DermRepair

Essential fatty acids (EFAs) offers a multifaceted approach to improving skin health in patients with conditions such as eczema and dry skin. 

Biochemical Brilliance

Essential fatty acids, including omega-3 and omega-6, are the building blocks of the skin's lipid barrier. This barrier acts as a protective shield, preventing excessive moisture loss and shielding the skin from external aggressors. EFAs play a pivotal role in maintaining this barrier's integrity by contributing to the synthesis of ceramides and lipids that bind skin cells together.

Pharmacological Advantages

EFAs are not only instrumental in maintaining the skin's structural integrity but also possess anti-inflammatory properties. They serve as precursors for pro-resolving lipid mediators like resolvins and protectins, which help reduce skin inflammation, itching, and redness—common symptoms of eczema.

Physiological Harmony

EFAs contribute to maintaining the balance of skin hydration. They enhance the skin's ability to retain water, leaving it supple and hydrated. Moreover, EFAs can modulate the skin's immune response, reducing the severity of allergic reactions and flare-ups often seen in dermatological conditions like eczema.

4-Ethoxybenzaldehyde is the first and only ingredient proven to inhibit the release of Prostaglandin E2 (PGE2).

Suppressing Prostaglandin E2 (PGE2) physiologically treats

• Inflammation
• Skin redness
• Skin aging

______

Prostaglandin E2 (PGE2) cause redness and inflammation

Prostaglandins are a group of physiologically active signalling molecules found in almost every tissue in humans.

• PGE2 is a potent inflammatory mediator leading to inflammation, pain, and cell injury.
• PGE2 exacerbates chronic inflammation and various autoimmune diseases.
• PGE2 exacerbates inflammation reactions by:

1. Inducing vascular hyperpermeability - the excessive leakage of fluid and proteins from blood vessels to the interstitial space.
2. Relaxing the vascular smooth muscle (causing vasodilatation). This process induces red flare, heat and swelling.

______

Prostaglandin E2 (PGE2) accelerate the skin aging process

• PGE2 inhibits collagen production.
• PGE2 induces matrix metallopeptidase 1 (MMP1) expression by fibroblasts. MMPs are responsible for degrading the extracellular matrix (ECM) proteins such as collagen, fibronectin, elastin, and proteoglycans, contributing to photoaging.

KEY BENEFITS

Medilan imitates many functions of human skin lipids, and it is nearly twice as effective as the physiological lipids in human skin.

Medilan™ has clinically proven safety and efficacy. It is designed to treat skin barrier impairment and severely compromised skin conditions such as rosacea, eczema, and psoriasis. Its exceptional purity surpasses monograph compliance and performs excellently in clinical trials.

In clinical trials, Medilan maintains skin hydration for up to 2 days after application and increases the rate of epidermal healing by 35% due to its ability to create a moist wound-healing environment. 

Medilan™ is hypoallergenic and delivers outstanding efficacy in dermatological applications. Studies have shown no allergic or irritant skin reactions to Medilan, even in severely compromised skin.

Lanolin's efficacy as a medical material and acceptance in the Pharmaceutical Industry is reflected in all major Pharmacopeia containing monographs on lanolin.

______

REPLENISHING ESSENTIAL LIPIDS

Medilan™ supplements the skin with the lipids essential to skin health.

Due to its chemical and physical similarity, it imitates and augments many of the skin's natural lipids.

______

REPAIRING THE SKIN’S NATURAL BARRIER

Medilan™ effectively accelerates the repair of the skin’s natural barrier function.

______

PROTECTING AGAINST MICROBIAL INFECTION

Medilan is proven to control a variety of microorganisms.

• Staphylococcus aureus is a gram-positive bacteria responsible for the infection that leads to inflammatory symptoms in eczema sufferers. Medilan has been proven to reduce colonies of this bacteria by 99% after 24 hours.
• Candidiasis is an overgrowth of yeast that leads to unpleasant symptoms, such as itching and soreness around the skin's mucous membranes. Medilan has been proven to reduce the levels of Candida albicans to a level that controls candidiasis symptoms.
• Pseudomonas aeruginosa is a gram-negative bacteria that can attack wound sites and lead to infection. Wound infection is common in immunocompromised individuals. Medilan has shown potent antibacterial effects against this organism.

Barrier Repair

Vitamin K strengthens the skin's natural barrier function, enabling it to grow stronger and retain hydration for longer. 

______

Anti-inflammatory

• Vitamin K inhibits the inflammation cascade and is, therefore, beneficial for conditions such as eczema and psoriasis. 
• Vitamin K acts as an anti-inflammatory by suppressing nuclear factor κB (NF-κB) signal transduction.
• Vitamin K protects against oxidative stress by blocking the generation of reactive oxygen species.

______

Wound Healing

Vitamin K is essential in the body's healing process as it is responsible for blood clotting and wound healing. 

______

Blood Vessel Repair

• Vitamin K improves and maintains blood vessel elasticity and vein integrity.
• Vitamin K can minimise broken capillaries under the skin and helps with varicose veins. Vitamin K produces a protein that lowers vascular proliferation and mineralisation, which can halt the development of varicose veins.
• Vitamin K has an important role in the 'mop-up' of extravasated breakdown products of blood – i.e. haemosiderin deposition. This is responsible for the change from reddish to the brownish colour of a bruise but also for the facilitation of the ultimate resolution in the aftermath of the bruising process.

______

Anti-aging

• Vitamin K is a coenzyme that works with Matrix γ-carboxyglutamic acid protein.
  This protein inhibits the calcification (hardening) of elastin. This calcification leads to an inflammatory process and is part of the aging process.
• In this action as a coenzyme, vitamin K keeps elastin (the soft connective tissue) from deterioration.

• Humectant. It allows the skin to retain moisture. It increases skin hydration, relieves dryness, and refreshes the skin’s surface.
• Emollient. Soften rough or dry patches on the skin.
• Anti-microbial. Help to protect the skin from harmful microorganisms.