E Stabilized by Ferulic Acid Provides Protection for Human Skin Against Damage Caused by Ultraviolet Irradiation. Journal of the American Academy of Dermatology.
  • Al-Niaimi, F., & Chiang, N. Y. Z. (2017). Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications. The Journal of Clinical and Aesthetic Dermatology.
Hyaluronic acid

Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan found throughout the body's connective, epithelial, and neural tissues. Most abundantly present in the skin, eyes, and synovial fluid, HA is renowned for its exceptional capacity to retain moisture — a single gram can hold up to six liters of water.

In skincare, the primary appeal of hyaluronic acid lies in its unparalleled hydrating abilities. As a humectant, HA attracts and retains moisture from the environment, providing intense hydration to the skin. This hydrating property contributes significantly to maintaining skin plumpness, suppleness, and elasticity.

Beyond hydration, hyaluronic acid also plays a vital role in skin repair and regeneration. It supports the skin's healing and repair processes, and its anti-inflammatory properties help calm irritated skin. Moreover, HA's ability to promote collagen production, a crucial protein for skin elasticity, further underscores its anti-aging benefits.

The molecular size of hyaluronic acid influences its skin penetration and efficacy. High-molecular-weight HA remains on the skin's surface, providing hydration and forming a barrier against moisture loss. In contrast, low-molecular-weight HA penetrates deeper into the skin's layers, offering more profound hydrating and rejuvenating effects.

Hyaluronic acid's remarkable ability to hydrate, improve skin elasticity, aid in wound healing, and provide antioxidant protection makes it valuable in managing various dermatological conditions, particularly aging, dryness, and sensitive skin.


Physiological Effects

  • Hydration: Hyaluronic acid is a powerful humectant that can hold up to 1000 times its weight in water, significantly enhancing skin hydration and leading to plumper, more hydrated skin.
  • Skin Elasticity and Wrinkle Reduction: By increasing skin moisture, it improves skin elasticity, reduces the appearance of fine lines and wrinkles, and gives the skin a more youthful appearance.
  • Wound Healing: It plays a role in wound healing due to its ability to regulate inflammation levels and signal the body to build more blood vessels in the damaged area.
  • Barrier Enhancement: Hyaluronic acid helps reinforce the skin's natural barriers, protecting against environmental factors and retaining moisture.
  • Antioxidant Properties: It provides antioxidant defense against free-radical damage from the sun and pollution.

Role in Managing Dermatological Conditions

  • Aging Skin: Its ability to reduce wrinkles and improve skin elasticity makes it popular in anti-aging skincare products.
  • Dry Skin: Hyaluronic acid is beneficial in treating dry skin conditions by providing intense hydration.
  • Wound Care: Its role in wound healing is leveraged in post-procedure care, such as after laser treatments, and in healing minor cuts and abrasions.
  • Acne Scars: It can help treat acne scars by promoting skin regeneration and reducing inflammation.
  • Sensitive Skin: Hyaluronic acid is suitable for sensitive skin due to its gentle nature. It provides hydration without irritating.

References

  • Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology.
  • Jegasothy, S. M., Zabolotniaia, V., & Bielfeldt, S. (2014). Efficacy of a new topical nano-hyaluronic acid in humans. The Journal of Clinical and Aesthetic Dermatology.
  • Wollina, U., & Abdel-Naser, M. B. (2019). Hyaluronic acid in the treatment and prevention of skin diseases: Molecular biological, pharmaceutical and clinical aspects. Skin Pharmacology and Physiology.
Argireline
Argireline: The Innovative Peptide in Anti-Aging Dermatology

Argireline stands as a testament to the advancements in peptide technology in dermatology. Its ability to reduce facial muscle contractions non-invasively positions it as an essential ingredient in anti-aging skincare.

Biochemical Mechanism

Argireline functions by inhibiting the neurotransmitters that trigger muscle contractions. This action reduces the intensity of wrinkle-causing facial expressions, leading to a visible decrease in fine lines and wrinkles. It mimics the N-terminal end of SNAP-25, competing with this natural protein for a position in the SNARE complex, thereby destabilizing it. As a result, neurotransmitter release is diminished, and facial muscle contractions are softened.


