DermExcel™ | Aging.Dry.Sensitive Treatment Plan

your dermal diagnosis™ results

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We're thrilled you're taking proactive steps to understand your skin better. Below, you'll find your most recent Dermal Diagnosis™ results. Use this data as a roadmap to achieving healthier skin.

Date	Dermal Diagnosis™	Profile and Treatment Plan

DERMAL DIAGNOSIS™ RESULT BREAKDOWN

Aging Score	Hydration Score	Pigmentation Score	Inflammation category

Date	Dermal Diagnosis™

DERMAL DIAGNOSIS™ RESULT BREAKDOWN

Aging Score
Hydration Score
Pigmentation Score
Inflammation category

's Dermal Diagnosis™ Profile

Aging . Dry . Sensitive

Your ADS Skin Type combines the unique challenges of Aging, Dryness, and Sensitivity, creating a delicate balance that requires thoughtful care. This type is marked not just by the visible signs of aging and dryness but also by sensory experiences of sensitivity, such as stinging, burning, or itching sensations that speak to the underlying vulnerability of your skin's nerve endings.

These sensations are not typically tied to allergic reactions but can be triggered by various factors, leading to discomfort and, in some instances, visible redness or inflammation. Each person's triggers can be different, so it is crucial to identify and avoid specific ingredients that may exacerbate these sensations. Common irritants include ascorbic acid, certain plant extracts, fragrances, alpha hydroxy acids, benzoic acid, and sodium lauryl sulfate.

Beyond sensitivity, your skin's dryness contributes to a feeling of tightness and a complexion that may appear dull, as dehydrated skin struggles to reflect light. This dryness and the natural aging process make your skin more prone to developing fine lines and wrinkles, highlighting the importance of hydration and gentle care.

Finding skincare products that cater to your ADS Skin Type without aggravating its sensitivities is vital. The proper regimen will provide the hydration and nourishment your skin craves, respect its delicate nature, and avoid harsh ingredients that can lead to discomfort.

Embracing a consistent skincare routine incorporating gentle, hydrating, and soothing products can transform your skin. Over time, it can help to repair the skin's barrier, improve moisture retention, and reduce sensitivity, leading to a more comfortable, radiant, and youthful appearance. The journey with ADS Skin Type is one of nurturing and understanding, with each step tailored to meet your skin's unique needs.

benefits

barriers

goals

YOUR SKIN'S MAIN CHARACTERISTICS

Aging skin

Sensitivity

Dehydration

↓ Barrier Function

Benefits of your ADS skin type

Even Skin Tone

no acne or rosacea

Reduced Oiliness

Even Skin Tone: ADS skin types often benefit from an even skin tone that can provide a smooth and uniform appearance.
Lower Risk of Acne: Due to the dry nature of your skin, there is typically a lower risk of acne breakouts than oilier skin types, as less sebum production can lead to clogged pores.
Reduced Oiliness: With dry skin, you're less likely to experience the issues associated with excess oil production, such as acne breakouts and a shiny complexion. This can result in a matte and even skin texture.

Barriers to your skin health

Aging skin

Sensitivity

Dehydrated Skin

↓ Barrier Function

Aging Skin: The natural aging process can lead to a decrease in collagen and elastin production, resulting in fine lines, wrinkles, and a loss of skin firmness and elasticity.
Sensitivity: Sensitive skin may react with stinging, burning, itching, or redness to various triggers, including certain skincare ingredients, environmental factors, and stress. This sensitivity can make finding suitable skincare products that do not exacerbate these symptoms challenging.
Dehydration: A lack of moisture is the hallmark of dry skin, which can lead to a compromised skin barrier. This makes it harder for your skin to retain water, leading to dehydration, flakiness, and a tight feeling.
Compromised Skin Barrier: Dry skin often signifies a weakened skin barrier, making it susceptible to external aggressors. This can increase sensitivity, irritation, and even conditions like eczema or dermatitis in severe cases.

your frustrations

Impaired and dehydrated skin barrier.
Premature skin aging.
Rough skin texture.
Sensitive skin that reacts to various stimuli and products.

your goals

No stinging, itching, burning, or other skin discomforts.
Prevention and correction of premature skin aging, including lines and wrinkles.
Protected, smooth and healed skin barrier.
Smooth skin texture.

