DermExcel™ | Aging.Dry.Allergy Treatment Plan

your dermal diagnosis™ results

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We're thrilled you're taking proactive steps to understand your skin better. Below, you'll find your most recent Dermal Diagnosis™ results. Use this data as a roadmap to achieving healthier skin.

Date	Dermal Diagnosis™	Profile and Treatment Plan

DERMAL DIAGNOSIS™ RESULT BREAKDOWN

Aging Score	Hydration Score	Pigmentation Score	Inflammation category

Date	Dermal Diagnosis™

DERMAL DIAGNOSIS™ RESULT BREAKDOWN

Aging Score
Hydration Score
Pigmentation Score
Inflammation category

's Dermal Diagnosis™ Profile

Aging . Dry . Allergy

Your ADA skin type, characterized by aging, dryness, and heightened sensitivity due to allergies, likely intersects with atopic dermatitis. This condition underscores the need for a more nuanced skin care approach. It showcases your skin's unique vulnerabilities and demands strategies to strengthen and protect its integrity actively.

The dryness you experience is profound, reflecting a deeper issue with your skin's barrier function. This compromised barrier struggles to retain moisture and defend against environmental allergens and irritants. Such deficiencies intensify the dryness and heighten your skin's susceptibility to these external factors, frequently leading to inflammation, irritation, and sensitivity—all hallmarks of atopic dermatitis.

With ADA skin, aging is manifested not only through visible signs like fine lines, wrinkles, and diminished elasticity but also through your skin's ongoing health and resilience. These aging indicators require attention for their appearance and a deeper need for a regimen that holistically supports the skin’s barrier, enhancing its natural defenses and repair mechanisms to mitigate the impact of atopic dermatitis.

Though fraught with challenges, your ADA skin type also possesses the potential for significant resilience and improvement. It is crucial to embrace a skincare routine that meticulously addresses the particular demands of atopic dermatitis—focusing on intense moisturization, barrier repair, and anti-inflammatory ingredients. By adopting this targeted approach and integrating supportive lifestyle habits, you can guide your skin toward better health and vitality. This dedicated care allows your skin to manage its conditions and thrive, reflecting both your personal journey and the thoughtful attention you've dedicated to it.

benefits

barriers

goals

YOUR SKIN'S MAIN CHARACTERISTICS

Dehydration

Aging Skin

Rough Texture

Allergy Prone

Benefits of your ADA skin type

Even Skin Tone

no acne or rosacea

skincare awareness

No Pigmentation: Your skin likely maintains an even tone without the common issues of dark spots or uneven pigmentation. This indicates a balanced distribution of melanin, which, while beneficial for an even complexion, may suggest a need for extra protection against UV radiation due to lower melanin levels.
Less Prone to Acne and Inflammatory Conditions: Your skin type, due to its dry nature, is less likely to develop acne, which is commonly associated with excess oil production. Moreover, the absence of inflammatory conditions like rosacea can contribute to a more uniform complexion.
Heightened Awareness of Ingredients: Being allergy-prone makes you more vigilant about the ingredients in your skincare products. This heightened awareness can lead to more informed choices, reducing the risk of adverse reactions and promoting skin health.

Barriers to your skin health

Dehydrated Skin

Aging skin

Allergy Prone

Rough Skin Texture

Dehydration: ADA Skin Type struggles with maintaining adequate hydration. This is exacerbated by an impaired skin barrier that cannot effectively retain moisture, leading to trans-epidermal water loss (TEWL). Insufficient moisture makes The skin feel dry, tight, and uncomfortable.
Skin Aging: The natural aging process can be more pronounced in ADA Skin Types due to the dry nature of the skin and the potential for allergic reactions that may further stress the skin. Aging in this context is characterized by developing fine lines, wrinkles, and a loss of elasticity and firmness.
Allergy prone: Being prone to allergies means your skin may react more sensitively to various external factors, including certain skincare ingredients, environmental allergens, or dietary triggers. This can lead to redness, itching, and irritation, making it crucial to identify and avoid known allergens in your skincare and lifestyle.
Compromised Skin Barrier: The combination of aging, dehydration, and allergy-proneness suggests that the skin barrier may be compromised, making it more susceptible to irritants, pollutants, and pathogens. This can exacerbate dryness and sensitivity, making diligent skincare and protection essential.