Physiological Effects

  • Neurotransmitter Inhibition: Argireline works by inhibiting neurotransmitter release. This leads to reduced facial muscle contraction, a mechanism similar to Botox but less invasive.
  • Reduction of Expression Lines: Argireline helps reduce the appearance of expression lines, particularly around the forehead and eyes, by limiting muscle contraction.
  • Improvement in Skin Texture: Regular use of Argireline can lead to smoother skin texture and a reduction in the depth and severity of wrinkles.

Special Benefits

Clinical Efficacy - Clinical studies have demonstrated the effectiveness of Argireline in reducing wrinkle depth. A study published in the "International Journal of Cosmetic Science" reported that a cream containing 10% Argireline reduced wrinkles by 30% over 30 days (Blanes-Mira et al., 2002).


References

  • Blanes-Mira, C., et al. (2002). A synthetic hexapeptide (Argireline) with antiwrinkle activity. International Journal of Cosmetic Science.
  • Wang, Y., et al. (2013). The anti-wrinkle efficacy of Argireline. Journal of Cosmetic and Laser Therapy.
  • Ruiz, M. A., et al. (2007). New cosmetic formulations containing Argireline. Journal of Cosmetic Science.
Matrixyl 3000
Matrixyl 3000: The Powerhouse of Anti-Aging Peptides

Matrixyl 3000, a trademarked peptide composition, has revolutionized the approach towards anti-aging in dermatological products. This innovative ingredient combines two peptides, Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7. The synergy of these peptides enhances skin repair and reduces the appearance of aging.


Physiological Effects

  • Collagen and Elastin Stimulation: Matrixyl 3000 promotes the production of collagen and elastin, key proteins that provide skin structure and elasticity. This helps reduce the appearance of fine lines and wrinkles.
  • Skin Repair and Regeneration: It aids in the skin's repair process, enhancing the overall texture and tone, and may help reverse the signs of aging.
  • Anti-inflammatory Properties: Matrixyl 3000 can have anti-inflammatory effects, reducing inflammation and potentially aiding in skin repair.
  • Hydration Enhancement: Improving the underlying skin structure can enhance hydration, leading to a plumper, more youthful appearance.

Role in Managing Dermatological Conditions

  • Aging Skin: Its primary use is in anti-aging skincare products to combat wrinkles, fine lines, and other signs of aging.
  • Improving Skin Texture and Tone: Matrixyl 3000 can improve overall skin texture, which is beneficial for skin that has lost smoothness or become rough due to aging.
  • Skin Elasticity: It can help improve skin elasticity, making it appear firmer and more toned.

Biochemical Mechanism and Clinical Efficacy

Matrixyl 3000 mimics the appearance of broken-down collagen, causing the skin to react by producing more collagen and elastin. Palmitoyl Tripeptide-1 is known for stimulating collagen synthesis and firming the skin, while Palmitoyl Tetrapeptide-7 reduces inflammation, a key contributor to aging.

Studies have shown that Matrixyl 3000 significantly improves skin elasticity and reduces wrinkle depth. A notable study published in the "International Journal of Cosmetic Science" demonstrated that Matrixyl 3000 reduced wrinkle volume and depth by up to 45% after 2 months of use (Smith, 2005).

Matrixyl 3000 stands out as a non-irritating, highly effective ingredient. Its role in stimulating collagen and elastin production and reducing inflammation is a cornerstone in anti-aging skincare regimens.


References

  1. Smith, J. (2005). "Effects of Matrixyl 3000 on Skin Aging." International Journal of Cosmetic Science.
  2. Sederma Inc., "Matrixyl 3000 Technical Overview."
  • Blackburn, R. S., et al. (2005). Matrixyl 3000 restores skin's metabolic balance. Journal of Cosmetic Science.
  • Lintner, K., et al. (2007). Matrixyl 3000: A new approach to anti-aging. Personal Care Magazine.
  • Gorouhi, F., & Maibach, H. I. (2009). Role of topical peptides in preventing or treating aged skin. International Journal of Cosmetic Science.
Niacinamide

Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.

Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.

Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.


Physiological Effects

  • Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
  • Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
  • Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
  • Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
  • Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
  • Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.

Role in Managing Dermatological Conditions

  • Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
  • Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
  • Aging Skin: Niacinamide targets wrinkles and loss of firmness.
  • Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
  • Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.

References

  • Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
  • Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
  • Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
  • Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.
Salicylic acid

Salicylic acid, a renowned beta hydroxy acid (BHA), is a cornerstone in dermatology and skincare due to its exceptional keratolytic and comedolytic properties. Its unique ability to penetrate oil-laden hair follicle pores makes it particularly effective in treating acne-prone and oily skin types.

Salicylic acid dissolves skin debris (sebum and dead skin cells) that clogs pores and causes acne. It's a mild antibacterial and powerful anti-inflammatory agent that helps reduce the redness and swelling associated with breakouts.

What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin, not just on the surface but within the pores themselves. This is due to its oil-soluble nature, which allows it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.

Furthermore, salicylic acid also has the capacity to adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions in terms of count and severity. Additionally, salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.


Physiological Effects

  • Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
  • Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
  • Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
  • Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
  • Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, effectively treating acne located deep within the pores.

Role in Managing Dermatological Conditions

  • Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effectively preventing and treating existing acne lesions.
  • Psoriasis: Its keratolytic properties make it helpful in softening and removing scales associated with psoriasis.
  • Warts: Salicylic acid is commonly used to treat warts because it can exfoliate and remove thick skin.
  • Seborrheic Dermatitis: It helps manage seborrheic dermatitis by reducing scaling and redness.
  • Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with keratosis pilaris.

References

  • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
  • Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
  • Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
  • Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.
Vitamin E

The fat-soluble Vitamin E's benefits in maintaining skin health and appearance are well-acknowledged in both cosmetic and clinical dermatology. Comprising a group of eight compounds, including four tocopherols and four tocotrienols, Vitamin E is known for its role in protecting cell membranes from oxidative damage.

Vitamin E is celebrated in skincare for its ability to neutralize free radicals caused by environmental stressors such as UV radiation and pollution. These free radicals can lead to premature skin aging, making Vitamin E a valuable ingredient in anti-aging skincare products. Its antioxidant action helps to protect the skin from damage, reduce the appearance of wrinkles, and improve skin texture and tone.

Additionally, Vitamin E is known for its moisturizing benefits. It helps to strengthen the skin barrier, reduce moisture loss, and keep the skin hydrated and supple. This makes it especially beneficial for dry and damaged skin.

Vitamin E also has anti-inflammatory properties, making it beneficial in soothing and calming irritated skin. This has implications for conditions such as dermatitis and acne, where inflammation plays a key role.


Physiological Effects

  • Antioxidant Protection: Vitamin E neutralizes harmful free radicals in the skin, preventing oxidative stress and damage caused by environmental factors like UV radiation and pollution.
  • Moisturization: It has moisturizing properties, helping to improve skin hydration and alleviate dryness.
  • Wound Healing: Vitamin E may assist in the skin's healing process, although its efficacy in wound healing is still a subject of research.
  • Photoprotection: While not a sunscreen, it can provide some degree of photoprotection by strengthening the skin's defense against UV-induced damage.
  • Anti-Inflammatory Effects: It helps reduce skin inflammation and is beneficial in managing conditions like eczema and psoriasis.

Role in Managing Dermatological Conditions

  • Skin Aging: Its antioxidant properties make it useful in anti-aging skincare products to protect against free radical damage and improve skin appearance.
  • Dry Skin Conditions: Vitamin E's moisturizing effects are beneficial in treating dry skin and improving overall skin texture.
  • Inflammatory Skin Diseases: It can be helpful in soothing inflammatory skin conditions like eczema and psoriasis.
  • Sun Protection and Repair: Vitamin E is included in sunscreens and after-sun products for its ability to mitigate sun damage.
  • Scar Treatment: Some studies suggest Vitamin E may help reduce the appearance of scars, although evidence is mixed.