Aging . Dry . Sensitive

treatment objectives

Smooth skin texture

Replace dull and dead skin cells with remodelled skin layers. Resurfacing procedures can induce new collagen formation with a more structured pattern.

Deeply Hydrate and Nourish

Advance the skin's hydration capabilities by boosting its capacity to attract and retain moisture at a cellular level. Promote the enhancement of the skin's own hydrating agents, ensuring sustained moisture balance and preventing dryness.

Skin Barrier Restoration

Repair damaged skin barrier and restore barrier function. Boost the protective skin layer by increasing the production of elastin, collagen, ceramides, and lipids.

Prevent & Repair Premature Aging

Protect the skin from factors that accelerate aging, such as UV exposure and pollution, and correct existing signs of aging, like fine lines, wrinkles, and loss of elasticity.

Reduce Inflammation

Alleviate inflammation and redness by restoring equilibrium to the skin's microbiome. Focus on creating a harmonious skin environment that supports healthy bacterial flora, essential for maintaining skin health and preventing breakouts.

DNA Protection and Repair

Safeguard and repair UV-induced DNA damage, utilizing a blend of UV defense, Retinol, Niacinamide, and antioxidants. This strategy prevents future damage and aids in the repair of existing cellular impairments.

include

Anti-inflammatory and anti-microbial agents.
Broad spectrum sunscreen with antioxidants - preventing premature aging and protecting DNA.
Chemical exfoliating ingredients that accelerate cell turnover and reveal new skin cells.
Effective barrier repair agents that restore your skin's natural barrier and prevent premature aging.
Skin-identical medical-grade ingredients that penetrate the skin to activate a biological response.

avoid

Damaging lifestyle habits, e.g., smoking, tanning beds, excessive sun, and sugar consumption.
Toners and foaming cleansers containing soap & sulfates.
Fragrance in skincare products.
Harsh anti-bacterial products that disrupt the skin's natural microbiome.
Irritating plant extracts and essential oils that will trigger adverse reactions.

Aging . Dry . Sensitive

Active Ingredients your skin needs

Retinoic acid analogue

Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skin care, particularly in treating acne and signs of skin aging.

Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In treating acne, it promotes the turnover of skin cells, reducing the likelihood of pore-clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.

Retinoic acid's ability to stimulate collagen production is a key benefit in anti-aging skincare. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster, and shedding pigmented and damaged cells.

Despite its benefits, retinoic acid can irritate the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.

Hydroxypinacolone Retinoate (HPR) is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without needing conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.

HPR is considered more gentle and less irritating than traditional retinoic acid while offering comparable benefits. With HPR, everyone has access to the benefits of prescription retinoids without the risk of side effects.

Physiological Effects

Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.

Special Benefits

Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.

References

Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.

Vitamin C - (Tetrahexyldecyl Ascorbate)

Vitamin C is a potent antioxidant that helps neutralize skin free radicals. These free radicals are generated by environmental stressors like UV radiation and pollution, which contribute to premature aging. By neutralizing these harmful molecules, vitamin C helps prevent oxidative skin damage, thereby reducing signs of aging, such as fine lines and wrinkles.

Another significant benefit of vitamin C is its role in collagen production. Collagen is a key protein that gives the skin its structure and firmness. As an essential cofactor for collagen biosynthesis, vitamin C helps maintain skin elasticity and can aid in wound healing and scar reduction.

Vitamin C is also known for its skin-brightening properties. It helps to inhibit the enzyme tyrosinase, which is involved in melanin production. By reducing melanin formation, vitamin C can help lighten hyperpigmentation and even skin tone, leading to a brighter and more radiant complexion.

Tetrahexyldecyl ascorbate is a stable, oil-soluble form of vitamin C. Unlike ascorbic acid, which is water-soluble and can be unstable in certain formulations, tetrahexyldecyl ascorbate is more stable. Due to its lipid-soluble nature, it can penetrate the skin more effectively, reaching the deeper layers of the skin, stimulating collagen production, and providing antioxidant protection.