your frustrations

Impaired and dehydrated skin barrier.
Visible signs of skin aging.
Rough skin texture.
Sensitive skin that reacts to various stimuli and products.
Skin prone to allergic reactions.

your goals

Restore hydration and moisture.
Strengthen skin barrier.
Smooth skin texture.
Reduce and prevent visible signs of skin aging.
No allergic skin reactions.

Aging . Dry . Allergy

treatment objectives

Allergy Management

Implement a skincare regimen that minimizes the risk of allergic reactions with hypoallergenic, fragrance-free, and non-irritating formulations.

Enhance Skin Texture

Employ mild resurfacing techniques that encourage collagen remodeling, improving skin resilience and reducing the appearance of fine lines and wrinkles.

Prevent & Repair Skin Aging

Address premature aging with ingredients that support skin renewal and repair DNA damage. Antioxidants can protect against oxidative stress, while peptides and retinoids can stimulate collagen production.

Skin Barrier Restoration

Repair and strengthen the skin's barrier function and enhance the production of natural barrier components like elastin and collagen to fortify the skin against allergens and environmental stressors.

Intensive Moisturization

Prioritize deep hydration to improve the skin's intrinsic ability to retain water and encourage the skin's production of natural moisturizing factors (NMFs) to sustain long-term hydration levels.

UV Protection

Ensure crucial sun protection, to shield the skin from UV-induced damage and premature aging.

include

Anti-inflammatory and anti-microbial agents.
Broad spectrum sunscreen with antioxidants - preventing premature aging and protecting DNA.
Chemical exfoliating ingredients that accelerate cell turnover and reveal new skin cells.
Effective barrier repair agents that restore your skin's natural barrier and prevent premature aging.
Skin-identical medical-grade ingredients that penetrate the skin to activate a biological response.

avoid

Damaging lifestyle habits, e.g., smoking, tanning beds, excessive sun, and sugar consumption.
Toners and foaming cleansers containing soap & sulfates.
Fragrance in skincare products.
Harsh anti-bacterial products that disrupt the skin's natural microbiome.
Irritating plant extracts and essential oils that will trigger adverse reactions.

Aging . Dry . Allergy

Active Ingredients your skin needs

Retinoic acid analogue

Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skin care, particularly in treating acne and signs of skin aging.

Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In treating acne, it promotes the turnover of skin cells, reducing the likelihood of pore-clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.

Retinoic acid's ability to stimulate collagen production is a key benefit in anti-aging skincare. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster, and shedding pigmented and damaged cells.

Despite its benefits, retinoic acid can irritate the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.

Hydroxypinacolone Retinoate (HPR) is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without needing conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.

HPR is considered more gentle and less irritating than traditional retinoic acid while offering comparable benefits. With HPR, everyone has access to the benefits of prescription retinoids without the risk of side effects.

Physiological Effects

Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.

Special Benefits

Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.

References

Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.

Azelaic acid

Azelaic acid, a naturally occurring dicarboxylic acid, is an effective ingredient in dermatological treatments, particularly for acne, rosacea, and hyperpigmentation, with antimicrobial and anti-inflammatory properties.

Physiological Effects

Anti-Inflammatory Properties: Azelaic acid reduces inflammation, effectively treating inflammatory skin conditions like acne and rosacea.
Antimicrobial Action: It possesses antimicrobial properties that target acne-causing bacteria (Propionibacterium acnes), helping to reduce acne outbreaks.
Keratolytic Effects: It helps unclog pores and reduce the formation of comedones (black and whiteheads) by normalizing the shedding of skin cells.
Depigmenting Agent: Azelaic acid effectively treats hyperpigmentation disorders, including melasma, as it inhibits tyrosinase, an enzyme involved in melanin production.