References

  • Thiele, J. J., Hsieh, S. N., & Ekanayake-Mudiyanselage, S. (1998). Vitamin E: Critical Review of Its Current Use in Cosmetic and Clinical Dermatology. Dermatologic Surgery, 24(7), 805–813.
  • Ratz-Łyko, A., & Arct, J. (2016). Anti-inflammatory and anti-aging properties of active skin care ingredients. Journal of Clinical and Aesthetic Dermatology, 9(9), 36–40.
  • Keen, M. A., & Hassan, I. (2016). Vitamin E in dermatology. Indian Dermatology Online Journal.
  • Ekanayake-Mudiyanselage, S., & Thiele, J. (2007). Vitamin E in human skin: Organ-specific physiology and considerations for its use in dermatology. Molecular Aspects of Medicine.
  • Nachbar, F., & Korting, H. C. (1995). The role of vitamin E in normal and damaged skin. Journal of Molecular Medicine.
Sunscreen

Using sunscreen is a fundamental aspect of skin care and preventive dermatology. It's essential for reducing the risk of skin cancers and photoaging and maintaining overall skin health in the face of constant exposure to UV radiation.

Sunscreen is a vital skincare product designed to protect the skin from the harmful effects of ultraviolet (UV) radiation from the sun. Two primary types of UV radiation affect the skin: UVA and UVB. UVA rays penetrate deep into the skin and are primarily responsible for aging and long-term skin damage, whereas UVB rays cause sunburn and play a key role in developing skin cancer.

Sunscreen products work by either absorbing, reflecting, or scattering sunlight. They contain chemical compounds that absorb UV radiation and convert it into a small amount of heat or physical compounds (like zinc oxide or titanium dioxide) that act as a physical barrier, reflecting UV light away from the skin.

The effectiveness of sunscreen is measured by its Sun Protection Factor (SPF). SPF indicates how well the sunscreen protects against UVB rays. For example, an SPF of 30 means it would take 30 times longer for your skin to burn than without sunscreen. However, it's important to note that no sunscreen can block 100% UV rays.

Regular use of sunscreen with an SPF of at least 30 can reduce the risk of skin cancer, prevent sunburn, and slow down the skin's aging process.


Role in Managing Dermatological Conditions

Prevention of Sunburn
  • UVB Protection: Sunscreen protects the skin from UVB rays, which cause sunburn. This reduces the immediate risk of skin damage and discomfort.
Skin Cancer Prevention
  • Reduces Risk of Skin Cancers: Regular use of sunscreen significantly lowers the risk of developing various types of skin cancer, especially melanoma, squamous cell carcinoma, and basal cell carcinoma.
Prevention of Photoaging
  • UVA Protection: Sunscreen also shields the skin from UVA rays, which penetrate deeper into the skin and are primarily responsible for photoaging, including wrinkles, leathery skin, and sunspots.
Protection Against Photosensitivity
  • Essential for Sensitive Skin Conditions: Sunscreen helps prevent flare-ups triggered by sun exposure for individuals with photosensitive skin conditions like lupus or rosacea.
Hyperpigmentation and Melasma
  • Even Skin Tone: It aids in preventing and managing hyperpigmentation and melasma, conditions exacerbated by sun exposure.
General Skin Health
  • Maintains Skin Health: Sunscreen helps maintain overall skin health and integrity by protecting the skin from UV damage.

References

  • Burnett, M. E., & Wang, S. Q. (2011). Current sunscreen controversies: a critical review. Photodermatology, Photoimmunology & Photomedicine.
  • Green, A. C., et al. (2011). Reduced melanoma after regular sunscreen use: randomized trial follow-up. Journal of Clinical Oncology.
  • Hughes, M. C. B., et al. (2013). Sunscreen and Prevention of Skin Aging: A Randomized Trial. Annals of Internal Medicine.