Physiological Effects

Antioxidant Properties: Powerful antioxidant that neutralizes free radicals caused by UV radiation and pollution, preventing oxidative stress and damage to the skin.
Collagen Synthesis: It plays a crucial role in collagen synthesis, aiding in maintaining skin firmness and elasticity and reducing the appearance of fine lines and wrinkles.
Skin Brightening: Effective in reducing hyperpigmentation and evening out skin tone by inhibiting the enzyme tyrosinase, which is responsible for melanin production.
Photoprotection: While not a sunscreen, it provides photoprotection by neutralizing free radicals induced by UV exposure.

Role in Managing Dermatological Conditions

Skin Aging: Reduce signs of aging and improve skin texture.
Hyperpigmentation: Effective in treating hyperpigmentation, sun spots, and melasma.
Sun Damage: Help mitigate the effects of sun damage and provide some level of photoprotection.
General Skin Health: Both forms can improve overall skin health by boosting collagen production and providing antioxidant protection.

THD Specific benefits

Stable form of Vitamin C: Tetrahexyldecyl Ascorbate is a more stable, lipid-soluble vitamin C, allowing for better skin penetration and less irritation than other forms.
Enhanced Collagen Production: It has been shown to stimulate collagen production more effectively than ascorbic acid, aiding in anti-aging and skin rejuvenation.
Hydration and Barrier Function: Due to its lipid-soluble nature, it enhances skin hydration and reinforces the skin barrier.

References

Pullar, J. M., et al. (2017). The Roles of Vitamin C in Skin Health. Nutrients.
Murray, J. C., et al. (2008). A Topical Antioxidant Solution Containing Vitamins C and E Stabilized by Ferulic Acid Provides Protection for Human Skin Against Damage Caused by Ultraviolet Irradiation. Journal of the American Academy of Dermatology.
Al-Niaimi, F., & Chiang, N. Y. Z. (2017). Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications. The Journal of Clinical and Aesthetic Dermatology.

Aloe Vera

Aloe vera is well-regarded for its medicinal applications and has been a staple in skincare and health for centuries. It’s rich in vitamins, enzymes, minerals, and amino acids, contributing to its many skin benefits.

Aloe vera contains polysaccharides, which are crucial in its moisturizing and anti-inflammatory properties. These polysaccharides help bind moisture to the skin, making aloe vera an excellent hydrating agent for dry and damaged skin.

One of the key benefits of aloe vera is its soothing and healing properties, particularly beneficial for burns, abrasions, and skin irritations. It has been shown to accelerate the healing of minor burns and reduce skin inflammation. Various studies have supported its effectiveness in treating first- and second-degree burns, highlighting its role in enhancing collagen synthesis and skin regeneration.

Aloe vera's anti-inflammatory properties are attributed to compounds like glycoproteins and polysaccharides. These compounds help reduce pain and swelling associated with skin irritations and wounds. Aloe vera also contains aloin and emodin, which provide analgesic, antibacterial, and antiviral properties, further extending its therapeutic potential.

Aloe Vera has numerous physiological effects on the skin due to its rich composition of vitamins, enzymes, minerals, and amino acids. The presence of antioxidants such as vitamins C and E, along with beta-carotene, contributes to its anti-aging benefits, helping to improve skin firmness and keep the skin hydrated.

Physiological Effects

Moisturizing and Hydrating: Aloe Vera enhances skin hydration, making it effective for dry and dehydrated skin. Its mucopolysaccharides help to bind moisture into the skin.
Wound Healing: It accelerates wound healing by enhancing collagen synthesis and cross-linking. This effect is particularly useful in healing burns, abrasions, and cuts.
Anti-inflammatory Properties: Aloe Vera contains compounds like aloin and anthraquinones that have anti-inflammatory properties, making it beneficial in reducing skin inflammation.
Antimicrobial Activity: It possesses antimicrobial properties, which help in preventing infections in wounds and burns.
Antioxidant Properties: The presence of vitamins C and E and beta-carotene provides it with antioxidant properties, which can help protect the skin from free radical damage.
Soothing Effect: Aloe Vera is known for its soothing effects on the skin, particularly in conditions like sunburn.

Role in Managing Dermatological Conditions

Burns and Wound Care: Aloe Vera's wound-healing and soothing properties make it effective in treating burns, including sunburns and minor skin abrasions.
Acne Treatment: Due to its antimicrobial and anti-inflammatory properties, it can help treat acne.
Eczema and