Role in Managing Dermatological Conditions

Acne: Azelaic acid inhibits the proliferation of acne-causing bacteria on the skin’s surface, thereby reducing bacterial growth and inflammation. Its antibacterial activity is primarily against Propionibacterium acnes, a key bacterium involved in the development of acne. Furthermore, azelaic acid helps unclog pores and reduce skin cell buildup, effectively treating mild to moderate acne.
Rosacea: Azelaic acid's anti-inflammatory action helps to reduce redness and swelling associated with rosacea. In addition, azelaic acid's ability to reduce keratinization (the process by which skin cells become more fibrous and less flexible) contributes to its effectiveness in this condition.
Pigmentation: Azelaic acid effectively treats melasma and post-inflammatory hyperpigmentation by inhibiting tyrosinase, an enzyme in melanin production. This helps to reduce the formation of excess pigment and can lead to a more even skin tone.

References

Fitton, A., & Goa, K. L. (1991). Azelaic Acid. Drugs.
Gollnick, H., & Schramm, M. (1998). Topical drug treatment in acne. Dermatology.
Passeron, T., et al. (2019). Melasma treatment: A novel approach using a topical agent that contains an anti-estrogen and a low-dose retinoid. G Ital Dermatol Venereol.
Wolf, J. E., Kerrouche, N., & Arsonnaud, S. (2006). Efficacy and safety of once-daily metronidazole 1% gel compared with twice-daily azelaic acid 15% gel in the treatment of rosacea. Cutis, 77(4 Suppl), 3-11.
Hollinger, J. C., Angra, K., & Halder, R. M. (2018). Are natural ingredients effective in the management of hyperpigmentation? A systematic review. The Journal of clinical and aesthetic dermatology, 11(2), 28.

Bakuchiol

Bakuchiol's mechanism of action is similar to retinol's; it stimulates collagen production and accelerates cell turnover, improving skin texture and tone. It also helps reduce the appearance of fine lines, wrinkles, and hyperpigmentation, making it an effective ingredient in anti-aging skincare products.

One of the key advantages of bakuchiol over traditional retinol is its gentleness on the skin. Retinol is known for potential side effects like dryness, redness, and irritation, particularly in sensitive skin or when used in high concentrations. Bakuchiol, however, is far less irritating. In addition to its anti-aging properties, bakuchiol exhibits antioxidant and anti-inflammatory properties, further contributing to its skin benefits. It helps protect the skin from oxidative stress and can soothe it, reducing redness and inflammation.

Bakuchiol's retinol-like effects and its antioxidant, anti-inflammatory, and antibacterial properties make it an effective ingredient for various skin concerns, especially for those seeking natural alternatives in anti-aging and acne treatment.

Physiological Effects

Retinol-like Function: Bakuchiol mimics the actions of retinol, stimulating collagen production. This helps reduce the appearance of fine lines and wrinkles and improves skin elasticity.
Antioxidant Properties: It offers antioxidant benefits, protecting the skin from oxidative stress and damage caused by environmental factors like UV radiation.
Anti-inflammatory Effects: Bakuchiol has anti-inflammatory properties, which can help soothe the skin and reduce redness and irritation.
Improved Skin Tone and Texture: Regular use of bakuchiol can improve skin tone and texture, making it smoother and more even.
Acne Management: Bakuchiol's antibacterial properties and ability to regulate sebum production make it effective in managing acne.

Role in Managing Dermatological Conditions

Aging Skin: Bakuchiol is popular in anti-aging skincare because it stimulates collagen production and reduces signs of aging.
Sensitive Skin: As a gentler alternative to retinol, it