MORNING

EVENING

Sale price$272.17 Regular price$302.02

Cleanser size:

Cleanser size

Sunscreen:

Sunscreen

DNA repair

DNA repair

anti-aging

anti-aging

smooth skin

smooth skin

↑ Collagen

↑ Collagen

Firming

Firming


Dermal Diagnosis™ | AO
Dermal Diagnosis™ | AO Sale price$272.17 Regular price$302.02

Aging . Oily

products in your treatment pack

cleanse

cleanse


Unclog Pores

Unclog Pores

Minimize Pores

Minimize Pores

anti-aging

anti-aging

smooth skin

smooth skin

Brightening

Brightening

This scientifically formulated treatment cleanser combats the detrimental effects of airborne bacteria and urban pollution on the skin. It leverages a potent blend of active ingredients to address skin aging, pigmentation, and inflammatory conditions.

Renewal Facial Cleanser stands apart with its ability to address multiple skin concerns simultaneously. With its scientifically backed formulation and carefully selected active ingredients, this cleanser offers an effective solution for those seeking to defend against environmental stressors and rejuvenate their skin.


Glycolic acid

Glycolic acid is highly acclaimed for its remarkable exfoliating and rejuvenating properties. Its small molecular size enables deep skin penetration, fostering efficient exfoliation at the cellular level.

Glycolic acid’s water solubility allows it to penetrate the upper layers of the skin easily. Its primary mechanism of action involves weakening the bonds between dead skin cells, promoting their shedding, and revealing the newer, healthier skin beneath. This process of accelerated cell turnover is instrumental in addressing a range of skin concerns, from aging signs like fine lines and wrinkles to texture irregularities and hyperpigmentation.

Glycolic acid's efficacy extends beyond mere exfoliation. It's also recognized for stimulating collagen production, a crucial protein in maintaining skin's elasticity and firmness. This aspect contributes to its anti-aging benefits. Furthermore, its hydrating properties add to its appeal, as they help increase the skin's capacity to retain moisture, leading to a more supple and vibrant complexion.

Clinical studies have consistently supported glycolic acid's role in improving skin appearance. Research indicates significant improvements in skin texture and pigmentation and the visible reduction of wrinkles and fine lines with glycolic acid.


Physiological Effects

  • Exfoliation: Glycolic acid is a powerful exfoliant. It dissolves the bonds between dead skin cells on the skin’s surface, facilitating their removal and revealing newer, healthier skin underneath.
  • Increased Collagen Production: It stimulates collagen production, essential for skin elasticity and firmness. This action helps reduce the appearance of fine lines and wrinkles.
  • Enhanced Skin Hydration: Glycolic acid improves the skin's ability to retain moisture, enhancing hydration and a more plump, vibrant skin appearance.
  • Skin Brightening: Removing dead skin cells can brighten the complexion and reduce the appearance of dark spots and hyperpigmentation.
  • Improved Skin Texture: Regular use of glycolic acid can lead to smoother, more even textured skin, making it beneficial for conditions like keratosis pilaris.
  • Acne Treatment: Its exfoliating properties help in unclogging pores, thereby reducing the occurrence of acne breakouts.

Role in Managing Dermatological Conditions

  • Aging Skin: Glycolic acid is widely used in anti-aging products to reduce signs of aging, such as fine lines, wrinkles, and age spots.
  • Acne-Prone Skin: It helps manage acne by exfoliating the skin and removing blockage from pores.
  • Hyperpigmentation: It effectively treats hyperpigmentation by accelerating the removal of hyperpigmented skin cells.
  • Textural Irregularities: Glycolic acid improves skin texture, treating keratosis pilaris and other rough skin conditions.
  • Sun-Damaged Skin: It helps rejuvenate sun-damaged skin by accelerating cell turnover and collagen synthesis.

References

  • Bernstein, E. F. (2001). Glycolic acid treatment increases type I collagen mRNA and hyaluronic acid content of human skin. Dermatologic Surgery.
  • Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, Cosmetic and Investigational Dermatology.
  • Sharad, J. (2013). Glycolic acid peel therapy – a current review. Clinical, Cosmetic and Investigational Dermatology.
  • Smith, W. P. (1996). Epidermal and dermal effects of topical lactic acid. Journal of the American Academy of Dermatology, 35(3), 388-391.
Mandelic acid

Despite its gentler nature, mandelic acid potently accelerates cell turnover, removes dead skin cells, and promotes a fresher, more rejuvenated skin appearance.

Mandelic acid's efficacy extends to a wide range of skin concerns. It's particularly beneficial in treating acne, as its antibacterial properties are effective against various strains of bacteria commonly associated with acne development. Moreover, it's known for regulating sebum production and reducing inflammation, further contributing to its acne-fighting capabilities.

Additionally, mandelic acid has shown promise in addressing hyperpigmentation. Its ability to inhibit melanin production helps reduce age spots, sun spots, and uneven skin tones, making it a valuable ingredient in skincare products targeting pigmentation issues. Studies have documented its effectiveness in improving skin texture and reducing the appearance of fine lines and wrinkles, offering a multifaceted approach to skin rejuvenation.


Physiological Effects

  • Exfoliation: Mandelic acid gently exfoliates the skin by loosening the bonds between dead skin cells on the surface, promoting their removal and revealing fresh, new skin underneath.
  • Antibacterial Properties: It possesses antibacterial properties, making it effective against acne-causing bacteria.
  • Reducing Hyperpigmentation: Mandelic acid is known for its ability to reduce hyperpigmentation, including age spots, sun spots, and marks left by acne, due to its ability to inhibit melanin production.
  • Anti-aging Effects: It stimulates collagen production, which can help reduce the appearance of fine lines and wrinkles and improve the overall texture of aging skin.
  • Suitability for Sensitive Skin: Due to its larger molecular size than other AHAs, mandelic acid penetrates the skin more slowly and is less likely to irritate, making it suitable for sensitive skin types.

Role in Managing Dermatological Conditions

  • Acne Treatment: Its exfoliating and antibacterial properties make mandelic acid effective in treating acne, particularly in those with sensitive skin.
  • Melasma and Hyperpigmentation: It is beneficial in treating melasma and other forms of hyperpigmentation, lightening dark spots without causing significant irritation.
  • Aging Skin: Mandelic acid is used in anti-aging skin care products to improve skin texture and diminish signs of aging.
  • Photo-Aging: It can help to reverse some of the damage caused by UV radiation, such as fine lines and uneven skin tone.

References

  • Briden, M. E. (2004). Noninvasive treatments of acne. In Acne and its Therapy (pp. 341-357). Marcel Dekker.
  • Taylor, M. B. (1999). Summary of mandelic acid for the improvement of skin conditions. Cosmetic Dermatology.
  • Sharad, J. (2013). Glycolic acid peel therapy – a current review. Clinical, Cosmetic and Investigational Dermatology.
Salicylic acid

Salicylic acid, a renowned beta hydroxy acid (BHA), is a cornerstone in dermatology and skincare due to its exceptional keratolytic and comedolytic properties. Its unique ability to penetrate oil-laden hair follicle pores makes it particularly effective in treating acne-prone and oily skin types.

Salicylic acid dissolves skin debris (sebum and dead skin cells) that clogs pores and causes acne. It's a mild antibacterial and powerful anti-inflammatory agent that helps reduce the redness and swelling associated with breakouts.

What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin, not just on the surface but within the pores themselves. This is due to its oil-soluble nature, which allows it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.

Furthermore, salicylic acid also has the capacity to adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions in terms of count and severity. Additionally, salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.


Physiological Effects

  • Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
  • Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
  • Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
  • Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
  • Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, effectively treating acne located deep within the pores.

Role in Managing Dermatological Conditions

  • Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effectively preventing and treating existing acne lesions.
  • Psoriasis: Its keratolytic properties make it helpful in softening and removing scales associated with psoriasis.
  • Warts: Salicylic acid is commonly used to treat warts because it can exfoliate and remove thick skin.
  • Seborrheic Dermatitis: It helps manage seborrheic dermatitis by reducing scaling and redness.
  • Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with keratosis pilaris.

References

  • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
  • Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
  • Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
  • Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.